The DOI matches its Crossref record; 208 of the 211 references it cites were found in a registry or an index.
Neuroimaging of children following prenatal drug exposure
Open accessAbstract
Recent advances in MR-based brain imaging methods have provided unprecedented capabilities to visualize the brain. Application of these methods has allowed identification of brain structures and patterns of functional activation altered in offspring of mothers who used licit (e.g., alcohol and tobacco) and illicit (e.g., cocaine, methamphetamine, and marijuana) drugs during pregnancy. Here we review that literature, which though somewhat limited by the complexities of separating the specific effects of each drug from other confounding variables, points to sets of interconnected brain structures as being altered following prenatal exposure to drugs of abuse. In particular, dopamine-rich cortical (e.g., frontal cortex) and subcortical (e.g., basal ganglia) fetal brain structures show evidence of vulnerability to intrauterine drug exposure suggesting that during brain development drugs of abuse share a specific profile of developmental neurotoxicity. Such brain malformations may shed light on mechanisms underlying prenatal drug-induced brain injury, may serve as bio-markers of significant intrauterine drug exposure, and may additionally be predictors of subsequent neuro-developmental compromise. Wider clinical use of these research-based non-invasive methods will allow for improved diagnosis and allocation of therapeutic resources for affected infants, children, and young adults.
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“Prenatal exposure to alcohol or other drugs of abuse also have important effects on developing brain structure”
From Imaging structural and functional brain development in early childhood (2018) · cites this paper as [180]
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Metadata
- Authors
- Derauf, C., Kekatpure, M., Neyzi, N., Lester, B., & Kosofsky, B.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- NewYork–Presbyterian Hospital (US)
- Brown University (US)
- Corresponding author
- Kosofsky, Barry
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2009-06
- Volume
- 20
- Issue
- 4
- Pages
- 441-454
- ISSN
- 1084-9521 (ISSN-L)
- PMC
- PMC2704485
- OpenAlex
- W1998660749
- Cited by
- 122
- References
- 211
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 15
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (K02DA000354, R01DA017905)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- prenatal drug exposure, developmental neurotoxicity, fetal brain development, brain malformations, frontal cortex, basal ganglia, maternal alcohol use, maternal smoking, maternal cocaine use, maternal marijuana use, neuroimaging biomarkers, children
- MeSH terms
- Adult, Brain, Child, Developmental Disabilities, Female, Humans, Magnetic Resonance Imaging, Maternal-Fetal Exchange, Pregnancy, Substance-Related Disorders
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