Interleukin-18, more than a Th1 cytokine

Cloning of a new cytokine that induces IFN-γ production by T cells

Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

Sutton, C. E., Lalor, S. J., Sweeney, C. M., Brereton, C. F., Lavelle, E. C., & Mills, K. H. G. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.001 · Cited by 1,553

Interleukin-18 Regulates Both Th1 and Th2 Responses

Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,319

A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis

Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,038

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

Aksentijevich, I. A., Masters, S. L., Ferguson, P. J., Dancey, P., Frenkel, J., van Royen‐Kerkhof, A., Laxer, R. M., Tedgård, U., Cowen, E. W., Pham, T., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807865 · Cited by 981

Interleukin-1 (IL-1) Pathway

Weber, A., Wasiliew, P., & Kracht, M. (2010) · Science Signaling · doi:10.1126/scisignal.3105cm1 · Cited by 962

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

Bauer, C. A., Duewell, P., Mayer, C., Lehr, H. A., Fitzgerald, K. A., Dauer, M., Tschopp, J., Endres, S., Latz, E., & Schnurr, M. M. (2010) · Gut · doi:10.1136/gut.2009.197822 · Cited by 928

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876

Anti–Interleukin-12 Antibody for Active Crohn's Disease

Mannon, P., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D. H., Dolin, B. J., Goodman, N., Groden, C. A., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 844

Mucosal-Associated Invariant T Cells in Multiple Sclerosis: The Jury is Still Out

Treiner, E., & Liblau, R. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00503 · Cited by 37

Evolution of developmental and comparative immunology in poultry: The regulators and the regulated

Lu, M., Lee, Y., & Lillehoj, H. S. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104525 · Cited by 43

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Hu, J., Li, Y., Lian, B., Mao, Y., & Zhao, L. (2025) · 癌症：英文版 · doi:10.1002/cac2.70064 · Cited by 40

Regulation of the gut microbiome by inflammasomes

Chen, G. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.011 · Cited by 35

Interleukin-36 cytokines may overcome microbial immune evasion strategies that inhibit interleukin-1 family signaling

Jensen, L. E. (2017) · Science Signaling · doi:10.1126/scisignal.aan3589 · Cited by 37

Inflammasomes inMycobacterium tuberculosis-Driven Immunity

Wawrocki, S., & Druszczyńska, M. (2017) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2017/2309478 · Cited by 36

Circulating inflammatory cytokines and psoriasis risk: A systematic review and meta-analysis

Liu, X.-Q., Zhou, P.-L., Yin, X., Wang, A.-X., Wang, D., Yang, Y. S., & Liu, Q. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293327 · Cited by 35

IL-18 receptor marks functional CD8+ T cells in non-small cell lung cancer

Timperi, E., Focaccetti, C., Gallerano, D., Panetta, M., Spada, S., Gallo, E., Visca, P., Venuta, F., Diso, D., Prelaj, A., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1328337 · Cited by 35

Cathelicidin Insufficiency in Patients with Fatal Leptospirosis

Lindow, J. C., Wunder, E. A., Popper, S. J., Jin-na, M., Mannam, P., Srivastava, A., Yao, Y., Hacker, K. P., Raddassi, K., Lee, P. J., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005943 · Cited by 34

Impaired Cytokine Responses to Epstein-Barr Virus Antigens in Systemic Lupus Erythematosus Patients

Draborg, A. H., Sandhu, N., Larsen, N., Larsen, J. L., Jacobsen, S., & Houen, G. (2016) · Journal of Immunology Research · doi:10.1155/2016/6473204 · Cited by 33

Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas

Dawod, B., Liu, J., Gebremeskel, S., Yan, C. W., Sappong‐Kumankumah, A., Johnston, B., Hoskin, D. W., Marshall, J. S., & Wang, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-70231-7 · Cited by 33

Cytokines and beyond: Regulation of innate immune responses during helminth infection

Oyesola, O. O., Früh, S. P., Webb, L. M., & Wojno, E. D. T. (2018) · Cytokine · doi:10.1016/j.cyto.2018.08.021 · Cited by 34

GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway.

Li, J.-H., Ma, J.-M., Li, M., Tao, J., Chen, J.-Y., Yao, C.-Y., & Yao, S. (2021) · Life Science · doi:10.1016/j.lfs.2021.119192 · Cited by 29

Interleukin-18 exacerbates skin inflammation and affects microabscesses and scale formation in a mouse model of imiquimod-induced psoriasis

Niu, X., Huang, Y., Gao, Y., Sun, Y., Yang, H., Chen, H., Gao, X., & Qi, R. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000140 · Cited by 32

Inflammasomes in the Pathophysiology of Kidney Diseases

Masood, H., Che, R., & Zhang, A. (2015) · Kidney Diseases · doi:10.1159/000438843 · Cited by 31

Extracellular vesicles in cancer immune responses: roles of purinergic receptors

Graner, M. W. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0706-9 · Cited by 31

UV-B-Induced Inflammasome Activation Can Be Prevented by Cis-Urocanic Acid in Human Corneal Epithelial Cells

Korhonen, E., Bisevac, J., Hyttinen, J. M. T., Piippo, N., Hytti, M., Kaarniranta, K., Petrovski, G., & Kauppinen, A. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.4.7 · Cited by 31

Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases

Park, S., Hisham, Y., Shin, H. M., Yeom, S. C., & Kim, S. (2022) · Biomedicines · doi:10.3390/biomedicines10071750 · Cited by 30

Structural basis of human IL-18 sequestration by the decoy receptor IL-18 binding protein in inflammation and tumor immunity

Detry, S., Andries, J., Bloch, Y., Gabay, C., Clancy, D. M., & Savvides, S. N. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101908 · Cited by 29

Susceptibility rhythm to bacterial endotoxin in myeloid clock-knockout mice

Lang, V., Ferencik, S., Ananthasubramaniam, B., Kramer, A., & Maier, B. (2021) · eLife · doi:10.7554/elife.62469 · Cited by 29

Pathological molecular mechanism of symptomatic late-onset Fuchs endothelial corneal dystrophy by bioinformatic analysis

Cui, Z., Zeng, Q., Guo, Y., Liu, S., Wang, P., Xie, M., & Chen, J. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197750 · Cited by 27

Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors

Garcia, M. D. C., Pazos, P., Lima, L., & Diéguez, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092569 · Cited by 27

Expression of Interferon γ by Decidual Cells and Natural Killer Cells at the Human Implantation Site: Implications for Preeclampsia, Spontaneous Abortion, and Intrauterine Growth Restriction

Chen, C., Piao, L., Chen, X., Yu, J., MASCH, R. J., Schatz, F., Lockwood, C. J., & Huang, S.-T. J. (2015) · Reproductive Sciences · doi:10.1177/1933719115585148 · Cited by 26

Cytokine Signature in Schnitzler Syndrome: Proinflammatory Cytokine Production Associated to Th Suppression

Regnault, M. M., Frouin, É., Jéru, I., Delwail, A., Charreau, S., Barbarot, S., Néel, A., MASSEAU, A., Puéchal, X., Kyndt, X., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.588322 · Cited by 25

Immune cells from patients with psoriasis are defective in inducing indoleamine 2,3-dioxygenase expression in response to inflammatory stimuli

Llamas‐Velasco, M., Bonay, P., Concha‐Garzón, M. J., Corvo, L., Vara, A., Cibrián, D., Sanguino-Pascual, A., Sánchez‐Madrid, F., de la Fuente, H., & Daudén, E. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14779 · Cited by 25

Readapting the adaptive immune response – therapeutic strategies for atherosclerosis

Sage, A. P., & Mallat, Z. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13700 · Cited by 24

Extremely elevated IL-18 levels may help distinguish systemic-onset juvenile idiopathic arthritis from other febrile diseases

Xia, Y., Cui, P., Li, Q., Liang, F., Li, C., & Yang, J. (2017) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20165958 · Cited by 25

Natural Killer-Like B Cells Secreting Interleukin-18 Induces a Proinflammatory Response in Periodontitis

Zhang, Y., Kuang, W., Li, D., Li, Y., Feng, Y., Lyu, X., Huang, G., Lian, J., Yang, X., Hu, C., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.641562 · Cited by 24

A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment

Dillemans, L., Somer, L. D., Neerinckx, B., & Proost, P. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04715-w · Cited by 23

Expression of interleukin-18 in muscle tissue of patients with polymyositis or dermatomyositis and effects of conventional immunosuppressive treatment

Helmers, S. B., Bruton, M., Loell, I., Ulfgren, A., Gracie, A., McInnes, I. B., & Lundberg, I. E. (2018) · Lara D. Veeken · doi:10.1093/rheumatology/key222 · Cited by 24

The intercorrelations between blood levels of ferritin, sCD163, and IL-18 in COVID-19 patients and their association to prognosis

Volfovitch, Y., Tsur, A. M., Gurevich, M., Novick, D., Rabinowitz, R., Mandel, M., Achiron, A., Rubinstein, M., Shoenfeld, Y., & Amital, H. (2022) · Immunologic Research · doi:10.1007/s12026-022-09312-w · Cited by 23

Dynamics of the Microbiota and Its Relationship with Post-COVID-19 Syndrome

Moreno-Corona, N. C., López‐Ortega, O., Pérez-Martínez, C. A., Castillo, M. M., Jesús‐González, L. A. D., León‐Reyes, G., & León‐Juárez, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914822 · Cited by 24

Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia

Ostertag, C., Friedman, T. N., Keough, M. B., Kerr, B. J., & Sankar, T. (2023) · PAIN Reports · doi:10.1097/pr9.0000000000001117 · Cited by 23

The potential of interleukin-37 as an effective therapeutic agent in asthma

Zhang, L., Zhang, J., & Gao, P. (2017) · Respiratory Research · doi:10.1186/s12931-017-0675-x · Cited by 23

Adaptive Natural Killer Cells Integrate Interleukin-18 during Target-Cell Encounter

Hammer, Q., Rückert, T., Dunst, J., & Romagnani, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01976 · Cited by 23

Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells

Littwitz-Salomon, E., Dittmer, U., & Sutter, K. (2016) · Retrovirology · doi:10.1186/s12977-016-0311-8 · Cited by 23

The Role of Interleukin-18 in the Development and Progression of Atherosclerosis

Bahrami, A., Sathyapalan, T., & Sahebkar, A. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200427095830 · Cited by 23

Novel Immunoregulatory Functions of IL-18, an Accomplice of TGF-β1

Casu, B., Dondero, A., Regis, S., Caliendo, F., Petretto, A., Bartolucci, M., Bellora, F., Bottino, C., & Castriconi, R. (2019) · Cancers · doi:10.3390/cancers11010075 · Cited by 22

Activation of mast cells mediates inflammatory response in psoriasis: Potential new therapeutic approach with IL‐37

Conti, P., Gallenga, C. E., Ronconi, G., Caraffa, A., & Kritas, S. K. (2019) · Dermatologic Therapy · doi:10.1111/dth.12943 · Cited by 22

Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells

Berkson, J. D., Slichter, C. K., DeBerg, H. A., Delaney, M. A., Davis, A. S. W., Maurice, N. J., Lwo, Y., Ko, A., Hsu, J., Chiu, Y.-W., et al. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.1900061 · Cited by 21

Viral Hepatitides, Inflammation and Tumour Microenvironment

Timperi, E., & Barnaba, V. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-44518-8_3 · Cited by 21

Card9 protects sepsis by regulating Ripk2-mediated activation of NLRP3 inflammasome in macrophages

Xu, Z., Li, D., Qu, W., Yin, Y., Qiao, S., Zhu, Y., Shen, S., Hou, Y., Yang, J. A., & Wang, T. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04938-y · Cited by 21

Trimetazidine Alleviates Bleomycin-Induced Pulmonary Fibrosis by Targeting the Long Noncoding RNA CBR3-AS1-Mediated miRNA-29 and Resistin-Like Molecule alpha 1: Deciphering a Novel Trifecta Role of LncRNA CBR3-AS1/miRNA-29/FIZZ1 Axis in Lung Fibrosis

Alzahrani, A. R., Mohamed, D. I., Nahas, H. H. A., El-Waseef, D. A. E.-D. A., Altamimi, A. S. A., Youssef, I. H., Ibrahim, I. A. A., Mohamed, S. M. Y., Sabry, Y. G., Falemban, A. H., et al. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s463626 · Cited by 20

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

Yu, Z., Yazdanpanah, G., Alam, J., de Paiva, C. S., & Pflugfelder, S. C. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.4.8 · Cited by 20

Attenuated in vitro effects of IFN‐&agr;, IL‐2 and IL‐12 on functional and receptor characteristics of peripheral blood lymphocytes in metastatic melanoma patients

Martinović, K. M., Vuletić, A., Babović, N. L., Dzodic, R., Konjević, G., & Jurišić, V. (2017) · Cytokine · doi:10.1016/j.cyto.2017.02.024 · Cited by 18

Autologous dendritic cells and activated cytotoxic T‑cells as combination therapy for breast cancer

Shevchenko, J. A., Khristin, A. A., Васильевич, К. В., Kuznetsova, M. S., Blinova, D. D., Михайловна, С. Н., Васильевич, С. С., & Sennikov, S. V. (2019) · Oncology Reports · doi:10.3892/or.2019.7435 · Cited by 20

Only IL‐1β release is inflammasome‐dependent upon ultraviolet B irradiation although IL‐18 is also secreted

Korhonen, E., Piippo, N., Hytti, M., Hyttinen, J. M. T., Kaarniranta, K., & Kauppinen, A. (2020) · The FASEB Journal · doi:10.1096/fj.201902355rr · Cited by 21

Effect of Traumatic Brain Injury, Erythropoietin, and Anakinra on Hepatic Metabolizing Enzymes and Transporters in an Experimental Rat Model

Anderson, G. D., Peterson, T. C., Haar, C. V., Farin, F. M., Bammler, T. K., MacDonald, J. W., Kantor, E. D., & Hoane, M. R. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9792-y · Cited by 21

Inflammasome Priming Is Similar for Francisella Species That Differentially Induce Inflammasome Activation

Ghonime, M. G., Mitra, S., El-Domany, R. A., Wewers, M. D., & Gavrilin, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127278 · Cited by 18

Role of interleukin-2 and interleukin-18 in newly diagnosed type 2 diabetes mellitus

Suri, S., Mitra, P., Abhilasha, A., Saxena, I., Garg, M. K., Bohra, G. K., & Sharma, P. (2021) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2020-0272 · Cited by 19

Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation

Pianko, M. J., & Golob, J. L. (2022) · Cancer and Metastasis Reviews · doi:10.1007/s10555-022-10033-7 · Cited by 20

Dendritic Cell Activity Driven by RecombinantMycobacterium bovisBCG Producing Human IL-18, in Healthy BCG Vaccinated Adults

Szpakowski, P., Biet, F., Locht, C., Paszkiewicz, M., Rudnicka, W., Druszczyńska, M., Allain, F., Fol, M., Pestel, J., & Kowalewicz‐Kulbat, M. (2015) · Journal of Immunology Research · doi:10.1155/2015/359153 · Cited by 19

The Mouse Idd2 Locus Is Linked to the Proportion of Immunoregulatory Double-Negative T Cells, a Trait Associated with Autoimmune Diabetes Resistance

Collin, R., Dugas, V., Pelletier, A., Chabot‐Roy, G., & Lesage, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400189 · Cited by 18

Interleukin-35 and Interleukin-37 anti-inflammatory effect on inflammatory bowel disease: Application of non-coding RNAs in IBD therapy

Lahimchi, M. R., Eslami, M., & Yousefi, B. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109932 · Cited by 19

Predominant Tubular Interleukin-18 Expression in Polyomavirus-Associated Nephropathy

Stokman, G., Kers, J., Yapici, Ü., Hoelbeek, J. J., Claessen, N., de Boer, O. J., Netea, M. G., Hilbrands, L. B., Bemelman, F. J., ten Berge, I. J. M., et al. (2016) · Transplantation · doi:10.1097/tp.0000000000001086 · Cited by 18

Autoantibodies and Cytokines

Khan, W. A. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.68834 · Cited by 19

Production of IL-18 Binding Protein by Radiosensitive and Radioresistant Cells in CpG-Induced Macrophage Activation Syndrome

Harel, M., Girard-Guyonvarc’h, C., Rodriguez, E., Palmer, G., & Gabay, C. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000168 · Cited by 18

MAP3K2 augments Th1 cell differentiation via IL-18 to promote T cell-mediated colitis

Wu, N., Chen, D., Sun, H., Tan, J., Zhang, Y., Zhang, T., Han, Y., Liu, H., Ouyang, X., Yang, X., et al. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1720-9 · Cited by 18

Immunological landscape of children with Mycoplasma pneumoniae pneumonia in the post-COVID-19 era reveals distinctive severity indicators

Jia, R., Guo, H., Lu, A., Zhang, C., Qi, Y., Wang, D., He, W., Wang, Q., Cheng, Z., Gao, Y., et al. (2025) · Respiratory Research · doi:10.1186/s12931-025-03189-7 · Cited by 17

The -137G/C single nucleotide polymorphism in IL-18 gene promoter contributes to tuberculosis susceptibility in Chinese Han population

Zhou, C., Ouyang, N., Li, Q. H., Luo, S. X., He, Q., Lei, H., & Liu, Q. F. (2015) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2015.10.014 · Cited by 17

Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway

Zhang, L., Zhang, J., Zhang, Y., Wang, L., Chang, F., Yi, Z.-W., & Dong, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.193 · Cited by 17

Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis

Wawrocki, S., Kielnierowski, G., Rudnicka, W., Seweryn, M. T., & Druszczyńska, M. (2020) · Pathogens · doi:10.3390/pathogens9060451 · Cited by 17

Biomarkers in Systemic Juvenile Idiopathic Arthritis, Macrophage Activation Syndrome and Their Importance in COVID Era

Ailioaie, L. M., Ailioaie, C., & Litscher, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112757 · Cited by 16

IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder

Borgonetti, V., Cruz, B., Vozella, V., Khom, S., Steinman, M. Q., Bullard, R., D’Ambrosio, S. R., Oleata, C. S., Vlkolinský, R., Bajo, M., et al. (2023) · Cells · doi:10.3390/cells12151943 · Cited by 16

A Narrative Review of the IL-18 and IL-37 Implications in the Pathogenesis of Atopic Dermatitis and Psoriasis: Prospective Treatment Targets

Rusiñol, L., & Puig, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158437 · Cited by 18

PD-1 immunobiology in autoimmune hepatitis and hepatocellular carcinoma

Curran, C. S., & Sharon, E. (2017) · Seminars in Oncology · doi:10.1053/j.seminoncol.2017.12.001 · Cited by 17

Low expression of IL-18 and IL-18 receptor in human skeletal muscle is associated with systemic and intramuscular lipid metabolism—Role of HIV lipodystrophy

Lindegaard, B., Hvid, T., Mygind, H. W., Mortensen, O. H., Grøndal, T., Abildgaard, J., Gerstoft, J., Pedersen, B. K., & Baranowski, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0186755 · Cited by 16

TNF and IL-18 cytokines may regulate liver fat storage under homeostasis conditions

Lana, J. P., Martins, L. B., Oliveira, M. C., Garcia, Z. M., Yamada, L. T. P., Vieira, L. Q., Teixeira, M. M., & Ferreira, A. V. M. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0265 · Cited by 15

Genetic ablation of interleukin-18 does not attenuate hypobaric hypoxia-induced right ventricular hypertrophy

Bruns, D. R., Buttrick, P. M., & Walker, L. A. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00166.2015 · Cited by 15

Effects of Zoledronate on Local and Systemic Production of IL-1β, IL-18, and TNF-α in Mice and Augmentation by Lipopolysaccharide

Funayama, H., Tashima, I., Okada, S., Ogawa, T., Yagi, H., Tada, H., Wakita, R., Asada, Y., & Endo, Y. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00923 · Cited by 15

Damage-induced IL-18 stimulates thymic NK cells limiting endogenous tissue regeneration

Granadier, D. W., Cooper, K., Acenas, D. D., II, Kousa, A. I., Warren, M., Hernandez, V. A., Iovino, L., DeRoos, P. C., Lederer, E. E., Shannon-Sevillano, S., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02270-z · Cited by 14

Architecture of skin inflammation in psoriasis revealed by spatial transcriptomics

Gniadecki, R., Osman, M. S., Hennessey, D., O’Keefe, S. L., Thomsen, S. F., & Iyer, A. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109771 · Cited by 13

Expression of Nutrient Transporters on NK Cells During Murine Cytomegalovirus Infection Is MyD88-Dependent

Khan, A. U. H., Almutairi, S. M., Ali, A. K., Salcedo, R., Stewart, C. A., Wang, L., & Lee, S.-H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.654225 · Cited by 14

Biomarker screening and validation for the differentiation of bloodstream infection from adult-onset Still’s disease: A prospective cohort study

Zhang, W., Yang, T., Zhang, H., Xu, Y., Yang, Q., Liu, Q., Gao, Y., Wu, J., Shao, L., & Zhang, W. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155642 · Cited by 14

Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice

Schirmer, B., Wedekind, D., Glage, S., & Neumann, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140173 · Cited by 14

Proteomic analysis reveals distinctive protein profiles involved in CD8+ T cell-mediated murine autoimmune cholangitis

Zhang, W., Zhang, R., Zhang, J., Sun, Y. H., Leung, P. S. C., Yang, G., Shuai, Z., Ridgway, W. M., & Gershwin, M. E. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.149 · Cited by 14

Longitudinal analysis of serum interleukin-18 in patients with familial Mediterranean fever carrying MEFV mutations in exon 10

Wada, T., Toma, T., Miyazawa, H., Koizumi, E., Shirahashi, T., Matsuda, Y., & Yachie, A. (2017) · Cytokine · doi:10.1016/j.cyto.2017.10.007 · Cited by 14

IL-18 Binding Protein–Producing Cells Attenuate Anemia in Murine Macrophage Activation Syndrome

Harel, M., Fauteux‐Daniel, S., Rodriguez, E., Palmer, G., & Gabay, C. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300065 · Cited by 12

The Next Frontier in ART: Harnessing the Uterine Immune Profile for Improved Performance

Lédée, N., Petitbarat, M., Prat-Ellenberg, L., Dray, G., Vaucoret, V., Kazhalawi, A., Pozo, A. R., Habeichi, N. J., Ruoso, L., Cassuto, N. G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411322 · Cited by 13

Increased IL18 mRNA levels in peripheral artery disease and its association with triglyceride and LDL cholesterol levels: a pilot study

Deşer, S. B., Bayoğlu, B., Beşirli, K., Cengiz, M., Arapi, B., Junusbekov, Y., Dırıcan, A., & Arslan, C. (2015) · Heart and Vessels · doi:10.1007/s00380-015-0753-2 · Cited by 13

Interleukin 18 and the brain: neuronal functions, neuronal survival and psycho-neuro-immunology during stress

Alboni, S., Tascedda, F., Uezato, A., Sugama, S., Chen, Z., Marcondes, M. C. G., & Conti, B. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02951-z · Cited by 13

Chronic suppurative otitis media: disrupted host-microbial interactions and immune dysregulation

Yuan, V. G., Xia, A., & Maria, P. L. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1547206 · Cited by 13

Interleukin-18 gene promoter 607A polymorphism, but not 137C polymorphism, is a protective factor for ischemic stroke in the Chinese population: A meta-analysis

Zhang, M.-J., Zhou, Y., Wang, X., Xue, C., ., Y. P., Guo, L., Gao, C., Li, J., & Zhang, L. (2016) · Meta Gene · doi:10.1016/j.mgene.2016.06.006 · Cited by 12

No association between interleukin-18 levels and risk of cardiovascular disease: A Mendelian randomization study

Fan, S., He, P., Guan, J., Song, W., Zhi, H., & Wang, L. (2020) · Hereditas · doi:10.1186/s41065-020-00121-5 · Cited by 12

Payload Delivery: Engineering Immune Cells to Disrupt the Tumour Microenvironment

Fowler, D. W., Nattress, C. B., Southern, A., Barisa, M., & Fisher, J. P. H. (2021) · Cancers · doi:10.3390/cancers13236000 · Cited by 12

Recent Advances in Progresses and Prospects of IL-37 in Central Nervous System Diseases

Li, X., Yan, B., Du, J., Xu, S., Liu, L., Pan, C., Kang, X., & Zhu, S. (2022) · Brain Sciences · doi:10.3390/brainsci12060723 · Cited by 12

Unraveling the Role of the NLRP3 Inflammasome in Lymphoma: Implications in Pathogenesis and Therapeutic Strategies

Stergiou, I. Ε., Tsironis, C., Papadakos, S. P., Tsitsilonis, O., Dimopoulos, M. A., & Theocharis, S. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042369 · Cited by 11

Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential

Zhang, Y., & Zhou, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116667 · Cited by 13

Inflammasomes in the Kidney

Hutton, H., Alikhan, M. A., & Kitching, A. R. (2018) · Experientia supplementum · doi:10.1007/978-3-319-89390-7_8 · Cited by 11

Tumor Time‐Course Predicts Overall Survival in Non‐Small Cell Lung Cancer Patients Treated with Atezolizumab: Dependency on Follow‐Up Time

Netterberg, I., Bruno, R., Chen, Y., Winter, H. R., Li, C., Jin, J. Y., & Friberg, L. E. (2020) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1002/psp4.12489 · Cited by 11

Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell Transplantation

Radujkovic, A., Kordelas, L., Bogdanov, R., Müller‐Tidow, C., Beelen, D. W., Dreger, P., & Luft, T. (2020) · Cancers · doi:10.3390/cancers12102789 · Cited by 11

Cytokine secretion and pyroptosis of cholesteatoma keratinocytes mediated by AIM2 inflammasomes in response to cytoplasmic DNA

Zhang, C., Chen, M., & Chi, Z. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.11983 · Cited by 11

Inhibitory axes impacting on the activity and fate of Innate Lymphoid Cells

Bottino, C., Dondero, A., & Castriconi, R. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100985 · Cited by 11

Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis

Arapi, B., Bayoğlu, B., Cengiz, M., Dırıcan, A., Deşer, S. B., Junusbekov, Y., & Arslan, C. (2018) · Balkan Medical Journal · doi:10.4274/balkanmedj.2017.0323 · Cited by 10

Interleukin-18: a biomarker with therapeutic potential in adult-onset Still’s disease

Chen, P., Wey, S.-J., & Chen, D. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2096592 · Cited by 10

The regulation of self-tolerance and the role of inflammasome molecules

Qi, K., Greenawalt, A. N., Manukonda, V., Ji, X., & Tisch, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154552 · Cited by 11

Evaluation of Functional NK Cell Responses in Vaccinated and SIV-Infected Rhesus Macaques

Vargas‐Inchaustegui, D. A., Ying, O., Demberg, T., & Robert-Guroff, M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00340 · Cited by 10

The 4th NextGen therapies of SJIA and MAS, part 4: it is time for IL-18 based trials in systemic juvenile idiopathic arthritis?

Canna, S., & Benedetti, F. D. (2024) · Pediatric Rheumatology · doi:10.1186/s12969-023-00867-y · Cited by 9

A Synthetic Human Antibody Antagonizes IL-18Rβ Signaling Through an Allosteric Mechanism

Liu, S., Miersch, S., Li, P., Bai, B., Liu, C., Qin, W., Su, J., Huang, H., Pan, J., Sidhu, S. S., et al. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.012 · Cited by 9

Interleukin-18 and Atherosclerosis: Mediator or Biomarker

Mahajan, K. (2014) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.1000352 · Cited by 9

Interleukin-18 and IL-18 Binding Protein

Dinarello, C. A., Novick, D., Kim, S., & Kaplanski, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00289 · Cited by 938

OLANZAPINE LONG-ACTING INJECTION FOR THE MAINTENANCE TREATMENT OF SCHIZOPHRENIA: A 24-WEEK, RANDOMIZED, DOUBLE-BLIND TRIAL

Detke, H. C., McDonnell, D., Kane, J. M., Naber, D., Sethuraman, G., & Lin, D. (2008) · Schizophrenia Research · doi:10.1016/s0920-9964(08)70791-6 · Cited by 6

Interleukin-18 (IL-18)

(2015) · Springer eBooks · doi:10.1007/978-3-642-54596-2_200832

Interleukin-18: a regulator of cancer and autoimmune diseases

Esmaeilbeig, M., & Ghaderi, A. A. (2017) · European Cytokine Network · doi:10.1684/ecn.2018.0401 · Cited by 111

IL-18: A TH1 -inducing, proinflammatory cytokine and new member of the IL-1 family

Dinarello, C. A. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70518-x · Cited by 817