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The role of CD40 and CD154/CD40L in dendritic cells
Open accessAbstract
In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.
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“Engagement of CD40 with its ligand induces recruitment of TNF receptor-associated factor family of proteins (TRAFs) and initiates signaling cascades that activate genes involved in cytokine production, as well as upregulation of co-stimulatory molecules such as CD80 and CD86 (37).”
From mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model (2022) · cites this paper as [37]
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1 retracted
RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
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Metadata
- Authors
- Ma, D. Y., & Clark, E. A.
- Corresponding author
- Clark, Edward A.
- ORCID
- Clark, Edward A.
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 21
- Issue
- 5
- Pages
- 265-272
- ISSN
- 1044-5323 (ISSN-L)
- PMC
- PMC2749083
- OpenAlex
- W1968783338
- Cited by
- 446
- References
- 131
- Citations by year
- 2026: 20 · 2025: 34 · 2024: 32 · 2023: 36 · 2022: 26 · 2021: 43 · 2020: 36 · 2019: 24 · 2018: 31 · 2017: 27 · 2016: 20 · 2015: 21 · 2014: 19 · 2013: 15 · 2012: 18
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM037905)
- National Institute of Allergy and Infectious Diseases (AI-52203, R37AI044257, R01AI052203)
- National Institute of Dental and Craniofacial Research (DE16381, R01DE016381)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- CD40, dendritic cells, innate immune receptors, dendritic cell vaccine, immunotherapy
- MeSH terms
- Animals, B-Lymphocytes, Cell Communication, Dendritic Cells, Humans, T-Lymphocytes, Signal Transduction, CD40 Antigens, Receptor Cross-Talk, CD40 Ligand
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