Cited by 62Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismMuscle Physiology and Disorders

Adipose–Muscle Crosstalk in Age-Related Metabolic Disorders: The Emerging Roles of Adipo-Myokines

Fang, Penghua, She, Yuqing, Yu, Mei, Min, Wen, Shang, Wenbin, Zhang, Zhenwen·2023·Ageing Research Reviews

Abstract

Obesity and type 2 diabetes account for a considerable proportion of the global burden of age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and metabolic regulation have been primarily linked to endocrine processes. Skeletal muscle and adipose tissue are endocrine organs that release myokines and adipokines into the bloodstream, respectively. These cytokines regulate metabolic responses in a variety of tissues, including skeletal muscle and adipose tissue. However, the intricate mechanisms underlying adipose-muscle crosstalk in age-related metabolic diseases are not fully understood. Recent exciting evidence suggests that myokines act to control adipose tissue functions, including lipolysis, browning, and inflammation, whereas adipokines mediate the beneficial actions of adipose tissue in the muscle, such as glucose uptake and metabolism. In this review, we assess the mechanisms of adipose-muscle crosstalk in age-related disorders and propose that the adipokines adiponectin and spexin, as well as the myokines irisin and interleukin-6 (IL-6), are crucial for maintaining the body's metabolic balance in age-related metabolic disorders. In addition, these changes of adipose-muscle crosstalk in response to exercise or dietary flavonoid consumption are part of the mechanisms of both functions in the remission of age-related metabolic disorders. A better understanding of the intricate relationships between adipose tissue and skeletal muscle could lead to more potent therapeutic approaches to prolong life and prevent age-related metabolic diseases.

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Crossref · 10.1016/j.arr.2022.101829

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  • Adiponectin is released from the AT and plays a key role in regulating metabolic functioning of the SM, including enhanced mitochondrial function, Glucose Transporter 4 (GLUT4) translocation (to improve glucose uptake), and fatty acid oxidation.

    “Adiponectin is released from the AT and plays a key role in regulating metabolic functioning of the SM, including enhanced mitochondrial function, Glucose Transporter 4 (GLUT4) translocation (to improve glucose uptake), and fatty acid oxidation [56].”
  • Disruption in signaling pathways of adipokines and myokines contributes to the pathogenesis of sarcopenic obesity, described as a convergence of high fat mass and declining muscle function with aging.

    “Disruption in these signaling pathways contributes to the pathogenesis of sarcopenic obesity, which Fang et al. describe as a convergence of high fat mass and declining muscle function with aging”

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Authors
Fang, P., She, Y., Yu, M., Min, W., Shang, W., & Zhang, Z.
Affiliations
  • Nanjing University of Chinese Medicine (CN)
  • Yangzhou University (CN)
Corresponding author
  • Fang, Penghua
  • Shang, Wenbin
  • Zhang, Zhenwen
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2023-02
Volume
84
Pages
101829
ISSN
1568-1637 (ISSN-L)
OpenAlex
W4312085090
Cited by
62
References
201
Citations by year
2026: 18 · 2025: 20 · 2024: 16 · 2023: 8
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Administration of Traditional Chinese Medicine of Jilin Province (YB2020087)
  • National Natural Science Foundation of China (81803792)
  • Nanjing University of Chinese Medicine (NZY81803792)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions (ZYX03KF058)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
myokines, adipokines, adiponectin, spexin, irisin, interleukin-6, obesity, type 2 diabetes, skeletal muscle glucose uptake, insulin sensitivity, lipolysis, brown adipose tissue browning, inflammation, physical activity, dietary flavonoids, aging
MeSH terms
Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Obesity, Muscle, Skeletal, Adipokines

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