Linking Metabolic Reprogramming, Plasticity and Tumor Progression
Open accessAbstract
The specific molecular features of cancer cells that distinguish them from the normal ones are denoted as “hallmarks of cancer”. One of the critical hallmarks of cancer is an altered metabolism which provides tumor cells with energy and structural resources necessary for rapid proliferation. The key feature of a cancer-reprogrammed metabolism is its plasticity, allowing cancer cells to better adapt to various conditions and to oppose different therapies. Furthermore, the alterations of metabolic pathways in malignant cells are heterogeneous and are defined by several factors including the tissue of origin, driving mutations, and microenvironment. In the present review, we discuss the key features of metabolic reprogramming and plasticity associated with different stages of tumor, from primary tumors to metastases. We also provide evidence of the successful usage of metabolic drugs in anticancer therapy. Finally, we highlight new promising targets for the development of new metabolic drugs.
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Metabolic rewiring, including different metabolic alterations, is considered to be one of the hallmarks of cancer.
“Metabolic rewiring, including different metabolic alterations, is considered to be one of the “hallmarks of cancer” [20].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [20]
Increased glycolysis and one-carbon metabolism are known to be widely observed in various malignancies.
“As stated earlier, increased glycolysis and one-carbon metabolism are known to be widely observed in various malignancies [20].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [20]
Different oncogenes and oncosuppressors have a critical impact on these metabolic pathways.
“Different oncogenes and oncosupressors have a critical impact on these metabolic pathways [20,40,46,47,75,76].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [20]
Metabolic rewiring is considered one of the hallmarks of cancer.
“Metabolic rewiring is considered one of the “hallmarks of cancer” [20].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [20]
A number of glycolytic and OxPHOS inhibitors are currently being investigated in preclinical and clinical studies.
“A number of glycolytic and OxPHOS inhibitors are currently being investigated in preclinical and clinical studies [20,77].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [20]
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Shuvalov, O., Kirdeeva, Y., Fefilova, E., Netsvetay, S., Zorin, M., Vlasova, Y., Fedorova, O., Daks, A., Parfenyev, S., & Barlev, N. (2023) · Metabolites · doi:10.3390/metabo13050656 · Cited by 21 · see citing works
Self-citationDaks, A., Shuvalov, O., Fedorova, O., Petukhov, A., Lezina, L., Zharova, A., Baidyuk, E., Khudiakov, A., & Barlev, N. A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.706668 · Cited by 15 · see citing works
Shuvalov, O., Kirdeeva, Y., Fefilova, E., Daks, A., Fedorova, O., Parfenyev, S., Nazarov, A., Vlasova, Y., Krasnov, G. S., & Barlev, N. A. (2024) · Antioxidants · doi:10.3390/antiox13111349 · Cited by 9 · see citing works
Self-citation
- Authors
- Shuvalov, O., Daks, A., Fedorova, O., Petukhov, A., & Barlev, N.
- Affiliations
- Institute of Cytology (RU)
- Federal Almazov North-West Medical Research Centre (RU)
- Moscow Institute of Physics and Technology (RU)
- Corresponding author
- Barlev, Nickolai
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2021-02-12
- Volume
- 13
- Issue
- 4
- Pages
- 762
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC7917602
- OpenAlex
- W3132705638
- Cited by
- 63
- References
- 205
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 10 · 2023: 6 · 2022: 14 · 2021: 7
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Russian Science Foundation (#19-45-02011)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- tumor metabolic reprogramming, metabolic plasticity, tumor progression, cancer hallmarks, tumor microenvironment, metastasis, metabolic drugs, cancer therapy, tumor heterogeneity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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