The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Among these mechanistic pathways are stress-sensitive systems like the hypothalamic-pituitary-adrenal axis, maternal inflammation or immune activation, and epigenetic modifications,16–19 see References 16 – 19 for comprehensive reviews of this research.”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [18]
In the citing paper
“A large body of preclinical research has established the mechanistic pathways by which environments impact the developing brain prenatally.”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [18]
In the citing paper
“Similarly, inflammatory makers have consistently been associated with white matter development and psychiatric risk in early development in human models, consistent with the direct and indirect pathways identified in preclinical studies.18”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [18]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cognitive and Behavioral Outcomes of School-Aged Children Who Were Born Preterm: A Meta-analysis
Bhutta, A. T., Cleves, M. A., Casey, P. H., Cradock, M. M., & Anand, K. J. S. (2002) · JAMA · doi:10.1001/jama.288.6.728 · Cited by 2,392
Genetics of attention deficit hyperactivity disorder
Faraone, S. V., & Larsson, H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0070-0 · Cited by 1,338
Transgenerational epigenetic programming via sperm microRNA recapitulates effects of paternal stress
Rodgers, A. B., Morgan, C. P., Leu, N. A., & Bale, T. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508347112 · Cited by 751
Early-life experience, epigenetics, and the developing brain
Kundakovic, M., & Champagne, F. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.140 · Cited by 304
Prenatal influences on temperament development: the role of environmental epigenetics
Gartstein, M. A., & Skinner, M. K. (2018) · Development and Psychopathology · doi:10.1017/s0954579417001730 · Cited by 161
Paternal Influences on Offspring Development: Behavioural and Epigenetic Pathways
Braun, K., & Champagne, F. A. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12174 · Cited by 157
Research works printed but not linked: 93
- Johnson, 2010, Psychiatric disorders in extremely preterm children: longitudinal finding at age 11 Years in the EPICure study, J Am Acad Child Adolesc Psychiatr, 49, 453
- Kuban, 2016, Girls and boys born before 28 Weeks gestation: risks of cognitive, behavioral, and neurologic outcomes at age 10 years, J Pediatr, 173, 69, 10.1016/j.jpeds.2016.02.048 · DOI
- Leviton, 2019, Socioeconomic status and early blood concentrations of inflammation-related and neurotrophic proteins among extremely preterm newborns, PloS One, 14, 10.1371/journal.pone.0214154 · DOI
- Romero, 2007, The role of inflammation and infection in preterm birth, Semin Reprod Med, 25, 21, 10.1055/s-2006-956773 · DOI
- Romero, 1998, A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition, Am J Obstet Gynecol, 179, 186, 10.1016/S0002-9378(98)70271-6 · DOI · Paper page
- McElrath, 2008, Pregnancy disorders that lead to delivery before the 28th week of gestation: an epidemiologic approach to classification, Am J Epidemiol, 168, 980, 10.1093/aje/kwn202 · DOI
- McElrath, 2011, Blood protein profiles of infants differ by the pregnancy complication in infants born before the 28th week of gestation, Am J Obstet Gynecol, 204, 10.1016/j.ajog.2010.12.010 · DOI
- Leviton, 2011, Inflammation-related proteins in the blood of extremely low gestational age newborns. The contribution of inflammation to the appearance of developmental regulation, Cytokine, 53, 66, 10.1016/j.cyto.2010.09.003 · DOI
- McElrath, 2013, Perinatal systemic inflammatory responses of growth-restricted preterm newborns, Acta Paediatr, 102, e439, 10.1111/apa.12339 · DOI
- Leviton, 2011, The relationship between early concentrations of 25 blood proteins and cerebral white matter injury in preterm newborns, J Pediatr, 158, 897, 10.1016/j.jpeds.2010.11.059 · DOI
- Bose, 2013, Systemic inflammation associated with mechanical ventilation among extremely preterm infants, Cytokine, 61, 315, 10.1016/j.cyto.2012.10.014 · DOI
- Martin, 2013, Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns, Fetal Pediatr Pathol, 32, 222, 10.3109/15513815.2012.721477 · DOI
- Bhatia, 2014, Cytokine levels in the preterm infant with neonatal intestinal injury, Am J Perinatol, 31, 489
- Leviton, 2012, Systemic responses of preterm newborns with presumed or documented bacteraemia, Acta Paediatr, 101, 355, 10.1111/j.1651-2227.2011.02527.x · DOI
- Nist, 2019, An integrative review of cytokine/chemokine predictors of neurodevelopment in preterm infants, Biol Res Nurs, 21, 366, 10.1177/1099800419852766 · DOI
- Gilles, 1976, Endotoxin leucoencephalopathy in the telencephalon of the newborn kitten, J Neurol Sci, 27, 183, 10.1016/0022-510X(76)90060-5 · DOI
- Hagberg, 2015, The role of inflammation in perinatal brain injury, Nat Rev Neurol, 11, 192, 10.1038/nrneurol.2015.13 · DOI
- Favrais, 2011, Systemic inflammation disrupts the developmental program of white matter, Ann Neurol, 70, 550, 10.1002/ana.22489 · DOI
- Fleiss, 2015, Inflammation-induced sensitization of the brain in term infants, Dev Med Child Neurol, 57, 17, 10.1111/dmcn.12723 · DOI
- Gilmore, 2003, Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat, J Neuroimmunol, 138, 49, 10.1016/S0165-5728(03)00095-X · DOI
- Bruce, 2019, Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain, J Neuroinflammation, 16, 200, 10.1186/s12974-019-1569-2 · DOI
- Jantzie, 2018, Repetitive neonatal erythropoietin and melatonin combinatorial treatment provides sustained repair of functional deficits in a rat model of cerebral palsy, Front Neurol, 9, 233, 10.3389/fneur.2018.00233 · DOI
- Bilbo, 2018, Beyond infection - maternal immune activation by environmental factors, microglial development, and relevance for autism spectrum disorders, Exp Neurol, 299, 241, 10.1016/j.expneurol.2017.07.002 · DOI
- Kim-Fine, 2012, Male gender promotes an increased inflammatory response to lipopolysaccharide in umbilical vein blood, J Matern Fetal Neonatal Med, 25, 2470, 10.3109/14767058.2012.684165 · DOI
- Wang, 2009, Lipopolysaccharide sensitizes neonatal hypoxic-ischemic brain injury in a MyD88-dependent manner, J Immunol, 183, 7471, 10.4049/jimmunol.0900762 · DOI
- Bilbo, 2005, Neonatal infection induces memory impairments following an immune challenge in adulthood, Behav Neurosci, 119, 293, 10.1037/0735-7044.119.1.293 · DOI
- Yanni, 2017, Both antenatal and postnatal inflammation contribute information about the risk of brain damage in extremely preterm newborns, Pediatr Res, 82, 691, 10.1038/pr.2017.128 · DOI
- Glass, 2018, Multiple postnatal infections in newborns born preterm predict delayed maturation of motor pathways at term-equivalent age with poorer motor outcomes at 3 years, J Pediatr, 196, 91, 10.1016/j.jpeds.2017.12.041 · DOI
- Nelson, 1985, Predictors of low and very low birth weight and the relation of these to cerebral palsy, J Am Med Assoc, 254, 1473, 10.1001/jama.1985.03360110063025 · DOI
- Wu, 2000, Chorioamnionitis as a risk factor for cerebral palsy - a meta-analysis, Jama-J Am Med Assoc, 284, 1417, 10.1001/jama.284.11.1417 · DOI
- Nelson, 1998, Neonatal cytokines and coagulation factors in children with cerebral palsy, Ann Neurol, 44, 665, 10.1002/ana.410440413 · DOI · Paper page
- Leviton, 2010, Microbiological and histologic characteristics of the extremely preterm infant's placenta predict white matter damage and later cerebral palsy. The ELGAN Study, Pediatr Res, 67, 95, 10.1203/PDR.0b013e3181bf5fab · DOI
- Leviton, 2016, The development of extremely preterm infants born to women who had genitourinary infections during pregnancy, Am J Epidemiol, 183, 28, 10.1093/aje/kwv129 · DOI
- Kuban, 2014, Systemic inflammation and cerebral palsy risk in extremely preterm infants, J Child Neurol, 29, 1692, 10.1177/0883073813513335 · DOI
- Carlo, 2011, Cytokines and neurodevelopmental outcomes in extremely low birth weight infants, J Pediatr, 159, 10.1016/j.jpeds.2011.05.042 · DOI
- Joseph, 2018, Maternal educational status at birth, maternal educational advancement, and neurocognitive outcomes at age 10 years among children born extremely preterm, Pediatr Res, 83, 767, 10.1038/pr.2017.267 · DOI
- van der Burg, 2016, The role of systemic inflammation linking maternal BMI to neurodevelopment in children, Pediatr Res, 79, 3, 10.1038/pr.2015.179 · DOI
- van der Burg, 2013, Is maternal obesity associated with sustained inflammation in extremely low gestational age newborns?, Early Hum Dev, 89, 949, 10.1016/j.earlhumdev.2013.09.014 · DOI
- Jensen, 2017, The relationship of maternal prepregnancy body mass index and pregnancy weight gain to neurocognitive function at age 10 Years among children born extremely preterm, J Pediatr, 187, 50, 10.1016/j.jpeds.2017.02.064 · DOI
- van der Burg, 2015, Maternal obesity and development of the preterm newborn at 2 years, Acta Paediatr, 104, 900, 10.1111/apa.13038 · DOI
- Fichorova, 2011, Maternal microbe-specific modulation of inflammatory response in extremely low-gestational-age newborns, mBio, 2, 10.1128/mBio.00280-10 · DOI
- Tomlinson, 2020, Neurocognitive and social-communicative function of children born very preterm at 10 years of age: associations with microorganisms recovered from the placenta parenchyma, J Perinatol, 40, 306, 10.1038/s41372-019-0505-8 · DOI
- O'Shea, 2012, Elevated concentrations of inflammation-related proteins in postnatal blood predict severe developmental delay at 2 Years of age in extremely preterm infants, J Pediatr, 160, 395, 10.1016/j.jpeds.2011.08.069 · DOI
- Kuban, 2015, The breadth and type of systemic inflammation and the risk of adverse neurological outcomes in extremely low gestation newborns, Pediatr Neurol, 52, 42, 10.1016/j.pediatrneurol.2014.10.005 · DOI
- O'Shea, 2013, Inflammation-initiating illnesses, inflammation-related proteins, and cognitive impairment in extremely preterm infants, Brain Behav Immun, 29, 104, 10.1016/j.bbi.2012.12.012 · DOI
- Kuban Kj, 2018, Among children born extremely preterm a higher level of circulating neurotrophins is associated with lower risk of cognitive impairment at school age, J Pediatr, 201, 40, 10.1016/j.jpeds.2018.05.021 · DOI
- Kuban, 2019, Association of circulating proinflammatory and anti-inflammatory protein biomarkers in extremely preterm born children with subsequent brain magnetic resonance imaging volumes and cognitive function at age 10 years, J Pediatr, 210, 81, 10.1016/j.jpeds.2019.03.018 · DOI
- Dammann, 1999, Brain damage in preterm newborns: might enhancement of developmentally regulated endogenous protection open a door for prevention?, Pediatrics, 104, 541, 10.1542/peds.104.3.541 · DOI
- Downey, 2015, Antenatal and early postnatal antecedents of parent-reported attention problems at 2 years of age, J Pediatr, 166, 20, 10.1016/j.jpeds.2014.08.004 · DOI
- O'Shea, 2014, Elevated blood levels of inflammation-related proteins are associated with an attention problem at age 24 mo in extremely preterm infants, Pediatr Res, 75, 781, 10.1038/pr.2014.41 · DOI
- Douglass, 2017, Cumulative incidence of seizures and epilepsy in ten-year-old children born before 28 Weeks' gestation, Pediatr Neurol, 73, 13, 10.1016/j.pediatrneurol.2017.05.009 · DOI
- Singh, 2019, Antecedents of epilepsy and seizures among children born at extremely low gestational age, J Perinatol, 39, 774, 10.1038/s41372-019-0355-4 · DOI
- Joseph, 2017, Extremely low gestational age and very low birthweight for gestational age are risk factors for autism spectrum disorder in a large cohort study of 10-year-old children born at 23-27 weeks' gestation, Am J Obstet Gynecol, 216, 304 e1, 10.1016/j.ajog.2016.11.1009 · DOI
- Korzeniewski Sa, 2018, Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation, Transl Psychiatry, 2018
- Bass, 2018, Genetic testing in children and adolescents with intellectual disability, Curr Opin Psychiatr, 31, 490, 10.1097/YCO.0000000000000456 · DOI
- Gaugler, 2014, Most genetic risk for autism resides with common variation, Nat Genet, 46, 881, 10.1038/ng.3039 · DOI · Paper page
- Eskandari-Nasab, 2017, Meta-analysis of risk association between interleukin-17a and F gene polymorphisms and inflammatory diseases, J Interferon Cytokine Res, 37, 165, 10.1089/jir.2016.0088 · DOI
- Smith, 2014, Angiogenic, neurotrophic, and inflammatory system SNPs moderate the association between birth weight and ADHD symptom severity, Am J Med Genet B Neuropsychiatr Genet, 165B, 691, 10.1002/ajmg.b.32275 · DOI
- Cuna, 2017, Genetic alterations in necrotizing enterocolitis, Semin Perinatol, 41, 61, 10.1053/j.semperi.2016.09.019 · DOI
- Srinivasan, 2017, Systematic review and meta-analysis: gene association studies in neonatal sepsis, Am J Perinatol, 34, 684
- Szpecht, 2017, The role of FV 1691G>A, FII 20210G>A mutations and MTHFR 677C>T; 1298A>C and 103G>T FXIII gene polymorphisms in pathogenesis of intraventricular hemorrhage in infants born before 32 weeks of gestation, Childs Nerv Syst, 33, 1201, 10.1007/s00381-017-3460-8 · DOI
- Ment, 2014, Gene-environment interactions in severe intraventricular hemorrhage of preterm neonates, Pediatr Res, 75, 241, 10.1038/pr.2013.195 · DOI
- Clark, 2018, Genetic variation, magnesium sulfate exposure, and adverse neurodevelopmental outcomes following preterm birth, Am J Perinatol, 35, 1012, 10.1055/s-0038-1635109 · DOI
- Kallankari, 2015, Cerebral palsy and polymorphism of the chemokine CCL18 in very preterm children, Neonatology, 108, 124, 10.1159/000430765 · DOI
- Kapitanovic Vidak, 2012, The association between proinflammatory cytokine polymorphisms and cerebral palsy in very preterm infants, Cytokine, 58, 57, 10.1016/j.cyto.2011.12.018 · DOI
- Auriti, 2014, MBL2 gene polymorphisms increase the risk of adverse neurological outcome in preterm infants: a preliminary prospective study, Pediatr Res, 76, 464, 10.1038/pr.2014.118 · DOI
- Chau, 2019, Morphine biotransformation genes and neonatal clinical factors predicted behaviour problems in very preterm children at 18months, EBioMedicine, 40, 655, 10.1016/j.ebiom.2019.01.042 · DOI
- Inbar-Feigenberg, 2013, Basic concepts of epigenetics, Fertil Steril, 99, 607, 10.1016/j.fertnstert.2013.01.117 · DOI
- Nicolia, 2017, DNA methylation profiles of selected pro-inflammatory cytokines in alzheimer disease, J Neuropathol Exp Neurol, 76, 27
- Aronica, 2010, Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy, Eur J Neurosci, 31, 1100, 10.1111/j.1460-9568.2010.07122.x · DOI · Paper page
- Ashraf, 2016, MicroRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11, J Virol, 90, 4780, 10.1128/JVI.02586-15 · DOI
- Zhu, 2015, MicroRNA-15b modulates Japanese encephalitis virus-mediated inflammation via targeting RNF125, J Immunol, 195, 2251, 10.4049/jimmunol.1500370 · DOI
- Tomlinson, 2017, Microorganisms in the human placenta are associated with altered CpG methylation of immune and inflammation-related genes, PloS One, 12, 10.1371/journal.pone.0188664 · DOI
- Provenzi, 2017, Maternal sensitivity buffers the association between SLC6A4 methylation and socio-emotional stress response in 3-month-old full term, but not very preterm infants, Front Psychiatr, 8, 171, 10.3389/fpsyt.2017.00171 · DOI
- Chau, 2014, Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age, Front Behav Neurosci, 8, 409, 10.3389/fnbeh.2014.00409 · DOI
- Bromer, 2013, Genetic and epigenetic variation of the glucocorticoid receptor (NR3C1) in placenta and infant neurobehavior, Dev Psychobiol, 55, 673, 10.1002/dev.21061 · DOI
- Maccani, 2013, Placental miRNA expression profiles are associated with measures of infant neurobehavioral outcomes, Pediatr Res, 74, 272, 10.1038/pr.2013.102 · DOI
- Dall'Aglio, 2018, The role of epigenetic modifications in neurodevelopmental disorders: a systematic review, Neurosci Biobehav Rev, 94, 17, 10.1016/j.neubiorev.2018.07.011 · DOI
- Lillycrop, 2015, Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour, Int J Epidemiol, 44, 1263, 10.1093/ije/dyv052 · DOI
- Tilley, 2018, Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life, PloS One, 13, 10.1371/journal.pone.0193271 · DOI
- Meakin, 2018, Placental CpG methylation of HPA-axis genes is associated with cognitive impairment at age 10 among children born extremely preterm, Horm Behav, 101, 29, 10.1016/j.yhbeh.2018.02.007 · DOI
- Stroustrup, 2017, The value of preterm infant environmental health cohorts: the canary in the coal mine, JAMA Pediatr, 171, 1139, 10.1001/jamapediatrics.2017.3230 · DOI
- Isles, 2015, Neural and behavioral epigenetics; what it is, and what is hype, Gene Brain Behav, 14, 64, 10.1111/gbb.12184 · DOI
- Kofink, 2013, Epigenetic dynamics in psychiatric disorders: environmental programming of neurodevelopmental processes, Neurosci Biobehav Rev, 37, 831, 10.1016/j.neubiorev.2013.03.020 · DOI · Paper page
- Martin, 2018, Environmental influences on the epigenome: exposure- associated DNA methylation in human populations, Annu Rev Publ Health, 39, 309, 10.1146/annurev-publhealth-040617-014629 · DOI
- Vaiserman, 2015, Epigenetic programming by early-life stress: evidence from human populations, Dev Dynam, 244, 254, 10.1002/dvdy.24211 · DOI
- Vaiserman, 2017, Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?, Hum Genom, 11, 34, 10.1186/s40246-017-0129-z · DOI
- Neuwald, 2014, Transgenerational effects of maternal care interact with fetal growth and influence attention skills at 18 months of age, Early Hum Dev, 90, 241, 10.1016/j.earlhumdev.2014.01.015 · DOI
- Hamada, 2019, Prenatal programming of stress responsiveness and behaviours: progress and perspectives, J Neuroendocrinol, 31, 10.1111/jne.12674 · DOI
- Juul, 2015, Neuroprotective potential of erythropoietin in neonates; design of a randomized trial, Matern Health Neonatol Perinatol, 1, 27, 10.1186/s40748-015-0028-z · DOI
- Robertson, 2013, Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model, Brain, 136, 90, 10.1093/brain/aws285 · DOI
- Beloosesky, 2013, Prophylactic maternal N-acetylcysteine in rats prevents maternal inflammation-induced offspring cerebral injury shown on magnetic resonance imaging, Am J Obstet Gynecol, 208, e1, 10.1016/j.ajog.2013.01.023 · DOI
- Allred, 2017, Systemic Inflammation during the First Postnatal Month and the Risk of Attention Deficit Hyperactivity Disorder Characteristics among 10 year-old Children Born Extremely Preterm, J Neuroimmune Pharmacol, 12, 531, 10.1007/s11481-017-9742-9 · DOI
Cited by
Liu, X., Zou, M., Sun, C., Wu, L., & Chen, W.-X. (2022) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-021-04951-8 · Cited by 58
Herzberg, M. P., & Smyser, C. D. (2024) · Pediatric Research · doi:10.1038/s41390-024-03345-7 · Cited by 22
Metadata
- Authors
- Oldenburg, K. S., O'Shea, T. M., & Fry, R. C.
- Venue
- Seminars in Fetal and Neonatal Medicine
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 25
- Issue
- 3
- Pages
- 101115
- ISSN
- 1744-165X
- Cited by
- 46
- References
- 6
- Language
- en
- Licence
- Funders
- National Institute of Neurological Disorders and Stroke (2R01NS040069-09, 5U01NS040069-05)
- National Institutes of Health (5UH3OD023348-04)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.