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Cited by 128Bariatric Surgery and OutcomesVitamin D Research StudiesBone health and osteoporosis research

The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.

Treatment of vitamin D depletion after Roux-en-Y gastric bypass: a randomized prospective clinical trial

Carlin, Arthur M., Rao, D. Sudhaker, Yager, Kelli M., Parikh, Nayana J., Kapke, Alissa·2009·Surgery for Obesity and Related Diseases
DOI 10.1016/j.soard.2008.08.004
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Abstract

Background A high prevalence (60%) of vitamin D (VitD) depletion, defined as a serum 25-hydroxyvitamin D level of < or =20 ng/mL, is present in preoperative morbidly obese patients. Despite daily supplementation with 800 IU VitD and 1500 mg calcium after Roux-en-Y gastric bypass (RYGB), VitD depletion persists in almost one half (44%) of patients. However, the optimal management of VitD depletion after RYGB and the potential benefits of such treatment are currently unknown.Methods A total of 60 VitD-depleted morbidly obese women were randomly assigned to receive 50,000 IU of VitD weekly after RYGB (group 1; n = 30) or no additional VitD after RYGB (group 2; n = 30). All patients received a daily supplement of 800 IU VitD and 1500 mg calcium. The serum calcium, parathyroid hormone, 25-hydroxyvitamin D, bone-specific alkaline phosphatase, urinary N-telopeptide, and bone mineral density were measured preoperatively and 1 year after RYGB. Questionnaires were used to assess other potential sources of VitD, including sunlight exposure and ingestion of VitD-containing foods/liquids.Results At 1 year after RYGB, VitD depletion and mean 25-hydroxyvitamin D level had improved significantly in group 1 (14% and 37.8 ng/mL, respectively) compared with the values in group 2 (85% and 15.2 ng/mL, respectively; P <.001 for both). A significant 33% retardation in hip bone mineral density decline (P = .043) and a significantly greater resolution of hypertension was seen in group 1 (75% versus 32%; P = .029). No significant adverse effects were encountered from pharmacologic VitD therapy.Conclusion The results of our study have shown that 50,000 IU of VitD weekly after RYGB safely corrects VitD depletion in most women, attenuates cortical bone loss, and improves resolution of hypertension.

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Crossref · 10.1016/j.soard.2008.08.004

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  1. 1992, National Institutes of Health Consensus Development Conference Statement: Gastrointestinal surgery for severe obesity, Am J Clin Nutr, 55, 615S

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Metadata

Authors
Carlin, A. M., Rao, D. S., Yager, K. M., Parikh, N. J., & Kapke, A.
Affiliations
  • Henry Ford Health (US)
  • Henry Ford Hospital (US)
ORCID
Carlin, Arthur M.
Venue
Surgery for Obesity and Related Diseases
Publisher
Elsevier BV
Published
2009-07
Volume
5
Issue
4
Pages
444-449
ISSN
1550-7289 (ISSN-L)
DOI
10.1016/j.soard.2008.08.004
OpenAlex
W2124633433
Cited by
128
References
28
Citations by year
2025: 1 · 2024: 9 · 2023: 6 · 2022: 7 · 2021: 8 · 2020: 10 · 2019: 3 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 13 · 2012: 11
FWCI
4.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Surgery for Obesity and Related Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
vitamin D deficiency, Roux-en-Y gastric bypass
MeSH terms
Adult, Female, Humans, Middle Aged, Obesity, Morbid, Parathyroid Hormone, Risk Factors, Vitamin D, Vitamin D Deficiency, Vitamins, Gastric Bypass, Weight Loss, Bone Density, Treatment Outcome, Dietary Supplements

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