The epigenetics of cancer etiology

The fundamental role of epigenetic events in cancer

Jones, P. A., & Baylin, S. B. (2002) · Nature Reviews Genetics · doi:10.1038/nrg816 · Cited by 5,648

Induction of apoptosis in fibroblasts by c-myc protein

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,935

The polycomb group protein EZH2 is involved in progression of prostate cancer

Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717

The history of cancer epigenetics

Feinberg, A. P., & Tycko, B. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1279 · Cited by 2,344

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,986

Tumor Suppressor Genes

Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,756

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

Herman, J. G., Latif, F., Weng, Y., Lerman, M. I., Zbar, B., Liu, S., Samid, D., Duan, D. S., Gnarra, J. R., & Linehan, W. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9700 · Cited by 1,529

Induction of tumors in mice by genomic hypomethylation

Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499

Rb Interacts with Histone Deacetylase to Repress Transcription

Luo, R. X., Postigo, A. A., & Dean, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)80940-x · Cited by 960

Retinoblastoma protein represses transcription by recruiting a histone deacetylase

Magnaghi-Jaulin, L., Groisman, R., Naguibneva, I., Robin, P., Lorain, S., Le Villain, J. P., Troalen, F., Trouche, D., & Harel-Bellan, A. (1998) · Nature · doi:10.1038/35410 · Cited by 909

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

Graff, J. R., Herman, J. G., Lapidus, R. G., Chopra, H., Xu, R., Jarrard, D. F., Isaacs, W. B., Pitha, P. M., Davidson, N. E., & Baylin, S. B. (1995) · PubMed · Cited by 796

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

Harrington, E. A., Bennett, M. R., Fanidi, A., & Evan, G. I. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06630.x · Cited by 742

Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk

Cui, H., Cruz-Correa, M., Giardiello, F. M., Hutcheon, D. F., Kafonek, D. R., Brandenburg, S., Wu, Y., He, X., Powe, N. R., & Feinberg, A. P. (2003) · Science · doi:10.1126/science.1080902 · Cited by 735

Suppression of intestinal neoplasia by DNA hypomethylation

Laird, P. W., Jackson-Grusby, L., Fazeli, A., Dickinson, S. L., Edward Jung, W., Li, E., Weinberg, R. A., & Jaenisch, R. (1995) · Cell · doi:10.1016/0092-8674(95)90329-1 · Cited by 710

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing.

Gonzalez‐Zulueta, M., Bender, C. M., Yang, A. S., Nguyen, T. T., Beart, R. W., Tornout, J. M. V., & Jones, P. A. (1995) · PubMed · Cited by 695

Cancer epidemiology in the last century and the next decade

Peto, J. (2001) · Nature · doi:10.1038/35077256 · Cited by 681

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

Dunaief, J. L., Strober, B. E., Guha, S., Khavari, P. A., Ålin, K., Luban, J., Begemann, M., Crabtree, G. R., & Goff, S. P. (1994) · Cell · doi:10.1016/0092-8674(94)90405-7 · Cited by 624

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

Greger, V., Passarge, E., H�pping, W., Messmer, E., & Horsthemke, B. (1989) · Human Genetics · doi:10.1007/bf00286709 · Cited by 574

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

De Smet, C., De Backer, O., Faraoni, I., Lurquin, C., Brasseur, F., & Boon, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.7149 · Cited by 542

Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using cDNA Microarrays

Iacobuzio-Donahue, C. A., Maitra, A., Olsen, M., Lowe, A. W., Van Heek, N. T., Rosty, C., Walter, K., Sato, N., Parker, A., Ashfaq, R., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63911-9 · Cited by 473

Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.

Sakai, T., Toguchida, J., Ohtani, N., Yandell, D. W., Rapaport, J. M., & Dryja, T. P. (1991) · PubMed · Cited by 466

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

Steenman, M. J. C., Rainier, S., Dobry, C. J., Grundy, P., Horon, I. L., & Feinberg, A. P. (1994) · Nature Genetics · doi:10.1038/ng0794-433 · Cited by 460

Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation

Takiguchi, M., Achanzar, W. E., Qu, W., Li, G., & Waalkes, M. P. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00062-4 · Cited by 457

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene

Bachman, K. E., Park, B. H., Rhee, I., Rajagopalan, H., Herman, J. G., Baylin, S. B., Kinzler, K. W., & Vogelstein, B. (2003) · Cancer Cell · doi:10.1016/s1535-6108(02)00234-9 · Cited by 418

A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis

Christofori, G., Naik, P., & Hanahan, D. (1994) · Nature · doi:10.1038/369414a0 · Cited by 390

Epigenetic lesions at the H19 locus in Wilms' tumour patients

Moulton, T., Crenshaw, T., Hao, Y., Moosikasuwan, J., Lin, N., Dembitzer, F., Hensle, T., Weiss, L., McMorrow, L., Loew, T., et al. (1994) · Nature Genetics · doi:10.1038/ng0794-440 · Cited by 316

Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.

Sato, N., Maitra, A., Fukushima, N., van Heek, N. T., Matsubayashi, H., Iacobuzio–Donahue, C. A., Rosty, C., & Goggins, M. (2003) · PubMed · Cited by 304

DNA methylation and gene silencing in cancer: which is the guilty party?

Clark, S. J., & Melki, J. (2002) · Oncogene · doi:10.1038/sj.onc.1205598 · Cited by 287

Tumour class prediction and discovery by microarray-based DNA methylation analysis

Adorjan, P. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.5.e21 · Cited by 285

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

Cui, H., Horon, I. L., Ohlsson, R., Hamilton, S. R., & Feinberg, A. P. (1998) · Nature Medicine · doi:10.1038/3260 · Cited by 284

Epigenetics and the Environment

SUTHERLAND, J. E., & COSTA, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb05970.x · Cited by 261

DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms

Feinberg, A. P., Cui, H., & Ohlsson, R. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00059-7 · Cited by 220

Overexpression of S100A4 in Pancreatic Ductal Adenocarcinomas Is Associated with Poor Differentiation and DNA Hypomethylation

Rosty, C., Ueki, T., Argani, P., Jansen, M., Yeo, C. J., Cameron, J. L., Hruban, R. H., & Goggins, M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64347-7 · Cited by 213

CpG Methylation of Human Papillomavirus Type 16 DNA in Cervical Cancer Cell Lines and in Clinical Specimens: Genomic Hypomethylation Correlates with Carcinogenic Progression

Badal, V., Chuang, L. S. H., Tan, E. H.-H., Badal, S., Villa, L. L., Wheeler, C. M., Li, B. F. L., & Bernard, H.-U. (2003) · Journal of Virology · doi:10.1128/jvi.77.11.6227-6234.2003 · Cited by 200

Hypomethylation of the synuclein gamma gene CpG island promotes its aberrant expression in breast carcinoma and ovarian carcinoma.

Gupta, A., Godwin, A. K., Vanderveer, L., et al. (2003) · PubMed · Cited by 184

Hypomethylation Status of CpG Sites at the Promoter Region and Overexpression of the Human MDR1 Gene in Acute Myeloid Leukemias

Nakayama, M., Wada, M., Harada, T., Nagayama, J., Kusaba, H., Ohshima, K., Kozuru, M., Komatsu, H., Ueda, R., & Kuwano, M. (1998) · Blood · doi:10.1182/blood.v92.11.4296 · Cited by 172

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor

Ravenel, J. D., Broman, K. W., Perlman, E. J., Niemitz, E. L., Jayawardena, T. M., Bell, D. W., Haber, D. A., Uejima, H., & Feinberg, A. P. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.22.1698 · Cited by 172

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.

Heijmans, B. T., Boer, J. M. A., Suchiman, H. E. D., Cornelisse, C. J., Westendorp, R. G. J., Kromhout, D., Feskens, E. J. M., & Slagboom, P. E. (2003) · PubMed · Cited by 154

Erratum: Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

(1994) · Nature Genetics · doi:10.1038/ng1094-203b · Cited by 144

Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma

Cho, B., Lee, H., Jeong, S., Bang, Y., Lee, H. J., Hwang, K. S., Kim, H., Lee, Y., Kang, G. H., & Jeoung, D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01121-5 · Cited by 133

Deregulation of both imprinted and expressed alleles of the insulin–like growth factor 2 gene during β–cell tumorigenesis

Christofori, G., Naik, P., & Hanahan, D. (1995) · Nature Genetics · doi:10.1038/ng0695-196 · Cited by 121

Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice

Okoji, R. S., Yu, R. C., Maronpot, R. R., & Froines, J. R. (2002) · Carcinogenesis · doi:10.1093/carcin/23.5.777 · Cited by 118

Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells

Akiyama, Y., Maesawa, C., Ogasawara, S., Terashima, M., & Masuda, T. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63549-3 · Cited by 114

Promoter methylation of cyclin D2 gene in gastric carcinoma

Oshimo, Y., Nakayama, H., Ito, R., Kitadai, Y., Yoshida, K., Chayama, K., & Yasui, W. (2003) · International Journal of Oncology · doi:10.3892/ijo.23.6.1663 · Cited by 109

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

Nakamura, N., & Takenaga, K. (1998) · Clinical & Experimental Metastasis · doi:10.1023/a:1006589626307 · Cited by 100

Loss of Insulin-Like Growth Factor-II Imprinting and the Presence of Screen-Detected Colorectal Adenomas in Women

Woodson, K. G., Flood, A. P., Green, L. D., Tangrea, J. A., Hanson, J., Cash, B. D., Schatzkin, A. G., & Schoenfeld, P. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh042 · Cited by 78

Methylation meets genomics

Feinberg, A. P. (2001) · Nature Genetics · doi:10.1038/83825 · Cited by 75

Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma

Cho, M., Uemura, H., Kim, S., Kawada, Y., Yoshida, K., Hirao, Y., Konishi, N., Saga, S., & Yoshikawa, K. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1951 · Cited by 67

Demethylation of the Synuclein γ Gene CpG Island in Primary Gastric Cancers and Gastric Cancer Cell Lines

Yanagawa, N., Tamura, G., Honda, T., Endoh, M., Nishizuka, S., & Motoyama, T. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0107 · Cited by 60

Unanswered Questions about the Role of Promoter Methylation in Carcinogenesis

Bestor, T. H. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb05959.x · Cited by 53

DNA demethylation is directly related to tumour progression: evidence in normal, pre-malignant and malignant cells from uterine cervix samples.

de Capoa, A., Musolino, A., Rosa, S. D., Caiafa, P., Mariani, L., Nonno, F. D., Vocaturo, A., Donnorso, R. P., Niveleau, A., & Grappelli, C. (2003) · PubMed · Cited by 44

The age of cancer: telomeres, checkpoints, and longevity.

DePinho, R. A., & Wong, K. (2003) · PubMed · Cited by 30

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536

An integrated epigenetic and genetic approach to common human disease

BJORNSSON, H. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.06.009 · Cited by 448

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

Calvisi, D. F., Ladu, S., Gorden, A., Farina, M., Lee, J.-S., Conner, E. A., Schroeder, I., Factor, V. M., & Thorgeirsson, S. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31457 · Cited by 393

Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

Albrengues, J., Bertero, T., Grasset, E., Bonan, S., Maiel, M., Bourget, I., Philippe, C., Herraiz Serrano, C., Benamar, S., Croce, O., et al. (2015) · Nature Communications · doi:10.1038/ncomms10204 · Cited by 367

Environmental epigenetics and a unified theory of the molecular aspects of evolution: a neo-lamarckian concept that facilitates neo-darwinian evolution

Skinner, M. K. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv073 · Cited by 342