The DOI matches its Crossref record; 94 of the 94 references it cites were found in a registry or an index.
Antioxidant and antimicrobial activities of Spirulina platensis extracts and biogenic selenium nanoparticles against selected pathogenic bacteria and fungi
Open accessAbstract
This study investigated the antimicrobial and antioxidant activity of three Spirulina extracts (methanol, acetone, and hexane) and the biological selenium nanoparticles (SeNPs) fabricated by Bacillus subtilis AL43. The results showed that Spirulina extracts exhibited antimicrobial activity against tested pathogens. Besides, Spirulina extracts significantly scavenged ABTS and DPPH radicals in a dose-dependent manner. The methanolic extract had higher total phenolic content, antimicrobial activity, and antioxidant activity than other extracts. The selenium nanoparticles were synthesized by Bacillus subtilis AL43 under aerobic conditions and were characterized as spherical, crystalline with a size of 65.23 nm and a net negative charge of −22.7. We evidenced that SeNPs possess considerable antimicrobial activity against three gram-positive, three gram-negative bacteria, and three strains from both Candida sp. and Aspergillus sp. Moreover, SeNPs were able to scavenge ABTS and DPPH radicals in a dose-dependent manner. An association was found between the total phenolic content of Spirulina and SeNPs and their biological activities. Our results indicate that Spirulina and SeNPs with significant antimicrobial and antioxidant activities seem to be successful candidates for safe and reliable medical applications.
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“Spirulina’s bioactive ingredients have shown to weaken bacterial cell walls making it more permeable, that subsequently led to leakage of cytoplasmic contents (65).”
From Potential of Spirulina platensis as a feed supplement for poultry to enhance growth performance and immune modulation (2023) · cites this paper as [65]
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“The methanolic extract has been shown to have the highest antioxidant and antimicrobial activity [67,68].”
From Application of Arthrospira platensis for Medicinal Purposes and the Food Industry: A Review of the Literature (2023) · cites this paper as [68]
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1 retracted
El-Hack, M. A. A., El-Saadony, M., Shafi, M., Zabermawi, N., Arif, M., Batiha, G., Khafaga, A., El-Hakim, Y. M. A., & Al‐Sagheer, A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.153 · Cited by 696
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Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It
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Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities
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Probiotics in poultry feed: A comprehensive review
El-Hack, M. E. A., El‐Saadony, M. T., Shafi, M. E., Qattan, S. Y. A., Batiha, G. E., Khafaga, A. F., Abdel‐Moneim, A. E., & Alagawany, M. M. (2020) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13454 · Cited by 449
Self-citationAntioxidant activity of different fractions of Spirulina platensis protean extract
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Selenium nanoparticles inhibit Staphylococcus aureus growth
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Research works printed but not linked: 1
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AlFadhly, N. K. Z., Alhelfi, N., Altemimi, A. B., Verma, D. K., Cacciola, F., & Narayanankutty, A. (2022) · Molecules · doi:10.3390/molecules27175584 · Cited by 225
Potential Feed Additives as Antibiotic Alternatives in Broiler Production
Ayalew, H., Zhang, H., Wang, J., Wu, S., Qiu, K., Qi, G., Tekeste, A., Wassie, T., & Chanie, D. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.916473 · Cited by 237
El-Hack, M. E. A., El‐Saadony, M. T., Saad, A. M., Salem, H. M., Ashry, N. M., Ghanima, M. M. A., Shukry, M., Swelum, A. A., Taha, A. E.-S., El-Tahan, A. M., et al. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101584 · Cited by 204
Self-citationEl-Hack, M. E. A., El‐Saadony, M. T., Elbestawy, A. R., El-Shall, N. A., Saad, A. M., Salem, H. M., El-Tahan, A. M., Khafaga, A. F., Taha, A. E.-S., AbuQamar, S. F., et al. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101590 · Cited by 172
Self-citationSpínola, M. P., Mendes, A. R., & Prates, J. A. M. (2024) · Foods · doi:10.3390/foods13223656 · Cited by 146
Metadata
- Authors
- Abdel-Moneim, A.-M. E., El-Saadony, M. T., Shehata, A. M., Saad, A. M., Aldhumri, S. A., Ouda, S. M., & Mesalam, N. M.
- Affiliations
- Al-Azhar University (EG)
- Zagazig University (EG)
- Taif University (SA)
- Egyptian Atomic Energy Authority (EG)
- Venue
- Saudi Journal of Biological Sciences
- Publisher
- Elsevier BV
- Published
- 2022-02
- Volume
- 29
- Issue
- 2
- Pages
- 1197-1209
- ISSN
- 1319-562X (ISSN-L)
- PMC
- PMC8848030
- OpenAlex
- W3200368356
- Cited by
- 229
- References
- 94
- Citations by year
- 2026: 22 · 2025: 44 · 2024: 52 · 2023: 53 · 2022: 44
- FWCI
- 29.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Saudi Journal of Biological Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Taif University (TURSP-2020/315)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Keywords
- Spirulina platensis, biogenic selenium nanoparticles, Bacillus subtilis, antimicrobial activity, antioxidant activity, free radical scavenging, total phenolic content, methanol extract, Candida, Aspergillus, pathogenic bacteria, green synthesis
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