Cited by 210Schizophrenia research and treatmentMental Health and PsychiatryNeurotransmitter Receptor Influence on Behavior

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Endophenotypes in schizophrenia: A selective review

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Allen, Allyssa J., Griss, Mélina E., Folley, Bradley S., Hawkins, Keith A., Pearlson, Godfrey D.·2009·Schizophrenia Research

DOI 10.1016/j.schres.2009.01.016PMC PMC2665704

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Abstract

Background Given the wealth of data in the literature on schizophrenia endophenotypes, it is useful to have one source to reference their frequency data. We reviewed the literature on disease-liability associated variants in structural and functional magnetic resonance images (MRI), sensory processing measures, neuromotor abilities, neuropsychological measures, and physical characteristics in schizophrenia patients (SCZ), their first-degree relatives (REL), and healthy controls (HC). The purpose of this review was to provide a summary of the existing data on the most extensively published endophenotypes for schizophrenia.Methods We searched PubMed and MedLine for all studies on schizophrenia endophenotypes comparing SCZ to HC and/or REL to HC groups. Percent abnormal values, generally defined as >2 SD from the mean (in the direction of abnormality) and/or associated effect sizes (Cohen's d) were calculated for each study.Results Combined, the articles reported an average 39.4% (SD=20.7%; range=2.2-100%) of abnormal values in SCZ, 28.1% (SD=16.6%; range=1.6-67.0%) abnormal values in REL, and 10.2% (SD=6.7%; range=0.0-34.6%) in HC groups.Conclusions These findings are reviewed in the context of emerging hypotheses on schizophrenia endophenotypes, as well as a discussion of clustering trends among the various intermediate phenotypes. In addition, programs for future research are discussed, as instantiated in a few recent large-scale studies on multiple endophenotypes across patients, relatives, and healthy controls.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
The file drawer problem and tolerance for null results.
Rosenthal, R. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.3.638 · Cited by 9,068
Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?
Neel, J. V. (1962) · Europe PMC (PubMed Central) · Cited by 3,172
Hudson et al.
Anderson, E. N. (1977) · eScholarship (California Digital Library) · Cited by 2,567
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356
Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?
(1962) · PubMed Central · Cited by 2,182
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800

Show all 274 references

Research works printed but not linked: 2

Altman, 1990, Neuropsychological test deficits are associated with smooth pursuit eye movement impairment in affective disorders but not in schizophrenia, International Journal of Clinical Neuropsychology, 12, 49
Lawrie, 1999, Magnetic resonance imaging of brain in people at high risk of developing schizophrenia [comment], Lancet, 353, 30, 10.1016/S0140-6736(98)06244-8 · DOI

Sorted by citations

Schizophrenia
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971
Schizophrenia, “just the facts” 4. Clinical features and conceptualization
Tandon, R., Nasrallah, H. A., & Keshavan, M. S. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.005 · Cited by 1,101
Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?
Kapur, S., Phillips, A. G., & Insel, T. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.105 · Cited by 980
Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia
Shepherd, A. M., Laurens, K. R., Matheson, S. L., Carr, V. J., & Green, M. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.015 · Cited by 412
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Meda, S. A., Gill, A., Stevens, M. C. G., Lorenzoni, R. P., Glahn, D. C., Calhoun, V. D., Sweeney, J. A., Tamminga, C. A., Keshavan, M. S., Thaker, G. K., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.025 · Cited by 273
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Self-citation
Research in people with psychosis risk syndrome: a review of the current evidence and future directions
Correll, C. U., Hauser, M., Auther, A. M., & Cornblatt, B. A. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02235.x · Cited by 204
Impact of Neurocognition on Social and Role Functioning in Individuals at Clinical High Risk for Psychosis
Carrión, R. E., Goldberg, T. E., McLaughlin, D., Auther, A. M., Correll, C. U., & Cornblatt, B. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10081209 · Cited by 184
Neuroimmune biomarkers in schizophrenia
Tomasik, J., Rahmoune, H., Guest, P. C., & Bahn, S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.025 · Cited by 158
Etiologic, Phenomenologic, and Endophenotypic Overlap of Schizophrenia and Bipolar Disorder
Pearlson, G. D. (2015) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032814-112915 · Cited by 154
Self-citation
Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task
Walter, H., Schnell, K., Erk, S., Arnold, C., Kirsch, P., Esslinger, C., Mier, D. U., Schmitgen, M. M., Rietschel, M., Witt, S. H., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.18 · Cited by 147
Individual differences in visual science: What can be learned and what is good experimental practice?
Mollon, J. D., Bosten, J. M., Peterzell, D. H., & Webster, M. A. (2017) · Vision Research · doi:10.1016/j.visres.2017.11.001 · Cited by 160
Criterios de valoración clínicos y de funcionamiento en un estudio de interacción gen-ambiente en primeros episodios psicóticos (PEPs)
Bernardo, M., Bioque, M., Parellada, M., Ruiz, J. S., Cuesta, M. J., LLerena, A., Sanjuán, J., Castro‐Fornieles, J., Arango, C., & Cabrera, B. (2012) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2012.11.001 · Cited by 113
The Major Histocompatibility Complex (MHC) in Schizophrenia: A Review
Mokhtari, R., & Lachman, H. M. (2016) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000479 · Cited by 117
Beyond the genome—Towards an epigenetic understanding of handedness ontogenesis
Schmitz, J., Metz, G. A. S., Güntürkün, O., & Ocklenburg, S. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.005 · Cited by 104
Revealing a Brain Network Endophenotype in Families with Idiopathic Generalised Epilepsy
Chowdhury, F. A., Woldman, W., FitzGerald, T. H. B., Elwes, R. D. C., Nashef, L. A. M., Terry, J. R., & Richardson, M. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110136 · Cited by 100
Assessing clinical and functional outcomes in a gene–environment interaction study in first episode of psychosis (PEPs)
Bernardo, M., Bioque, M., Parellada, M., Ruiz, J. S., Cuesta, M. J., LLerena, A., Sanjuán, J., Castro‐Fornieles, J., Arango, C., & Cabrera, B. (2012) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/j.rpsmen.2012.11.001 · Cited by 97
Smooth pursuit and visual occlusion: active inference and oculomotor control in schizophrenia
Adams, R. A., Perrinet, L. U., & Friston, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047502 · Cited by 91
COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation
Ira, E., Zanoni, M., Ruggeri, M., Dazzan, P., & Tosato, S. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120178 · Cited by 90
Components of Cross-Frequency Modulation in Health and Disease
Allen, E. A., Liu, J., Kiehl, K. A., Gelernter, J. E., Pearlson, G. D., Perrone‐Bizzozero, N. I., & Calhoun, V. D. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00059 · Cited by 90
Self-citation
Decreased left middle temporal gyrus volume in antipsychotic drug-naive, first-episode schizophrenia patients and their healthy unaffected siblings
Hu, M., Li, J., Eyler, L. T., Guo, X., Wei, Q., Tang, J., Liu, F., He, Z., Li, L., Jin, H., et al. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.12.018 · Cited by 88
Beyond the Broken Error-Related Negativity: Functional and Diagnostic Correlates of Error Processing in Psychosis
Foti, D., Kotov, R., Bromet, E. J., & Hajcak, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.007 · Cited by 85
Reimagining psychoses: An agnostic approach to diagnosis
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Self-citation
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Nanda, P., Tandon, N., Mathew, I. T., Giakoumatos, C. I., Abhishekh, H. A., Clementz, B. A., Pearlson, G. D., Sweeney, J. A., Tamminga, C. A., & Keshavan, M. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.018 · Cited by 80
Self-citation
Hippocampal–prefrontal connectivity as a translational phenotype for schizophrenia
Bähner, F., & Meyer‐Lindenberg, A. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.12.007 · Cited by 84
Animal models to improve our understanding and treatment of suicidal behavior
Gould, T. D., Georgiou, P., Brenner, L. A., Brundin, L., Can, A., Courtet, P., Donaldson, Z. R., Dwivedi, Y., Guillaume, S., Gottesman, I. I., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.50 · Cited by 85
Narrative identity in the psychosis spectrum: A systematic review and developmental model
Cowan, H. R., Mittal, V. A., & McAdams, D. P. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102067 · Cited by 82
Heterogeneity and symptom structure of schizophrenia
Picardi, A., Viroli, C., Tarsitani, L., Miglio, R., de Girolamo, G., Dell’Acqua, G., & Biondi, M. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.12.051 · Cited by 77
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Oerlemans, A. M., van der Meer, J. M. J., van Steijn, D. J., de Ruiter, S. W., de Bruijn, Y. G. E., de Sonneville, L. M. J., Buitelaar, J. K., & Rommelse, N. N. J. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0446-2 · Cited by 84
Neurological soft signs in non-psychotic first-degree relatives of patients with schizophrenia: A systematic review and meta-analysis
Chan, R. C. K., Xu, T., Heinrichs, R. W., Yu, Y., & Gong, Q. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.012 · Cited by 76
Auditory verbal hallucinations in schizophrenia correlate with P50 gating.
Smith, D., Grant, B., Fisher, D., Borracci, G., Labelle, A., & Knott, V. (2013) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.02.004 · Cited by 71
Motor Deficits in Schizophrenia Quantified by Nonlinear Analysis of Postural Sway
Kent, J. S., Hong, S. L., Bolbecker, A. R., Klaunig, M. J., Forsyth, J. K., O’Donnell, B. F., & Hetrick, W. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041808 · Cited by 73
Behavioral response inhibition in psychotic disorders: Diagnostic specificity, familiality and relation to generalized cognitive deficit
Ethridge, L. E., Soilleux, M., Nakonezny, P. A., Reilly, J. L., Hill, S. K., Keefe, R. S. E., Gershon, E. S., Pearlson, G. D., Tamminga, C. A., Keshavan, M. S., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.08.025 · Cited by 71
Self-citation
Schizophrenia
Kirkpatrick, B. W., Miller, B. J., García‐Rizo, C., & Fernández-Egea, E. (2013) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.kimi.031513 · Cited by 74
Motor dysfunction as research domain in the period preceding manifest schizophrenia: A systematic review
Hirjak, D., Meyer‐Lindenberg, A., Kubera, K. M., Thomann, P. A., & Wolf, R. C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.011 · Cited by 78
Pharmacology of epigenetics in brain disorders
Narayan, P. J., & Dragunow, M. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00526.x · Cited by 67
Transcription factor 4 (TCF4) and schizophrenia: integrating the animal and the human perspective
Quednow, B. B., Brzózka, M. M., & Rossner, M. J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1553-4 · Cited by 65
Schizo-obsessive spectrum disorders: an update
Scotti-Muzzi, E., & Saide, O. L. (2017) · CNS Spectrums · doi:10.1017/s1092852916000390 · Cited by 65
Altered voxel-wise gray matter structural brain networks in schizophrenia: Association with brain genetic expression pattern
Liu, F., Tian, H., Li, J., Li, S., & Zhuo, C. (2018) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9880-6 · Cited by 64
Pathways from Cannabis to Psychosis: A Review of the Evidence
Burns, J. K. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00128 · Cited by 61
Psychometric considerations in using error-related brain activity as a biomarker in psychotic disorders.
Foti, D., Kotov, R., & Hajcak, G. (2013) · Journal of Abnormal Psychology · doi:10.1037/a0032618 · Cited by 61
Increased Cerebellar Functional Connectivity With the Default-Mode Network in Unaffected Siblings of Schizophrenia Patients at Rest
Guo, W., Liu, F., Zhang, Z., Liu, G., Liu, J., Yu, L., Xiao, C., & Zhao, J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv062 · Cited by 61
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Luo, Y., Tian, Q., Wang, C., Zhang, K., Wang, C., & Zhang, J. (2020) · IEEE Access · doi:10.1109/access.2020.3037658 · Cited by 59
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Jagannathan, K., Calhoun, V. D., Gelernter, J. E., Stevens, M. C. G., Liu, J., Bolognani, F., Windemuth, A., Ruaño, G., Assaf, M., & Pearlson, G. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.002 · Cited by 55
Self-citation
A Role for Oxytocin in the Etiology and Treatment of Schizophrenia
Rich, M. E., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00090 · Cited by 60
White matter alterations in first episode treatment-naïve patients with deficit schizophrenia: a combined VBM and DTI study
Lei, W., Li, N., Deng, W., Li, M., Huang, C., Ma, X., Wang, Q., Guo, W., Li, Y., Jiang, L., et al. (2015) · Scientific Reports · doi:10.1038/srep12994 · Cited by 56
A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
Meda, S. A., Jagannathan, K., Gelernter, J. E., Calhoun, V. D., Liu, J., Stevens, M. C. G., & Pearlson, G. D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.052 · Cited by 52
Self-citation
DISC1 is associated with cortical thickness and neural efficiency
Brauns, S., Gollub, R. L., Roffman, J. L., Yendiki, A., Ho, B., Wassink, T. H., Heinz, A., & Ehrlich, S. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.058 · Cited by 51
Grey matter volume patterns in thalamic nuclei are associated with familial risk for schizophrenia
Pergola, G., Trizio, S., Carlo, P. D., Taurisano, P., Mancini, M., Amoroso, N., Nettis, M. A., Andriola, I., Caforio, G., Popolizio, T., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.07.005 · Cited by 51
Decreased gray matter volume in the left middle temporal gyrus as a candidate biomarker for schizophrenia: A study of drug naive, first-episode schizophrenia patients and unaffected siblings
Guo, W., Hu, M., Fan, X., Liu, F., Wu, R., Chen, J., Guo, X., Xiao, C., Quan, M., Chen, H., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.07.051 · Cited by 50
Cognitive disorganisation in schizotypy is associated with deterioration in visual backward masking
Cappe, C., Herzog, M. H., Herzig, D. A., Brand, A., & Möhr, C. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.001 · Cited by 49
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Su, T.-W., Lan, T., Hsu, T., Biswal, B. B., Tsai, P.-J., Lin, W., & Lin, C. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.05.005 · Cited by 50
Functional connectivity measures as schizophrenia intermediate phenotypes: advances, limitations, and future directions
Cao, H., Dixson, L., Meyer‐Lindenberg, A., & Tost, H. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.07.008 · Cited by 52
Aberrant processing of deviant stimuli in schizophrenia revealed by fusion of fMRI and EEG data
Calhoun, V. D., Wu, L., Kiehl, K. A., Eichele, T., & Pearlson, G. D. (2010) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2010.00467.x · Cited by 45
Self-citation
Failure of deactivation in the default mode network: a trait marker for schizophrenia?
Landín-Romero, R., McKenna, P. J., Salgado‐Pineda, P., Sarró, S., Aguirre, C., Sarri, C., Compte, A., Bosque, C., Blanch, J., Salvador, R. M., et al. (2014) · Psychological Medicine · doi:10.1017/s0033291714002426 · Cited by 47
Is Schizotypy per se a Suitable Endophenotype of Schizophrenia? – Do Not Forget to Distinguish Positive from Negative Facets
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Cariaga-Martínez, A. E., Sáiz-Ruiz, J., & Alelú‐Paz, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00202 · Cited by 48
Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia part I: Neurophysiology
Thibaut, F., Boutros, N. N., Jarema, M., Oranje, B., Hasan, A., Daskalakis, Z. J., Wichniak, A., Schmitt, A., Riederer, P. F., Falkai, P., et al. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1050061 · Cited by 43
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McManus, I. C. (2022) · Symmetry · doi:10.3390/sym14040814 · Cited by 39
Measuring behaviour in rodents: Towards translational neuropsychiatric research
Homberg, J. R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.09.005 · Cited by 45
Retinal function anomalies in young offspring at genetic risk of schizophrenia and mood disorder: The meaning for the illness pathophysiology
Gagné, A.-M., Moreau, I., St‐Amour, I., Marquet, P. P., & Maziade, M. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.06.021 · Cited by 41
Separate and combined effects of low dose ketamine and nicotine on behavioural and neural correlates of sustained attention
Knott, V., Millar, A., McIntosh, J. F., Shah, D. K., Fisher, D. J., Blais, C. M., Ilivitsky, V., & Horn, E. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.06.012 · Cited by 37
Convergent approaches for defining functional imaging endophenotypes in schizophrenia
Pearlson, G. D. (2009) · Frontiers in Human Neuroscience · doi:10.3389/neuro.09.037.2009 · Cited by 35
Self-citation
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Wang, F., Hujjaree, K., & Wang, X. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.638722 · Cited by 34
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Arslan, A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.018 · Cited by 38
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Schmitt, A., Rujescu, D., Gawlik, M., Hasan, A., Hashimoto, K., Iceta, S., Jarema, M., Kambeitz, J. P., Kasper, S. F., Keeser, D., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1183043 · Cited by 39
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Jundong, J., Kuja‐Halkola, R., Hultman, C. M., Långström, N., D'Onofrio, B. M., & Lichtenstein, P. (2011) · Psychological Medicine · doi:10.1017/s0033291711001127 · Cited by 30
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Lien, Y., Liu, C., Faraone, S. V., Tsuang, M. T., Hwu, H., Hsiao, P., & Chen, W. J. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00599.x · Cited by 18
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Authors: Allen, A. J., Griss, M. E., Folley, B. S., Hawkins, K. A., & Pearlson, G. D.
Affiliations: Hartford Hospital (US)
Yale University (US)
Corresponding author: Allen, Allyssa J.
ORCID: Hawkins, Keith A.
Pearlson, Godfrey D.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2009-04
Volume: 109
Issue: 1-3
Pages: 24-37
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2009.01.016
PMC: PMC2665704
OpenAlex: W2102684787
Cited by: 210
References: 274
Citations by year: 2026: 5 · 2024: 3 · 2023: 6 · 2022: 2 · 2021: 9 · 2020: 11 · 2019: 10 · 2018: 6 · 2017: 16 · 2016: 15 · 2015: 21 · 2014: 20 · 2013: 21 · 2012: 29
FWCI: 2.53
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Korea Electrotechnology Research Institute
National Institute of Mental Health (MH074797, R01MH074797, R37MH043775, R01MH077945)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: schizophrenia, endophenotypes
MeSH terms: Cognition Disorders, Family, Humans, Phenotype, Schizophrenia, Schizophrenic Psychology, Statistics as Topic, Biomarkers, Cluster Analysis

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Endophenotypes in schizophrenia: A selective review

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