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Exercise training modulates adipokine dysregulations in metabolic syndrome
Open accessAbstract
Metabolic syndrome (MetS) is a cluster of risk factors for various metabolic diseases, and it is characterized by central obesity, dyslipidemia, hypertension, and insulin resistance. The core component for MetS is adipose tissue, which releases adipokines and influences physical health. Adipokines consist of pro and anti-inflammatory cytokines and contribute to various physiological functions. Generally, a sedentary lifestyle promotes fat accumulation and secretion of pro-inflammatory adipokines. However, regular exercise has been known to exert various beneficial effects on metabolic and cognitive disorders. Although the mechanisms underlying exercise beneficial effects in MetS are not fully understood, changes in energy expenditure, fat accumulation, circulatory level of myokines, and adipokines might be involved. This review article focuses on some of the selected adipokines in MetS, and their responses to exercise training considering possible mechanisms.
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“Although improvements in fitness and reductions in adiposity were recorded after 8 weeks of training”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [76]
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“the acute cytokine response remained comparable, reflecting a similar per-exercise immune reaction despite physiological adaptations”
From Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging (2025) · cites this paper as [76]
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Metadata
- Authors
- Babaei, P., & Hoseini, R.
- Affiliations
- Guilan University of Medical Sciences (IR)
- Razi University (IR)
- Corresponding author
- Babaei, Parvin
- Venue
- Sports Medicine and Health Science
- Publisher
- Elsevier BV
- Published
- 2022-03
- Volume
- 4
- Issue
- 1
- Pages
- 18-28
- ISSN
- 2666-3376 (ISSN-L)
- PMC
- PMC9219261
- OpenAlex
- W4205977718
- Cited by
- 52
- References
- 230
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 8 · 2023: 13 · 2022: 5
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Sports Medicine and Health Science (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- metabolic syndrome, exercise training, adipokines, adipose tissue, inflammation, insulin resistance, myokines, abdominal obesity, energy expenditure, fat deposition
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