Cited by 447Seaweed-derived Bioactive CompoundsPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress

Antioxidant activity of different fractions of Spirulina platensis protean extract

Piñero Estrada, J·2001·Il Farmaco

Abstract

Spirulina platensis, planktonic blue-green algae, is gaining increasing attention because of its nutritional and medicinal properties. This microalgae contains phycobiliproteins (phycocyanin and allophycocyanin). Previous reports from our laboratory have shown that a protean extract of S. platensis is a potent free-radical scavenger (hydroxyl and peroxyl radicals) and inhibits microsomal lipid peroxidation. The aim of this study was to purify and characterize phycocyanin of S. platensis. Besides, we tried to demonstrate that one of the main components responsible for this antioxidant activity is a biliprotein phycocyanin. For this purpose, we studied the antioxidant activity of different fractions obtained during the phycocyanin purification process, through the scavenger activity of hydroxyl radical. We also observed that an increase in phycocyanin content was related to an increase in the antioxidant activity in different fractions, and therefore phycobiliprotein phycocyanin is the component mainly responsible for the antioxidant activity.

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Crossref · 10.1016/s0014-827x(01)01084-9

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18 of 18 references verified0 citation errors · 0 not checkable

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  • The antioxidant activity of spirulina is directly proportional to the quantity of phycocyanin.

    “The antioxidant activity of spirulina has been proven to be directly proportional to the quantity of phycocyanin (which contains phycocyanobilin).12–14 45”
  • Phycocyanobilin is structurally similar to bilirubin and can inhibit NADPH oxidase.

    “Phycocyanobilin is structurally similar to bilirubin and can inhibit NADPH oxidase.”

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Authors
Piñero Estrada, J.
Venue
Il Farmaco
Publisher
Elsevier BV
Published
2001-07-01
Volume
56
Issue
5-7
Pages
497-500
ISSN
0014-827X (ISSN-L)
OpenAlex
W2122583090
Cited by
447
References
18
Citations by year
2026: 11 · 2025: 11 · 2024: 20 · 2023: 21 · 2022: 28 · 2021: 24 · 2020: 32 · 2019: 23 · 2018: 33 · 2017: 17 · 2016: 18 · 2015: 30 · 2014: 20 · 2013: 16 · 2012: 20
FWCI
5.58
Type
journal article
Language
en
Open access
closed
Locations
  • Il Farmaco (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Keywords
Spirulina platensis, phycocyanin, phycobiliproteins, antioxidant activity, hydroxyl radical scavenging, free radical scavenging, phycocyanin purification, microalgae, microsomal lipid peroxidation, cyanobacteria
MeSH terms
Cyanobacteria, Antioxidants, Ascorbic Acid, Chromatography, DEAE-Cellulose, Chromatography, Gel, Electrophoresis, Polyacrylamide Gel, Hydrogen Peroxide, Iron, Molecular Weight, Phycocyanin, Free Radical Scavengers, Hydroxyl Radical

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