Cited by 389T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisMultiple Sclerosis Research Studies

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The plasticity of human Treg and Th17 cells and its role in autoimmunity

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Kleinewietfeld, Markus, Hafler, David A.·2013·Seminars in Immunology

DOI 10.1016/j.smim.2013.10.009PMC PMC3905679

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Abstract

CD4(+) T helper cells are a central element of the adaptive immune system. They protect the organism against a wide range of pathogens and are able to initiate and control many immune reactions in combination with other cells of the adaptive and the innate immune system. Starting from a naive cell, CD4(+) T cells can differentiate into various effector cell populations with specialized function. This subset specific differentiation depends on numerous signals and the strength of stimulation. However, recent data have shown that differentiated CD4(+) T cell subpopulations display a high grade of plasticity and that their initial differentiation is not an endpoint of T cell development. In particular, FoxP3(+) regulatory T cells (Treg) and Th17 effector T cells demonstrate a high grade of plasticity, which allow a functional adaptation to various physiological situations during an immune response. However, the plasticity of Treg and Th17 cells might also be a critical factor for autoimmune disease. Here we discuss the recent developments in CD4(+) T cell plasticity with a focus on Treg and Th17 cells and its role in human autoimmune disease, in particular multiple sclerosis (MS).

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Authors: Kleinewietfeld, M., & Hafler, D. A.
Affiliations: Broad Institute (US)
ORCID: Kleinewietfeld, Markus
Hafler, David A.
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2013-11
Volume: 25
Issue: 4
Pages: 305-312
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2013.10.009
PMC: PMC3905679
OpenAlex: W2070685885
Cited by: 389
References: 152
Citations by year: 2026: 14 · 2025: 24 · 2024: 34 · 2023: 38 · 2022: 32 · 2021: 46 · 2020: 32 · 2019: 30 · 2018: 33 · 2017: 35 · 2016: 32 · 2015: 27 · 2014: 12
FWCI: 2.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Nancy Taylor Foundation for Chronic Diseases
Multiple Sclerosis Society
National Institutes of Health (AI039671)
National Institute of Allergy and Infectious Diseases (U19AI070352, U19AI046130, P01AI045757, R01AI091568, P01AI039671)
National Institute of Neurological Disorders and Stroke (R37NS024247)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: T cell plasticity, regulatory T cells, Foxp3, Th17 cells, CD4+ T cell differentiation, autoimmune disease, multiple sclerosis, effector T cell differentiation
MeSH terms: Animals, Cell Communication, Humans, Multiple Sclerosis, Autoimmunity, T-Lymphocyte Subsets, T-Lymphocytes, Regulatory, Th17 Cells

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The plasticity of human Treg and Th17 cells and its role in autoimmunity

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