CoChat
Sign Up
Cited by 58Schizophrenia research and treatmentMaternal Mental Health During Pregnancy and PostpartumFamily Support in Illness

Differences in maternal and paternal age between Schizophrenia and other psychiatric disorders

Lopez-Castroman, Jorge, Gómez, David Delgado, Belloso, Juan José Carballo, Fernandez-Navarro, Pablo, Perez-Rodriguez, M. Mercedes, Villamor, Ignacio Basurte, Navarrete, Francisco Ferre, Ginestar, Consuelo Morant +6 more·2010·Schizophrenia Research
DOI 10.1016/j.schres.2009.11.006
Open this paper in CoChat — free account

Abstract

Advanced parental age has been shown to increase offspring risk for a number of neuropsychiatric disorders including schizophrenia and Down's syndrome. Other psychiatric disorders have been less studied with respect to the effect of parental age on offspring risk. In this study we examine if advanced parental age increased risk for ICD-10 diagnoses. We hypothesized that advanced parental age would increase risk for offspring psychotic disorders and mental retardation but not other ICD-10 diagnoses. We examined follow-up data for 30,965 subjects treated in outpatient psychiatric facilities between 1980 and 2007. Subjects were younger than 18 years of age at their first outpatient visit. A comparison group was obtained from data on registered births in Spain from 1975. We compared parental age (maternal, paternal, combined) across diagnostic categories using ANOVA and logistic regression was used to estimate the risk of psychopathology in the offspring with advanced parental age (maternal, paternal, combined). Maternal and paternal ages were higher for subjects diagnosed with mental retardation. Risk for psychotic disorders showed a significant linear increase only with advancing maternal age, and not paternal age as is more often reported.

Integrity signals

Registry

Crossref · 10.1016/j.schres.2009.11.006

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Paternal age effects on psychological disease might be attributed to elevated sperm mutation rates, but other hypotheses are equally compatible, and maternal age effects operate in the opposite direction.

    “Paternal age effects on psychological disease63 might be attributed to elevated mutation rates in sperm, but other hypotheses are equally compatible with the data, and maternal age effects operate in the opposite direction as younger mothers have higher likelihoods of having affected children64.”

    From Rare and common variants: twenty arguments (2012) · cites this paper as [64]

Cites

Flagged first, then by citations

1 of the 34 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Lopez-Castroman, J., Gómez, D. D., Belloso, J. J. C., Fernandez-Navarro, P., Perez-Rodriguez, M. M., Villamor, I. B., Navarrete, F. F., Ginestar, C. M., Currier, D., Torres, M. R., Navio-Acosta, M., Saiz-Ruiz, J., Jimenez-Arriero, M. A., & Baca-Garcia, E.
Affiliations
  • Hospital General Universitario Gregorio Marañón (ES)
  • New York State Psychiatric Institute (US)
  • Centro de Investigación Biomédica en Red de Salud Mental (ES)
ORCID
Currier, Dianne
Venue
Schizophrenia Research
Publisher
Elsevier BV
Published
2010-02
Volume
116
Issue
2-3
Pages
184-190
ISSN
0920-9964 (ISSN-L)
DOI
10.1016/j.schres.2009.11.006
OpenAlex
W2106779641
Cited by
58
References
34
Citations by year
2024: 3 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 8 · 2013: 2 · 2012: 3
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Schizophrenia Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centro de Investigación Biomédica en Red de Salud Mental
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Social Sciences › Sociology and Political Science › Family Support in Illness
Keywords
advanced parental age, maternal age
MeSH terms
Adolescent, Adult, Age Factors, Aged, Analysis of Variance, Child, Female, Humans, Longitudinal Studies, Male, Maternal Age, Middle Aged, Paternal Age, Psychotic Disorders, Retrospective Studies, Schizophrenia, Spain, Chi-Square Distribution, Logistic Models, International Classification of Diseases, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review