Mitigation of oxidative stress damage caused by abiotic stress to improve biomass yield of microalgae: A review
Open accessAbstract
Microalgae have been recognized as emerging cell factories due to the high value-added bio-products. However, the balance between algal growth and the accumulation of metabolites is always the main contradiction in algal biomass production. Hence, the security and effectiveness of regulating microalgal growth and metabolism simultaneously have drawn substantial attention. Since the correspondence between microalgal growth and reactive oxygen species (ROS) level has been confirmed, improving its growth under oxidative stress and promoting biomass accumulation under non-oxidative stress by exogenous mitigators is feasible. This paper first introduced ROS generation in microalgae and described the effects of different abiotic stresses on the physiological and biochemical status of microalgae from these aspects associated with growth, cell morphology and structure, and antioxidant system. Secondly, the role of exogenous mitigators with different mechanisms in alleviating abiotic stress was concluded. Finally, the possibility of exogenous antioxidants regulating microalgal growth and improving the accumulation of specific products under non-stress conditions was discussed.
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Antioxidant defenses may be stimulated to eliminate ROS, protecting cyanobacteria from ROS-induced injury.
“Conversely, antioxidant defenses may be stimulated to eliminate ROS, thereby protecting cyanobacteria from ROS-induced injury (Zhu et al. 2023).”
From Integrated morpho-physiological and biochemical description of the mechanisms leading stress responses in cyanobacteria (Arthrospira platensis) upon exposure to Erythromycin (2025) · cites this paper as Zhu et al. 2023
Augmentation in cellular APX enzyme is pivotal for eradicating H2O2, maintaining cellular oxidative status, and enhancing tolerance and biotransformation capabilities against ERY.
“An augmentation in cellular APX enzyme is pivotal for eradicating H2O2, essential for maintaining cellular oxidative status, thereby enhancing tolerance and biotransformation capabilities against ERY (Zhu et al. 2023).”
From Integrated morpho-physiological and biochemical description of the mechanisms leading stress responses in cyanobacteria (Arthrospira platensis) upon exposure to Erythromycin (2025) · cites this paper as Zhu et al. 2023
POD serves as a crucial enzyme in xenobiotic detoxification and converts H2O2 to H2O during oxidative stress.
“Simultaneously, POD serves as a crucial enzyme in xenobiotic detoxification and functions as an antioxidant enzyme that converts H2O2 to H2O during oxidative stress (Zhu et al. 2023).”
From Integrated morpho-physiological and biochemical description of the mechanisms leading stress responses in cyanobacteria (Arthrospira platensis) upon exposure to Erythromycin (2025) · cites this paper as Zhu et al. 2023
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“Conversely, antioxidant defenses may be stimulated to eliminate ROS, thereby protecting cyanobacteria from ROS-induced injury (Zhu et al. 2023).”
- Authors
- Zhu, J., Cai, Y., Wakisaka, M., Yang, Z., Yin, Y., Fang, W., Xu, Y., Omura, T., Yu, R., & Zheng, A. L. T.
- Affiliations
- Kyushu Institute of Technology (JP)
- Yangzhou University (CN)
- Fukuoka Women's University (JP)
- The University of Tokyo (JP)
- Anhui University of Finance and Economics (CN)
- Universiti Putra Malaysia (MY)
- Corresponding author
- Zhu, Jiangyu
- Wakisaka, Minato
- ORCID
- Venue
- Science of The Total Environment
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 896
- Pages
- 165200
- ISSN
- 0048-9697 (ISSN-L)
- OpenAlex
- W4382796433
- Cited by
- 135
- References
- 90
- Citations by year
- 2026: 43 · 2025: 50 · 2024: 35 · 2023: 7
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 646 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- The Science of The Total Environment (acceptedVersion)
- PubMed (publishedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- Funders
- National Natural Science Foundation of China (22208285)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Growth Enhancement Techniques
- Keywords
- microalgae, oxidative stress, reactive oxygen species, abiotic stress, biomass yield, antioxidant defense, exogenous antioxidants, hormesis, heavy metals, superoxide dismutase, carotenoids, algal ultrastructure, cell morphology, stress reduction
- MeSH terms
- Antioxidants, Stress, Physiological, Reactive Oxygen Species, Oxidative Stress, Biomass, Biofuels, Microalgae
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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