Cited by 446Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

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The role of CD40 and CD154/CD40L in dendritic cells

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Ma, Daphne Y., Clark, Edward A.·2009·Seminars in Immunology

DOI 10.1016/j.smim.2009.05.010PMC PMC2749083

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Abstract

In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.

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RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
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Authors: Ma, D. Y., & Clark, E. A.
Corresponding author: Clark, Edward A.
ORCID: Clark, Edward A.
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2009-10
Volume: 21
Issue: 5
Pages: 265-272
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2009.05.010
PMC: PMC2749083
OpenAlex: W1968783338
Cited by: 446
References: 131
Citations by year: 2026: 20 · 2025: 34 · 2024: 32 · 2023: 36 · 2022: 26 · 2021: 43 · 2020: 36 · 2019: 24 · 2018: 31 · 2017: 27 · 2016: 20 · 2015: 21 · 2014: 19 · 2013: 15 · 2012: 18
FWCI: 1.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM037905)
National Institute of Allergy and Infectious Diseases (AI-52203, R37AI044257, R01AI052203)
National Institute of Dental and Craniofacial Research (DE16381, R01DE016381)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: CD40, dendritic cells, innate immune receptors, dendritic cell vaccine, immunotherapy
MeSH terms: Animals, B-Lymphocytes, Cell Communication, Dendritic Cells, Humans, T-Lymphocytes, Signal Transduction, CD40 Antigens, Receptor Cross-Talk, CD40 Ligand

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The role of CD40 and CD154/CD40L in dendritic cells

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