Cited by 202Fibromyalgia and Chronic Fatigue Syndrome ResearchPsychosomatic Disorders and Their TreatmentsMusculoskeletal pain and rehabilitation

The DOI matches its Crossref record; 69 of the 70 references it cites were found in a registry or an index.

The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review

Open access

Kleykamp, Bethea A., Ferguson, McKenzie C., McNicol, Ewan, Bixho, Ida, Arnold, Lesley M., Edwards, Robert R., Fillingim, Roger, Grol-Prokopczyk, Hanna, Turk, Dennis C., Dworkin, Robert H.·2021·Seminars in Arthritis and Rheumatism

DOI 10.1016/j.semarthrit.2020.10.006

Open this paper in CoChat — free account

Abstract

Fibromyalgia (FM) is a chronic widespread pain condition that overlaps with multiple comorbid health conditions and contributes to considerable patient distress. The aim of this review was to provide a systematic overview of psychiatric and chronic pain comorbidities among patients diagnosed with FM and to inform the development of recommendations for the design of clinical trials. Thirty-one, cross-sectional, clinical epidemiology studies that evaluated patients diagnosed with FM were included for review. None of the reviewed studies reported on the incidence of these comorbidities. Sample size-weighted prevalence estimates were calculated when prevalence data were reported in 2 or more studies for the same comorbid condition. The most prevalent comorbidity across all studies reviewed was depression/major depressive disorder (MDD) with over half of the patients included having this diagnosis in their lifetime (weighted prevalence up to 63%). In addition, nearly one-third of FM patients examined had current or lifetime bipolar disorder, panic disorder, or post-traumatic stress disorder. Less common psychiatric disorders reported included generalized anxiety disorder, obsessive compulsive disorder, and specific phobias (agoraphobia, social phobia). There were fewer studies that examined chronic pain comorbidities among FM patients, but when evaluated, prevalence was also high ranging from 39% to 76% (i.e., chronic tension-type or migraine headache, irritable bowel syndrome, myofascial pain syndrome, and temporomandibular disorders). The results of the review suggest that depression and chronic pain conditions involving head/jaw pain and IBS were elevated among FM patients compared to other conditions in the clinic-based studies. In contrast, anxiety-related disorders were much less common. Addressing the presence of these comorbid health conditions in clinical trials of treatments for FM would increase the generalizability and real-world applicability of FM research.

Integrity signals

Registry

Crossref · 10.1016/j.semarthrit.2020.10.006

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The american college of rheumatology 1990 criteria for the classification of fibromyalgia
Wolfe, F., Smythe, H. A., Yunus, M. B., Bennett, R. M., Bombardier, C., Goldenberg, D. L., Tugwell, P., Campbell, S. M., Abeles, M., Clark, P., et al. (1990) · Arthritis & Rheumatism · doi:10.1002/art.1780330203 · Cited by 9,563
The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity
Wolfe, F., Clauw, D. J., Fitzcharles, M., Goldenberg, D. L., Katz, R. S., Mease, P., Russell, A. S., Russell, I. J., Winfield, J. B., & Yunus, M. B. (2010) · Arthritis Care & Research · doi:10.1002/acr.20140 · Cited by 3,952
Chronic pain as a symptom or a disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11)
Treede, R.-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., et al. (2019) · Pain · doi:10.1097/j.pain.0000000000001384 · Cited by 3,478
Methodological guidance for systematic reviews of observational epidemiological studies reporting prevalence and cumulative incidence data
Munn, Z., Moola, S., Lisy, K., Riitano, D., & Tufanaru, C. (2015) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000054 · Cited by 3,131
A classification of chronic pain for ICD-11
Treede, R.-D., Rief, W., Barke, A., Aziz, Q., Bennett, M. I., Benoliel, R., Cohen, M., Evers, S., Finnerup, N. B., First, M. B., et al. (2015) · Pain · doi:10.1097/j.pain.0000000000000160 · Cited by 2,822
2016 revisions to the 2010/2011 fibromyalgia diagnostic criteria
Wolfe, F., Clauw, D. J., Fitzcharles, M.-A., Goldenberg, D. L., Häuser, W., Katz, R. L., Mease, P. J., Russell, A. S., Russell, I. J., & Walitt, B. (2016) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2016.08.012 · Cited by 2,232
Epidemiology of anxiety disorders in the 21st century
Bandelow, B., & Michaelis, S. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/bbandelow · Cited by 2,079
Fibromyalgia Criteria and Severity Scales for Clinical and Epidemiological Studies: A Modification of the ACR Preliminary Diagnostic Criteria for Fibromyalgia
WOLFE, F., CLAUW, D. J., FITZCHARLES, M.-A., GOLDENBERG, D. L., HÄUSER, W., KATZ, R. S., MEASE, P., RUSSELL, A. S., RUSSELL, I. J., & WINFIELD, J. B. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.100594 · Cited by 1,499
Systematic review of the comorbidity of irritable bowel syndrome with other disorders: What are the causes and implications?
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116
The epidemiology of irritable bowel syndrome
Card, T., Canavan, C., & West, J. (2014) · Clinical Epidemiology · doi:10.2147/clep.s40245 · Cited by 889

Show all 70 references

Research works printed but not linked: 2

Brody, 2018, Prevalence of depression among adults aged 20 and over: United States, 2013-2016: US department of health and human services, Cent Dis Control
Maixner, 2016, Overlapping chronic pain conditions: implications for diagnosis and classification, J Pain: Off J Am Pain Soc, 17, T93, 10.1016/j.jpain.2016.06.002 · DOI · Paper page

Sorted by citations

The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis
Antoniou, G., Lambourg, E. J., Steele, J. D., & Colvin, L. (2023) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.03.008 · Cited by 133
Debate: differences and similarities between tension-type headache and migraine
Onan, D., Younis, S., Wells-Gatnik, W. D., Farham, F., Andruškevičius, S., Abashidze, A., Jusupova, A., Romanenko, Y., Grosu, O., Moldokulova, M. Z., et al. (2023) · The Journal of Headache and Pain · doi:10.1186/s10194-023-01614-0 · Cited by 108
The prevalence of comorbid chronic pain conditions among patients with temporomandibular disorders
Kleykamp, B. A., Ferguson, M. C., McNicol, E. D., Bixho, I., Arnold, L. M., Edwards, R. R., Fillingim, R. B., Grol-Prokopczyk, H., Ohrbach, R. K., Turk, D. C., et al. (2021) · The Journal of the American Dental Association · doi:10.1016/j.adaj.2021.08.008 · Cited by 97
Gut Dysbiosis in Irritable Bowel Syndrome: A Narrative Review on Correlation with Disease Subtypes and Novel Therapeutic Implications
Napolitano, M., Fasulo, E., Ungaro, F., Massimino, L., Sinagra, E., Danese, S., & Mandarino, F. V. (2023) · Microorganisms · doi:10.3390/microorganisms11102369 · Cited by 100
Identifying and Managing Nociplastic Pain in Individuals With Rheumatic Diseases: A Narrative Review
Murphy, A. E., Minhas, D., Clauw, D. J., & Lee, Y. (2023) · Arthritis Care & Research · doi:10.1002/acr.25104 · Cited by 84
Fibromyalgia and Depression: A Literature Review of Their Shared Aspects
Yepez, D., Grandes, X. A., Manjunatha, R. T., Habib, S., & Sangaraju, S. L. (2022) · Cureus · doi:10.7759/cureus.24909 · Cited by 72
Neurophysiological and psychosocial mechanisms of fibromyalgia: A comprehensive review and call for an integrative model
Pinto, A. M., Luís, M., Geenen, R., Palavra, F., Lumley, M. A., Ablin, J. N., Amris, K., Branco, J., Buskila, D., Castelhano, J., et al. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105235 · Cited by 75
The Efficacy of Vitamin D Supplementation in the Treatment of Fibromyalgia Syndrome and Chronic Musculoskeletal Pain
Lombardo, M., Feraco, A., Ottaviani, M., Rizzo, G., Camajani, E., Caprio, M., & Armani, A. (2022) · Nutrients · doi:10.3390/nu14153010 · Cited by 66
Glutamatergic systems in neuropathic pain and emerging non-opioid therapies
Temmermand, R., Barrett, J. E., & Fontana, A. C. K. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106492 · Cited by 64
Fibromyalgia and Inflammation: Unrevealing the Connection
García‐Domínguez, M. (2025) · Cells · doi:10.3390/cells14040271 · Cited by 69
The role of the vagus nerve in fibromyalgia syndrome
Martins, D. F., Viseux, F., Salm, D. C., Ribeiro, A. C. A., da Silva, H. K. L., Seim, L. A., Bittencourt, E. B., Bianco, G., Moré, A. O. O., Reed, W. R., et al. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.021 · Cited by 58
Patients With Fibromyalgia, Depression, and/or Anxiety and Sex Differences
Henao-Pérez, M., López-Medina, D. C., Ramírez, A. A., Monsalve, S., & Osorio, J. A. Z. (2022) · American Journal of Men s Health · doi:10.1177/15579883221110351 · Cited by 52
Pain Burden in Post-COVID-19 Syndrome following Mild COVID-19 Infection
Bilevičiūtė-Ljungar, I., Norrefalk, J., & Borg, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030771 · Cited by 51
Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research
Bourke, S. L., Schlag, A. K., O’Sullivan, S. E., Nutt, D., & Finn, D. P. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108216 · Cited by 46
The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence
de Tommaso, M., Vecchio, E., & Nolano, M. (2022) · Neurological Sciences · doi:10.1007/s10072-021-05806-x · Cited by 45
Visual snow syndrome, the spectrum of perceptual disorders, and migraine as a common risk factor: A narrative review
Klein, A. N., & Schankin, C. J. (2021) · Headache The Journal of Head and Face Pain · doi:10.1111/head.14213 · Cited by 42
Effectiveness of two video-based multicomponent treatments for fibromyalgia: The added value of cognitive restructuring and mindfulness in a three-arm randomised controlled trial
Serrat, M., Albajes, K., Navarrete, J., Almirall, M., Girbés, E. L., Neblett, R., Luciano, J. V., Queraltó, J. M., & Feliu‐Soler, A. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104188 · Cited by 44
Comorbid Conditions in Temporomandibular Disorders Myalgia and Myofascial Pain Compared to Fibromyalgia
Barjandi, G., Kosek, E., Hedenberg‐Magnusson, B., Velly, A. M., & Ernberg, M. M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143138 · Cited by 35
Perceived Efficacy, Reduced Prescription Drug Use, and Minimal Side Effects of Cannabis in Patients with Chronic Orthopedic Pain
Greis, A. C., Larsen, E., Liu, C., Renslo, B., Radakrishnan, A., & Wilson‐Poe, A. R. (2021) · Cannabis and Cannabinoid Research · doi:10.1089/can.2021.0088 · Cited by 34
A multicenter study to evaluate pain characteristics in osteogenesis imperfecta
Celin, M. R., Kruger, K. M., Caudill, A. K., Murali, C. N., Nagamani, S. C. S., Smith, P. A., & Harris, G. F. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.63009 · Cited by 33
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement
Hohenschurz‐Schmidt, D., Cherkin, D. C., Rice, A. S. C., Dworkin, R. H., Turk, D. C., McDermott, M. P., Bair, M. J., DeBar, L., Edwards, R. R., Farrar, J. T., et al. (2023) · Pain · doi:10.1097/j.pain.0000000000002888 · Cited by 28
Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes
Bogaerts, K., Houte, M. V. D., Jongen, D., Ly, H. G., Coppens, E., Schruers, K. R. J., Diest, I. V., Jan, T., Wambeke, P. V., Petre, B., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02567-3 · Cited by 23
Cationic liposome-encapsulated carotenoids as a potential treatment for fibromyalgia in an animal model
Elkholy, N. S., Shafaa, M. W., & Mohammed, H. S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166150 · Cited by 22
Sex effects in the interaction of acute stress and pain perception
Geva, N., Golan, S., Pinchas, L., & Defrin, R. (2022) · Pain · doi:10.1097/j.pain.0000000000002743 · Cited by 22
The role of mind body interventions in the treatment of irritable bowel syndrome and fibromyalgia
Islam, Z., D’Silva, A., Raman, M., & Nasser, Y. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1076763 · Cited by 26
Cognitive-behavioral therapy and acceptance and commitment therapy for anxiety and depression in patients with fibromyalgia: a systematic review and meta-analysis
Cojocaru, C. M., Popa, C. O., Schenk, A., Suciu, B. A., & Szasz, S. (2023) · Medicine and Pharmacy Reports · doi:10.15386/mpr-2661 · Cited by 21
“Given its multiple implications for the quality of life, besides the numerous physical comorbidities, emotional disorders such as depression and anxiety are frequently co-occurring with fibromyalgia [4].”
Background
Overcoming treatment gaps in the management of depression with non-pharmacological adjunctive strategies
Purebl, G., Schnitzspahn, K. M., & Zsák, É. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1268194 · Cited by 23
Shared comorbidity of depression, migraine, insomnia, and fibromyalgia in a population-based sample
Lee, W., Shin, H. J., Min, I. K., Kim, C., Kim, K. M., Heo, K., & Chu, M. K. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.03.077 · Cited by 22
Psychiatric disorders comorbid with general medical illnesses and functional somatic disorders: The Lifelines cohort study
Creed, F. H. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286410 · Cited by 18
A behavioral and brain imaging dataset with focus on emotion regulation of women with fibromyalgia
Balducci, T., Rasgado‐Toledo, J., Valencia, A., van Tol, M., Aleman, A., & Garza‐Villarreal, E. A. (2022) · Scientific Data · doi:10.1038/s41597-022-01677-9 · Cited by 17
Fibromyalgia predicts increased odds of pain-related addiction exacerbation among individuals with pain and opioid use disorder
Hall, O. T., Teater, J. E., Entrup, P., Deaner, M., Bryan, C. J., Harte, S. E., Kaplan, C. M., Phan, K. L., & Clauw, D. J. (2023) · Pain · doi:10.1097/j.pain.0000000000002878 · Cited by 16
Abnormal functional neurocircuitry underpinning emotional processing in fibromyalgia
Balducci, T., Garza‐Villarreal, E. A., Valencia, A., Aleman, A., & van Tol, M. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01578-x · Cited by 16
The frequency of psychiatric disorder co‐morbidities in patients with fibromyalgia: A cross‐sectional study in Iran
Sadr, S., Mobini, M., Tabarestani, M., Parkoohi, P. I., & Elyasi, F. (2023) · Nursing Open · doi:10.1002/nop2.1731 · Cited by 15
Fibromyalgia and the painful self: A meta-analysis of resting-state fMRI data
Cavicchioli, M., Scalabrini, A., Nimbi, F. M., Torelli, A., Bottiroli, S., Pichiecchio, A., Prodi, E., Trentini, C., Sarzi‐Puttini, P., & Galli, F. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.01.048 · Cited by 16
Comorbid extra‐intestinal central sensitization conditions worsen irritable bowel syndrome in primary care patients
Wang, X. J., Ebbert, J. O., Loftus, C. G., Rosedahl, J. K., & Philpot, L. M. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14546 · Cited by 13
Why Does It Hurt So Much? Emotion Regulation Mediates the Association between Fibromyalgia Symptoms and Psychological Distress
Frumer, L., Marom-Harel, H., & Horesh, D. (2023) · Healthcare · doi:10.3390/healthcare11101368 · Cited by 13
Exploring Adherence to Moderate to High-Intensity Exercises in Patients with Fibromyalgia: The Role of Physiological and Psychological Factors—A Narrative Literature Review
Sarmento, C. V. M., Liu, Z., Smirnova, I. V., & Liu, W. (2023) · Physiologia · doi:10.3390/physiologia3030034 · Cited by 12
Whole-genome methylation profiling reveals regions associated with painful temporomandibular disorders and active recovery processes
Ao, X., Parisien, M., Fillingim, R. B., Ohrbach, R. K., Slade, G. D., Diatchenko, L. B., & Smith, S. B. (2023) · Pain · doi:10.1097/j.pain.0000000000003104 · Cited by 13
A bibliometric analysis and visualization of tension-type headache
Fan, X., Fu, G.-J., Wang, L., Shen, W., & Zhang, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.980096 · Cited by 12
Functional neurological disorder and functional somatic syndromes among sexual and gender minority people: A scoping review
Lerario, M. P., Fusunyan, M. A., Stave, C. D., Roldán, V., Keuroghlian, A. S., Turban, J. L., Perez, D. L., Maschi, T. M., & Rosendale, N. (2023) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2023.111491 · Cited by 13
Fibromyalgia interventions, obstacles and prospects: narrative review.
Wasti, A. Z., Mackawy, A. M. H., Hussain, A., Huq, M., Ahmed, H., & Memon, A. G. (2023) · Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology / edited by the Gaetano Conte Academy for the study of striated muscle diseases · doi:10.36185/2532-1900-334 · Cited by 15
Variability in the prevalence of depression among adults with chronic pain: UK Biobank analysis through clinical prediction models
Chen, L., Ashton-James, C. E., Shi, B., Radojčić, M. R., Anderson, D., Chen, Y., Preen, D. B., Hopper, J. L., Li, S., Bui, M., et al. (2024) · BMC Medicine · doi:10.1186/s12916-024-03388-x · Cited by 11
Assessing comorbid PTSD, depression, and anxiety in fibromyalgia patients: a retrospective observational study
Rahangdale, A., & Ferraro, J. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06708-4 · Cited by 11
Cognitive-Behavioral and Personal Construct Therapies for Depression in Women with Fibromyalgia: A Randomized Controlled Trial
Aguilera, M., Paz, C., Salla, M., Compañ, V., Medina, J. C., Medeiros-Ferreira, L., & Feixas, G. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100296 · Cited by 16
The global prevalence of depression and anxiety among fibromyalgia patients: A systematic review and meta-analysis
Jafari, M., Zadgari, E., Lichahi, M. A., Vesali-Moghaddam, A., Amirian, B., Kazemian, N., Mirkalaie, S. M. M., Reyhani, H., Saeedi, C., Ghavidel‐Parsa, B., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120340 · Cited by 10
Psychiatric disorders and the onset of self-reported fibromyalgia and chronic fatigue syndrome: The lifelines cohort study
Creed, F. H. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1120250 · Cited by 12
Prehabilitation: The underutilised weapon for chronic pain management
Tidmarsh, L. V., Harrison, R. N., & Finlay, K. A. (2024) · British Journal of Pain · doi:10.1177/20494637241250239 · Cited by 10
Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample
Siwek, M., Chrobak, A. A., Sołtys, Z., Dudek, D., & Krupa, A. J. (2024) · Brain Sciences · doi:10.3390/brainsci14090890 · Cited by 10
Long-Lasting Nociplastic Pain Modulation by Repeated Administration of Sigma-1 Receptor Antagonist BD1063 in Fibromyalgia-like Mouse Models
Álvarez-Pérez, B., Bagó‐Mas, A., Deulofeu, M., Vela, J. M., Merlos, M., Verdú, E., & Boadas‐Vaello, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911933 · Cited by 11
Bipolar Spectrum Symptoms in Patients with Fibromyalgia: A Dimensional Psychometric Evaluation of 120 Patients
Schweiger, V., Perini, G., Piccolo, L. D., Perlini, C., Donisi, V., Gottin, L., Martini, A., Donadello, K., Balzo, G. D., Moro, V., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192416395 · Cited by 10
Changes in the mean incidence and variance of orthopedic diseases before and during the COVID-19 pandemic in Korea: a retrospective study
Kim, J., Kwon, M. J., Choi, H. G., Lee, S. J., Hwang, S., Lee, J., Lee, J. W., & Lee, J. W. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-06634-0 · Cited by 12
Evaluating Oxidative Stress in Fibromyalgia: Diagnostic Utility and Its Relationship with Clinical and Psychological Parameters
Uslu, E. Y., Uslu, M. F., Yıldız, S., & Tabara, M. F. (2025) · Medicina · doi:10.3390/medicina61071248 · Cited by 10
Comprehensive Preclinical Assessment of Sensory, Functional, Motivational-Affective, and Neurochemical Outcomes in Neuropathic Pain: The Case of the Sigma-1 Receptor
de la Puente, B., Zamanillo, D., Romero, L. I., Carceller, A., Vela, J. M., Merlos, M., & Portillo-Salido, E. F. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00005 · Cited by 9
Drug Safety and Suicidality Risk of Chronic Pain Medications
Syed, O., Jancic, P., Fink, A. B., & Knežević, N. N. (2023) · Pharmaceuticals · doi:10.3390/ph16101497 · Cited by 9
Pain intensity and physical performance among individuals with fibromyalgia in mid-to-late life: The influence of depressive symptoms
Serpas, D. G., Zettel‐Watson, L., & Cherry, B. J. (2021) · Journal of Health Psychology · doi:10.1177/13591053211009286 · Cited by 9
Hierarchical Clustering Applied to Chronic Pain Drawings Identifies Undiagnosed Fibromyalgia: Implications for Busy Clinical Practice
Alter, B. J., Moses, M., DeSensi, R., O’Connell, B., Bernstein, C., McDermott, S. P., Jeong, J., & Wasan, A. D. (2024) · Journal of Pain · doi:10.1016/j.jpain.2024.02.003 · Cited by 8
Investigation of neurochemical and behavioral alterations in the brain during fibromyalgia with supplementation of Spirulina platensis
Tranchida, N., Inferrera, F., Impellizzeri, D., D’Amico, R., Siracusa, R., Fusco, R., Cuzzocrea, S., Cordaro, M., & Paola, R. D. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106387 · Cited by 9
Exploring the psychopathological profile of fibromyalgia: insights from the personality assessment inventory and its association with disease impact
Doreste, A., Pujol, J., Penelo, E., Pérez, V., Blanco‐Hinojo, L., Martínez‐Vilavella, G., Pardina-Torner, H., Ojeda, F., Monfort, J., & Deus, J. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1418644 · Cited by 11
Affective scaffolding and chronic illness
Byrne, E. A. (2022) · Philosophical Psychology · doi:10.1080/09515089.2022.2147422 · Cited by 8
Exercise Training for Chronic Pain: Available Evidence, Current Recommendations, and Potential Mechanisms
Ninneman, J. V., Roberge, G. A., Stegner, A. J., & Cook, D. B. (2024) · Current topics in behavioral neurosciences · doi:10.1007/7854_2024_504 · Cited by 9
Milnacipran and Vanillin Alleviate Fibromyalgia-Associated Depression in Reserpine-Induced Rat Model: Role of Wnt/β-Catenin Signaling
Kamaly, N. A., Kamel, A. S. E. D., Sadik, N. A. H., & Shahin, N. N. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04723-w · Cited by 8
Managing Pain in Fibromyalgia: Current and Future Options
Clarke, H. A., Peer, M., Miles, S. J., & Fitzcharles, M. (2025) · Drugs · doi:10.1007/s40265-025-02204-x · Cited by 9
Applying Lessons From Rheumatology to Better Understand Long COVID
Goldenberg, D. L. (2023) · Arthritis Care & Research · doi:10.1002/acr.25210 · Cited by 8
Concerns about the taxonomy, definition and coding of fibromyalgia syndrome in ICD-11: the potential for negative consequences for patient care and research
Häuser, W., Clauw, D. J., Wolfe, F., Sarzi‐Puttini, P., Ablin, J. N., Usui, C., Littlejohn, G. O., Morlion, B. J., Kosek, E., Fors, E. A., et al. (2022) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/3bt9qx · Cited by 8
Perceived Injustice and Anger in Fibromyalgia With and Without Comorbid Mental Health Conditions: A Hebrew Validation of the Injustice Experience Questionnaire
Gilam, G., Silvert, J., Raev, S., Malka, D., Gluzman, I., Rush, M., Elkana, O., & Aloush, V. (2024) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000001204 · Cited by 7
PTSD symptoms, pain catastrophizing, and pain outcomes after acute orthopedic injury
McDermott, K. A., Rush, C. L., Pham, T. V., Hooker, J. E., Louis, C. C., Rochon, E. A., & Vranceanu, A. (2024) · Pain Medicine · doi:10.1093/pm/pnae068 · Cited by 7
Mental effects of physical activity in patients with fibromyalgia: A narrative review
Talotta, R., Porcello, M., Restuccia, R., & Magaudda, L. (2024) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2024.10.067 · Cited by 8
The pivotal role of central sensitization in long COVID, fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome
Goldenberg, D. L. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2516097 · Cited by 9
The role of stress in the comorbidity of migraine and other chronic primary pain
Zhao, S., Wang, T., Zhang, Q., Akerman, S., & Cao, D. (2025) · Headache The Journal of Head and Face Pain · doi:10.1111/head.70004 · Cited by 8
Temporomandibular Disorders and Fibromyalgia Prevalence: A Systematic Review and Meta-Analysis
Yakkaphan, P., Smith, J. G., Chana, P., Tan, H. L., Ravindranath, P. T., Lambru, G., & Renton, T. F. (2023) · Journal of Oral & Facial Pain and Headache · doi:10.11607/ofph.3260 · Cited by 8
Impact of multiple-session home-based transcranial direct current stimulation (M-HB-tDCS) on eating behavior in fibromyalgia: A factorial randomized clinical trial
da Jornada, M. N., Antunes, L. D. C., Alves, C. F. D. S., Torres, I. L. D. S., Fregni, F., Sanches, P. R. S., Silva, D. P., & Caumo, W. (2024) · Brain stimulation · doi:10.1016/j.brs.2024.02.001 · Cited by 8
The Role of Depressive Disorders in Autonomic Cardiovascular Dysregulation in Fibromyalgia
del Paso, G. A. R., Contreras‐Merino, A. M., & Duschek, S. (2022) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001097 · Cited by 6
Sedentary time is associated with depressive symptoms and state anxiety in women with fibromyalgia. Could physical activity and fitness modify this association? The al-Ándalus project
Gavilán‐Carrera, B., Delgado‐Fernández, M., Sierra-Nieto, E., Acosta‐Manzano, P., Borges‐Cosic, M., Soriano‐Maldonado, A., & Segura‐Jiménez, V. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2122602 · Cited by 10
The Contribution of the Psychologist in the Assessment and Treatment of Fibromyalgia
Luciano, J. V., Neblett, R., Peñacoba, C., Suso‐Ribera, C., & McCracken, L. M. (2023) · Current Treatment Options in Rheumatology · doi:10.1007/s40674-023-00200-4 · Cited by 10
Stress, perceived competence and guilt as predictors of depression in parents with chronic pain
Peña, I. J. M., González, J. L., Yunta-Rua, L., Pacho-Hernández, J. C., & López‐López, A. (2025) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1473955 · Cited by 6
Trauma and psychological impact in fibromyalgia and other central sensitization syndromes: the role of anxiety and pain acceptance
Maire, C., Miró, E., Sánchez, A. I., Cáliz, R., & Martínez, M. P. (2025) · BMC Psychology · doi:10.1186/s40359-025-03429-x · Cited by 6
Mind the Mood: Momentary Depression and Anxiety Moderate the Correspondence Between Subjective and Objective Cognitive Functioning in Fibromyalgia
Kairys, A. E., Valentine, T. R., Whibley, D., & Kratz, A. L. (2023) · Arthritis Care & Research · doi:10.1002/acr.25086 · Cited by 6
The Role of Obsessive Compulsive Traits in Fibromyalgia: Is Pain-Related Obsessive Ideation Involved in Pathogenesis?
Galper, B.-E. L., Amital, M., Amital, H., Buskila, D., & Amital, D. (2024) · Medicina · doi:10.3390/medicina60071027 · Cited by 5
Chronic postsurgical pain increases postoperative depression risk
Sun, M., Wang, X., Lu, Z., Yang, Y., Lv, S., Miao, M., Chen, W., Wu, S., & Zhang, J. (2025) · Journal of Epidemiology & Community Health · doi:10.1136/jech-2024-222761 · Cited by 6
Psychiatric Comorbidities in Fibromyalgia
Avni, C., Morr, M., Sinai, D., & Toren, P. (2025) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001836 · Cited by 7
Neuronutritional enhancement of antioxidant defense system through Nrf2/HO1/NQO1 axis in fibromyalgia
Inferrera, F., Tranchida, N., Fusco, R., Cuzzocrea, S., Impellizzeri, D., Siracusa, R., D’Amico, R., Rashan, L. J., Badaeva, A. V., Danilov, A. B., et al. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106057 · Cited by 5
Evaluation of the Cardiac Conduction System in Fibromyalgia Patients With Complaints of Palpitations
Günlü, S., & Aktan, A. (2022) · Cureus · doi:10.7759/cureus.28784 · Cited by 5
Comorbid psychiatric conditions with temporomandibular disorders (TMD) in a tertiary referral clinic
Gadd, M., Attard, A., Green, J. L., & Elledge, R. O. C. (2024) · British Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.bjoms.2023.12.020 · Cited by 5
Measurement of event-related potentials from electroencephalography to evaluate emotional processing in Fibromyalgia Syndrome: A systematic review and meta-analysis
Fischer-Jbali, L. R., Alacreu‐Crespo, A., Galvez-Sánchez, C. M., & Montoro, C. I. (2024) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2024.112327 · Cited by 6
“Zooming” in the association between rosacea and fibromyalgia syndrome: ıs it worth mentioning?
Kulaklı, S., Oğuz, I. D., Sarı, İ. F., Şengül, İ., Kulaklı, F., Akşan, B., & Şengül, D. (2023) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.20230256 · Cited by 5
Chronic post-traumatic pain: rheumatological and orthopedic aspects
Karateev, A. E., Nesterenko, V. А., Макаров, М. А., & Lila, A. M. (2022) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2022-526-537 · Cited by 4
The prevalence of fibromyalgia in adults at Al-Karak Jordan: a cross-sectional study
Akel, A. Y., Sarhan, M. Y., Dwairy, M. A., Al-zu’bi, B., Al-Qudah, A., Alsmarat, O. A., AlSaraireh, T. H., & Abu‐Jeyyab, M. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001722 · Cited by 4
Body awareness, stress and symptoms in autonomic dysfunction in patients with chronic pain: an explorative study
Varkey, E., Gottfridsson, R., Grimby‐Ekman, A., Sellius, A. B., Östman, M., & Andréll, P. (2024) · Journal of Rehabilitation Medicine – Clinical Communications · doi:10.2340/jrmcc.v7.13374 · Cited by 4
Exploring the lived experiences of patients with fibromyalgia in the United Kingdom: a study of patient-general practitioner communication
Maher, C., & Gaffiero, D. (2025) · Psychology and Health · doi:10.1080/08870446.2025.2474013 · Cited by 5
Conocimientos, actitudes y creencias hacia la enfermedad en mujeres con fibromialgia. Un estudio cualitativo basado en grupo focal
Pérez, I. M. M., Pérez, S. E. M., Rampérrez, R. M., Vaswani, S. S. V., & Borges, M. F. D. (2023) · Revista de la Sociedad Española del Dolor · doi:10.20986/resed.2023.4022/2022 · Cited by 7
Screening for depressive symptoms in patients with rheumatoid arthritis: relationship with pain severity, disease activity, and sleep quality
Azzam, A. I., Lamlom, M., & Khalifa, A. M. (2022) · Middle East Current Psychiatry · doi:10.1186/s43045-022-00239-4 · Cited by 3
Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review
Tocchetto, B. F., Moreira, A. C. J., Franco, Á. D. O., Torres, I. L. D. S., Fregni, F., & Caumo, W. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1548617 · Cited by 3
Pain in the brain: Psychological correlates of chronic pain and fibromyalgia
Passarelli, M., Rizzi, L., Casetta, L., Guerrieri, V., Rocco, D., & Perrella, R. (2025) · PLoS ONE · doi:10.1371/journal.pone.0324457 · Cited by 3
Accuracy of screening for symptoms of anxiety and depression among patients with fibromyalgia in physiotherapy
Vancampfort, D., de Bruin, E. D., Bernar, K., Hemmings, L., & Damme, T. V. (2025) · Clinical Rehabilitation · doi:10.1177/02692155251351899 · Cited by 3
Valproate attenuates neuroinflammation and glial activation in a rat model of fibromyalgia: Evidence for antioxidant and nociceptive modulation
Ahmed, E. A., Abd-ellatief, R. B., Ali, M. F., & Abd-Eldayem, A. M. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150033 · Cited by 3
The Relationship Between Pain and Depression in Fibromyalgia: Structural Equation Modeling and Network Analysis
Oliva, F., Merola, M., Olivero, A., & Leombruni, P. (2026) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph23030316 · Cited by 3
Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care
d’Incau, E., Kaplan, C. M., Micoulaud‐Franchi, J., Veasley, C., & Ohrbach, R. K. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15124835 · Cited by 3
Is Irritable Bowel Syndrome Considered as Comorbidity in Clinical Trials of Physical Therapy Interventions in Fibromyalgia? A Scoping Review
Rodríguez-Castillejo, P. M., Fernández‐de‐las‐Peñas, C., Alburquerque‐Sendín, F., & Rodrigues‐de‐Souza, D. P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10204776 · Cited by 3
Patient Perspectives of Disease Activity, Medications and Substance Use in People with Fibromyalgia
Khoo, T., Hill, C. L., Hoon, E. A., & Whittle, S. (2022) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s361804 · Cited by 5
A history of depression in patients attending a chronic pain management clinic in South Africa: A retrospective chart review
van Vreede, J. J., Parker, R., & van Nugteren, J. (2022) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v28i0.1673 · Cited by 3

Authors: Kleykamp, B. A., Ferguson, M. C., McNicol, E., Bixho, I., Arnold, L. M., Edwards, R. R., Fillingim, R., Grol-Prokopczyk, H., Turk, D. C., & Dworkin, R. H.
Affiliations: University of Rochester Medicine (US)
Southern Illinois University Edwardsville (US)
Massachusetts College of Pharmacy and Health Sciences (US)
University of Cincinnati (US)
Harvard University (US)
University of Florida (US)
University at Buffalo, State University of New York (US)
University of Washington (US)
Corresponding author: Kleykamp, Bethea A.
ORCID: Kleykamp, Bethea A.
Ferguson, McKenzie C.
Arnold, Lesley M.
Edwards, Robert R.
Fillingim, Roger
Grol-Prokopczyk, Hanna
Dworkin, Robert H.
Venue: Seminars in Arthritis and Rheumatism
Publisher: Elsevier BV
Published: 2021-02
Volume: 51
Issue: 1
Pages: 166-174
ISSN: 0049-0172 (ISSN-L)
DOI: 10.1016/j.semarthrit.2020.10.006
OpenAlex: W3118172474
Cited by: 202
References: 70
Citations by year: 2026: 28 · 2025: 47 · 2024: 39 · 2023: 39 · 2022: 39 · 2021: 9
FWCI: 3.61
Type: journal article
Language: en
Open access: green
www.sciencedirect.com
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Seminars in Arthritis and Rheumatism (publishedVersion)
PubMed (publishedVersion)
SPARK (Southern Illinois University Edwardsville) (submittedVersion, cc-by-nc-nd)
Funders: U.S. Food and Drug Administration
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: fibromyalgia, psychiatric comorbidity, chronic pain comorbidity, depression, major depressive disorder, bipolar disorder, panic disorder, post-traumatic stress disorder, generalized anxiety disorder, obsessive-compulsive disorder, irritable bowel syndrome, tension-type headache, migraine, myofascial pain syndrome, temporomandibular disorders, prevalence, clinical trial design
MeSH terms: Cross-Sectional Studies, Major Depressive Disorder, Fibromyalgia, Humans, Comorbidity, Prevalence, Chronic Pain

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Prevalence of Psychiatric and Chronic Pain Comorbidities in Fibromyalgia: an ACTTION systematic review

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks