The future of cerebral organoids in drug discovery
Abstract
Until the discovery of human embryonic stem cells and human induced pluripotent stem cells, biotechnology companies were severely limited in the number of human tissues that they could model in large-scale in vitro studies. Until this point, companies have been limited to immortalized cancer lines or a small number of primary cell types that could be extracted and expanded. Nowadays, protocols continue to be developed in the stem cell field, enabling researchers to model an ever-growing library of cell types in controlled, large-scale screens. One differentiation method in particular- cerebral organoids- shows substantial potential in the field of neuroscience and developmental neurobiology. Cerebral organoid technology is still in an early phase of development, and there are several challenges that are currently being addressed by academic and industrial researchers alike. Here we briefly describe some of the early adopters of cerebral organoids, several of the challenges that they are likely facing, and various technologies that are currently being implemented to overcome them.
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Cerebral organoids derived from AD patient-specific iPSCs can recapture patient-specific phenotypes and hence serve as excellent disease models for AD research and drug development.
“Cerebral organoids derived from AD patient-specific iPSCs can recapture patient-specific phenotypes and hence serve as excellent disease models for AD research and drug development [51–53].”
From CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease (2026) · cites this paper as [53]
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Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems
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- Authors
- Salick, M. R., Lubeck, E., Riesselman, A., & Kaykas, A.
- Affiliations
- insitro, inc. (United States) (US)
- Corresponding author
- Kaykas, Ajamete
- Venue
- Seminars in Cell & Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 111
- Pages
- 67-73
- ISSN
- 1084-9521 (ISSN-L)
- OpenAlex
- W3040839760
- Cited by
- 29
- References
- 9
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 3
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- brain organoids, drug discovery, human induced pluripotent stem cells, human embryonic stem cells, in vitro disease model, stem cell differentiation, developmental neuroscience
- MeSH terms
- Machine Learning, Cell Differentiation, Cerebral Cortex, Humans, Models, Biological, Mutation, Nerve Tissue Proteins, Neurons, Organoids, Drugs, Investigational, Sequence Analysis, RNA, Neuroprotective Agents, Neurodegenerative Diseases, Drug Discovery, Induced Pluripotent Stem Cells, Single-Cell Analysis, CRISPR-Cas Systems
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