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Increased levels of etheno-DNA adducts and genotoxicity biomarkers of long-term exposure to pure diesel engine exhaust

Shen, Meili, Bin, Ping, Li, Haibin, Zhang, Xiao, Sun, Xin, Duan, Huawei, Niu, Yong, Meng, Tao, Dai, Yufei, Gao, Weimin, Yu, Shanfa, Gu, Guizhen, Zheng, Yuxin·2016·Science of The Total Environment
DOI 10.1016/j.scitotenv.2015.10.165
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Abstract

Etheno-DNA adducts are biomarkers for assessing oxidative stress. In this study, the aim was to detect the level of etheno-DNA adducts and explore the relationship between the etheno-DNA adducts and genotoxicity biomarkers of the diesel engine exhaust (DEE)-exposed workers. We recruited 86 diesel engine testing workers with long-term exposure to DEE and 99 non-DEE-exposed workers. The urinary mono-hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) and etheno-DNA adducts (εdA and εdC) were detected by HPLC-MS/MS and UPLC-MS/MS, respectively. Genotoxicity biomarkers were also evaluated by comet assay and cytokinesis-block micronucleus assay. The results showed that urinary εdA was significantly higher in the DEE-exposed workers (p<0.001), exhibited 2.1-fold increase compared with the non-DEE-exposed workers. The levels of urinary OH-PAHs were positively correlated with the level of εdA among all the study subjects (p<0.001). Moreover, we found that the increasing level of εdA was significantly associated with the increased olive tail moment, percentage of tail DNA, or frequency of micronucleus in the study subjects (p<0.01). No significant association was observed between the εdC level and any measured genotoxicity biomarkers. In summary, εdA could serve as an indicator for DEE exposure in the human population.

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Metadata

Authors
Shen, M., Bin, P., Li, H., Zhang, X., Sun, X., Duan, H., Niu, Y., Meng, T., Dai, Y., Gao, W., Yu, S., Gu, G., & Zheng, Y.
Venue
Science of The Total Environment
Publisher
Elsevier BV
Published
2016-02
Volume
543
Pages
267-273
ISSN
0048-9697
DOI
10.1016/j.scitotenv.2015.10.165
Cited by
17
References
1
Language
en
Licence
Funders
National Natural Science Foundation of China (81130050, 81428021)

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