Cited by 210Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

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Endophenotypes in schizophrenia: A selective review

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Allen, Allyssa J., Griss, Mélina E., Folley, Bradley S., Hawkins, Keith A., Pearlson, Godfrey D.·2009·Schizophrenia Research

DOI 10.1016/j.schres.2009.01.016PMC PMC2665704

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Abstract

Background Given the wealth of data in the literature on schizophrenia endophenotypes, it is useful to have one source to reference their frequency data. We reviewed the literature on disease-liability associated variants in structural and functional magnetic resonance images (MRI), sensory processing measures, neuromotor abilities, neuropsychological measures, and physical characteristics in schizophrenia patients (SCZ), their first-degree relatives (REL), and healthy controls (HC). The purpose of this review was to provide a summary of the existing data on the most extensively published endophenotypes for schizophrenia.Methods We searched PubMed and MedLine for all studies on schizophrenia endophenotypes comparing SCZ to HC and/or REL to HC groups. Percent abnormal values, generally defined as >2 SD from the mean (in the direction of abnormality) and/or associated effect sizes (Cohen's d) were calculated for each study.Results Combined, the articles reported an average 39.4% (SD=20.7%; range=2.2-100%) of abnormal values in SCZ, 28.1% (SD=16.6%; range=1.6-67.0%) abnormal values in REL, and 10.2% (SD=6.7%; range=0.0-34.6%) in HC groups.Conclusions These findings are reviewed in the context of emerging hypotheses on schizophrenia endophenotypes, as well as a discussion of clustering trends among the various intermediate phenotypes. In addition, programs for future research are discussed, as instantiated in a few recent large-scale studies on multiple endophenotypes across patients, relatives, and healthy controls.

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Authors: Allen, A. J., Griss, M. E., Folley, B. S., Hawkins, K. A., & Pearlson, G. D.
Affiliations: Hartford Hospital (US)
Yale University (US)
Corresponding author: Allen, Allyssa J.
ORCID: Hawkins, Keith A.
Pearlson, Godfrey D.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2009-04
Volume: 109
Issue: 1-3
Pages: 24-37
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2009.01.016
PMC: PMC2665704
OpenAlex: W2102684787
Cited by: 210
References: 274
Citations by year: 2026: 5 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 16 · 2016: 15 · 2015: 21 · 2014: 20 · 2013: 21 · 2012: 29
FWCI: 2.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Korea Electrotechnology Research Institute
National Institute of Mental Health (MH074797, R01MH074797, R37MH043775, R01MH077945)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, endophenotypes
MeSH terms: Cognition Disorders, Family, Humans, Phenotype, Schizophrenia, Schizophrenic Psychology, Statistics as Topic, Biomarkers, Cluster Analysis

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Endophenotypes in schizophrenia: A selective review

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