The DOI matches its Crossref record; 242 of the 244 references it cites were found in a registry or an index.
Fibromyalgia and Overlapping Disorders: The Unifying Concept of Central Sensitivity Syndromes
Abstract
Objectives To discuss fibromyalgia syndrome (FMS) and overlapping conditions, eg, irritable bowel syndrome, headaches, and chronic fatigue syndrome, within the concept of central sensitivity syndromes (CSS).Methods A critical overview of the literature and incorporation of the author's own views.Results The concept of CSS seems viable. It is based on mutual associations among the CSS conditions as well as the evidence for central sensitization (CS) among several CSS members. However, such evidence is weak or not available in other members at this time, requiring further studies. The biology of CSS is based on neuroendocrine aberrations, including CS, that interact with psychosocial factors to cause a number of symptoms.Conclusions CSS is an important new concept that embraces the biopsychosocial model of disease. Further critical studies are warranted to fully test this concept. However, it seems to have important significance for new directions for research and patient care involving physician and patient education. Each patient, irrespective of diagnosis, should be treated as an individual considering both the biological and psychosocial contributions to his or her symptoms and suffering.
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“According to the classification developed by M. B. Yunus on central sensitization syndromes (2007; 2009; 2015), those that involve the experience of chronic pain could be considered as CPSS [9,10,11].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [10]
In the citing paper
“Against this background, the similarity in widespread hypersensitivity between IBS patients and CPCS, such as FMS, led to the view that IBS is another CCS [10,11].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [10]
In the citing paper
“Although it is not clear how these physiologic alterations are generated, there is a wide agreement that FMS should be considered as a CPSS [9,10,11,32,33,34].”
From Effectiveness of acceptance and commitment therapy in central pain sensitization syndromes: A systematic review (2021) · cites this paper as [10]
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Metadata
- Authors
- Yunus, M. B.
- Affiliations
- Peoria campus of the University of Illinois System (US)
- Corresponding author
- Yunus, Muhammad B.
- Venue
- Seminars in Arthritis and Rheumatism
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 36
- Issue
- 6
- Pages
- 339-356
- ISSN
- 0049-0172 (ISSN-L)
- OpenAlex
- W1967034335
- Cited by
- 780
- References
- 244
- Citations by year
- 2026: 32 · 2025: 30 · 2024: 43 · 2023: 36 · 2022: 38 · 2021: 55 · 2020: 44 · 2019: 35 · 2018: 56 · 2017: 41 · 2016: 42 · 2015: 58 · 2014: 46 · 2013: 51 · 2012: 38
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Arthritis and Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- fibromyalgia, central sensitivity syndromes, central sensitization, irritable bowel syndrome, headache, chronic fatigue syndrome, biopsychosocial model, neuroendocrine dysfunction, psychosocial factors
- MeSH terms
- Fibromyalgia, Humans, Fatigue Syndrome, Chronic, Headache Disorders, Irritable Bowel Syndrome
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