Dense connectomic reconstruction in layer 4 of the somatosensory cortex
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Abstract
Brain anatomy revealed in startling detail: The mammalian cerebral cortex is an enormously complex network of neuronal processes that are long and thin, branching, and extremely densely packed. This high packing density has made the reconstruction of cortical neuronal networks challenging. Motta et al. used advanced automated imaging and analysis tools to reconstruct with high spatial resolution the morphological features of 89 neurons and their connections in the mouse barrel cortex. The reconstruction covered an area more than two orders of magnitude larger than earlier neuroanatomical mapping attempts. This approach revealed information about the connectivity of inhibitory and excitatory synapses of corticocortical as well as excitatory thalamocortical connections. Science , this issue p. eaay3134
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The preference of glutamatergic axons for spines and GABAergic axons for shafts is often misinterpreted as implying that synapses on dendritic shafts are mostly SS.
“However, this characteristic is often misinterpreted as implying that synapses on dendritic shafts are mostly SS (Motta et al., 2019; Karimi et al., 2020; Loomba et al., 2022).”
From Unambiguous identification of asymmetric and symmetric synapses using volume electron microscopy (2024) · cites this paper as Motta et al., 2019
The Synaptic specificity section (page unavailable) reports that excitatory glutamatergic axons preferentially innervate spine heads and inhibitory axons preferentially innervate dendritic shafts. It does not say that this preference is often misinterpreted, or establish whether shaft synapses are mostly SS. (LLM, conf=0.84)
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“We also considered the possibility of correlations in pairs of synapses sharing the same presynaptic cell but not the same postsynaptic cell, or pairs of synapses sharing the same postsynaptic cell but not the same presynaptic cell (Bartol et al., 2015; Kasthuri et al., 2015; Dvorkin and Ziv, 2016; Bloss et al., 2018;…”
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“When combined with neuronal reconstructions, these datasets enable new analyses of richly annotated connectomes 16–22 .”
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An interactive deep learning-based approach reveals mitochondrial cristae topologies
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Oligodendrocyte precursor cells prune axons in the mouse neocortexPreprint
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New light on cortical neuropeptides and synaptic network plasticity
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- Authors
- Motta, A., Berning, M., Boergens, K. M., Staffler, B., Beining, M., Loomba, S., Hennig, P., Wissler, H., & Helmstaedter, M.
- Affiliations
- Max Planck Institute for Brain Research (DE)
- Max Planck Society (DE)
- Corresponding author
- Motta, Alessandro
- Berning, Manuel
- Boergens, Kevin M.
- Staffler, Benedikt
- Wissler, Heiko
- ORCID
- Venue
- Science
- Published
- 2019-11-29
- Volume
- 366
- Issue
- 6469
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2982268628
- Cited by
- 333
- References
- 101
- Citations by year
- 2026: 23 · 2025: 37 · 2024: 62 · 2023: 55 · 2022: 60 · 2021: 52 · 2020: 40 · 2019: 2
- FWCI
- 18.45
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Max-Planck-Gesellschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Keywords
- connectome reconstruction, barrel cortex, layer 4, somatosensory cortex, mice, Hebbian synaptic plasticity, long-term potentiation, neural circuits, 3D electron microscopy
- MeSH terms
- Animals, Axons, Male, Mice, Inbred C57BL, Microscopy, Electron, Neurons, Somatosensory Cortex, Synapses, Neuropil, Imaging, Three-Dimensional, Mice, Connectome
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