Reproductive patterns in psychotic patients
Abstract
Context Longitudinal epidemiological studies have shown worse outcomes in patients with psychotic disorder than in the general population. The reproductive pattern may be seen as a measure of outcome following psychotic disorder onset, and it may be measured as the rate of child births where the rate is a proxy measure of well-being.Objective To examine reproductive patterns following psychotic disorder onset by comparing the fertility rates of patients with schizophrenia and bipolar disorder with those of other psychiatric patients and the general population, taking into account parental status at disease-onset, time since onset, and the possible effect of abortions-rates.Methods A prospective register-based cohort study drawing on the entire Danish population born after 1950. Incidence Rate Ratios (IRRs) of fertility were analysed using survival analysis.Results Compared with the general population, the lowest first-child fertility rate was found among men (IRR=0.10) and women (IRR=0.18) with schizophrenia. In comparison, bipolar male patients had an IRR=0.32 and female patients an IRR=0.36, while male unipolar patients had an IRR=0.46 and female patients an IRR=0.57. In the group with other psychiatric disorders men had an IRR=0.51 and women an IRR=0.70.Conclusions The results of the present study show a selection process where persons with more severe disorders are less likely to become parents. The reduced fertility was strongly influenced by the time since psychiatric disorder onset; thus, the longer the time since onset, the higher the fertility.
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CNVs with large effects on risk are likely to be rapidly removed from the population by natural selection because of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes.
“As a consequence of the low fecundity in people with schizophrenia and other neurodevelopmental phenotypes to which these CNVs contribute, CNVs with large effects on risk are likely to be rapidly removed from the population by natural selection.”
From De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia (2012) · cites this paper as [21]
Schizophrenia is associated with reduced fecundity, ∼40% that of the general population.
“Schizophrenia is associated with reduced fecundity, ∼40% that of the general population,20 or even lower according to the largest population-based study.21”
From De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia (2012) · cites this paper as [21]
De novo missense mutations in TRIO significantly disrupted the exons preceding or containing the RhoGEF domain.
“De novo missense mutations in TRIO significantly disrupted the exons preceding or containing the RhoGEF domain (Figure 5C)37,38”
From Rare coding variants in ten genes confer substantial risk for schizophrenia (2022) · cites this paper as [38]
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- Authors
- Laursen, T. M., & Munk-Olsen, T.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Laursen, T.M.
- ORCID
- Laursen, T.M.
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 121
- Issue
- 1-3
- Pages
- 234-240
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2149782832
- Cited by
- 111
- References
- 34
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 11
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Demography › Family Dynamics and Relationships
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- reproductive patterns, fertility
- MeSH terms
- Abortion, Induced, Adolescent, Adult, Bipolar Disorder, Birth Rate, Child, Child, Preschool, Denmark, Female, Fertility, Humans, Infant, Longitudinal Studies, Male, Psychotic Disorders, Reproduction, Retrospective Studies, Proportional Hazards Models, Parturition, Young Adult
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