Olive Oils High in Phenolic Compounds Modulate Oxidative/antioxidative Status in Men
Open accessAbstract
The aim of the present study was to evaluate whether olive oils high in phenolic compounds influence the oxidative/antioxidative status in humans. Healthy men (n = 12) participated in a double-blind, randomized, crossover study in which 3 olive oils with low (LPC), moderate (MPC), and high (HPC) phenolic content were given as raw doses (25 mL/d) for 4 consecutive days preceded by 10-d washout periods. Volunteers followed a strict very low-antioxidant diet the 3 d before and during the intervention periods. Short-term consumption of olive oils decreased plasma oxidized LDL (oxLDL), 8-oxo-dG in mitochondrial DNA and urine, malondialdehyde in urine (P < 0.05 for linear trend), and increased HDL cholesterol and glutathione peroxidase activity (P < 0.05 for linear trend), in a dose-dependent manner with the phenolic content of the olive oil administered. At d 4, oxLDL after MPC and HPC, and 8-oxo-dG after HPC administration (25 mL, respectively), were reduced when the men were in the postprandial state (P < 0.05). Phenolic compounds in plasma increased dose dependently during this stage with the phenolic content of the olive oils at 1, 2, 4, and 6 h, respectively (P < 0.01). Their concentrations increased in plasma and urine samples in a dose-dependent manner after short-term consumption of the olive oils (P < 0.01). In conclusion, the olive oil phenolic content modulated the oxidative/antioxidative status of healthy men who consumed a very low-antioxidant diet.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Only 4 of the 10 selected studies performed the dietary intervention in a double-blind way.
“Only 4 of the 10 selected studies performed the dietary intervention in a double-blind way [31,33,35,40].”
Ten RCTs met the inclusion criteria and were included in the meta-analysis.
“After reviewing the full text of the remaining records, only 10 met the inclusion criteria and were included in the meta-analysis [31,32,33,34,35,36,37,38,39,40].”
Randomized controlled trials have reported a dose-dependent increment in HDL levels with EVOO.
“In addition, randomized controlled trials have reported a dose-dependent increment in high-density lipoprotein (HDL) levels with EVOO [211,212]”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [211]
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944 · see citing works
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011 · see citing works
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198 · see citing works
Krauss, R. M., Eckel, R. H., Howard, B., Appel, L. J., Daniels, S. R., Deckelbaum, R. J., Erdman, J. W., Kris-Etherton, P., Goldberg, I. J., Kotchen, T. A., et al. (2000) · Circulation · doi:10.1161/01.cir.102.18.2284 · Cited by 1,458 · see citing works
Cancer risk and oxidative DNA damage in man
Loft, S. H., & Poulsen, H. E. (1996) · Journal of Molecular Medicine · doi:10.1007/bf00207507 · Cited by 955 · see citing works
Holvoet, P., Vanhaecke, J., Janssens, S., de Werf, F. V., & Collen, D. (1998) · Circulation · doi:10.1161/01.cir.98.15.1487 · Cited by 673 · see citing works
Ceriello, A., Taboga, C., Tonutti, L., Quagliaro, L., Piconi, L., Bais, B., Da Ros, R., & Motz, E. (2002) · Circulation · doi:10.1161/01.cir.0000027569.76671.a8 · Cited by 655 · see citing works
Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents
Visioli, F., Bellomo, G., Montedoro, G. F., & Galli, C. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05546-9 · Cited by 422 · see citing works
Antioxidant Activities and Oxidative Stress Byproducts in Human Hypertension
Redón, J., Oliva, M. R., Tormos, C., Giner, V., Chaves, F. J., Iradi, A., & Sáez, G. T. (2003) · Hypertension · doi:10.1161/01.hyp.0000068370.21009.38 · Cited by 417 · see citing works
Consumption of Olive Oil and Specific Food Groups in Relation to Breast Cancer Risk in Greece
Trichopoulou, A., Katsouyanni, K., Stuver, S. O., Tzala, L., Gnardellis, C., Rimm, E. B., & Trichopoulos, D. (1995) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/87.2.110 · Cited by 365 · see citing works
Mediterranean Dietary Pattern in a Randomized Trial
de Lorgeril, M., Salen, P., Martin, J., Monjaud, I., Boucher, P., & Mamelle, N. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.11.1181 · Cited by 364 · see citing works
Cretan Mediterranean diet for prevention of coronary heart disease
Renaud, S., de Lorgeril, M., Delaye, J., Guidollet, J., Jacquard, F., MAMELLE, N., Martin, J., Monjaud, I., Salen, P., & Toubol, P. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1360s · Cited by 341 · see citing works
Hydroxytyrosol Disposition in Humans
Miró‐Casas, E., Covas, M.-I., Farré, M., Fitó, M., Ortuño, J., Weinbrenner, T., Roset, P. N., & de la Torre, R. (2003) · Clinical Chemistry · doi:10.1373/49.6.945 · Cited by 293 · see citing works
HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia
Kurowska, E. M., Spence, J. D., Jordan, J., Wetmore, S., Freeman, D. J., Piché, L. A., & Serratore, P. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.5.1095 · Cited by 290 · see citing works
and the members of the SOLOS Investigators*, Marrugat, J., Covas, M.-I., Fitó, M., Schröder, H., Miró-Casas, E., Gimeno, E., López-Sabater, M. C., de la Torre, R., & Farré, M. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0452-8 · Cited by 259 · see citing works
Self-citationWilcox, L. J., Borradaile, N. M., de Dreu, L. E., & Huff, M. W. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31634-5 · Cited by 254 · see citing works
Nielsen, S. E., Young, J. F., Daneshvar, B., Lauridsen, S. T., Knuthsen, P., Sandström, B., & Dragsted, L. O. (1999) · British Journal Of Nutrition · doi:10.1017/s000711459900080x · Cited by 254 · see citing works
Effects of four different single exercise sessions on lipids, lipoproteins, and lipoprotein lipase
Ferguson, M. A., Alderson, N. L., Trost, S. G., Essig, D. A., Burke, J. R., & Durstine, J. L. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.1169 · Cited by 245 · see citing works
Olive Phenol Hydroxytyrosol Prevents Passive Smoking–Induced Oxidative Stress
Visioli, F., Galli, C., Plasmati, E., Viappiani, S., Hernandez, A., Colombo, C., & Sala, A. (2000) · Circulation · doi:10.1161/01.cir.102.18.2169 · Cited by 192 · see citing works
Protective effect of olive oil and its phenolic compounds against low density lipoprotein oxidation
Fitó, M., Covas, M. I., Lamuela-Raventós, R. M., Vila, J., Torrents, J., de la Torre, C., & Marrugat, J. (2000) · Lipids · doi:10.1007/s11745-000-0567-1 · Cited by 189 · see citing works
Suzuki, K., Koike, H., Matsui, H., Ono, Y., Hasumi, M., Nakazato, H., Okugi, H., Sekine, Y., Oki, K., Ito, K., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10428 · Cited by 184 · see citing works
Reaven, P. D., Grasse, B. J., & Tribble, D. L. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.4.557 · Cited by 181 · see citing works
High oxidative stress in patients with stable coronary heart disease
Weinbrenner, T., Cladellas, M., Covas, M. I., Fitó, M., Tomás, M., Sentı́, M., Bruguera, J., & Marrugat, J. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00053-4 · Cited by 154 · see citing works
Ramírez-Tortosa, M. C., Urbano, G., López-Jurado, M., Nestares, T., Gómez, M. C., MIR, A., Ros, E., Mataix, J., & Gil, Á. (1999) · Journal of Nutrition · doi:10.1093/jn/129.12.2177 · Cited by 151 · see citing works
Miró‐Casas, E., Farré, M., Covas, M., Rodriguez, J. O., Colomer, E. M., Lamuela-Raventós, R. M., & de la Torre, R. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5160 · Cited by 150 · see citing works
Leighton, F., Cuevas, A. M., Guasch, V., Pérez, D. D., Strobel, P., Martín, A. S., Urzua, U., Diez, M. S., Foncea, R. E., Castillo, O., et al. (1999) · PubMed · Cited by 139 · see citing works
Borradaile, N. M., de Dreu, L. E., & Huff, M. W. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2554 · Cited by 135 · see citing works
Aviram, M., & Eias, K. (1993) · Annals of Nutrition and Metabolism · doi:10.1159/000177753 · Cited by 128 · see citing works
Oxidative DNA damage in human white blood cells in dietary antioxidant intervention studies
Möller, P., & Loft, S. H. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.303 · Cited by 125 · see citing works
Antioxidant enzyme activities and the production of MDA and 8-oxo-dG in chronic lymphocytic lerkenia
Oltra, A. M., Carbonell, F., Tormos, C., Iradi, A., & Sáez, G. T. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00521-4 · Cited by 122 · see citing works
What are the health effects of fat?
Wahrburg, U. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1103-9 · Cited by 121 · see citing works
Effect of ingestion of virgin olive oil on human low-density lipoprotein composition
Gimeno, E., Fitó, M., Lamuela-Raventós, R. M., Castellote, A. I., Covas, M., Farré, M., de la Torre-Boronat, M. C., & López‐Sabater, M. C. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601293 · Cited by 117 · see citing works
Mata, P., Varela, O., Rodrigo Alonso, K., Lahoz, C., de Oya, M., & Badimón, L. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.2088 · Cited by 116 · see citing works
Larsen, L. F., Jespersen, J., & Marckmann, P. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.976 · Cited by 101 · see citing works
The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers
Klaunig, J. E., Xu, Y., Han, C., Kamendulis, L. M., Chen, J., Heiser, C., Gordon, M. S., & Mohler, E. R. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-43.x · Cited by 101 · see citing works
Evidence of postprandial absorption of olive oil phenols in humans.
Bonanome, A., Pagnan, A., Caruso, D., Toia, A., Xamin, A., Fedeli, E., Berra, B., Zamburlini, A., Ursini, F., & Galli, G. (2000) · PubMed · Cited by 100 · see citing works
Sajjadi, S. E., Atar, A. M., & Yektaian, A. (1998) · Pharmaceutica Acta Helvetiae · doi:10.1016/s0031-6865(98)00016-8 · Cited by 89 · see citing works
Role of naringin supplement in regulation of lipid and ethanol metabolism in rats
Seo, H.-J., Jeong, K., Lee, M., Park, Y. B., Jung, U. J., Kim, H.-J., & Choi, M. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00358-8 · Cited by 79 · see citing works
Tomato Consumption Modulates Oxidative DNA Damage in Humans
Rehman, A., Bourne, L., Halliwell, B. B., & Rice-Evans, C. A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1235 · Cited by 76 · see citing works
Nicolaı̈ew, N., Lemort, N., Adorni, L., Berra, B., Montorfano, G., Rapelli, S., Cortesi, N., & JACOTOT, B. (1998) · Annals of Nutrition and Metabolism · doi:10.1159/000012741 · Cited by 75 · see citing works
Differences in postprandial lipaemic response between Northern and Southern Europeans
Zampelas, A., Roche, H. M., Knapper, J. M. E., Jackson, K. G., Tornaritis, M. J., Hatzis, C., Gibney, M. J., Kafatos, A., GOULD, B. J., Wright, J., et al. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00061-6 · Cited by 74 · see citing works
Cruz, J. P. D. L., Quintero, L., Villalobos, M. A., & de la Cuesta, F. S. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00027-5 · Cited by 70 · see citing works
Effect of phenol-rich extra virgin olive oil on markers of oxidation in healthy volunteers
Vissers, M. N., Zock, P. L., Wiseman, S. A., Meyboom, S., & Katan, M. (2001) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601161 · Cited by 68 · see citing works
Pérez‐Jiménez, F., Espino, A., Lopez‐Segura, F., Blanco, J., Ruíz-Gutiérrez, V., Prada, J. L., López‐Miranda, J., Jiménez-Perepérez, J., & Ordovás, J. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.4.769 · Cited by 67 · see citing works
Masella, R., Giovannini, C., Varı́, R., Benedetto, R. D., Coni, E., Volpe, R., Fraone, N., & Bucci, A. (2001) · Lipids · doi:10.1007/s11745-001-0832-3 · Cited by 66 · see citing works
Postprandial and short‐term effects of dietary virgin olive oil on oxidant/antioxidant status
Fitó, M., Gimeno, E., Covas, M., Miró‐Casas, E., López‐Sabater, M. C., Farré, M., de la Torre, R., & Marrugat, J. (2002) · Lipids · doi:10.1007/s11745-002-0887-1 · Cited by 50 · see citing works
Antioxidant intervention studies related to DNA damage, DNA repair and gene expression.
Loft, S. H., & Poulsen, H. E. (2000) · PubMed · Cited by 47 · see citing works
Covas, M.-I., Fitó, M., Lamuela-Raventós, R. M., Sebastià, N., de la Torre-Boronat, C., & Marrugat, J. (2000) · PubMed · Cited by 47 · see citing works
Moschandreas, J. A., Vissers, M. N., Wiseman, S. A., van Putte, K. P. A. M., & Kafatos, A. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601444 · Cited by 43 · see citing works
The Effect of Tea Consumption on Oxidative Stress in Smokers and Nonsmokers
Klaunig, J. E., Xu, Y., Han, C., Kamendulis, L. M., Chen, J., Heiser, C., Gordon, M. S., & Mohler, E. R. (1999) · Experimental Biology and Medicine · doi:10.3181/00379727-220-44375 · Cited by 32 · see citing works
Mangas-Cruz, M.-A., Fernández-Moyano, A., Albi, T., Guinda, Á., Relimpio, F., Lanzón, A., Pereira, J. L. S., Serrera, J. L., Montilla, C., Astorga, R., et al. (2001) · Clinical Nutrition · doi:10.1054/clnu.2000.0382 · Cited by 31 · see citing works
Olive oil phenolics protect LDL and spare vitamin E in the hamster
Wiseman, S. A., Tijburg, L. B. M., & van de Put, F. H. M. M. (2002) · Lipids · doi:10.1007/s11745-002-1000-5 · Cited by 23 · see citing works
Zoppi, S., Vergani, C., Giorgietti, P., Rapelli, S., & Berra, B. (1985) · PubMed · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
EFSA Panel on Dietetic Products, N. A. A. (. (2011) · EFSA Journal · doi:10.2903/j.efsa.2011.2033 · Cited by 491 · see citing works
Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil
Cicerale, S., Lucas, L., & Keast, R. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.09.006 · Cited by 467 · see citing works
Biological Activities of Phenolic Compounds Present in Virgin Olive Oil
Cicerale, S., Lucas, L., & Keast, R. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11020458 · Cited by 449 · see citing works
Polyphenols: Benefits to the Cardiovascular System in Health and in Aging
Khurana, S., Venkataraman, K., Hollingsworth, A., Piché, M., & Tai, T. C. (2013) · Nutrients · doi:10.3390/nu5103779 · Cited by 438 · see citing works
Olive oil and the cardiovascular system
Covas, M. I. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.01.010 · Cited by 401 · see citing works
Protective mechanisms of the Mediterranean diet in obesity and type 2 diabetes
Schröder, H. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.05.006 · Cited by 334 · see citing works
Chemistry and Health of Olive Oil Phenolics
Cicerale, S., Conlan, X. A., Sinclair, A. J., & Keast, R. (2008) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390701856223 · Cited by 335 · see citing works
The role of virgin olive oil components in the modulation of endothelial function
Perona, J. S., Cabello-Moruno, R., & Ruíz-Gutiérrez, V. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.11.007 · Cited by 278 · see citing works
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272 · see citing works
“In addition, randomized controlled trials have reported a dose-dependent increment in high-density lipoprotein (HDL) levels with EVOO [211,212], and these, contrary to LDL species, are strongly inversely associated with CVD [213].”
BackgroundMartín‐Peláez, S., Covas, M. I., Fitó, M., Kušar, A., & Pravst, I. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200421 · Cited by 259 · see citing works
The influence of olive oil on human health: not a question of fat alone
Pérez‐Jiménez, F., Ruano, J., Pérez‐Martínez, P., Lopez‐Segura, F., & López‐Miranda, J. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600273 · Cited by 257 · see citing works
Ruano, J., López‐Miranda, J., Fuentes, F. J., Moreno, J. A., Bellido, C., Pérez‐Martínez, P., Lozano, A., Gómez, P., Jiménez, Y., & Pérez‐Jiménez, F. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.078 · Cited by 234 · see citing works
Extra virgin olive oil: More than a healthy fat
Yubero‐Serrano, E. M., López-Moreno, J., Gómez-Delgado, F., & López‐Miranda, J. (2018) · European Journal of Clinical Nutrition · doi:10.1038/s41430-018-0304-x · Cited by 226 · see citing works
Fabiani, R., Rosignoli, P., Bartolomeo, A. D., Fuccelli, R., Servili, M., Montedoro, G. F., & Morozzi, G. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1411 · Cited by 225 · see citing works
Minor Components of Olive Oil: Evidence to Date of Health Benefits in Humans
Covas, M.-I., Ruíz-Gutiérrez, V., de la Torre, R., Kafatos, A., Lamuela-Raventós, R. M., Osada, J., Owen, R. W., & Visioli, F. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00260.x · Cited by 209 · see citing works
Sánchez, C. S., Troncoso, A. M., García-Parrilla, M. C., Granados, J. J. Q., de la Serrana, H. L. G., & Martínez, M. C. L. (2007) · Analytica Chimica Acta · doi:10.1016/j.aca.2007.04.037 · Cited by 202 · see citing works
Mitjavila, M. T., Fandos, M., Salas‐Salvadó, J., Covas, M., Borrego, S., Estruch, R., Lamuela-Raventós, R. M., Corella, D., Martínez‐González, M. Á., Sánchez, J. M., et al. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.002 · Cited by 200 · see citing works
Nutrigenomics of extra‐virgin olive oil: A review
Piroddi, M., Albini, A., Fabiani, R., Giovannelli, L., Luceri, C., Natella, F., Rosignoli, P., Rossi, T., Taticchi, A., Servili, M., et al. (2016) · BioFactors · doi:10.1002/biof.1318 · Cited by 200 · see citing works
Hydroxytyrosol and Its Potential Therapeutic Effects
Hu, T., He, X., Jiang, J., & Xu, X.-L. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf405820v · Cited by 192 · see citing works
Gaforio, J. J., Visioli, F., Alarcón-de-la-Lastra, C., Castañer, O., Delgado-Rodríguez, M., Fitó, M., Hernández, A. F., Huertas, J. R., Martínez-González, M. A., Menendez, J. A., et al. (2019) · Nutrients · doi:10.3390/nu11092039 · Cited by 187 · see citing works
González-Santiago, M., Martín-Bautista, E., Carrero, J. J., Fonollá, J., Baró, L., Bartolomé, M. V., Gil-Loyzaga, P. E., & López‐Huertas, E. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.022 · Cited by 183 · see citing works
Rietjens, S. J., Bast, A., & Haenen, G. R. M. M. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0706934 · Cited by 180 · see citing works
The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds
Parkinson, L., & Cicerale, S. (2016) · Molecules · doi:10.3390/molecules21121734 · Cited by 179 · see citing works
Hamden, K., Allouche, N., Mohamed Damak, A., & Elfeki, A. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.04.002 · Cited by 175 · see citing works
Virgin olive oil: a key food for cardiovascular risk protection
Covas, M., de la Torre, R., & Fitó, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000136 · Cited by 174 · see citing works
Effects of dietary factors on oxidation of low-density lipoprotein particles
Lapointe, A., Couillard, C., & Lemieux, S. (2006) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.01.001 · Cited by 169 · see citing works
Salvini, S., Sera, F., Caruso, D., Giovannelli, L., Visioli, F., Saieva, C., Masala, G., Ceroti, M., Giovacchini, V., Pitozzi, V., et al. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051674 · Cited by 166 · see citing works
Sirianni, R., Chimento, A., Luca, A. D., Casaburi, I., Rizza, P., Onofrio, A., Iacopetta, D., Puoci, F., Andò, S., Maggiolini, M., et al. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900111 · Cited by 162 · see citing works
Hydrolyzed Olive Vegetation Water in Mice Has Anti-Inflammatory Activity
Bitler, C. M., Viale, T. M., Damaj, B. B., & Crea, R. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1475 · Cited by 161 · see citing works
MAPK signalling pathway in cancers: Olive products as cancer preventive and therapeutic agents
Peluso, I., Yarla, N. S., Ambra, R., Pastore, G., & Perry, G. L. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.002 · Cited by 159 · see citing works
Olive oil and cardiovascular health
Covas, M.-I., Konstantinidou, V., & Fitó, M. (2009) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3181c5e7fd · Cited by 158 · see citing works
Uylaşer, V., & Yıldız, G. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.626874 · Cited by 153 · see citing works
Fabiani, R., Bartolomeo, A. D., Rosignoli, P., Servili, M., Selvaggini, R., Montedoro, G. F., Saverio, C. D., & Morozzi, G. (2006) · Journal of Nutrition · doi:10.1093/jn/136.3.614 · Cited by 150 · see citing works
Dietary antioxidants and beneficial effect on oxidatively damaged DNA
Möller, P., & Loft, S. H. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.04.001 · Cited by 146 · see citing works
Hydroxytyrosol Protects against Oxidative DNA Damage in Human Breast Cells
Warleta, F., Sánchez‐Quesada, C., Campos, M., Allouche, Y., Beltrán, G., & Gaforio, J. J. (2011) · Nutrients · doi:10.3390/nu3100839 · Cited by 145 · see citing works
Olive oil and oxidative stress
Fitó, M., de la Torre, R., & Covas, M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600308 · Cited by 143 · see citing works
Anti-cancer properties of olive oil secoiridoid phenols: a systematic review of in vivo studies
Fabiani, R. (2016) · Food & Function · doi:10.1039/c6fo00958a · Cited by 144 · see citing works
Nutritional and biological properties of extra virgin olive oil
Frankel, E. N. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103813t · Cited by 143 · see citing works
Casaburi, I., Puoci, F., Chimento, A., Sirianni, R., Ruggiero, C., Avena, P., & Pezzi, V. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200503 · Cited by 139 · see citing works
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Nurmi, T., Poulsen, H. E., Gaddi, A. V., Kaikkonen, J., Zunft, H.-F., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.112912 · Cited by 132 · see citing works
Antioxidants in Sport Nutrition
Lamprecht, M. (2014) · CRC Press eBooks · doi:10.1201/b17442 · Cited by 133 · see citing works
Aguilera, Y., Martin-Cabrejas, M. A., & de Mejı́a, E. G. (2015) · Phytochemistry Reviews · doi:10.1007/s11101-015-9443-z · Cited by 129 · see citing works
Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders
Peyrol, J., Riva, C., & Amiot, M. J. (2017) · Nutrients · doi:10.3390/nu9030306 · Cited by 122 · see citing works
Antioxidant Activity of Olive Polyphenols in Humans: a Review
Raederstorff, D. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.3.152 · Cited by 122 · see citing works
Vasculoprotective potential of olive oil components
Carluccio, M. A., Massaro, M., Scoditti, E., & Caterina, R. D. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600305 · Cited by 114 · see citing works
Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review.
Fitó, M., de la Torre, R., Farré, M., Khymenetz, O., Marrugat, J., & Covas, M. (2007) · PubMed · Cited by 112 · see citing works
Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation
Ahmadi, A., Jamialahmadi, T., & Sahebkar, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106414 · Cited by 111 · see citing works
Zamora‐Ros, R., Urpí-Sardà, M., Lamuela-Raventós, R. M., Estruch, R., Martínez‐González, M. Á., Bulló, M., Arós, F., Cherubini, A., & Andrés‐Lacueva, C. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.12.023 · Cited by 108 · see citing works
Costa, M., Bayındır, Z. S., Losada‐Barreiro, S., Paiva‐Martins, F., Saso, L., & Bravo‐Díaz, C. (2021) · Biomedicines · doi:10.3390/biomedicines9121909 · Cited by 108 · see citing works
Cardiovascular friendly natural products: a promising approach in the management of CVD
Shukla, S. K., Gupta, S., Ojha, S. K., & Sharma, S. B. (2010) · Natural Product Research · doi:10.1080/14786410903417378 · Cited by 102 · see citing works
2: Phenolic Compounds Potential Health Benefits and Toxicity
Street, R. A., Prinsloo, G., & McGaw, L. J. (2017) · CRC Press eBooks · doi:10.1201/9781315151540-3 · Cited by 98 · see citing works
Oliveras‐López, M., Berná, G., Jurado‐Ruiz, E., de la Serrana, H. L.-G., & Martı́n, F. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.07.013 · Cited by 98 · see citing works
Andrés‐Lacueva, C., Macarulla, M. T., Rotchés-Ribalta, M., Boto‐Ordóñez, M., Urpí-Sardà, M., Rodríguez, V. M., & Portillo, M. P. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf3001108 · Cited by 96 · see citing works
da Silva, S. R. A., Sepodes, B. M. N., Rocha, J. P., Direito, R., Fernandes, A. M. A., Brites, D. M. T. O., Freitas, M., Fernandes, E. G. R., Bronze, M. R., & Figueira, M. E. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.11.011 · Cited by 93 · see citing works
Colica, C., Renzo, L. D., Trombetta, D., Smeriglio, A., Bernardini, S., Cioccoloni, G., de Miranda, R. C., Gualtieri, P., Salimei, P. S., & LORENZO, A. D. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2473495 · Cited by 90 · see citing works
Oliveras‐López, M., Muros, J. J., Mir, M. V., Rey, E. F., Martín, F., & de la Serrana, H. L.-G. (2013) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2013.04.002 · Cited by 91 · see citing works
Extra-virgin olive oil for potential prevention of Alzheimer disease
Román, G. C., Jackson, R. E., Reis, J. J., Roman, A., Toledo, J. B., & Toledo, E. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.07.017 · Cited by 91 · see citing works
Mediterranean food and health: building human evidence.
Visioli, F., Bogani, P., Grande, S., & Galli, C. L. (2005) · PubMed · Cited by 86 · see citing works
Micheli, L., Bertini, L., Bonato, A., Villanova, N., Caruso, C., Caruso, M., Bernini, R., & Tirone, F. (2023) · Nutrients · doi:10.3390/nu15071767 · Cited by 85 · see citing works
Development of a Phenol-Enriched Olive Oil with Phenolic Compounds from Olive Cake
Suárez, M., Romero, M., & Motilva, M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102203x · Cited by 85 · see citing works
Antimicrobial and Antioxidant Activities of Turkish Extra Virgin Olive Oils
Karaosmanoğlu, H., Soyer, F., Ozen, B. F., & Tokatlı, F. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf1012105 · Cited by 84 · see citing works
Tsartsou, E., Proutsos, N. D., Castanas, E., & Kampa, M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00006 · Cited by 84 · see citing works
Phenolic Profile and Antioxidant Activity of Italian Monovarietal Extra Virgin Olive Oils
Negro, C., Aprile, A., Luvisi, A., Nicolì, F., Nutricati, E., Vergine, M., Miceli, A., Blando, F., Sabella, E., & Bellis, L. D. (2019) · Antioxidants · doi:10.3390/antiox8060161 · Cited by 82 · see citing works
Hydroxytyrosol Administration Enhances Atherosclerotic Lesion Development in Apo E Deficient Mice
Acı́n, S., Navarro, M. Á., Arbonés-Mainar, J. M., Guillén, N., Sarría, A. J., Carnicer, R., Surra, J. C., Orman, I., Segovia, J. C., de la Torre, R., et al. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj166 · Cited by 82 · see citing works
Is dopamine behind the health benefits of red wine?
de la Torre, R., Covas, M. I., Pujadas, M. A., Fitó, M., & Farré, M. (2006) · European Journal of Nutrition · doi:10.1007/s00394-006-0596-9 · Cited by 82 · see citing works
Weikert, C., Hoffmann, K., Dierkes, J., Zyriax, B., Klipstein‐Grobusch, K., Schulze, M. B., Jung, R., Windler, E. E. T., & Boeing, H. (2005) · Journal of Nutrition · doi:10.1093/jn/135.8.1981 · Cited by 82 · see citing works
Toto, A., Wild, P. P., Graille, M., Turcu, V., Crézé, C., Hemmendinger, M., Sauvain, J., Bergamaschi, E., Canu, I. G., & Hopf, N. B. (2022) · Toxics · doi:10.3390/toxics10040160 · Cited by 81 · see citing works
Evaluation of antioxidant activities of phenolic compounds from two extra virgin olive oils
Nakbi, A., Issaoui, M., Dabbou, S., Koubaa, N., Echbili, A., Hammami, M., & Attia, N. (2010) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2010.05.003 · Cited by 81 · see citing works
Olive Oil Phenols as Promising Multi-targeting Agents Against Alzheimer’s Disease
Rigacci, S. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-18365-7_1 · Cited by 80 · see citing works
Olive Oil Nutraceuticals in the Prevention and Management of Diabetes: From Molecules to Lifestyle
AlKhatib, A. H., Tsang, C., & Tuomilehto, J. O. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072024 · Cited by 79 · see citing works
Rietjens, S. J., Bast, A., de Vente, J., & Haenen, G. R. M. M. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00755.2006 · Cited by 78 · see citing works
Cornwell, D. G., & Ma, J. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8015877 · Cited by 78 · see citing works
Jiménez‐Sánchez, A., Martínez-Ortega, A. J., Remón-Ruiz, P., Piñar-Gutiérrez, A., Cunill, J. L. P., & García‐Luna, P. P. (2022) · Nutrients · doi:10.3390/nu14071440 · Cited by 76 · see citing works
Antioxidant vitamins and cancer risk: is oxidative damage to DNA a relevant biomarker?
Loft, S. H., Möller, P., Cooke, M. S., Różalski, R., & Oliński, R. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-2004-0 · Cited by 76 · see citing works
Nakbi, A., Tayeb, W., Grissa, A. K., Issaoui, M., Dabbou, S., Chargui, I., Ellouz, M., Miled, A., & Hammami, M. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-80 · Cited by 76 · see citing works
de la Torre‐Carbot, K., Chávez‐Servín, J. L., Jáuregui, O., Castellote, A. I., Lamuela-Raventós, R. M., Fitó, M., Covas, M., Muñoz‐Aguayo, D., & López‐Sabater, M. C. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.10.029 · Cited by 76 · see citing works
Gimeno, E., de la Torre‐Carbot, K., Lamuela-Raventós, R. M., Castellote, A. I., Fitó, M., de la Torre, R., Covas, M., & López‐Sabater, M. C. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507778698 · Cited by 76 · see citing works
Extra virgin olive oil blunt post-prandial oxidative stress via NOX2 down-regulation
Carnevale, R., Pignatelli, P., Nocella, C., Loffredo, L., Pastori, D., Vicario, T., Petruccioli, A., Bartimoccia, S., & Violi, F. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.954 · Cited by 74 · see citing works
Wang, N., Ma, Y., Liu, Z., Liu, L., Yang, K., Wei, Y., Liu, Y., Chen, X., Sun, X., & Wen, D. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.07.002 · Cited by 73 · see citing works
Wang, M., Zhang, S., Zhong, R., Wan, F., Chen, L., Liu, L., Yi, B., & Zhang, H. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.645099 · Cited by 70 · see citing works
Acetylation of hydroxytyrosol enhances its transport across differentiated Caco-2 cell monolayers
Mateos, R., Pereira‐Caro, G., Saha, S., Cert, R., Redondo‐Horcajo, M., Bravo, L., & Kroon, P. A. (2010) · Food Chemistry · doi:10.1016/j.foodchem.2010.09.054 · Cited by 70 · see citing works
Khymenets, O., Fitó, M., Covas, M.-I., Farré, M., Pujadas, M.-A., Muñoz, D., Konstantinidou, V., & Torre, R. D. L. (2009) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2008.0079 · Cited by 68 · see citing works
Rosenblat, M., Volkova, N., Coleman, R., Almagor, Y., & Aviram, M. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.06.007 · Cited by 68 · see citing works
Sánchez-Rodríguez, E., Biel-Glesson, S., Fernandez-Navarro, J. R., Calleja, M. Á., Espejo-Calvo, J. A., Extremera, B. G., de la Torre, R., Fitó, M., Covas, M., Vílchez, P., et al. (2019) · Nutrients · doi:10.3390/nu11030561 · Cited by 67 · see citing works
Calabriso, N., Massaro, M., Scoditti, E., D’Amore, S., Gnoni, A., Pellegrino, M., Storelli, C., Caterina, R. D., Palasciano, G., & Carluccio, M. A. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.09.026 · Cited by 66 · see citing works
Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under Inflammatory Condition
Scoditti, E., Carpi, S., Massaro, M., Pellegrino, M., Polini, B., Carluccio, M. A., Wabitsch, M., Verri, T., Nieri, P., & Caterina, R. D. (2019) · Nutrients · doi:10.3390/nu11102493 · Cited by 65 · see citing works
Squalene: a multi-task link in the crossroads of cancer and aging
Ronco, Á. L., & Stéfani, E. D. (2013) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v3i12.30 · Cited by 65 · see citing works
Franconi, F., Coinu, R., Carta, S., Urgeghe, P. P., Ieri, F., Mulinacci, N., & Romani, A. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf053003+ · Cited by 64 · see citing works
Can the Mediterranean diet prevent prostate cancer?
Itsiopoulos, C., Hodge, A. M., & Kaimakamis, M. A. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800207 · Cited by 64 · see citing works
Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans
Alemán-Jiménez, C., Domínguez‐Perles, R., Medina, S., Prgomet, I., López-González, I., Simonelli‐Muñoz, A. J., Cano, M. C., Auñón, D., Ferreres, F., & Gil‐Izquierdo, Á. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02295-0 · Cited by 63 · see citing works
Helal, O., Berrougui, H., Loued, S., & Khalil, A. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003856 · Cited by 63 · see citing works
Anter, J., Tasset, I., Demyda-Peyrás, S., Ranchal, I., Moreno‐Millán, M., Romero-Jiménez, M., Muntané, J., de Castro, M. D. L., Muñoz-Serrano, A., & Alonso-Moraga, Á. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.07.002 · Cited by 63 · see citing works
Fabiani, R., Fuccelli, R., Pieravanti, F., Bartolomeo, A. D., & Morozzi, G. (2009) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800376 · Cited by 62 · see citing works
Frank, T., Netzel, G. A., Kammerer, D. R., Carle, R., Kler, A., Kriesl, E., Bitsch, I., Bitsch, R., & Netzel, M. E. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5615 · Cited by 61 · see citing works
Paiva‐Martins, F., Fernandes, J. C., Santos, V. P., Silva, L. M., Borges, F., Rocha, S., Belo, L., & Santos‐Silva, A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9031052 · Cited by 61 · see citing works
Khymenets, O., Fitó, M., Touriño, S., Muñoz‐Aguayo, D., Pujadas, M., Torres, J. L., Joglar, J., Farré, M., Covas, M.-I., & de la Torre, R. (2010) · Drug Metabolism and Disposition · doi:10.1124/dmd.110.032821 · Cited by 61 · see citing works
Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary Modulation
Fernández‐García, J. C., Cardona, F., & Tinahones, F. J. (2014) · Current Vascular Pharmacology · doi:10.2174/15701611113116660175 · Cited by 61 · see citing works
Oral Bioavailability and Metabolism of Hydroxytyrosol from Food Supplements
Bender, C., Straßmann, S., & Golz, C. (2023) · Nutrients · doi:10.3390/nu15020325 · Cited by 60 · see citing works
Camargo, A., Rangel-Zúñiga, O. A., Haro, C., Meza-Miranda, E. R., Peña‐Orihuela, P. J., Meneses, M. E. P. D., Marı́n, C., Yubero‐Serrano, E. M., Pérez‐Martínez, P., Delgado‐Lista, J., et al. (2014) · Food Chemistry · doi:10.1016/j.foodchem.2014.04.047 · Cited by 60 · see citing works
Beneficial effects of olive oil and Mediterranean diet on cancer physio-pathology and incidence
Farràs, M., Almanza‐Aguilera, E., Hernáez, Á., Agustí, N., Julve, J., Fitó, M., & Castañer, O. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.011 · Cited by 59 · see citing works
- Authors
- Weinbrenner, T., Fitó, M., Torre, R. D. L., Saez, G. T., Rijken, P., Tormos, C., Coolen, S., Albaladejo, M. F., Abanades, S., Schroder, H., Marrugat, J., & Covas, M.-I.
- Affiliations
- Municipal Institute for Medical Research (ES)
- Universitat Pompeu Fabra (ES)
- Universitat de València (ES)
- Universitat Autònoma de Barcelona (ES)
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 134
- Issue
- 9
- Pages
- 2314-2321
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2097668260
- Cited by
- 272
- References
- 54
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 9 · 2021: 10 · 2020: 10 · 2019: 14 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 17 · 2014: 19 · 2013: 13 · 2012: 18
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Keywords
- olive oil, phenolic compounds, oxidative stress, antioxidant status, oxidized LDL, 8-oxoguanine, malondialdehyde, HDL cholesterol, glutathione peroxidase, urinary biomarkers, dose-dependent effects, healthy men
- MeSH terms
- Olive Oil, 8-Hydroxy-2'-Deoxyguanosine, Adult, Antioxidants, Deoxyguanosine, Diet, DNA, Mitochondrial, Dose-Response Relationship, Drug, Double-Blind Method, Glutathione Peroxidase, Humans, Cholesterol, HDL, Lipoproteins, LDL, Male, Malondialdehyde, Oxidation-Reduction, Phenols, Plant Oils, Time Factors, Cross-Over Studies, Postprandial Period
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
