Cited by 53Analytical Chemistry and SensorsElectrochemical sensors and biosensorsElectrochemical Analysis and Applications

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Zero-consumption Clark-type microsensor for oxygen monitoring in cell culture and organ-on-chip systems

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Crossref · 10.1016/j.snb.2020.128652

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  • They monitored oxygen in monolayer cultures with T-47D breast cancer cells, demonstrating the applicability of the sensor in cell culture oxygen concentration detection.

    “They also monitored oxygen in monolayer cultures with T-47D breast cancer cells, which further demonstrates the applicability of the sensor in cell culture oxygen concentration detection.”
  • Liebisch et al. [233] prepared Clark-type oxygen microsensors that can operate in an aqueous environment using a PHEMA hydrogel layer containing a buffer solution as the electrolyte, platinum as the electrode material, and PDMS as the gas permeable membrane.

    “Liebisch et al. [233] prepared a Clark-type oxygen microsensors that can operate in an aqueous environment. They used a PHEMA hydrogel layer containing a buffer solution as the electrolyte, platinum as the electrode material for the sensor, and polydimethylsiloxane (PDMS) as the gas permeable membrane.”

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Research works printed but not linked: 28

  1. Ebbesen, 2009, Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies, J. Enzyme Inhib. Med. Chem., 24, 1, 10.1080/14756360902784425 · DOI
  2. Pettersen, 2015, Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium, J. Enzyme Inhib. Med. Chem., 30, 689, 10.3109/14756366.2014.966704 · DOI
  3. Lavrentieva, 2010, Effects of hypoxic culture conditions on umbilical cord-derived human mesenchymal stem cells, Cell Commun. Signal, 8, 18, 10.1186/1478-811X-8-18 · DOI · Paper page
  4. Kieninger, 2018, Microsensor systems for cell metabolism – from 2D culture to organ-on-chip, Lab Chip, 18, 1274, 10.1039/C7LC00942A · DOI
  5. Pettersen, 2005, Pericellular oxygen depletion during ordinary tissue culturing, measured with oxygen microsensors, Cell Prolif., 38, 257, 10.1111/j.1365-2184.2005.00345.x · DOI
  6. Weltin, 2014, Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem, Lab Chip, 14, 138, 10.1039/C3LC50759A · DOI
  7. Kieninger, 2014, Pericellular oxygen monitoring with integrated sensor chips for reproducible cell culture experiments, Cell Prolif., 47, 180, 10.1111/j.1365-2184.2013.12089.x · DOI
  8. Weltin, 2017, Accessing 3D microtissue metabolism: lactate and oxygen monitoring in hepatocyte spheroids, Biosens. Bioelectron., 87, 941, 10.1016/j.bios.2016.07.094 · DOI
  9. Kieninger, 2018, Sensor access to the cellular microenvironment using the sensing cell culture flask, Biosensors, 8, 44, 10.3390/bios8020044 · DOI
  10. Marzioch, 2018, On-chip photodynamic therapy – monitoring cell metabolism using electrochemical microsensors, Lab Chip, 18, 3353, 10.1039/C8LC00799C · DOI
  11. Guarino, 2004, Method for determining oxygen consumption rates of static cultures from microplate measurements of pericellular dissolved oxygen concentration, Biotechnol. Bioeng., 86, 775, 10.1002/bit.20072 · DOI
  12. Beckers, 2010, High throughput, non-invasive and dynamic toxicity screening on adherent cells using respiratory measurements, Toxicol. In Vitro, 24, 686, 10.1016/j.tiv.2009.04.018 · DOI
  13. Clark Jr, 1956, Monitor and control of blood and tissue oxygen tensions, Trans. Am. Soc. Artif. Intern. Organs, 2, 41
  14. Koudelka, 1986, Performance characteristics of a planar ‘clark-type’ oxygen sensor, Sens. Actuators, 9, 249, 10.1016/0250-6874(86)80025-7 · DOI
  15. Suzuki, 1990, Miniature Clark-type oxygen electrode with a three-electrode configuration, Sens. Actuators B. Chem., 2, 297, 10.1016/0925-4005(90)80157-U · DOI
  16. Suzuki, 1993, Micromachined Clark oxygen electrode, Sens. Actuators B. Chem., 10, 91, 10.1016/0925-4005(93)80031-6 · DOI
  17. Jobst, 1993, Thin-film Clark-type oxygen sensor based on novel polymer membrane systems for in vivo and biosensor applications, Biosens. Bioelectron., 8, 123, 10.1016/0956-5663(93)85024-I · DOI
  18. Suzuki, 1994, Disposable clark oxygen electrode using recycled materials and its application, Sens. Actuators B Chem., 21, 17, 10.1016/0925-4005(93)01207-K · DOI
  19. Yang, 1997, Fabrication of oxygen electrode arrays and their incorporation into sensors for measuring biochemical oxygen demand, Anal. Chim. Acta, 357, 41, 10.1016/S0003-2670(97)00560-6 · DOI
  20. Suzuki, 1998, A novel thin-film Ag/AgCl anode structure for microfabricated Clark-type oxygen electrodes, Sens. Actuators B Chem., 53, 140, 10.1016/S0925-4005(99)00009-X · DOI
  21. McLaughlin, 2002, Microfabricated solid-state dissolved oxygen sensor, Sens. Actuators B Chem., 83, 138, 10.1016/S0925-4005(02)00021-7 · DOI
  22. Wu, 2005, Fabrication of miniature Clark oxygen sensor integrated with microstructure, Sens. Actuators B Chem., 110, 342, 10.1016/j.snb.2005.02.014 · DOI
  23. Wu, 2010, A Clark-type oxygen chip for in situ estimation of the respiratory activity of adhering cells, Talanta, 81, 228, 10.1016/j.talanta.2009.11.062 · DOI
  24. Park, 2010, A microfabricated reservoir-type oxygen sensor for measuring the real-time cellular oxygen consumption rate at various conditions, Sensors Actuators B Chem., 147, 263, 10.1016/j.snb.2010.03.069 · DOI
  25. Park, 2013, A reservoir-type oxygen sensor with 2×3 array for measuring cellular respiration levels, Sensors Actuators, B Chem., 176, 913, 10.1016/j.snb.2012.09.037 · DOI
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  27. Keydar, 1979, Establishment and characterization of a cell line of human breast carcinoma origin, Eur. J. Cancer, 15, 659, 10.1016/0014-2964(79)90139-7 · DOI
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Metadata

Authors
Liebisch, F., Weltin, A., Marzioch, J., Urban, G. A., & Kieninger, J.
Affiliations
University of Freiburg (DE)
Corresponding author
Kieninger, Jochen
Venue
Sensors and Actuators B: Chemical
Publisher
Elsevier BV
Published
2020-11
Volume
322
Pages
128652
ISSN
0925-4005 (ISSN-L)
OpenAlex
W3044607496
Cited by
53
References
0
Citations by year
2026: 6 · 2025: 5 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 9
FWCI
3.74
Type
journal article
Language
en
Open access
closed
Locations
Sensors and Actuators B Chemical (publishedVersion)
Funders
European Commission
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
  • Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
  • Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
Keywords
feedback mode, platinum electrode, chronoamperometry, long-term sensor stability, one-point calibration, T47D cells, organ-on-a-chip

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