Cited by 120Circadian rhythm and melatoninSchizophrenia research and treatmentSleep and related disorders

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Altered circadian clock gene expression in patients with schizophrenia

Johansson, Anne-Sofie, Owe-Larsson, Björn, Hetta, Jerker, Lundkvist, Gabriella B.·2016·Schizophrenia Research

DOI 10.1016/j.schres.2016.04.029

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Abstract

Impaired circadian rhythmicity has been reported in several psychiatric disorders. Schizophrenia is commonly associated with aberrant sleep-wake cycles and insomnia. It is not known if schizophrenia is associated with disturbances in molecular rhythmicity. We cultured fibroblasts from skin samples obtained from patients with chronic schizophrenia and from healthy controls, respectively, and analyzed the circadian expression during 48h of the clock genes CLOCK, BMAL1, PER1, PER2, CRY1, CRY2, REV-ERBα and DBP. In fibroblasts obtained from patients with chronic schizophrenia, we found a loss of rhythmic expression of CRY1 and PER2 compared to cells from healthy controls. We also estimated the sleep quality in these patients and found that most of them suffered from poor sleep in comparison with the healthy controls. In another patient sample, we analyzed mononuclear blood cells from patients with schizophrenia experiencing their first episode of psychosis, and found decreased expression of CLOCK, PER2 and CRY1 compared to blood cells from healthy controls. These novel findings show disturbances in the molecular clock in schizophrenia and have important implications in our understanding of the aberrant rhythms reported in this disease.

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Authors: Johansson, A.-S., Owe-Larsson, B., Hetta, J., & Lundkvist, G. B.
Affiliations: Karolinska Institutet (SE)
Karolinska University Hospital (SE)
Corresponding author: Lundkvist, Gabriella B.
ORCID: Johansson, Anne-Sofie
Lundkvist, Gabriella B.
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2016-07
Volume: 174
Issue: 1-3
Pages: 17-23
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2016.04.029
OpenAlex: W2344601571
Cited by: 120
References: 38
Citations by year: 2026: 9 · 2025: 10 · 2024: 11 · 2023: 9 · 2022: 16 · 2021: 17 · 2020: 13 · 2019: 13 · 2018: 12 · 2017: 8 · 2016: 1
FWCI: 7.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Funders: The Stanley Medical Research Institute
Foundations of Söderström Königska sjukhemmet (SLS-230721)
Magnus Bergvall (4-422/2014, 24942-1/2011)
Märta Lundkvist
Rut and Astrid Wolff (2008-09)
Fredrik and Ingrid Thuring (2009-12)
Golje (LA2011-0481)
ALF (20060679)
Swedish Society of Medical Research (SLS-100171)
Swedish Society of Medicine (SLS-178551)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords: schizophrenia, clock genes
MeSH terms: Adolescent, Adult, Cells, Cultured, Female, Fibroblasts, Gene Expression Regulation, Humans, Male, Middle Aged, RNA, Messenger, Schizophrenia, Sleep, Sleep Wake Disorders, Young Adult, CLOCK Proteins, Cryptochromes, Period Circadian Proteins, Circadian Clocks

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Altered circadian clock gene expression in patients with schizophrenia

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