The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells
Open accessAbstract
Nanoparticles (NPs), including nano metal oxides, are being used in diverse applications such as medicine, clothing, cosmetics and food. In order to promote the safe development of nanotechnology, it is essential to assess the potential adverse health consequences associated with human exposure. The liver is a target site for NP toxicity, due to NP accumulation within it after ingestion, inhalation or absorption. The toxicity of nano-ZnO, TiO2, CuO and Co3O4 was investigated using a primary culture of channel catfish hepatocytes and human HepG2 cells as in vitro model systems for assessing the impact of metal oxide NPs on human and environmental health. Some mechanisms of nanotoxicity were determined by using phase contrast inverted microscopy, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays, reactive oxygen species (ROS) assays, and flow cytometric assays. Nano-CuO and ZnO showed significant toxicity in both HepG2 cells and catfish primary hepatocytes. The results demonstrate that HepG2 cells are more sensitive than catfish primary hepatocytes to the toxicity of metal oxide NPs. The overall ranking of the toxicity of metal oxides to the test cells is as follows: TiO2 < Co3O4< ZnO < CuO. The toxicity is due not only to ROS-induced cell death, but also damages to cell and mitochondrial membranes.
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Inorganic and organic UV filters: Their role and efficacy in sunscreens and suncare products
Serpone, N., Dondi, D., & Albini, A. (2007) · Inorganica Chimica Acta · doi:10.1016/j.ica.2005.12.057 · Cited by 711
Cited by
A review of mammalian toxicity of ZnO nanoparticles
Vandebriel, R., & De Jong, W. (2012) · Nanotechnology, Science and Applications · doi:10.2147/nsa.s23932 · Cited by 494
Toxicity of copper oxide nanoparticles: a review study
Naz, S., Gul, A., & Zia, M. (2020) · IET Nanobiotechnology · doi:10.1049/iet-nbt.2019.0176 · Cited by 447
Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells
Siddiqui, M. A., Alhadlaq, H. A., Ahmad, J., Al-Khedhairy, A. A., Musarrat, J., & Ahamed, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069534 · Cited by 366
Wang, Z., Li, N., Zhao, J., White, J. C., Qu, P., & Xing, B. (2012) · Chemical Research in Toxicology · doi:10.1021/tx3002093 · Cited by 340
High‐Density Stretchable Electrode Grids for Chronic Neural Recording
Tybrandt, K., Khodagholy, D., Dielacher, B., Stauffer, F., Renz, A. F., Buzsáki, G., & Vörös, J. (2018) · Advanced Materials · doi:10.1002/adma.201706520 · Cited by 286
Metadata
- Authors
- Wang, Y., Aker, W. G., Hwang, H.-M., Yedjou, C. G., Yu, H., & Tchounwou, P. B.
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 409
- Issue
- 22
- Pages
- 4753-4762
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W2041319302
- Cited by
- 172
- References
- 3
- FWCI
- 6.04
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, Y., Aker, W. G., Hwang, H.-M., Yedjou, C. G., Yu, H., & Tchounwou, P. B. (2011). A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Science of The Total Environment. https://doi.org/10.1016/j.scitotenv.2011.07.039
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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