The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Targeting cytokines for treatment of neuropathic pain
Open accessAbstract
BACKGROUND: Neuropathic pain is a challenging condition often refractory to existing therapies. An increasing number of studies have indicated that the immune system plays a crucial role in the mediation of neuropathic pain. Exploration of the various functions of individual cytokines in neuropathic pain will provide greater insight into the mechanisms of neuropathic pain and suggest potential opportunities to expand the repertoire of treatment options. METHODS: A literature review was performed to assess the role of pro-inflammatory and anti-inflammatory cytokines in the development of neuropathic pain. Both direct and indirect therapeutic approaches that target various cytokines for pain were reviewed. The current understanding based on preclinical and clinical studies is summarized. RESULTS AND CONCLUSIONS: In both human and animal studies, neuropathic pain has been associated with a pro-inflammatory state. Analgesic therapies involving direct manipulation of various cytokines and indirect methods to alter the balance of the immune system have been explored, although there have been few large-scale clinical trials evaluating the efficacy of immune modulators in the treatment of neuropathic pain. TNF-α is perhaps the widely studied pro-inflammatory cytokine in the context of neuropathic pain, but other pro-inflammatory (IL-1β, IL-6, and IL-17) and anti-inflammatory (IL-4, IL-10, TGF-β) signaling molecules are garnering increased interest. With better appreciation and understanding of the interaction between the immune system and neuropathic pain, novel therapies may be developed to target this condition.
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“Increased peripheral and central inflammatory activity has also been demonstrated across a wide range of pain diagnoses [5], such as fibromyalgia [6], neuropathic pain [7] and low back pain [8].”
From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [7]
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Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management
Vanderwall, A. G., & Milligan, E. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03009 · Cited by 227
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Metadata
- Authors
- Hung, A. L., Lim, M., & Doshi, T. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Doshi, Tina L.
- Venue
- Scandinavian Journal of Pain
- Publisher
- Walter de Gruyter GmbH
- Published
- 2017-10-01
- Volume
- 17
- Issue
- 1
- Pages
- 287-293
- ISSN
- 1877-8860 (ISSN-L)
- 1877-8879
- PMC
- PMC5774983
- OpenAlex
- W2748786482
- Cited by
- 174
- References
- 118
- Citations by year
- 2026: 5 · 2025: 19 · 2024: 29 · 2023: 22 · 2022: 29 · 2021: 30 · 2020: 29 · 2019: 7 · 2018: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Scandinavian Journal of Pain (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM075774)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuropathic pain, cytokines, inflammatory cytokines, anti-inflammatory cytokines, immune system, TNF-α, IL-1β, interleukin-6, IL-17, IL-10, TGF-beta, immunomodulation, analgesic treatment, cytokine-targeted therapy
- MeSH terms
- Animals, Humans, Inflammation, Neuralgia, Cytokines
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