The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents
Abstract
The mitogen-activated protein kinases (MAPKs) are fundamental in inflammation and cancer control, through the crosstalk between the redox regulated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream kinases is a current therapeutic strategy. However, these therapies are associated with some adverse effects and with the paradoxical activation of the MAPKs pathway. In the context of cancer prevention and treatment, it has been suggested that dietary factors are able to modulate cancer initiation and progression by interacting with the MAPKs. Within these dietary factors, virgin olive oil (VOO) is of particular interest due to its content in squalene, already used as drug delivery system in cancer therapy. The aim of this review is to discuss the studies pointing to the effects of olive-derived foodstuff and nutraceuticals on MAPKs signalling cascades. The reviewed experimental studies suggest that the stress-activated JNK and p38 MAPKs could be targets of olive-derived nutraceuticals. The latter, including phytochemicals from olive cultivation and processing wastes, could be adjuvants in chemotherapies, whereas VOO could be considered a "natural delivery system" of bioactive phytochemicals due to its high content in squalene.
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Long, G. V., Fung, C., Menzies, A. M., Pupo, G. M., Carlino, M. S., Hyman, J., Shahheydari, H., Tembe, V., Thompson, J. F., Saw, R. P., et al. (2014) · Nature Communications · doi:10.1038/ncomms6694 · Cited by 375
Druesne‐Pecollo, N., Latino‐Martel, P., Norat, T., Barrandon, E., Bertrais, S., Galan, P., & Hercberg, S. (2010) · International Journal of Cancer · doi:10.1002/ijc.25008 · Cited by 283
Olive Oils High in Phenolic Compounds Modulate Oxidative/antioxidative Status in Men
Weinbrenner, T., Fitó, M., Torre, R. D. L., Saez, G. T., Rijken, P., Tormos, C., Coolen, S., Albaladejo, M. F., Abanades, S., Schroder, H., et al. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.9.2314 · Cited by 272
and the members of the SOLOS Investigators*, Marrugat, J., Covas, M.-I., Fitó, M., Schröder, H., Miró-Casas, E., Gimeno, E., López-Sabater, M. C., de la Torre, R., & Farré, M. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0452-8 · Cited by 259
Nair, S., Doh, S. T., Chan, J. Y., Kong, A.-N., & Cai, L. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604703 · Cited by 167
Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes
Miller, T. A., LeBrasseur, N. K., Cote, G. M., Trucillo, M. P., Pimentel, D. R., Ido, Y., Ruderman, N. B., & Sawyer, D. B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.088 · Cited by 146
Tanvetyanon, T., & Bepler, G. (2008) · Cancer · doi:10.1002/cncr.23527 · Cited by 122
Cited by
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., et al. (2023) · Cancer Communications · doi:10.1002/cac2.12392 · Cited by 280
Metadata
- Authors
- Peluso, I., Yarla, N. S., Ambra, R., Pastore, G., & Perry, G.
- Venue
- Seminars in Cancer Biology
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 56
- Pages
- 185-195
- ISSN
- 1044-579X (ISSN-L)
- OpenAlex
- W2754622726
- Cited by
- 159
- References
- 7
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Peluso, I., Yarla, N. S., Ambra, R., Pastore, G., & Perry, G. (2019). MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2017.09.002
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