The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway
Open accessAbstract
Vertebrate gastrulation entails massive cell movements that establish and shape the germ layers. During gastrulation, the individual cell behaviors are strictly coordinated in time and space by various signaling pathways. These pathways instruct the cells about proliferation, shape, fate and migration into proper location. Convergence and extension (C&E) movements during vertebrate gastrulation play a major role in the shaping of the embryonic body. In vertebrates, the Wnt/Planar Cell Polarity (Wnt/PCP) pathway is a key regulator of C&E movements, essential for several polarized cell behaviors, including directed cell migration, and mediolateral and radial cell intercalation. However, the molecular mechanisms underlying the acquisition of planar cell polarity by highly dynamic mesenchymal cells engaged in C&E is still not well understood. Each cell in the embryo needs spatial and temporal information, which are required for its appropriate behavior, and the Wnt/PCP pathway provides this information by a yet unclear mechanism. Here we review new evidence implicating the Wnt/PCP pathway in specific cell behaviors required for C&E during zebrafish gastrulation, in comparison to other vertebrates. We also discuss findings on the molecular regulation and the interaction of the Wnt/PCP pathway with other signaling pathways during gastrulation movements.
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Cites
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Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation
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Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
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Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
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Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation
Simões, S. D. M., Blankenship, J. T., Weitz, O., Farrell, D. L., Tamada, M., Fernandez-Gonzalez, R., & Zallen, J. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.08.011 · Cited by 274
Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity
Mahuzier, A., Gaudé, H.-M., Grampa, V., Anselme, I., Silbermann, F., Leroux-Berger, M., Delacour, D., Ezan, J., Montcouquiol, M., Saunier, S., et al. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201111009 · Cited by 79
“Other examples of PCP signaling-dependent mechanisms in vertebrates include polarized cell intercalation and directed cell migration leading to convergence-extension (CE) movements (Karner et al., 2009; Roszko et al., 2009), and oriented cell division (Fischer and Pontoglio, 2009; Ségalen et al.”
Background
Metadata
- Authors
- Roszko, I., Sawada, A., & Solnica-Krezel, L.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 20
- Issue
- 8
- Pages
- 986-997
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W1986158200
- Cited by
- 234
- References
- 14
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Roszko, I., Sawada, A., & Solnica-Krezel, L. (2009). Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2009.09.004
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