The role of interleukin-18 in the metabolic syndrome
Open accessAbstract
The metabolic syndrome is thought to be associated with a chronic low-grade inflammation, and a growing body of evidence suggests that interleukin-18 (IL-18) might be closely related to the metabolic syndrome and its consequences. Circulating levels of IL-18 have been reported to be elevated in subjects with the metabolic syndrome, to be closely associated with the components of the syndrome, to predict cardiovascular events and mortality in populations with the metabolic syndrome and to precede the development of type 2 diabetes. IL-18 is found in the unstable atherosclerotic plaque, in adipose tissue and in muscle tissue, and is subject to several regulatory steps including cleavage by caspase-1, inactivation by IL-18 binding protein and the influence of other cytokines in modulating its interaction with the IL-18 receptor. The purpose of this review is to outline the role of IL-18 in the metabolic syndrome, with particular emphasis on cardiovascular risk and the potential effect of life style interventions.
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In combination with IL-2, IL-18 can promote a Th2 response, while a Th1 response is promoted in response to IL-12.
“For instance, in combination with IL-2, IL-18 can promote a Th2 response, while a Th1 response will be promoted in response to IL-12 (reviewed here [239]).”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [239]
IL-18 enhances both T cell and natural killer cell maturation and promotes proinflammatory cytokine release.
“IL-18 is known to enhance both T cell and natural killer cell maturation and promote proinflammatory cytokine release [239].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [239]
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“As already stated, adipocytes behave as immune cells [72– 75] and are able to synthesize and release a huge amount of proinflammatory adipokines and cytokines including leptin, resistin, PAI-1, IL-6, TNFα, retinol-binding protein 4 (see [16]), IL-1β, monocyte chemoattractant protein-1 (MCP1), CRP, macrophage migration…”
BackgroundInterleukin-18 and IL-18 Binding Protein
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“For instance, in combination with IL-2, IL-18 can promote a Th2 response, while a Th1 response will be promoted in response to IL-12 (reviewed here [239]).”
BackgroundThe role of cytokines in the development of atherosclerosis
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- Authors
- Trøseid, M., Seljeflot, I., & Arnesen, H.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Trøseid, Marius
- Venue
- Cardiovascular Diabetology
- Published
- 2010
- Volume
- 9
- Issue
- 1
- Pages
- 11
- ISSN
- 1475-2840 (ISSN-L)
- PMC
- PMC2858122
- OpenAlex
- W2116389925
- Cited by
- 155
- References
- 117
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 4 · 2021: 11 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 10 · 2015: 6 · 2014: 11 · 2013: 18 · 2012: 8
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Cardiovascular Diabetology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- IL-18, metabolic syndrome, low-grade inflammation, cardiovascular risk, type 2 diabetes, atherosclerotic plaque, adipose tissue, caspase-1, IL-18 binding protein, IL-18 receptor, lifestyle intervention
- MeSH terms
- Adipose Tissue, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Humans, Life Style, Muscles, Risk Factors, Cytokines, Caspase 1, Interleukin-18, Metabolic Syndrome, Intercellular Signaling Peptides and Proteins, Atherosclerosis
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