Cited by 280Cytokine Signaling Pathways and InteractionsInflammasome and immune disordersT-cell and B-cell Immunology

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Interleukin-18, more than a Th1 cytokine

Novick, Daniela, Kim, Soohyun, Kaplanski, Gilles, Dinarello, Charles A.·2013·Seminars in Immunology

DOI 10.1016/j.smim.2013.10.014

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Abstract

Together with IL-12 or IL-15, interleukin-18 (IL-18) plays a major role in the production of interferon-γ from T-cells and natural killer cells; thus, IL-18 is considered to have a major role in the Th1 response. However, without IL-12, IL-18 is proinflammatory in an IFNγ independent manner. IL-18 is a member of the IL-1 family of cytokines and similar to IL-1β, the cytokine is synthesized as an inactive precursor requiring processing by caspase-1 into an active cytokine. IL-18 is also present as an integral membrane protein but requires caspase-1 for full activity in order to induce IFNγ. Uniquely, unlike IL-1β, the IL-18 precursor is constitutively present in nearly all cells in healthy humans and animals. The activity of IL-18 is balanced by the presence of a high-affinity, naturally occurring IL-18 binding protein (IL-18BP). In humans, increased disease severity can be associated with an imbalance of IL-18 to IL-18BP such that the levels of free IL-18 are elevated in the circulation. Increasing number of studies have expanded the role of IL-18 in mediating inflammation in animal models of disease using the IL-18BP, IL-18 deficient mice, neutralization of IL-18 or deficiency in the IL-18 receptor alpha chain. A role for IL-18 has been implicated in several autoimmune diseases, myocardial function, emphysema, metabolic syndromes, psoriasis, inflammatory bowel disease, macrophage activation syndrome, sepsis and acute kidney injury, although paradoxically, in some models of disease, IL-18 is protective. The IL-18BP has been used safely in humans and clinical trials of IL-18BP as well as neutralizing anti-IL-18 antibodies are being tested in various diseases.

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Cloning of a new cytokine that induces IFN-γ production by T cells
Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe, K., Okura, T., Nukada, Y., Hattori, K., et al. (1995) · Nature · doi:10.1038/378088a0 · Cited by 2,602
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024
Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity
Sutton, C. E., Lalor, S. J., Sweeney, C. M., Brereton, C. F., Lavelle, E. C., & Mills, K. H. G. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.001 · Cited by 1,553
Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,319
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,038
An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist
Aksentijevich, I. A., Masters, S. L., Ferguson, P. J., Dancey, P., Frenkel, J., van Royen‐Kerkhof, A., Laxer, R. M., Tedgård, U., Cowen, E. W., Pham, T., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0807865 · Cited by 981
Interleukin-1 (IL-1) Pathway
Weber, A., Wasiliew, P., & Kracht, M. (2010) · Science Signaling · doi:10.1126/scisignal.3105cm1 · Cited by 962
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
Bauer, C. A., Duewell, P., Mayer, C., Lehr, H. A., Fitzgerald, K. A., Dauer, M., Tschopp, J., Endres, S., Latz, E., & Schnurr, M. M. (2010) · Gut · doi:10.1136/gut.2009.197822 · Cited by 928
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876
Anti–Interleukin-12 Antibody for Active Crohn's Disease
Mannon, P., Fuss, I. J., Mayer, L., Elson, C. O., Sandborn, W. J., Present, D. H., Dolin, B. J., Goodman, N., Groden, C. A., Hornung, R. L., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033402 · Cited by 844
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
Allen, I. C., TeKippe, E. M., Woodford, R.-M. T., Uronis, J. M., Holl, E. K., Rogers, A. B., Herfarth, H. H., Jobin, C., & Ting, J. P.-Y. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100050 · Cited by 826
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)
Ridker, P. M., Thuren, T., Zalewski, A., & Libby, P. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.012 · Cited by 799
Interleukin-18 Binding Protein
Novick, D., Kim, S. H., Fantuzzi, G., Reznikov, L. L., Dinarello, C. A., & Rubinstein, M. (1999) · Immunity · doi:10.1016/s1074-7613(00)80013-8 · Cited by 781
Self-citation
A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease
Sandborn, W. J., Feagan, B. G., Fedorak, R. N., Scherl, E., Fleisher, M. R., Katz, S., Johanns, J., BLANK, M. A., & Rutgeerts, P. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.014 · Cited by 772
Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
NAKANISHI, K., YOSHIMOTO, T., Tsutsui, H., & Okamura, H. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00015-0 · Cited by 666
Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery
Parikh, C. R., Mishra, J., Thiessen‐Philbrook, H., Dursun, B., Ma, Q., Kelly, C. N., Krawczeski, C. D., Devarajan, P., & Edelstein, C. L. (2006) · Kidney International · doi:10.1038/sj.ki.5001527 · Cited by 612
IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells
Coccia, M., Harrison, O. J., Schiering, C., Asquith, M. J., Becher, B., Powrie, F. M., & Maloy, K. J. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111453 · Cited by 606
IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells
Pizarro, T. T., Michie, M. H., Bentz, M., Woraratanadharm, J., Smith, M. F., Foley, E. F., Moskaluk, C. A., Bickston, S. J., & Cominelli, F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6829 · Cited by 573
Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit
Parikh, C. R., Abraham, E. H., Ancukiewicz, M., & Edelstein, C. L. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005030236 · Cited by 563
Familial and Acquired Hemophagocytic Lymphohistiocytosis
Janka, G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-041610-134208 · Cited by 550
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
ten Hove, T. (2002) · Gut · doi:10.1136/gut.50.2.206 · Cited by 545
Interleukin-32
Kim, S. H., Han, S.-Y., Azam, T., Yoon, D., & Dinarello, C. A. (2005) · Immunity · doi:10.1016/j.immuni.2004.12.003 · Cited by 537
Self-citation
Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
Dupaul-Chicoine, J., Yeretssian, G., Doiron, K., Bergstrom, K. S. B., McIntire, C. R., LeBlanc, P. M., Meunier, C., Turbide, C., Gros, P., Beauchemin, N., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.012 · Cited by 517
Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure
Melnikov, V. Y., Ecder, T., Fantuzzi, G., Siegmund, B., Lucia, M. S., Dinarello, C. A., Schrier, R. W., & Edelstein, C. L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12089 · Cited by 476
Self-citation
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
Hirota, S. A., Ng, J., Lueng, A., Khajah, M. A., Parhar, K. K. S., Li, Y., Lam, V. L., Potentier, M. S., Ng, K., Bawa, M., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21478 · Cited by 440
NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components
Doyle, S., Campbell, M., Ozaki, E., Salomon, R. G., Mori, A., Kenna, P. F., Farrar, G. J., Kiang, A., Humphries, M. M., Lavelle, E. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2717 · Cited by 428
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
Netea, M. G., Joosten, L. A. B., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J., van Krieken, H., Kim, S.-H., Stalenhoef, A. F., et al. (2006) · Nature Medicine · doi:10.1038/nm1415 · Cited by 424
Self-citation
IL-1β-converting enzyme (caspase-1) in intestinal inflammation
Siegmund, B., Lehr, H.-A., Fantuzzi, G., & Dinarello, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231473998 · Cited by 421
Self-citation
An Autoinflammatory Disease Due to Homozygous Deletion of the IL1RN Locus
Reddy, S. T., Jia, S., Geoffrey, R., Lorier, R., Suchi, M., Broeckel, U., Hessner, M. J., & Verbsky, J. W. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0809568 · Cited by 408
Interleukin-18/Interleukin-18 Binding Protein Signaling Modulates Atherosclerotic Lesion Development and Stability
Mallat, Z., Corbaz, A., Scoazec, A., Graber, P., Alouani, S., Esposito, B., Humbert, Y., Chvatchko, Y., & Tedgui, A. (2001) · Circulation Research · doi:10.1161/hh1901.098735 · Cited by 404
Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease
Monteleone, G., Trapasso, F., Parrello, T., Biancone, L., Stella, A., Iuliano, R., Luzza, F., Fusco, A., & Pallone, F. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.143 · Cited by 398
Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells
Puren, A. J., Fantuzzi, G., & Dinarello, C. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2256 · Cited by 379
Self-citation
Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction
Abbate, A., Salloum, F. N., Vecile, E., Das, A., Hoke, N. N., Straino, S., Biondi‐Zoccai, G., Houser, J.-E., Qureshi, I., Ownby, E. D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.740233 · Cited by 364
IL-1 family nomenclature
Dinarello, C. A., Arend, W. P., Sims, J. E., Smith, D. E., Blumberg, H., O'Neill, L. A. J., Goldbach‐Mansky, R. T., Pizarro, T. T., Hoffman, H. M., Bufler, P., et al. (2010) · Nature Immunology · doi:10.1038/ni1110-973 · Cited by 351
Self-citation
Rapid responses to anakinra in patients with refractory adult‐onset Still's disease
Fitzgerald, A. A., LECLERCQ, S. A., Yan, A., Homik, J., & Dinarello, C. A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21061 · Cited by 349
Self-citation
Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity
Lalor, S. J., Dungan, L. S., Sutton, C. E., Basdeo, S. A., Fletcher, J. M., & Mills, K. H. G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003597 · Cited by 347
A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock
Okamura, H., Nagata, K., Komatsu, T., Tanimoto, T., Nukata, Y., Tanabe, F., Akita, K., Torigoe, K., Okura, T., & Fukuda, S. (1995) · Infection and Immunity · doi:10.1128/iai.63.10.3966-3972.1995 · Cited by 345
Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
Kim, S. H., Eisenstein, M., Reznikov, L. L., Fantuzzi, G., Novick, D., Rubinstein, M., & Dinarello, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1190 · Cited by 342
Self-citation
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
Brydges, S. D., Mueller, J. L., McGeough, M. D., Pena, C. A., Misaghi, A., Gandhi, C., Putnam, C. D., Boyle, D. L., Firestein, G. S., Horner, A. A., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.005 · Cited by 339
Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Humans
Vaidya, V. S., Waikar, S. S., Ferguson, M. A., Collings, F. B., Sunderland, K., Gioules, C. J., Bradwin, G., Matsouaka, R., Betensky, R. A., Curhan, G. C., et al. (2008) · Clinical and Translational Science · doi:10.1111/j.1752-8062.2008.00053.x · Cited by 339
IL-18 regulates IL-1 β -dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1
Vidal‐Vanaclocha, F., Fantuzzi, G., Mendoza, L., Fuentes, A. M., Anasagasti, M. J., Martin, J. J., Carrascal, T., Walsh, P., Reznikov, L. L., Kim, S. H., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.734 · Cited by 338
Self-citation
Interleukin-18 and the Risk of Coronary Heart Disease in European Men
Blankenberg, S., Luc, G., Ducimetière, P., Arveiler, D., Ferrières, J., Amouyel, P., Evans, A., Cambien, F., & Tiret, L. (2003) · Circulation · doi:10.1161/01.cir.0000099509.76044.a2 · Cited by 332
Leptin-deficient ( ob / ob ) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18
Faggioni, R., Jones‐Carson, J., Reed, D. A., Dinarello, C. A., Feingold, K. R., Grünfeld, C., & Fantuzzi, G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040561297 · Cited by 320
Self-citation
Interleukin 37 expression protects mice from colitis
McNamee, E. N., Masterson, J. C., Jedlicka, P., McManus, M. C., Grenz, A., Collins, C. B., Nold, M. F., Nold‐Petry, C. A., Bufler, P., Dinarello, C. A., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111982108 · Cited by 320
Self-citation
Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1β
Pomerantz, B. J., Reznikov, L. L., Harken, A. H., & Dinarello, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041611398 · Cited by 310
Self-citation
Neutrophil Proteinase 3-Mediated Induction of Bioactive IL-18 Secretion by Human Oral Epithelial Cells
Sugawara, S., Uehara, A., Nochi, T., Yamaguchi, T., Ueda, H., Sugiyama, A., Hanzawa, K., Kumagai, K., Okamura, H., & Takada, H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6568 · Cited by 297
Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome
Mazodier, K. (2005) · Blood · doi:10.1182/blood-2005-05-1980 · Cited by 290
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-γ and TNF-α production
Siegmund, B., Fantuzzi, G., Rieder, F., Gamboni-Robertson, F., Lehr, H.-A., Hartmann, G., Dinarello, C. A., Endres, S., & Eigler, A. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.4.r1264 · Cited by 289
Self-citation
Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
Bossaller, L., Chiang, P.-I., Schmidt‐Lauber, C., Ganesan, S., Kaiser, W. J., Rathinam, V. A. K., Mocarski, E. S., Subramanian, D., Green, D. R., Silverman, N. S., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202121 · Cited by 287
Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome
Grom, A. A., Villanueva, J. M., Lee, S., Goldmuntz, E. A., Passo, M. H., & Filipovich, A. H. (2003) · The Journal of Pediatrics · doi:10.1067/mpd.2003.110 · Cited by 284
A NOVEL IL-18BP ELISA SHOWS ELEVATED SERUM IL-18BP IN SEPSIS AND EXTENSIVE DECREASE OF FREE IL-18
Novick, D., Schwartsburd, B. I., Pinkus, R., Suissa, D., Belzer, I., Sthoeger, Z. M., Keane, W. F., Chvatchko, Y., Kim, S. H., Fantuzzi, G., et al. (2001) · Cytokine · doi:10.1006/cyto.2001.0914 · Cited by 278
Self-citation
Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor
Hoshino, K., Tsutsui, H., Kawai, T., Takeda, K., Nakanishi, K., Takeda, Y., & Akira, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.9.5041 · Cited by 277
Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
Sivakumar, P. V., Westrich, G. M., Kanaly, S., Garka, K., Born, T. L., Derry, J. M. J., & Viney, J. L. (2002) · Gut · doi:10.1136/gut.50.6.812 · Cited by 267
Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice
Bersudsky, M., Luski, L., Fishman, D., White, R. M., Ziv‐Sokolovskaya, N., Dotan, S., Rider, P., Kaplanov, I., Aychek, T., Dinarello, C. A., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303329 · Cited by 256
Self-citation
A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
Bufler, P., Azam, T., Gamboni-Robertson, F., Reznikov, L. L., Kumar, S., Dinarello, C. A., & Kim, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212519099 · Cited by 252
Self-citation
Interleukin-18 and the Pathogenesis of Inflammatory Diseases
Dinarello, C. A. (2007) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2006.09.013 · Cited by 249
Self-citation
Caspase-1-Independent, Fas/Fas Ligand–Mediated IL-18 Secretion from Macrophages Causes Acute Liver Injury in Mice
Tsutsui, H., Kayagaki, N., Kuida, K., Nakano, H., Hayashi, N., Takeda, K., Matsui, K., Kashiwamura, S., Hada, T., Akira, S., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80111-9 · Cited by 243
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
Plater-Zyberk, C., Joosten, L. A. B., Helsen, M. M. A., Sattonnet‐Roche, P., Siegfried, C., Alouani, S., van de Loo, F. A. J., Graber, P., Aloni, S., Cirillo, R., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12097 · Cited by 240
Self-citation
Differences in signaling pathways by IL-1β and IL-18
Lee, J.-K., Kim, S.-H., Lewis, E. C., Azam, T., Reznikov, L. L., & Dinarello, C. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402800101 · Cited by 237
Self-citation
Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies
Brydges, S. D., Broderick, L., McGeough, M. D., Peña, C. A., Mueller, J. L., & Hoffman, H. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71543 · Cited by 234
Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure
Tassell, B. W. V., Arena, R. A., Toldo, S. A., Mezzaroma, E., Azam, T., Seropian, I. M., Shah, K. B., Canada, J. M., Voelkel, N. F., Dinarello, C. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033438 · Cited by 229
Self-citation
Pathogenesis of hemophagocytic syndrome (HPS)
Larroche, C., & Mouthon, L. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(03)00091-0 · Cited by 220
Neutralization of IL-18 Reduces Neutrophil Tissue Accumulation and Protects Mice Against Lethal Escherichia coli and Salmonella typhimurium Endotoxemia
Netea, M. G., Fantuzzi, G., Kullberg, B. J., Stuyt, R. J. L., Pulido, E. J., McIntyre, R. C., Joosten, L. A. B., van der Meer, J. W. M., & Dinarello, C. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2644 · Cited by 210
Self-citation
Macrophage activation syndrome: advances towards understanding pathogenesis
Grom, A. A., & Mellins, E. (2010) · Current Opinion in Rheumatology · doi:10.1097/01.bor.0000381996.69261.71 · Cited by 209
IL-18 in autoimmunity: review.
Boraschi, D., & Dinarello, C. A. (2006) · PubMed · Cited by 208
Self-citation
Identification of a novel gene expressed in activated natural killer cells and T cells
Dahl, C. A., Schall, R. P., He, H., & Cairns, J. S. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.2.597 · Cited by 208
Reduced Incidence and Severity of Collagen-Induced Arthritis in Mice Lacking IL-18
Wei, X., Leung, B. P. L., Arthur, H. M., McInnes, I. B., & Liew, F. Y. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.517 · Cited by 206
Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
Plater-Zyberk, C., Joosten, L. A. B., Helsen, M. M. A., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112097 · Cited by 206
Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-α production in mice
ten Hove, T., Corbaz, A., Amitai, H., Aloni, S., Belzer, I., Graber, P., Drillenburg, P., van Deventer, S. J. H., Chvatchko, Y., & Velde, A. A. T. (2001) · Gastroenterology · doi:10.1053/gast.2001.29579 · Cited by 203
Pathophysiological roles of interleukin-18 in inflammatory liver diseases
Tsutsui, H., Matsui, K., Okamura, H., & Nakanishi, K. (2000) · Immunological Reviews · doi:10.1034/j.1600-0528.2002.017418.x · Cited by 198
Caspase-1 Regulates the Inflammatory Process Leading to Autoimmune Demyelination
Furlan, R., Martino, G., Galbiati, F., Poliani, P. L., Smiroldo, S., Bergami, A., Desina, G., Comı, G., Flavell, R. A., Su, M. S. S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2403 · Cited by 194
IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor
Fantuzzi, G., Reed, D. A., & Dinarello, C. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7501 · Cited by 189
Self-citation
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Yatsiv, I., Morganti-Kossmann, M. C., Perez, D. R., Dinarello, C. A., Novick, D., Rubinstein, M., Otto, V. I., Rancan, M., Kossmann, T., Redaelli, C., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200208000-00008 · Cited by 183
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Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
Zorrilla, E. P., Sánchez-Alavez, M., Sugama, S., Brennan, M., Fernandez, R. E., Bartfai, T., & Conti, B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611523104 · Cited by 170
Clinical and Biological Effects of Recombinant Human Interleukin-18 Administered by Intravenous Infusion to Patients with Advanced Cancer
Robertson, M. J., Mier, J. W., Logan, T. F., Atkins, M. B., Koon, H. B., Koch, K. M., Kathman, S. J., Pandite, L. N., Oei, C., Kirby, L. C., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0121 · Cited by 170
A Novel Role for Interleukin-18 in Adhesion Molecule Induction through NFκB and Phosphatidylinositol (PI) 3-Kinase-dependent Signal Transduction Pathways
Morel, J., Park, C. C., Woods, J. M., & Koch, A. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103574200 · Cited by 168
Evidence for altered interleukin (IL)‐18 pathway in human heart failure
Mallat, Z., Heymes, C., Corbaz, A., Logeart, D., Alouani, S., Solal, A. C., Seidler, T., Hasenfuss, G. P., Chvatchko, Y., Shah, A. M., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-2426fje · Cited by 160
The role of interleukin-18 in the metabolic syndrome
Trøseid, M., Seljeflot, I., & Arnesen, H. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-11 · Cited by 155
Specific gene expression profiles in systemic juvenile idiopathic arthritis
Ogilvie, E. M., Khan, A., Hubank, M. J. F., Kellam, P., & Woo, P. M. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22644 · Cited by 151
Contrasting Action of IL-12 and IL-18 in the Development of Dextran Sodium Sulphate Colitis in Mice
Takagi, H., Kanai∥, T., Okazawa, A., Kishi, Y., Sato, T., Takaishi, H., Inoue, N., Ogata, H., Iwao, Y., Hoshino, K., et al. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310004047 · Cited by 151
Macrophage activation syndrome and reactive hemophagocytic lymphohistiocytosis: the same entities?
Grom, A. A. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200309000-00011 · Cited by 150
A case of macrophage activation syndrome successfully treated with anakinra
Kelly, A., & Ramanan, A. V. (2008) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0919 · Cited by 147
Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein
Banda, N. K., Vondracek, A., Kraus, D., Dinarello, C. A., Kim, S., Bendele, A. M., Senaldi, G., & Arend, W. P. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.4.2100 · Cited by 146
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Treatment of T Cell-Dependent Experimental Colitis in SCID Mice by Local Administration of an Adenovirus Expressing IL-18 Antisense mRNA
Wirtz, S. J., Becker, C., Blumberg, R. S., Galle, P. R., & Neurath, M. F. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.1.411 · Cited by 127
The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor 1 and CCAAT/enhancer binding protein β
Hurgin, V., Novick, D., & Rubinstein, M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.262663399 · Cited by 123
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IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
Bossù, P., Neumann, D., Giudice, E. D., Ciaramella, A., Gloaguen, I., Fantuzzi, G., Dinarello, C. A., Carlo, E. D., Musiani, P., Meroni, P. L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336094100 · Cited by 120
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IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice
Faggioni, R., Cattley, R. C., Guo, J., Flores, S., Brown, H., Qi, M., Yin, S., Hill, D., Scully, S. A., Chen, C., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.10.5913 · Cited by 119
An IFN-γ-Independent Proinflammatory Role of IL-18 in Murine Streptococcal Cell Wall Arthritis
Joosten, L. A. B., van de Loo, F. A. J., Lubberts, E., Helsen, M. M. A., Netea, M. G., van der Meer, J. W. M., Dinarello, C. A., & van den Berg, W. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6553 · Cited by 119
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The Interleukin-1β-Converting Enzyme Inhibitor Pralnacasan Reduces Dextran Sulfate Sodium-Induced Murine Colitis and T Helper 1 T-Cell Activation
Loher, F., Bauer, C. A., Landauer, N., Schmall, K., Siegmund, B., Lehr, H. A., Dauer, M., Schoenharting, M., Endres, S., & Eigler, A. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.057059 · Cited by 116
IFN-γ-Dependent and -Independent Mechanisms in Adverse Effects Caused by Concomitant Administration of IL-18 and IL-12
Nakamura, S., Otani, T., Ijiri, Y., Motoda, R., Kurimoto, M., & Orita, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.3330 · Cited by 113
Interleukin-1β Modulation Using a Genetically Engineered Antibody Prevents Adverse Cardiac Remodelling Following Acute Myocardial Infarction in the Mouse
Abbate, A., Tassell, B. W. V., Seropian, I. M., Toldo, S. A., Robati, R., Varma, A., Salloum, F. N., Smithson, L. A., & Dinarello, C. A. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq017 · Cited by 113
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Prointerleukin-18 Is Activated by Meprin β in Vitro and in Vivo in Intestinal Inflammation
Banerjee, S., & Bond, J. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802814200 · Cited by 110
Interleukin-18 in Intestinal Inflammation: Friend and Foe?
Siegmund, B. (2010) · Immunity · doi:10.1016/j.immuni.2010.03.010 · Cited by 102
Interleukin-18 binding protein reduces b16 melanoma hepatic metastasis by neutralizing adhesiveness and growth factors of sinusoidal endothelium.
Carrascal, M. T., Mendoza, L., Valcárcel, M., Salado, C., Egilegor, E., Tellería, N., Vidal‐Vanaclocha, F., & Dinarello, C. A. (2003) · PubMed · Cited by 102
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IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction
Wang, M., Tan, J., Wang, Y., Meldrum, K. K., Dinarello, C. A., & Meldrum, D. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908924106 · Cited by 98
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Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis
Sümegi, J., Barnes, M., Nestheide, S. V., Molleran-Lee, S., Villanueva, J. M., Zhang, K., Risma, K., Grom, A. A., & Filipovich, A. H. (2011) · Blood · doi:10.1182/blood-2010-08-300046 · Cited by 98
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice
Woldbæk, P. R., Sande, J. B., Strømme, T. A., Lunde, P., Djurovic, S., Lyberg, T., Christensen, G., & Tønnessen, T. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01179.2004 · Cited by 97
Interferon-γ Mediates Gene Expression of IL-18 Binding Protein in Nonleukocytic Cells
Mühl, H., Kämpfer, H., Bosmann, M., Frank, S., Radeke, H. H., & Pfeilschifter, J. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.2064 · Cited by 97
Urine IL-18, NGAL, IL-8 and serum IL-8 are biomarkers of acute kidney injury following liver transplantation
Sirota, J. C., Walcher, A. M., Faubel, S. G., Jani, A. H., McFann, K., Devarajan, P., Davis, C. L., & Edelstein, C. L. (2013) · BMC Nephrology · doi:10.1186/1471-2369-14-17 · Cited by 96
High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein
Novick, D., Elbirt, D., Miller, G., Dinarello, C. A., Rubinstein, M., & Sthoeger, Z. M. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.08.002 · Cited by 95
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Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines, and natural killer cells in the pathogenesis of interstitial pneumonia
Okamoto, M. (2002) · Blood · doi:10.1182/blood.v99.4.1289 · Cited by 95
M‐CSF induces the expression of a membrane‐bound form of IL ‐18 in a subset of human monocytes differentiating in vitro toward macrophages
Bellora, F., Castriconi, R., Doni, A., Cantoni, C., Moretta, L., Mantovani, A., Moretta, A., & Bottino, C. (2012) · European Journal of Immunology · doi:10.1002/eji.201142173 · Cited by 92
Increased interleukin‐18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage‐activation syndrome
Maeno, N., Takei, S., Imanaka, H., Yamamoto, K., Kuriwaki, K., Kawano, Y., & Oda, H. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20268 · Cited by 91
Adenoviral delivery of IL-18 binding protein C ameliorates Collagen-Induced Arthritis in mice
Smeets, R. L., van de Loo, F. A. J., Arntz, O. J., Bennink, M. B., Joosten, L. A. B., & van den Berg, W. B. (2003) · Gene Therapy · doi:10.1038/sj.gt.3301986 · Cited by 91
Vaccination with Allergen-IL-18 Fusion DNA Protects Against, and Reverses Established, Airway Hyperreactivity in a Murine Asthma Model
Maecker, H. T., Hansen, G., Walter, D. M., DeKruyff, R. H., Levy, S., & Umetsu, D. T. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.959 · Cited by 90
Interleukin-1β converting enzyme (caspase-1) in intestinal inflammation
Siegmund, B. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01064-x · Cited by 89
Plasma Levels of Interleukin-18 and Interleukin-18 Binding Protein Are Elevated in Patients with Chronic Liver Disease
Ludwiczek, O., Kaser, A., Novick, D., Dinarello, C. A., Rubinstein, M., Vogel, W., & Tilg, H. (2002) · Journal of Clinical Immunology · doi:10.1023/a:1020600230977 · Cited by 87
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Pharmacokinetics of IL-18 binding protein in healthy volunteers and subjects with rheumatoid arthritis or plaque psoriasis
Tak, P. P., Bacchi, M., & Bertolino, M. (2006) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/bf03191127 · Cited by 87
IL‐18 Activity in Systemic Lupus Erythematosus
Favilli, F., Anzilotti, C., Martinelli, L., Quattroni, P., Martino, S. D., Pratesi, F., Neumann, D., Beermann, S., Novick, D., Dinarello, C. A., et al. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04742.x · Cited by 87
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Interleukin 18 causes hepatic ischemia/reperfusion injury by suppressing anti-inflammatory cytokine expression in mice
Takeuchi, D., Yoshidome, H., Kato, A., Ito, H., Kimura, F., Shimizu, H., Ohtsuka, M., Morita, Y., & Miyazaki, M. (2004) · Hepatology · doi:10.1002/hep.20117 · Cited by 84
Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction
Raeburn, C. D., Dinarello, C. A., Zimmerman, M. A., Calkins, C. M., Pomerantz, B. J., McIntyre, R. C., Harken, A. H., & Meng, X. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00043.2002 · Cited by 83
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Reactive macrophage activation ayndrome: validation of a simple screening strategy and its potential in early treatment initiation
Reimers, A., Fux, C., & Spaeth, P. (2002) · Swiss Medical Weekly · doi:10.4414/smw.2002.09941 · Cited by 82
DIFFERENTIAL REGULATION OF SYSTEMIC IL-18 AND IL-12 RELEASE DURING POSTOPERATIVE SEPSIS: HIGH SERUM IL-18 AS AN EARLY PREDICTIVE INDICATOR OF LETHAL OUTCOME
Emmanuilidis, K., Weighardt, H., Matevossian, E., Heidecke, C.-D., Ulm, K., Bartels, H., Siewert, J. R., & Holzmann, B. (2002) · Shock · doi:10.1097/00024382-200210000-00002 · Cited by 80
IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ
Reznikov, L. L., Kim, S. H., Westcott, J. Y., Frishman, J. I., Fantuzzi, G., Novick, D., Rubinstein, M., & Dinarello, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040582597 · Cited by 79
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Interleukin-18, together with interleukin-12, induces severe acute pancreatitis in obese but not in nonobese leptin-deficient mice
Sennello, J. A., Fayad, R., Pini, M., Gove, M. E., Ponemone, V., Cabay, R. J., Siegmund, B., Dinarello, C. A., & Fantuzzi, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804091105 · Cited by 79
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Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury
He, Z., Lu, L., Altmann, C. J., Hoke, T. S., Ljubanović, D. G., Jani, A. H., Dinarello, C. A., Faubel, S. G., & Edelstein, C. L. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90288.2008 · Cited by 76
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Lack of response to anakinra in rheumatoid arthritis following failure of tumor necrosis factor α blockade
Buch, M. H., Bingham, S. J., Seto, Y., McGonagle, D., Bejarano, V., White, J., & Emery, P. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20115 · Cited by 75
Protection from Inflammatory Organ Damage in a Murine Model of Hemophagocytic Lymphohistiocytosis Using Treatment with IL-18 Binding Protein
Chiossone, L., Audonnet, S., Chetaille, B., Chasson, L., Farnarier, C., Berda‐Haddad, Y., Jordan, S., Koszinowski, U. H., Dalod, M., Mazodier, K., et al. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00239 · Cited by 75
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The ICE Inhibitor Pralnacasan Prevents DSS-Induced Colitis in C57BL/6 Mice and Suppresses IP-10 mRNA but Not TNF-α mRNA Expression
Bauer, C. A., Loher, F., Dauer, M., Mayer, C., Lehr, H. A., Schönharting, M., Hallwachs, R., Endres, S., & Eigler, A. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9802-8 · Cited by 75
Accessory Protein-Like Is Essential for IL-18-Mediated Signaling
Cheung, H., Chen, N., Cao, Z., Ono, N., Ohashi, P. S., & Yeh, W. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5351 · Cited by 73
Correspondence of the Functional Epitopes of Poxvirus and Human Interleukin-18-Binding Proteins
Xiang, Y., & Moss, B. A. (2001) · Journal of Virology · doi:10.1128/jvi.75.20.9947-9954.2001 · Cited by 73
Higher-dose Anakinra Is Effective in a Case of Medically Refractory Macrophage Activation Syndrome
Kahn, P. J., & Cron, R. Q. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.121098 · Cited by 72
Effect of interleukin-18 on mouse core body temperature
Gatti, S., Beck, J., Fantuzzi, G., Bartfai, T., & Dinarello, C. A. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00393.2001 · Cited by 72
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Elevated systemic levels of free interleukin-18 (IL-18) in patients with Crohn's disease.
Ludwiczek, O., Kaser, A., Novick, D., Dinarello, C. A., Rubinstein, M., & Tilg, H. (2005) · PubMed · Cited by 69
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Blockade of IL-18 Receptor Signaling Delays the Onset of Autoimmune Disease in MRL- Fas lpr Mice
Kinoshita, K., Yamagata, T., Nozaki, Y., Sugiyama, M., Ikoma, S., Funauchi, M., & Kanamaru, A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.8.5312 · Cited by 66
Intracerebroventricular interleukin-6, macrophage inflammatory protein-1β and IL-18: pyrogenic and PGE2-mediated?
Li, S., Goorha, S., Ballou, L. R., & Blatteis, C. M. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.033 · Cited by 64
The effect of daily administration of IL-18 on cardiac structure and function
Platis, A. G., Yu, Q., Moore, D., Khojeini, E., Tsau, P. H., & Larson, D. (2008) · Perfusion · doi:10.1177/0267659108101511 · Cited by 58
Suppression of experimental myasthenia gravis, a B cell‐mediated autoimmune disease, by blockade of IL‐18
Im, S., Barchan, D., Maiti, P. K., Raveh, L., Souroujon, M. C., & Fuchs, S. (2001) · The FASEB Journal · doi:10.1096/fj.01-0072com · Cited by 57
Interferon-αinduces interleukin-18 binding protein in chronic hepatitis C patients
Kaser, A., Novick, D., Rubinstein, M., Siegmund, B., Enrich, B., Koch, R., Vogel, W., Kim, S. H., Dinarello, C. A., & Tilg, H. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01911.x · Cited by 56
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Cytokine profiles in children with primary Epstein–Barr virus infection
Wada, T., Muraoka, M., Yokoyama, T., Toma, T., Kanegane, H., & Yachie, A. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24480 · Cited by 56
Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
Lewis, E. C., & Dinarello, C. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607917103 · Cited by 55
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Generation and characterization of mice transgenic for human IL-18-binding protein isoforma
Fantuzzi, G., Banda, N. K., Guthridge, C. J., Vondracek, A., Kim, S., Siegmund, B., Azam, T., Sennello, J. A., Dinarello, C. A., & Arend, W. P. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0503230 · Cited by 54
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IL-27 Regulates IL-18 Binding Protein in Skin Resident Cells
Wittmann, M., Doble, R., Bachmann, M., Pfeilschifter, J. M., Werfel, T., & Mühl, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038751 · Cited by 52
Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis
Jelušić, M., Lukić, I. K., Tambić-Bukovac, L., Dubravčić, K., Malčić, I., Rudan, I., & Batinić, D. (2006) · Clinical Rheumatology · doi:10.1007/s10067-006-0474-0 · Cited by 49
Successful treatment of macrophage activation syndrome complicating adult S till disease with anakinra
Loh, N. K., Lucas, M., Fernández, S., & Prentice, D. A. (2012) · Internal Medicine Journal · doi:10.1111/imj.12002 · Cited by 42
Frontline: Interferon regulatory factor‐1 as a protective gene in intestinal inflammation: role of TCR γ δ T cells and interleukin‐18‐binding protein
Siegmund, B., Sennello, J. A., Lehr, H. A., Senaldi, G., Dinarello, C. A., & Fantuzzi, G. (2004) · European Journal of Immunology · doi:10.1002/eji.200425124 · Cited by 41
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Interleukin-18 Binding Protein in the Sera of Patients with Wegener’s Granulomatosis
Novick, D., Elbirt, D., Dinarello, C. A., Rubinstein, M., & Sthoeger, Z. M. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9217-0 · Cited by 41
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Multimodality Imaging of IL-18–Binding Protein-Fc Therapy of Experimental Lung Metastasis
Cao, Q., Cai, W., Niu, G., He, L., & Chen, X. S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0049 · Cited by 40
Free Interleukin (IL)-18 Levels, and the Impact of IL18 and IL18BP Genetic Variation, in CHD Patients and Healthy Men
Thompson, S. R., Novick, D., Stock, C. J. W., Sanders, J., Brull, D. J., Cooper, J. A., Woo, P. M., Miller, G. J., Rubinstein, M., & Humphries, S. E. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.149245 · Cited by 39
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Elevated systemic IL-18 and neopterin levels are associated with posttraumatic complications among patients with multiple injuries: A prospective cohort study
Mommsen, P., Frink, M., Pape, H., van Griensven, M., Probst, C. P., Gaulke, R., Krettek, C., & Hildebrand, F. (2008) · Injury · doi:10.1016/j.injury.2008.08.007 · Cited by 39
β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo
Murray, D. R. P., Mummidi, S., Valente, A. J., Yoshida, T., Somanna, N. K., Delafontaine, P., Dinarello, C. A., & Chandrasekar, B. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.09.022 · Cited by 38
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The heart on fire: inflammasome and cardiomyopathy
Abbate, A. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2012.069021 · Cited by 37
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
Palladino, I., Salani, F., Ciaramella, A., Rubino, I. A., Caltagirone, C., Fagioli, S., Spalletta, G., & Bossù, P. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-206 · Cited by 35
Heterogeneity of response of rheumatoid synovium cell subsets to interleukin‐18 in relation to differential interleukin‐18 receptor expression
Kawashima, M., & Miossec, P. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10825 · Cited by 33
Failure of Interferon γ to Induce the Anti-Inflammatory Interleukin 18 Binding Protein in Familial Hemophagocytosis
Nold‐Petry, C. A., Lehrnbecher, T., Jarisch, A., Schwabe, D., Pfeilschifter, J. M., Mühl, H., & Nold, M. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008663 · Cited by 32
Interleukin-18 Affects Local Cytokine Expression But Does Not Impact on the Development of Kidney Allograft Rejection
Wyburn, K., Wu, H., Chen, G., Yin, J. K., Eris, J., & Chadban, S. J. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01536.x · Cited by 30
Activation of caspase-1 dependent interleukins in developmental brain trauma
Sifringer, M., Stefovska, V. G., Endesfelder, S., Stahel, P. F., Genz, K., Dzietko, M., Ikonomidou, C., & Felderhoff‐Mueser, U. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.11.003 · Cited by 26
Regulation of Staphylococcus epidermidis-induced IFN-γ in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
Stuyt, R. J. L., Kim, S. H., Reznikov, L. L., Fantuzzi, G., Novick, D., Rubinstein, M., Kullberg, B. J., van der Meer, J. W. M., Dinarello, C. A., & Netea, M. G. (2003) · Cytokine · doi:10.1016/s1043-4666(02)00501-x · Cited by 26
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Immunotherapeutic Applications of IL-18
Tsutsui, H., & Nakanishi, K. (2012) · Immunotherapy · doi:10.2217/imt.12.137 · Cited by 26
Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction
Narins, C. R., Lin, D. A., Burton, P. B. J., Jin, Z., & Berk, B. C. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.07.114 · Cited by 25
Excessive interleukin‐1 signaling determines the development of Th1 and Th17 responses in chronic inflammation
Joosten, L. A. B. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27242 · Cited by 23
The Protective Effect of Intrasplenic Transplantation of Ad-IL-18BP/IL-4 Gene-Modified Fetal Hepatocytes on ConA-Induced Hepatitis in Mice
Shao, X., Qian, Y., Xu, C.-H., Hong, B., Xu, W., Shen, L., Jin, C., Wu, Z., Tong, X., & Yao, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058836 · Cited by 22
Interleukin-18 serum levels in inflammatory bowel diseases: correlation with disease activity and inflammatory markers
Haas, S., Abbatista, M., Brade, J., Singer, M., & Böcker, U. (2009) · Swiss Medical Weekly · doi:10.4414/smw.2009.12482 · Cited by 22
Neuron-specific enolase in hemophagocytic lymphohistiocytosis: a potential indicator for macrophage activation?
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Authors: Novick, D., Kim, S., Kaplanski, G., & Dinarello, C. A.
Affiliations: Weizmann Institute of Science (IL)
Konkuk University (KR)
Aix-Marseille Université (FR)
University of Colorado Denver (US)
Corresponding author: Dinarello, Charles A.
ORCID: Novick, Daniela
Kim, Soohyun
Kaplanski, Gilles
Dinarello, Charles A.
Venue: Seminars in Immunology
Publisher: Elsevier BV
Published: 2013-12
Volume: 25
Issue: 6
Pages: 439-448
ISSN: 1044-5323 (ISSN-L)
DOI: 10.1016/j.smim.2013.10.014
OpenAlex: W2005242977
Cited by: 280
References: 165
Citations by year: 2026: 7 · 2025: 13 · 2024: 16 · 2023: 23 · 2022: 20 · 2021: 23 · 2020: 36 · 2019: 21 · 2018: 29 · 2017: 28 · 2016: 35 · 2015: 20 · 2014: 9
FWCI: 2.19
Type: journal article
Language: en
Open access: closed
Locations: Seminars in Immunology (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: National Cancer Institute (CA 046934, P30CA046934)
National Institute of Allergy and Infectious Diseases (AI‑15614)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR‑45584, R01AR045584)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: IL-18, IL-18BP, Th1 response, interferon-gamma, IL-18 receptor alpha, IL-1 family cytokines, pro-inflammatory effects, autoimmune disease, macrophage activation syndrome, sepsis, acute kidney injury
MeSH terms: Animals, Autoimmune Diseases, Heart Diseases, Humans, Inflammation, Interferon-gamma, Killer Cells, Natural, Shock, Septic, Th1 Cells, Interleukin-12, Inflammation Mediators, Caspase 1, Interleukin-18, Intercellular Signaling Peptides and Proteins, Mice, Macrophage Activation Syndrome

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Interleukin-18, more than a Th1 cytokine

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