Cited by 446Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

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The role of CD40 and CD154/CD40L in dendritic cells

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Ma, Daphne Y., Clark, Edward A.·2009·Seminars in Immunology

DOI 10.1016/j.smim.2009.05.010PMC PMC2749083

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Abstract

In this review, we focus on the function of CD40-CD40L (CD154) interactions in the regulation of dendritic cell (DC)-T cell and DC-B cell crosstalk. In addition, we examine differences and similarities between the CD40 signaling pathway in DCs and other innate immune cell receptors, and how these pathways integrate DC functions. As research into DC vaccines and immunotherapies progresses, further understanding of CD40 and DC function will advance the applicability of DCs in immunotherapy for human diseases.

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RETRACTED ARTICLE: DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL
Litinskiy, M. B., Nardelli, B., Hilbert, D. M., He, B., Schaffer, A., Casali, P., & Cerutti, A. (2002) · Nature Immunology · doi:10.1038/ni829 · Cited by 1,252
Retracted
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
Sallusto, F., & Lanzavecchia, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1109 · Cited by 5,129
Tolerogenic Dendritic Cells
Steinman, R. M., Hawiger, D., & Nussenzweig, M. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141040 · Cited by 3,162
Signaling to NF-κB by Toll-like receptors
Kawai, T., & Akira, S. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.09.002 · Cited by 2,468
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Mouse and human dendritic cell subtypes
Shortman, K., & Liu, Y.-J. (2002) · Nature reviews. Immunology · doi:10.1038/nri746 · Cited by 2,289
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P. J. L., Lanzavecchia, A., & Alber, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.747 · Cited by 1,982
Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation
Rissoan, M., Soumelis, V., Kadowaki, N., Grouard, G., Brière, F., Malefyt, R. D. W., & Liu, Y.-J. (1999) · Science · doi:10.1126/science.283.5405.1183 · Cited by 1,835
CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,609

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Wang, Z., Xing, Y., Liu, B., Lü, L., Huang, X. L., Ge, C., Yao, W., Xu, M., Gao, Z., Cao, R., et al. (2012) · 癌症：英文版 · doi:10.5732/cjc.011.10384 · Cited by 8
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Authors: Ma, D. Y., & Clark, E. A.
Corresponding author: Clark, Edward A.
ORCID: Clark, Edward A.
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2009-10
Volume: 21
Issue: 5
Pages: 265-272
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2009.05.010
PMC: PMC2749083
OpenAlex: W1968783338
Cited by: 446
References: 131
Citations by year: 2026: 20 · 2025: 34 · 2024: 32 · 2023: 36 · 2022: 26 · 2021: 43 · 2020: 36 · 2019: 24 · 2018: 31 · 2017: 27 · 2016: 20 · 2015: 21 · 2014: 19 · 2013: 15 · 2012: 18
FWCI: 1.59
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM037905)
National Institute of Allergy and Infectious Diseases (AI-52203, R37AI044257, R01AI052203)
National Institute of Dental and Craniofacial Research (DE16381, R01DE016381)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: CD40, dendritic cells, innate immune receptors, dendritic cell vaccine, immunotherapy
MeSH terms: Animals, B-Lymphocytes, Cell Communication, Dendritic Cells, Humans, T-Lymphocytes, Signal Transduction, CD40 Antigens, Receptor Cross-Talk, CD40 Ligand

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The role of CD40 and CD154/CD40L in dendritic cells

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