Cited by 130Hemoglobin structure and functionReceptor Mechanisms and SignalingNitric Oxide and Endothelin Effects

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Soluble guanylate cyclase

Poulos, Thomas L·2006·Current Opinion in Structural Biology

DOI 10.1016/j.sbi.2006.09.006

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Abstract

Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep mechanism of sGC activation that involves at least two NO-binding sites. The crystal structure of a member of a recently discovered family of prokaryotic sGC homologues has provided important insights into structure-function relationships within the sGC family of proteins.

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Authors: Poulos, T. L.
Affiliations: University of California, Irvine (US)
Corresponding author: Poulos, Thomas L
ORCID: Poulos, Thomas L
Venue: Current Opinion in Structural Biology
Publisher: Elsevier BV
Published: 2006-12
Volume: 16
Issue: 6
Pages: 736-743
ISSN: 0959-440X (ISSN-L)
DOI: 10.1016/j.sbi.2006.09.006
OpenAlex: W2074306377
Cited by: 129
References: 29
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 9 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 14 · 2013: 10 · 2012: 12
FWCI: 0.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Structural Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: soluble guanylate cyclase, nitric oxide sensor, cyclic GMP, crystal structure, structure-function relationship, heme
MeSH terms: Animals, Enzyme Activation, Guanylate Cyclase, Heme, Kinetics, Ligands, Models, Molecular, Nitric Oxide, Prokaryotic Cells, Recombinant Proteins, Solubility, Signal Transduction, In Vitro Techniques

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