Cited by 174Pain Mechanisms and TreatmentsPain Management and TreatmentNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.

Targeting cytokines for treatment of neuropathic pain

Open access

Hung, Alice L., Lim, Michael, Doshi, Tina L.·2017·Scandinavian Journal of Pain

DOI 10.1016/j.sjpain.2017.08.002PMC PMC5774983

Open this paper in CoChat — free account

Abstract

BACKGROUND: Neuropathic pain is a challenging condition often refractory to existing therapies. An increasing number of studies have indicated that the immune system plays a crucial role in the mediation of neuropathic pain. Exploration of the various functions of individual cytokines in neuropathic pain will provide greater insight into the mechanisms of neuropathic pain and suggest potential opportunities to expand the repertoire of treatment options. METHODS: A literature review was performed to assess the role of pro-inflammatory and anti-inflammatory cytokines in the development of neuropathic pain. Both direct and indirect therapeutic approaches that target various cytokines for pain were reviewed. The current understanding based on preclinical and clinical studies is summarized. RESULTS AND CONCLUSIONS: In both human and animal studies, neuropathic pain has been associated with a pro-inflammatory state. Analgesic therapies involving direct manipulation of various cytokines and indirect methods to alter the balance of the immune system have been explored, although there have been few large-scale clinical trials evaluating the efficacy of immune modulators in the treatment of neuropathic pain. TNF-α is perhaps the widely studied pro-inflammatory cytokine in the context of neuropathic pain, but other pro-inflammatory (IL-1β, IL-6, and IL-17) and anti-inflammatory (IL-4, IL-10, TGF-β) signaling molecules are garnering increased interest. With better appreciation and understanding of the interaction between the immune system and neuropathic pain, novel therapies may be developed to target this condition.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.sjpain.2017.08.002

Cites

118 of 118 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Neuropathic pain: aetiology, symptoms, mechanisms, and management
Woolf, C. J., & Mannion, R. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01307-0 · Cited by 2,231
Secukinumab in plaque psoriasis—results of two phase 3 trials
Langley, R. G., Elewski, B. E., Lebwohl, M., Reich, K., Griffiths, C. E. M., Papp, K., Puig, L., Nakagawa, H., Spelman, L., Sigurgeirsson, B., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1314258 · Cited by 1,997
Pathobiology of neuropathic pain
Zimmermann, M. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01303-6 · Cited by 935
Interactions between the immune and nervous systems in pain
Ren, K., & Dubner, R. A. (2010) · Nature Medicine · doi:10.1038/nm.2234 · Cited by 817
Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain
Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 807
Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators
Burke, J. G., Watson, R. W. G., McCormack, D., Dowling, F. E., Walsh, M. G., & Fitzpatrick, J. M. (2002) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.84b2.12511 · Cited by 705
The neuro-immune balance in neuropathic pain: Involvement of inflammatory immune cells, immune-like glial cells and cytokines
Austin, P. J., & Moalem-Taylor, G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.013 · Cited by 607
Herniated Lumbar Intervertebral Discs Spontaneously Produce Matrix Metalloproteinases, Nitric Oxide, Interleukin-6, and Prostaglandin E2
Kang, J. D., Georgescu, H. I., McIntyre, L. A., Stefanović-Račić, M., Donaldson, W. F., & Evans, C. H. (1996) · Spine · doi:10.1097/00007632-199602010-00003 · Cited by 565
Towards a mechanism-based classification of pain?
Woolf, C. J., Bennett, G. J., Doherty, M., Dubner, R. A., Kidd, B. L., Koltzenburg, M., Lipton, R. B., Loeser, J. D., Payne, R., & Torebjork, E. (1998) · Pain · doi:10.1016/s0304-3959(98)00099-2 · Cited by 553

Show all 118 references

Sorted by citations

Cytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management
Vanderwall, A. G., & Milligan, E. D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03009 · Cited by 227
A review of cytokine-based pathophysiology of Long COVID symptoms
Low, R. N., Low, R. J., & Akrami, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1011936 · Cited by 205
Anti-inflammatory and modulatory effects of steroidal saponins and sapogenins on cytokines: A review of pre-clinical research
Passos, F. R. S., Araújo-Filho, H. G., Monteiro, B. S., Shanmugam, S., Araújo, A. A. D. S., Almeida, J. R. G. D. S., Thangaraj, P., Quintans‐Júnior, L. J., & Quintans, J. D. S. S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153842 · Cited by 114
Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies
Teixeira-Santos, L., Albino‐Teixeira, A., & Pinho, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105280 · Cited by 108
Autoimmune Neuroinflammatory Diseases: Role of Interleukins
Khan, A. W., Farooq, M., Hwang, M.-J., Haseeb, M., & Choi, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097960 · Cited by 107
β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
Aly, E., Khajah, M. A., & Masocha, W. (2019) · Molecules · doi:10.3390/molecules25010106 · Cited by 95
Repetitive transcranial magnetic stimulation regulates neuroinflammation in neuropathic pain
Bai, Y.-W., Yang, Q., Chen, P., & Wang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1172293 · Cited by 91
Wound healing and antibacterial chitosan-genipin hydrogels with controlled drug delivery for synergistic anti-inflammatory activity
del Olmo, J. A., Pérez‐Álvarez, L., Sáez‐Martínez, V., Cid, S. B., Ruiz‐Rubio, L., Pérez-González, R., Vilas‐Vilela, J. L., & Alonso, J. M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.01.193 · Cited by 80
The mechanism of action of pulsed radiofrequency in reducing pain: a narrative review
Park, D., & Chang, M. C. (2022) · Journal of Yeungnam Medical Science · doi:10.12701/jyms.2022.00101 · Cited by 72
Cutaneous Neuroimmune Interactions in Peripheral Neuropathic Pain States
Lowy, D. B., Makker, P. G. S., & Moalem‐Taylor, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.660203 · Cited by 69
Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel
Huang, Y., Lu, Y., Zhao, X., Zhang, J., Zhang, F., Chen, Y., Bi, L., Gu, J., Jiang, Z., Wu, X., et al. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15284 · Cited by 66
Non-Hematologic Toxicity of Bortezomib in Multiple Myeloma: The Neuromuscular and Cardiovascular Adverse Effects
Pancheri, E., Guglielmi, V., Wilczynski, G. M., Malatesta, M., Tonin, P., Tomelleri, G., Nowis, D., & Vattemi, G. N. A. (2020) · Cancers · doi:10.3390/cancers12092540 · Cited by 62
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
Bogacka, J., Pawlik, K., Ciapała, K., Ciechanowska, A., & Mika, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415638 · Cited by 48
IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10
Fonseca, M. M., Davoli-Ferreira, M., Santa-Cecília, F. V., Guimarães, R. M., de Oliveira, F. F. B., Kusuda, R., Ferreira, D. W., Alves-Filho, J. C., Cunha, F. Q., & Cunha, T. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03059 · Cited by 52
Inflammation-related molecules in tears of patients with chronic ocular pain and dry eye disease
Blanco‐Vázquez, M., Vázquez, A., Fernández, I., Novo‐Diez, A., Plaza, E. M., García‐Vázquez, C., González-García, M. J., Sobas, E. M., Calonge, M., & Enríquez‐de‐Salamanca, A. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109057 · Cited by 45
Fgr contributes to hemorrhage-induced thalamic pain by activating NF-κB/ERK1/2 pathways
Huang, T., Fu, G., Gao, J., Zhang, Y., Cai, W., Wu, S., Jia, S., Xia, S., Bachmann, T., Bekker, A., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.139987 · Cited by 43
Tumor Necrosis Factor and Interleukin Modulators for Pathologic Pain States: A Narrative Review
Kaye, A. D., Perilloux, D. M., Hawkins, A. M., Wester, G. C., Ragaland, A. R., Hebert, S. V., Kim, J. S., Heisler, M. B., Kelkar, R. A., Chami, A. A., et al. (2024) · Pain and Therapy · doi:10.1007/s40122-024-00603-8 · Cited by 40
Platelet‐rich plasma and cytokines in neuropathic pain: A narrative review and a clinical perspective
Bohren, Y., Timbolschi, D. I., Muller, A., Barrot, M., Yalçın, İ., & Salvat, É. (2021) · European Journal of Pain · doi:10.1002/ejp.1846 · Cited by 39
Exploring Pro-Inflammatory Immunological Mediators: Unraveling the Mechanisms of Neuroinflammation in Lysosomal Storage Diseases
Pandey, M. K. (2023) · Biomedicines · doi:10.3390/biomedicines11041067 · Cited by 40
miR-129-5p Alleviates Neuropathic Pain Through Regulating HMGB1 Expression in CCI Rat Models
Tian, J., Song, T., Wang, W., Wang, H., & Zhang, Z. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01403-y · Cited by 38
Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System
Villarreal, C. F., Santos, D. S., Lauria, P. S. S., Gama, K. B., Santo, R. F. D. E., Juíz, P. J. L., Alves, C. Q., David, J. M., & Soares, M. B. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144850 · Cited by 40
A peripheral CB2 cannabinoid receptor mechanism suppresses chemotherapy-induced peripheral neuropathy: evidence from a CB2 reporter mouse
Lin, X., Xu, Z., Carey, L. M., Romero, J., Makriyannis, A., Hillard, C. J., Ruggiero, E., Dockum, M., Houk, G., Mackie, K., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002502 · Cited by 36
The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain
Osthues, T., Zimmer, B., Rimola, V., Klann, K., Schilling, K., Mathoor, P., Angioni, C., Weigert, A., Geißlinger, G., Münch, C., et al. (2020) · Cells · doi:10.3390/cells9071740 · Cited by 40
Pregabalin inhibits in vivo and in vitro cytokine secretion and attenuates spleen inflammation in Lipopolysaccharide/Concanavalin A -induced murine models of inflammation
Abu-rish, E. Y., Mansour, A. T., Mansour, H. T., Dahabiyeh, L. A., Aleidi, S. M., & Bustanji, Y. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-61006-1 · Cited by 37
The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain
Pawlik, K., Piotrowska, A., Kwiatkowski, K., Ciapała, K., Popiołek-Barczyk, K., Makuch, W., & Mika, J. (2020) · Immunology · doi:10.1111/imm.13172 · Cited by 35
The Role of TNF-α in Neuropathic Pain: An Immunotherapeutic Perspective
García‐Domínguez, M. (2025) · Life · doi:10.3390/life15050785 · Cited by 40
Effects of long non-coding RNA Gm14461 on pain transmission in trigeminal neuralgia
Xu, M., Yan, Y., Zhu, M., Wang, Z., Zhang, X., & Zhang, D. (2020) · Journal of Inflammation · doi:10.1186/s12950-019-0231-1 · Cited by 34
Analgesic Effect of Noninvasive Brain Stimulation for Neuropathic Pain Patients: A Systematic Review
Zhang, K.-L., Yuan, H. M., Wu, F., Pu, X.-Y., Liu, B.-Z., Li, Z., Li, K.-F., Liu, H., Yang, Y., & Wang, Y. (2021) · Pain and Therapy · doi:10.1007/s40122-021-00252-1 · Cited by 36
Characterizing shared and distinct symptom clusters in common chronic conditions through natural language processing of nursing notes
Koleck, T. A., Topaz, M., Tatonetti, N. P., George, M., Miaskowski, C., Smaldone, A., & Bakken, S. (2021) · Research in Nursing & Health · doi:10.1002/nur.22190 · Cited by 33
Puerarin alleviates vincristine-induced neuropathic pain and neuroinflammation via inhibition of nuclear factor-κB and activation of the TGF-β/Smad pathway in rats
Xie, H., Chen, Y., Du, K., Wu, W., & Feng, X. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107060 · Cited by 34
The Antinociceptive Role of Nrf2 in Neuropathic Pain: From Mechanisms to Clinical Perspectives
Petrikonis, K., Bernatonienė, J., Kopustinskienė, D. M., Casale, R., Davinelli, S., & Saso, L. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16081068 · Cited by 36
Comparison of the beneficial effects of RS504393, maraviroc and cenicriviroc on neuropathic pain-related symptoms in rodents: behavioral and biochemical analyses
Kwiatkowski, K., Ciapała, K., Rojewska, E., Makuch, W., & Mika, J. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106540 · Cited by 32
Experimental Drugs for Neuropathic Pain
Sałat, K., Gryzło, B., & Kulig, K. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180510151241 · Cited by 31
Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain
Pawlik, K., Ciechanowska, A., Ciapała, K., Rojewska, E., Makuch, W., & Mika, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.781310 · Cited by 30
Evaluation of the immediate effects of a single transcranial direct current stimulation session on astrocyte activation, inflammatory response, and pain threshold in naïve rats
Callai, E. M. M., Zin, L. E. F., Catarina, L. S., Ponzoni, D., Gonçalves, C. A., Vizuete, A. F. K., Cougo, M. C. R., Boff, J., Puricelli, E., Fernandes, E. K., et al. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113880 · Cited by 30
TNFα in MS and Its Animal Models: Implications for Chronic Pain in the Disease
Maguire, A. D., Bethea, J. R., & Kerr, B. J. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.780876 · Cited by 33
Causal association between circulating inflammatory markers and sciatica development: a Mendelian randomization study
Wu, Y., Lin, Y., Zhang, M., He, K., & Tian, G. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1380719 · Cited by 28
Purinergic Profiling of Regulatory T-cells in Patients With Episodic Migraine
Nurkhametova, D., Kudryavtsev, I. V., Khayrutdinova, O., Серебрякова, М. К., Altunbaev, R. A., Malm, T., & Giniatullin, R. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00326 · Cited by 29
Thiamine, riboflavin, and nicotinamide inhibit paclitaxel-induced allodynia by reducing TNF-α and CXCL-1 in dorsal root ganglia and thalamus and activating ATP-sensitive potassium channels
Braga, A. V., Costa, S. O. A. M., Rodrigues, F. F., Melo, I. S. F., Morais, M. Í., Coelho, M. M., & Machado, R. R. (2019) · Inflammopharmacology · doi:10.1007/s10787-019-00625-1 · Cited by 28
Molecular Mechanism of Gelsemium elegans (Gardner and Champ.) Benth. Against Neuropathic Pain Based on Network Pharmacology and Experimental Evidence
Que, W., Wu, Z., Chen, M., Zhang, B., You, C., Lin, H., Zhao, Z., Liu, M., Qiu, H., & Cheng, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.792932 · Cited by 28
miR‐21‐5p inhibits neuropathic pain development via directly targeting C‐C motif ligand 1 and tissue inhibitor of metalloproteinase‐3
Zhong, L., Xiao, W., Wang, F., Liu, J., & Zhi, L. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28920 · Cited by 27
Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study
Mercan, A., Uzun, S. T., Keleş, S., Hacıbeyoğlu, G., Yılmaz, R., & Reıslı, R. (2021) · The Korean journal of pain · doi:10.3344/kjp.2021.34.4.463 · Cited by 29
Repetitive transcranial magnetic stimulation regulates neuroinflammation, relieves hyperalgesia and reverses despair‐like behaviour in chronic constriction injury rats
Hu, Y., Zhu, Y., Xin, W., Zeng, F., Feng, Y., Xu, Z., Xu, F., & Wang, J. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15779 · Cited by 27
A systematic review of steroid use in peripheral nerve pathologies and treatment
Couch, B., Hayward, D., Baum, G. R., Sakthiyendran, N. A., Harder, J. G., Hernandez, E. J., & MacKay, B. J. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1434429 · Cited by 26
Coriandrum sativum improve neuronal function via inhibition of oxidative/nitrosative stress and TNF-α in diabetic neuropathic rats
Kajal, A., & Singh, R. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112959 · Cited by 26
The analgesic potential of cytokine neutralization with biologicals
Ebersberger, A. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.040 · Cited by 26
Single cell analysis of short-term dry eye induced changes in cornea immune cell populations
Alam, J., Yaman, E., Silva, G. C. V., Chen, R., de Paiva, C. S., Stepp, M. A., & Pflugfelder, S. C. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1362336 · Cited by 25
Chanling Gao Attenuates Bone Cancer Pain in Rats by the IKKβ/NF-κB Signaling Pathway
Yang, B., Zhang, Z., Zhu, Y., Ruan, J., Luo, L., Long, F., & Tang, D. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00525 · Cited by 25
Peripheral Nerve-Derived Stem Cell Spheroids Induce Functional Recovery and Repair after Spinal Cord Injury in Rodents
Lee, H.-L., Yeum, C.-E., Lee, H. Y., Oh, J., Kim, J.-T., Lee, W., Ha, Y., Yang, Y., & Kim, K. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084141 · Cited by 25
Basolateral amygdala astrocytes modulate diabetic neuropathic pain and may be a potential therapeutic target for koumine
Lu, J., Yang, L., Chen, J., Xiong, F., Cai, P., Wang, X., Xiong, B.-J., Chen, Z., Chen, L., Yang, J., et al. (2022) · British Journal of Pharmacology · doi:10.1111/bph.16011 · Cited by 25
Mesenchymal stem cells reduce the oxaliplatin-induced sensory neuropathy through the reestablishment of redox homeostasis in the spinal cord.
Santos, G. G. L. D., Oliveira, A. L. L., Santos, D., Santo, R. F. D. E., Silva, D. N., Juiz, P. J. L., Soares, M., & Villarreal, C. (2020) · Life Science · doi:10.1016/j.lfs.2020.118755 · Cited by 20
Novel Analgesics with Peripheral Targets
Ciotu, C. I., & Fischer, M. J. M. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00937-z · Cited by 22
Can noninvasive Brain Stimulation Improve Pain and Depressive Symptoms in Patients With Neuropathic Pain? A Systematic Review and Meta-Analysis
Gao, C., Zhu, Q., Gao, Z., Zhao, J., Jia, M., & Li, T. (2022) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2022.05.002 · Cited by 20
Interleukin-17 is involved in neuropathic pain and spinal synapse plasticity on mice
Sun, J., Dai, W., Shen, X., Lü, N., & Zhang, Y. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578068 · Cited by 20
Mitochondrial transplantation attenuates traumatic neuropathic pain, neuroinflammation, and apoptosis in rats with nerve root ligation
Huang, C.-C., Chiu, H., Lee, P., Fang, S., Lin, M., Chen, H., & Lee, J. (2023) · Molecular Pain · doi:10.1177/17448069231210423 · Cited by 20
Cytokines, Masticatory Muscle Inflammation, and Pain: an Update
Ayoub, S., Berbéri, A., & Fayyad‐Kazan, M. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01491-1 · Cited by 21
Pathophysiological Mechanisms That Alter the Autonomic Brain-Liver Communication in Metabolic Diseases
Silva, A. J., & Caron, A. (2021) · Endocrinology · doi:10.1210/endocr/bqab164 · Cited by 19
Spinal Cord Stimulation Paradigms and Pain Relief: A Preclinical Systematic Review on Modulation of the Central Inflammatory Response in Neuropathic Pain
de Geus, T. J., Franken, G., & Joosten, E. A. J. (2022) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2022.04.049 · Cited by 19
Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model—In Vivo and In Vitro Study
Piotrowska, A., Ciapała, K., Pawlik, K., Kwiatkowski, K., Rojewska, E., & Mika, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011074 · Cited by 18
MiR-30b-5p attenuates neuropathic pain by the CYP24A1-Wnt/β-catenin signaling in CCI rats
Liao, J., Liu, J. L., Long, G., & Lv, X. (2021) · Experimental Brain Research · doi:10.1007/s00221-021-06253-y · Cited by 19
The Prognostic Significance of 5-Fluorouracil Induced Inflammation and Immuno-Modulation in Colorectal Cancer Patients
Abdellateif, M. S., Salem, S., Badr, D. M., Shaarawy, S., Hussein, M. M., Zekri, A. N., & Fouad, M. A. (2020) · Journal of Inflammation Research · doi:10.2147/jir.s283069 · Cited by 18
Inhibition of the RNA Regulator HuR by SRI-42127 Attenuates Neuropathic Pain After Nerve Injury Through Suppression of Neuroinflammatory Responses
Sorge, R. E., Si, Y., Norian, L. A., Guha, A., Moore, G. E., Nabors, B., Filippova, N., Yang, X., Smith, R., Chellappan, R., et al. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01278-9 · Cited by 17
Proinflammatory cytokines and their receptors as druggable targets to alleviate pathological pain
Kalpachidou, T., Riehl, L., Schöpf, C. L., Uçar, B., & Kress, M. (2022) · Pain · doi:10.1097/j.pain.0000000000002737 · Cited by 17
Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice
McDonough, K. E., Hammond, R. M., Wang, J., Tierney, J. A., Hankerd, K., Chung, J. M., & La, J. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.10.013 · Cited by 17
Daphnetin Improves Neuropathic Pain by Inhibiting the Expression of Chemokines and Inflammatory Factors in the Spinal Cord and Interfering with Glial Cell Polarization
Zhang, T., Liang, W., Zhang, M., Cui, S., Huang, X., Ou, W., Huang, R., Gao, J., Jia, Z., & Zhang, S. (2023) · Pharmaceuticals · doi:10.3390/ph16020243 · Cited by 18
Conventional, high frequency and differential targeted multiplexed spinal cord stimulation in experimental painful diabetic peripheral neuropathy: Pain behavior and role of the central inflammatory balance
de Geus, T. J., Franken, G., & Joosten, E. A. J. (2023) · Molecular Pain · doi:10.1177/17448069231193368 · Cited by 17
Mitigation of sciatica injury-induced neuropathic pain through active metabolites derived from medicinal plants
Nasır, A., Afridi, O. K., Ullah, S., Khan, H. Z., & Bai, Q. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107076 · Cited by 17
Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain
Kalpachidou, T., Malsch, P., Qi, Y., Mair, N., Geley, S., Quarta, S., Kummer, K. K., & Kress, M. (2021) · Pain · doi:10.1097/j.pain.0000000000002402 · Cited by 17
Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study
Royds, J., Conroy, M. J., Dunne, M. R., Cassidy, H., Matallanas, D., Lysaght, J., & McCrory, C. R. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577249 · Cited by 18
Bone-Marrow-Derived Mononuclear Cells Relieve Neuropathic Pain after Spinal Nerve Injury in Mice
Takamura, H., Terashima, T., Mori, K., Katagi, M., Okano, J., Suzuki, Y., Imai, S., & Kojima, H. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.03.020 · Cited by 16
Mesenchymal stem cell spheroids alleviate neuropathic pain by modulating chronic inflammatory response genes
Lee, N., Park, G. T., Lim, J. K., Choi, E.-B., Moon, H. J., Kim, D. K., Choi, S. M., Song, Y. C., Kim, T. K., & Kim, J. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940258 · Cited by 16
Transcriptional Profiling of TGF-β Superfamily Members in Lumbar DRGs of Rats Following Sciatic Nerve Axotomy and Activin C Inhibits Neuropathic Pain
Liu, X., Zhang, F., Wang, B., Hu, H., Li, Q., Chen, H., Luo, L.-T., Jiang, Z., & Zeng, M.-X. (2022) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530322666221006114557 · Cited by 16
Antinociceptive Effects of Aaptamine, a Sponge Component, on Peripheral Neuropathy in Rats
Sung, C., Cheng, H., Chen, N., Tang, S.-H., Kuo, H., Sung, P., Chen, W.-F., & Wen, Z. (2023) · Marine Drugs · doi:10.3390/md21020113 · Cited by 19
High‐Frequency Spinal Stimulation Suppresses Microglial Kaiso‐P2X7 Receptor Axis‐Induced Inflammation to Alleviate Neuropathic Pain in Rats
Yu, J., Wong, S. S. C., Lin, Z., Shan, Z., Fan, C., Xia, Z., Cheung, M. C. H., Zhu, X., Liu, J. A., & Cheung, C. W. (2024) · Annals of Neurology · doi:10.1002/ana.26898 · Cited by 16
Neuroprotective and anti-neuropathic actions of pulsed magnetic fields with low frequencies in rats with chronic peripheral neuropathic pain
Mert, T., Metin, T. Ö., Şahın, E., Yaman, S., & Sahin, M. A. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.10.012 · Cited by 16
Potentiation of morphine antinociception and inhibition of diabetic neuropathic pain by the multi-chemokine receptor antagonist peptide RAP-103
Ruff, M. R., Inan, S., Shi, X., Meissler, J. J., Adler, M. W., Eisenstein, T. K., & Zhang, J. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120788 · Cited by 16
The emerging potential of Aptamers as therapeutic agents in infection and inflammation
Stephens, M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108173 · Cited by 15
Herbal Decoction Divya-Peedantak-Kwath Alleviates Allodynia and Hyperalgesia in Mice Model of Chemotherapy-Induced Peripheral Neuropathy via Modulation in Cytokine Response
Balkrishna, A., Sakat, S. S., Karumuri, S., Singh, H., Tomer, M., Kumar, A., Sharma, N., Nain, P., Haldar, S., & Varshney, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.566490 · Cited by 15
The role of cytokines in acute and chronic postsurgical pain after major musculoskeletal surgeries in a quaternary pediatric center
Chidambaran, V., Duan, Q., Pilipenko, V. V., Glynn, S. M., Sproles, A. A., Martin, L. J., Lacagnina, M. J., King, C. D., & Ding, L. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.08.056 · Cited by 14
Effects of external low intensity focused ultrasound on inflammatory markers in neuropathic pain
Hellman, A., Clum, A., Maietta, T., Srikanthan, A., Patel, V., Panse, D., Zimmerman, O., Neubauer, P. D., Nalwalk, J. W., Williams, E., et al. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135977 · Cited by 14
Whole-Body Cryostimulation in Fibromyalgia: A Scoping Review
Fontana, J. M., Gobbi, M., Piterà, P., Giusti, E. M., & Capodaglio, P. (2022) · Applied Sciences · doi:10.3390/app12094794 · Cited by 15
A Cytokine-based model for the pathophysiology of Long COVID symptomsPreprint
Low, R. N., Low, R. J., & Akrami, A. (2020) · doi:10.31219/osf.io/7gcnv · Cited by 14
Injury-Driven Structural and Molecular Modifications in Nociceptors
García‐Domínguez, M. (2025) · Biology · doi:10.3390/biology14070788 · Cited by 18
Fabry Disease Beyond Storage: The Role of Inflammation in Disease Progression
Biddeci, G., Spinelli, G., Colomba, P., Duro, G., Giacalone, I., & Blasi, F. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157054 · Cited by 13
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis
Fu, Y.-Y., Cen, J.-K., Song, H.-L., Song, S., Zhang, Z., & Lu, H.-J. (2022) · Molecular Pain · doi:10.1177/17448069221126078 · Cited by 12
Role of peripheral and central sensitization in the anti-hyperalgesic effect of hecogenin acetate, an acetylated sapogenin, complexed with β-cyclodextrin: Involvement of NFκB and p38 MAPK pathways
Passos, F. R. S., Pereira, E. W. M., Heimfarth, L., Monteiro, B. S., de Carvalho, Y. M. B. G., Siqueira-Lima, P. S., Coutinho, H. D. M., Araújo, A. A. D. S., Almeida, J. R. G. D. S., Barreto, R. D. S. S., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108395 · Cited by 12
Manifestation of lipopolysaccharide-induced tolerance in neuro-glial primary cultures of the rat afferent somatosensory system
Nürnberger, F., Leisengang, S., Ott, D., Murgott, J., Gerstberger, R., Rummel, C. D., & Roth, J. (2021) · Inflammation Research · doi:10.1007/s00011-021-01440-7 · Cited by 12
Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models
Chindo, B. A., Howes, M. R., Abuhamdah, S. M. A., Mallam, D., Micah, T., Awotula, R. I., Battison, R., & Chazot, P. L. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117500 · Cited by 11
microRNA‐125b‐5p alleviated CCI‐induced neuropathic pain and modulated neuroinflammation via targeting SOX11
Wang, L., Wang, B., Xia, G., Guo, X., Wang, T., Xu, J., Jiang, L., & Zhen, H. (2024) · Synapse · doi:10.1002/syn.22306 · Cited by 11
Effects of co‐administration of vitamin E and lithium chloride on chronic constriction injury‐induced neuropathy in male Wistar rats: Focus on antioxidant and anti‐inflammatory mechanisms
Esu, K. D., Bakare, A. O., & Owoyele, B. V. (2021) · Pain Practice · doi:10.1111/papr.13064 · Cited by 11
rTMS and TENS Relieve Neuropathic Pain in CCI Model Rats by Modulating Central Nervous System TRPV1 and Neuroinflammation
Xu, Z., Zhong, Q., Xing, F., Zhu, Y., Hu, Y., Huang, M., Zhou, M., & Wang, J. (2024) · Mediators of Inflammation · doi:10.1155/mi/8500317 · Cited by 11
Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain
Ciapała, K., Pawlik, K., Ciechanowska, A., Mika, J., & Rojewska, E. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116382 · Cited by 10
Can FDA-Approved Immunomodulatory Drugs be Repurposed/Repositioned to Alleviate Chronic Pain?
Inyang, K. E., Folger, J. K., & Laumet, G. O. (2021) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-021-10000-z · Cited by 9
Inhibition of Spinal Interleukin-33 Attenuates Peripheral Inflammation and Hyperalgesia in Experimental Arthritis
Huang, S.-J., Zhou, L.-Y., Ren, F., Zou, W., Yan, J., & Luo, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02754-1 · Cited by 10
Therapeutic Potential of Combinative shRNA-Encoded Lentivirus-Mediated Gene Silencing to Accelerate Somatosensory Recovery After Spinal Cord Trauma
Park, J., Farmer, M. A., Casson, C. L., Kalashnikova, I. V., & Kolpek, D. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01331-7 · Cited by 9
Preemptive transcranial direct current stimulation induces analgesia, prevents chronic inflammation and fibrosis, and promotes tissue repair in a rat model of postoperative pain
Zancanaro, M., Stein, D. J., Lopes, B. C., de Souza, A., Toledo, R. S., de Souza, A. H., Oliveira, S. M., Visioli, F., Sanches, P. R. S., Fregni, F., et al. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137407 · Cited by 9
The binding of PKCε and MEG2 to STAT3 regulates IL ‐6‐mediated microglial hyperalgesia during inflammatory pain
Li, X., Wang, J., Liao, C., Yang, X., Zhao, Z., Liu, Y., Xue, Q., Luo, Y., Liu, X., & Liu, Z. (2024) · The FASEB Journal · doi:10.1096/fj.202300152rr · Cited by 9
Preemptive administration of mesenchymal stem cells-derived conditioned medium can attenuate the development of neuropathic pain in rats via downregulation of proinflammatory cytokines
Nazemi, S., Helmi, M., Kafami, M., Amin, B., & Mojadadi, M. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.114858 · Cited by 8
Decoding of the Role of TREM2 in Neuropathic Pain: Molecular Pathway and Neuroinflammatory Mechanism
Vijayan, N., Veeraveedu, P. T., & Patel, S. (2025) · Drug Development Research · doi:10.1002/ddr.70111 · Cited by 10
Photobiomodulation therapy in neuropathic pain: mechanisms, evidence, and future directions
Martins, D. O., Rocha, I. R. C., Watkins, L. R., & Chacur, M. (2025) · Frontiers in Photonics · doi:10.3389/fphot.2025.1730347 · Cited by 10

Authors: Hung, A. L., Lim, M., & Doshi, T. L.
Affiliations: Johns Hopkins University (US)
Corresponding author: Doshi, Tina L.
ORCID: Hung, Alice L.
Lim, Michael
Doshi, Tina L.
Venue: Scandinavian Journal of Pain
Publisher: Walter de Gruyter GmbH
Published: 2017-10-01
Volume: 17
Issue: 1
Pages: 287-293
ISSN: 1877-8860 (ISSN-L)
1877-8879
DOI: 10.1016/j.sjpain.2017.08.002
PMC: PMC5774983
OpenAlex: W2748786482
Cited by: 174
References: 118
Citations by year: 2026: 5 · 2025: 19 · 2024: 29 · 2023: 22 · 2022: 29 · 2021: 30 · 2020: 29 · 2019: 7 · 2018: 4
FWCI: 1.34
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Scandinavian Journal of Pain (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (T32GM075774)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: neuropathic pain, cytokines, inflammatory cytokines, anti-inflammatory cytokines, immune system, TNF-α, IL-1β, interleukin-6, IL-17, IL-10, TGF-beta, immunomodulation, analgesic treatment, cytokine-targeted therapy
MeSH terms: Animals, Humans, Inflammation, Neuralgia, Cytokines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Targeting cytokines for treatment of neuropathic pain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks