Cited by 780Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsGastrointestinal motility and disorders

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Fibromyalgia and Overlapping Disorders: The Unifying Concept of Central Sensitivity Syndromes

Yunus, Muhammad B.·2007·Seminars in Arthritis and Rheumatism

DOI 10.1016/j.semarthrit.2006.12.009

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Abstract

Objectives To discuss fibromyalgia syndrome (FMS) and overlapping conditions, eg, irritable bowel syndrome, headaches, and chronic fatigue syndrome, within the concept of central sensitivity syndromes (CSS).Methods A critical overview of the literature and incorporation of the author's own views.Results The concept of CSS seems viable. It is based on mutual associations among the CSS conditions as well as the evidence for central sensitization (CS) among several CSS members. However, such evidence is weak or not available in other members at this time, requiring further studies. The biology of CSS is based on neuroendocrine aberrations, including CS, that interact with psychosocial factors to cause a number of symptoms.Conclusions CSS is an important new concept that embraces the biopsychosocial model of disease. Further critical studies are warranted to fully test this concept. However, it seems to have important significance for new directions for research and patient care involving physician and patient education. Each patient, irrespective of diagnosis, should be treated as an individual considering both the biological and psychosocial contributions to his or her symptoms and suffering.

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Authors: Yunus, M. B.
Affiliations: Peoria campus of the University of Illinois System (US)
Corresponding author: Yunus, Muhammad B.
Venue: Seminars in Arthritis and Rheumatism
Publisher: Elsevier BV
Published: 2007-06
Volume: 36
Issue: 6
Pages: 339-356
ISSN: 0049-0172 (ISSN-L)
DOI: 10.1016/j.semarthrit.2006.12.009
OpenAlex: W1967034335
Cited by: 780
References: 244
Citations by year: 2026: 32 · 2025: 30 · 2024: 43 · 2023: 36 · 2022: 38 · 2021: 55 · 2020: 44 · 2019: 35 · 2018: 56 · 2017: 41 · 2016: 42 · 2015: 58 · 2014: 46 · 2013: 51 · 2012: 38
FWCI: 4.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Arthritis and Rheumatism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: fibromyalgia, central sensitivity syndromes, central sensitization, irritable bowel syndrome, headache, chronic fatigue syndrome, biopsychosocial model, neuroendocrine dysfunction, psychosocial factors
MeSH terms: Fibromyalgia, Humans, Fatigue Syndrome, Chronic, Headache Disorders, Irritable Bowel Syndrome

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Fibromyalgia and Overlapping Disorders: The Unifying Concept of Central Sensitivity Syndromes

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