Sternberg working memory performance following treatment with pramipexole in patients with moderate-to-severe restless legs syndrome
Open accessAbstract
Objectives We recently reported that the P300 amplitude related to the Sternberg working memory (WM) task was significantly lower in drug-naïve severe restless legs syndrome (RLS) patients than controls. Here, we evaluated the effects of pramipexole on the Sternberg WM task performance by event-related potential (ERP) study.Methods Thirteen drug-naïve RLS patients (52.0 ± 9.48 years) were enrolled in the study. Pramipexole was administered over a period of 12 weeks every night 1 h before bedtime. Two ERP studies were carried out: the first was performed just before giving the first dose of pramipexole and the second was conducted at 12-16 weeks after commencement of pramipexole administration. P300 amplitudes and reaction times were compared before and after treatment considering brain regions and memory load as within-subject factors. Clinical and sleep-related variables were correlated with P300 amplitude.Results After treatment with pramipexole, the International RLS Severity Scale (IRLS) score was significantly decreased. Sleep quality and depression were also significantly improved. Omission error was significantly reduced without significant change of commission error. Reaction time was significantly shortened, regardless of memory load size, following treatment with pramipexole. Parietal P300 amplitude was significantly increased after treatment with pramipexole for all memory load sizes. Increase of frontal P300 amplitude was significantly correlated with improvement of sleep duration, IRLS, Insomnia Severity Index, and Pittsburgh Sleep Quality Index score.Conclusion Our study suggested that pramipexole improves WM performance in patients with RLS in addition to improving RLS symptoms, sleep disturbance, and depression.
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Pramipexole has been shown to improve sustained attention, particularly in baseline low performers.
“Finally, the D3 agonist pramipexole has recently been shown to improve sustained attention, particularly in baseline low performers120.”
From Paying attention to attention in depression (2019) · cites this paper as [120]
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- Authors
- Jung, K.-Y., Kim, S. M., Song, J.-Y., Lee, B. U., Lee, C., Lee, S. K., Koo, Y. S., Cho, Y. W., Choi, J. W., & Kim, K. H.
- Affiliations
- Seoul National University (KR)
- Korea University Medical Center (KR)
- Hanyang University (KR)
- Keimyung University Dongsan Medical Center (KR)
- Yonsei University (KR)
- Corresponding author
- Jung, Ki-Young
- Kim, Kyung Hwan
- ORCID
- Venue
- Sleep Medicine
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 16
- Issue
- 6
- Pages
- 703-708
- ISSN
- 1389-9457 (ISSN-L)
- OpenAlex
- W2084729711
- Cited by
- 14
- References
- 35
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 2 · 2015: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Sleep Medicine (publishedVersion)
- PubMed (publishedVersion)
- KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation of Korea (20110029740)
- Korea Environmental Industry and Technology Institute (RE201206020)
- Topics
- Health Sciences › Medicine › Epidemiology › Restless Legs Syndrome Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- restless legs syndrome, pramipexole, P300 amplitude, event-related potentials, sleep disorders, insomnia, depression, reaction time, memory load
- MeSH terms
- Pramipexole, Adult, Depression, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Reaction Time, Restless Legs Syndrome, Event-Related Potentials, P300, Benzothiazoles
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