Cited by 413Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSchizophrenia research and treatment

Effects of bromocriptine on human subjects depend on working memory capacity

Kimberg, Daniel Y., DʼEsposito, Mark, Farah, Martha J.·1997·Neuroreport

Abstract

Pharmacological manipulation of brain dopamine concentration affects visuospatial working memory in humans and in animals, the latter effects localized to the prefrontal cortex. However, the effects of dopamine agonists on humans are poorly understood. We hypothesized that bromocriptine would have an effect on cognitive functions associated with the prefrontal cortex via its effects on cortical dopamine receptors and on subcortical receptors in areas that project to the neocortex. We found that the effect of bromocriptine on young normal subjects depended on the subjects' working memory capacity. High-capacity subjects performed more poorly on the drug, while low-capacity subjects improved. These results demonstrate an empirical link between a dopamine-mediated working memory system and higher cognitive function in humans.

Integrity signals

Registry

Crossref · 10.1097/00001756-199711100-00032

Cites

14 of 14 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Effects of methylphenidate and related drugs on cognition are baseline performance-dependent.

    “Based on accumulating evidence that effects of methylphenidate and related drugs on cognition are baseline performance-dependent (Kimberg et al., 1997; Mattay et al., 2000; Mehta et al., 2000; Gibbs and D’Esposito, 2005; Tipper et al., 2005; Finke et al., 2010), changes in sustained attention following methylphenidate were assessed as a function of baseline A’ scores, independent of group.”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kimberg, D. Y., DʼEsposito, M., & Farah, M. J.
Affiliations
  • National Institutes of Health (US)
  • Hospital of the University of Pennsylvania (US)
Venue
Neuroreport
Published
1997-11
Volume
8
Issue
16
Pages
3581-3585
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2073452891
Cited by
413
References
14
Citations by year
2025: 6 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 11 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 10 · 2014: 23 · 2013: 29 · 2012: 19
FWCI
2.23
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k08ns001762-05, 7r01ag013483-05)
  • National Institute on Aging (AG 13483)
  • National Institute of Neurological Disorders and Stroke (NS 01762)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
bromocriptine, dopamine agonists, working memory capacity, visuospatial working memory, prefrontal cortex, dopamine receptors, drug effects on cognition
MeSH terms
Association Learning, Bromocriptine, Cerebral Cortex, Color, Humans, Language, Memory, Random Allocation, Reaction Time, Reproducibility of Results, Dopamine Agonists, Cross-Over Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review