The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Fumarate hydratase in cancer: A multifaceted tumour suppressor
Open accessAbstract
Cancer is now considered a multifactorial disorder with different aetiologies and outcomes. Yet, all cancers share some common molecular features. Among these, the reprogramming of cellular metabolism has emerged as a key player in tumour initiation and progression. The finding that metabolic enzymes such as fumarate hydratase (FH), succinate dehydrogenase (SDH) and isocitrate dehydrogenase (IDH), when mutated, cause cancer suggested that metabolic dysregulation is not only a consequence of oncogenic transformation, but that it can act as cancer driver. However, the mechanisms underpinning the link between metabolic dysregulation and cancer remain only partially understood. In this review we discuss the role of FH loss in tumorigenesis, focusing on the role of fumarate as a key activator of a variety of oncogenic cascades. We also discuss how these alterations are integrated and converge towards common biological processes. This review highlights the complexity of the signals elicited by FH loss, describes that fumarate can act as a bona fide oncogenic event, and provides a compelling hypothesis of the step wise neoplastic progression after FH loss.
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NRF2 and the Hallmarks of Cancer
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“Interestingly, the sporadic loss of FH has been reported in other tumour types such as pheochromocytomas, paragangliomas [26,27], adrenocortical carcinoma [28], neuroblastomas [28,29], glioma, ependymoma, osteosarcoma, and Erwing’s sarcoma [28] (Fig.”
BackgroundComprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma
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Reductive carboxylation supports growth in tumour cells with defective mitochondria
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Role of TET enzymes in DNA methylation, development, and cancer
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Background
Cited by
Revisiting the Warburg effect: historical dogma versus current understanding
Vaupel, P., & Multhoff, G. (2021) · The Journal of Physiology · doi:10.1113/jp278810 · Cited by 830
Linking Metabolic Reprogramming, Plasticity and Tumor Progression
Shuvalov, O., Daks, A., Fedorova, O., Petukhov, A., & Barlev, N. (2021) · Cancers · doi:10.3390/cancers13040762 · Cited by 63
Metadata
- Authors
- Schmidt, C., Sciacovelli, M., & Frezza, C.
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 98
- Pages
- 15-25
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W2945788288
- Cited by
- 160
- References
- 30
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
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