Hafler, David A.

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Farh, K. K.-H., Marson, A., Zhu, J., Kleinewietfeld, M., Housley, W. J., Beik, S., Shoresh, N., Whitton, H., Ryan, R. J. H., Shishkin, A. A., et al. (2015) · Nature

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 1,956

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Kleinewietfeld, M., Manzel, A., Titze, J., Kvakan, H., Yosef, N., Linker, R. A., Muller, D. N., & Hafler, D. A. (2013) · Nature

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,394

Induction and molecular signature of pathogenic TH17 cells

Lee, Y., Awasthi, A., Yosef, N., Quintana, F. J., Xiao, S., Peters, A., Wu, C., Kleinewietfeld, M., Kunder, S., Hafler, D. A., et al. (2012) · Nature Immunology

Psoriasis: Treatment and PathogenesisT-cell and B-cell Immunology

Cited by 1,174

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 800

A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

de Bakker, P. I. W., McVean, G., Sabeti, P. C., Miretti, M. M., Green, T., Marchini, J., Ke, X., Monsuur, A. J., Whittaker, P., Delgado, M., et al. (2006) · Nature Genetics

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 766

Regulatory T cells in autoimmune disease

Dominguez-Villar, M., & Hafler, D. A. (2018) · Nature Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 713

Pervasive Sharing of Genetic Effects in Autoimmune Disease

Cotsapas, C., Voight, B. F., Rossin, E., Lage, K., Neale, B. M., Wallace, C., Abecasis, G. R., Barrett, J. C., Behrens, T., Cho, J., et al. (2011) · PLoS Genetics

Genetic Associations and EpidemiologyMultiple Sclerosis Research Studies

Cited by 606

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

Dominguez-Villar, M., Baecher-Allan, C. M., & Hafler, D. A. (2011) · Nature Medicine

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 526

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Raj, T., Rothamel, K., Mostafavi, S., Ye, C., Lee, M. N., Replogle, J. M., Feng, T., Lee, M., Asinovski, N., Frohlich, I., et al. (2014) · Science

Genetic Associations and EpidemiologyGenomics and Chromatin Dynamics

Cited by 506

Multiple sclerosis

Nylander, A., & Hafler, D. A. (2012) · Journal of Clinical Investigation

Multiple Sclerosis Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 495

A High-Density Admixture Map for Disease Gene Discovery in African Americans

Smith, M. W., Patterson, N., Lautenberger, J. A., Truelove, A. L., McDonald, G. J., Waliszewska, A., Kessing, B. D., Malasky, M. J., Scafe, C., Le, E., et al. (2004) · The American Journal of Human Genetics

Forensic and Genetic ResearchGenetic Associations and Epidemiology

Cited by 459

Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

Marsh, S. E., Walker, A. J., Kamath, T., Dissing-Olesen, L., Hammond, T. R., de Soysa, T. Y., Young, A. M. H., Murphy, S., Abdulraouf, A., Nadaf, N., et al. (2022) · Nature Neuroscience

Single-cell and spatial transcriptomicsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 431

High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq

Liu, Y., DiStasio, M., Su, G., Asashima, H., Enninful, A., Qin, X., Deng, Y., Nam, J., Gao, F., Bordignon, P., et al. (2023) · Nature Biotechnology

Single-cell and spatial transcriptomicsBiotin and Related Studies

Cited by 418

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Kent, S. C., Chen, Y., Bregoli, L., Clemmings, S. M., Kenyon, N. S., Ricordi, C., Hering, B. J., & Hafler, D. A. (2005) · Nature

Diabetes and associated disordersT-cell and B-cell Immunology

Cited by 409

The plasticity of human Treg and Th17 cells and its role in autoimmunity

Kleinewietfeld, M., & Hafler, D. A. (2013) · Seminars in Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 389

Fine-Mapping the Genetic Association of the Major Histocompatibility Complex in Multiple Sclerosis: HLA and Non-HLA Effects

Patsopoulos, N. A., Barcellos, L. F., Hintzen, R. Q., Schaefer, C., van Duijn, C. M., Noble, J. A., Raj, T., IMSGC, ANZgene, Gourraud, P.-A., et al. (2013) · PLoS Genetics

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 312

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

Jakkula, E., Leppä, V., Sulonen, A.-M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.-L., et al. (2010) · The American Journal of Human Genetics

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 245

Locus for severity implicates CNS resilience in progression of multiple sclerosis

International Multiple Sclerosis Genetics Consortium, Harroud, A., Stridh, P., McCauley, J. L., Saarela, J., van den Bosch, A. M. R., Engelenburg, H. J., Beecham, A. H., Alfredsson, L., Alikhani, K., et al. (2023) · Nature

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 243

NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data

He, L., Davila-Velderrain, J., Sumida, T. S., Hafler, D. A., Kellis, M., & Kulminski, A. M. (2021) · Communications Biology

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 181

Microbial Reprogramming Inhibits Western Diet-Associated Obesity

Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2013) · PLoS ONE

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 164

Immune-mediated disease genetics: the shared basis of pathogenesis

Cotsapas, C., & Hafler, D. A. (2013) · Trends in Immunology

Genetic Associations and EpidemiologyT-cell and B-cell Immunology

Cited by 109

Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci

The International Multiple Sclerosis Genetics Consortium (IMSGC), McCauley, J. L., Zuvich, R. L., Beecham, A. H., De Jager, P. L., Konidari, I., Whitehead, P. L., Aubin, C., Ban, M., Pobywajlo, S., et al. (2010) · Human Molecular Genetics

Multiple Sclerosis Research StudiesGenetic Associations and Epidemiology

Cited by 106

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults

Mohanty, S., Joshi, S. R., Ueda, I., Wilson, J., Blevins, T. P., Siconolfi, B., Meng, H., Devine, L., Raddassi, K., Tsang, S., et al. (2015) · Journal of Infectious Diseases

Immune responses and vaccinationsInfluenza Virus Research Studies

Cited by 67

National Heart, Lung, and Blood Institute Working Group Report on Salt in Human Health and Sickness: Building on the Current Scientific Evidence

Oh, Y. S., Appel, L. J., Galis, Z. S., Hafler, D. A., He, J., Hernandez, A. L., Joe, B., Karumanchi, S. A., Maric-Bilkan, C., Mattson, D., et al. (2016) · Hypertension

Sodium Intake and HealthBlood Pressure and Hypertension Studies

Cited by 52