Gastric bypass surgery for morbid obesity leads to an increase in bone turnover and a decrease in bone mass
Abstract
Little is known about the effects on the skeleton of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity and subsequent weight loss. We compared 25 patients who had undergone LRGB 11 ± 3 months previously with 30 obese controls matched for age, gender, and menopausal status. Compared with obese controls, patients post LRGB had significantly lower weight (92 ± 16 vs. 133 ± 20 kg; P < 0.001) and body mass index (31 ± 5 vs. 48 ± 7 kg/m2; P < 0.001). Markers of bone turnover were significantly elevated in patients post LRGB compared with controls (urinary N-telopeptide cross-linked collagen type 1, 93 ± 38 vs. 24 ± 11 nmol bone collagen equivalents per mmol creatinine; and osteocalcin, 11.6 ± 3.4 vs. 7.6 ± 3.6 ng/ml; both P < 0.001). Fifteen patients were studied prospectively for an average of 9 months after LRGB. They lost 37 ± 9 kg and had a 29 ± 8% fall in body mass index (both P < 0.001). Urinary N-telopeptide cross-linked collagen type 1 increased by 174 ± 168% at 3 months (P < 0.01) and 319 ± 187% at 9 months (P < 0.01). Bone mineral density decreased significantly at the total hip (7.8 ± 4.8%; P < 0.001), trochanter (9.3 ± 5.7%; P < 0.001), and total body (1.6 ± 2.0%; P < 0.05), with significant decreases in bone mineral content at these sites. In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Vitamin D deficiency is widespread.
“Vitamin D deficiency is widespread9, 10”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [10]
Cites
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190 · see citing works
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,804 · see citing works
Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery.
Cummings, D., Weigle, D., Frayo, R. S., Breen, P. A., Ma, M. K., Dellinger, E., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,499 · see citing works
Pories, W. J., Swanson, M. S., MacDonald, K. G., Long, S. B., Morris, P. G., Brown, B. M., Barakat, H. A., deRamon, R. A., Israel, G., Dolezal, J. M., et al. (1995) · Annals of Surgery · doi:10.1097/00000658-199509000-00011 · Cited by 2,293 · see citing works
Evidence for alteration of the vitamin D-endocrine system in obese subjects.
Bell, N. H., Epstein, S., Greene, A. S., Shary, J., Oexmann, M. J., & Shaw, S. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111971 · Cited by 685 · see citing works
Prentice, A., Parsons, T., & Cole, T. J. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.6.837 · Cited by 578 · see citing works
Bariatric surgery and long-term control of morbid obesity
Brolin, R. E. (2002) · JAMA · doi:10.1001/jama.288.22.2793 · Cited by 474 · see citing works
Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans
Holdstock, C., Engström, B. E., Öhrvall, M., Lind, L., Sundbom, M., & Karlsson, F. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021734 · Cited by 315 · see citing works
Pi-Sunyer, F. X. (1996) · Clinical Therapeutics · doi:10.1016/s0149-2918(96)80057-9 · Cited by 224 · see citing works
National Trends in Utilization and In-Hospital Outcomes of Bariatric Surgery
Pope, G. D., Birkmeyer, J. D., & Finlayson, S. R. G. (2002) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(02)00085-9 · Cited by 204 · see citing works
Ghrelin and Gastric Bypass: Is There a Hormonal Contribution to Surgical Weight Loss?
Cummings, D. E., & Shannon, M. H. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030705 · Cited by 184 · see citing works
Leonetti, F., Silecchia, G., Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Tiberti, C., Iannucci, C. V., Perrotta, N., Bacci, V., Basso, M. S., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030133 · Cited by 167 · see citing works
Guney, E., Kisakol, G., Ozgen, G., Yilmaz, C., Yilmaz, R., & Kabalak, T. (2003) · Obesity Surgery · doi:10.1381/096089203765887705 · Cited by 151 · see citing works
Severe Metabolic Bone Disease as a Long-Term Complication of Obesity Surgery
Goldner, W. S., O’Dorisio, T. M., Dillon, J. S., & Mason, E. E. (2002) · Obesity Surgery · doi:10.1381/096089202321019693 · Cited by 146 · see citing works
High prevalence of bone disorders after gastrectomy
Zittel, T. T., Zeeb, B., Maier, G. W., Kaiser, G., Zwirner, M., Liebich, H. M., Starlinger, M. J., & Becker, H. D. (1997) · The American Journal of Surgery · doi:10.1016/s0002-9610(97)00123-2 · Cited by 140 · see citing works
Sex Hormone Changes in Morbidly Obese Patients after Vertical Banded Gastroplasty
Bastounis, E., Karayiannakis, A. J., Syrigos, K., Zbar, A. P., Makri, G. G., & Alexiou, D. (1998) · European Surgical Research · doi:10.1159/000008556 · Cited by 133 · see citing works
Bisballe, S., Eriksen, E. F., Melsen, F., Mosekilde, L., Sørensen, O. H., & Hessov, I. (1991) · Gut · doi:10.1136/gut.32.11.1303 · Cited by 128 · see citing works
Effect of weight loss on bone mineral content and bone mineral density in obese women
Loan, M. V., Johnson, H., & Barbieri, T. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.4.734 · Cited by 119 · see citing works
Metabolic Bone Disease After Intestinal Bypass for Treatment of Obesity
PARFITT, A. M., MILLER, M. J., FRAME, B., VILLANUEVA, A. R., RAO, D. S., OLIVER, I., & THOMSON, D. L. (1978) · Annals of Internal Medicine · doi:10.7326/0003-4819-89-2-193 · Cited by 108 · see citing works
Does bone change after biliopancreatic diversion?
Marceau, P., Biron, S., Lebel, S., Marceau, S., Hould, F. S., Simard, S., Dumont, M., & Fitzpatrick, L. A. (2002) · Journal of Gastrointestinal Surgery · doi:10.1016/s1091-255x(01)00086-5 · Cited by 105 · see citing works
Dietary calcium intake and bone loss from the spine in healthy postmenopausal women
Dawson‐Hughes, B., Jacques, P. F., & Shipp, C. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.4.685 · Cited by 101 · see citing works
Ott, M. T., Fanti, P., Malluche, H. H., Ryo, U. Y., Whaley, F. S., Strodel, W. E., & Colacchio, T. A. (1992) · Obesity Surgery · doi:10.1381/096089292765559936 · Cited by 96 · see citing works
Bone histomorphometry and vitamin D status after biliopancreatic bypass for obesity
Compston, J. E., Vedi, S., Gianetta, E., Watson, G., Civalleri, D., & Scopinaro, N. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90712-1 · Cited by 93 · see citing works
Shaker, J. L., Norton, A. J., Woods, M., Fallon, M. D., & Findling, J. W. (1991) · Osteoporosis International · doi:10.1007/bf01625450 · Cited by 77 · see citing works
Mitka, M. (2003) · JAMA · doi:10.1001/jama.289.14.1761 · Cited by 75 · see citing works
Geloneze, B., Tambascia, M. A., Repetto, E., Pereira, S. G., Pareja, J. C., & Magna, L. A. (2001) · Obesity Surgery · doi:10.1381/09608920160558623 · Cited by 66 · see citing works
Critical analysis of results: weight loss and quality of data
Brolin, R. E. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.2.577s · Cited by 63 · see citing works
Effects of vertical-banded gastroplasty on bone and mineral metabolism in obese patients
Cundy, T., Evans, M. C., Kay, R. G., Dowman, M., Wattie, D., & Reid, I. R. (1996) · Journal of British Surgery · doi:10.1002/bjs.1800831046 · Cited by 53 · see citing works
Reduced bone mineral density after surgical treatment for obesity
Bano, G., Rodin, D. A., Pazianas, M., & Nussey, S. S. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800827 · Cited by 51 · see citing works
Adachi, Y., Shiota, E., Matsumata, T., Iso, Y., Yoh, R., & Kitano, S. (2000) · Calcified Tissue International · doi:10.1007/s002230010025 · Cited by 43 · see citing works
Rickers, H., Christiansen, C., Balslev, I., & Rødbro, P. (1984) · PubMed · Cited by 37 · see citing works
Impairment of Vitamin D Metabolism and Bone Mineral Content after Intestinal Bypass for Obesity
Rickers, H., Christiansen, C., Balslev, I., & Rødbro, P. (1984) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1984.12005707 · Cited by 24 · see citing works
Bone disorders following total gastrectomy
Wetscher, G. J., Redmond, E. J., Watfah, C., Perdikis, G., Gadenstätter, M., & Pointner, R. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02087683 · Cited by 19 · see citing works
Flagged first, then by citations
1 of the 34 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies
Batsis, J. A., & Villareal, D. T. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0062-9 · Cited by 1,382 · see citing works
KANALEY, J. A., COLBERG, S. R., CORCORAN, M. H., MALIN, S. K., RODRIGUEZ, N. R., CRESPO, C. J., KIRWAN, J. P., & ZIERATH, J. R. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002800 · Cited by 931 · see citing works
Interdisciplinary European Guidelines on Metabolic and Bariatric Surgery
Fried, M., Yumuk, V., Oppert, J., Scopinaro, N., Torres, A., Weiner, R. A., Yashkov, Y. I., & Frühbeck, G. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1079-8 · Cited by 753 · see citing works
ASMBS Allied Health Nutritional Guidelines for the Surgical Weight Loss Patient
Aills, L., Blankenship, J. D., Buffington, C. K., Furtado, M. M., & Parrott, J. M. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.03.002 · Cited by 595 · see citing works
Nutritional Deficiencies following Bariatric Surgery: What Have We Learned?
Bloomberg, R. D., Fleishman, A., Nalle, J. E., Herron, D. M., & Kini, S. U. (2005) · Obesity Surgery · doi:10.1381/0960892053268264 · Cited by 514 · see citing works
Long-Term Impact of Bariatric Surgery on Body Weight, Comorbidities, and Nutritional Status
Shah, M., Simha, V., & Garg, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0557 · Cited by 425 · see citing works
Mechanick, J. I., Kushner, R. F., Sugerman, H. J., González-Campoy, J. M., Collazo–Clavell, M. L., Guven, S., Spitz, A. F., Apovian, C. M., Livingston, E. H., Brolin, R. E., et al. (2008) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.08.009 · Cited by 372 · see citing works
Bone Metabolism in Obesity and Weight Loss
Shapses, S. A., & Sukumar, D. (2012) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104655 · Cited by 347 · see citing works
Nutrient deficiencies secondary to bariatric surgery
Alvarez-Leite, J. I. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200409000-00010 · Cited by 343 · see citing works
Mechanick, J. I., Kushner, R. F., Sugerman, H. J., González-Campoy, J. M., Collazo–Clavell, M. L., Spitz, A. F., Apovian, C. M., Livingston, E. H., Brolin, R. E., Sarwer, D. B., et al. (2009) · Obesity · doi:10.1038/oby.2009.28 · Cited by 338 · see citing works
Olbers, T., Bj??rkman, S., Lindroos, A., Maleckas, A., L??nn, L., Sj??str??m, L., & L??nroth, H. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000218085.25902.f8 · Cited by 340 · see citing works
Interdisciplinary European Guidelines on Metabolic and Bariatric Surgery
Fried, M., Yumuk, V., Oppert, J., Scopinaro, N., Torres, A. J., Weiner, R. A., Yashkov, Y. I., & Frühbeck, G. (2013) · Obesity Facts · doi:10.1159/000355480 · Cited by 320 · see citing works
Prevalence of nutrient deficiencies in bariatric patients
Toh, S. Y., Zarshenas, N., & Jorgensen, J. (2009) · Nutrition · doi:10.1016/j.nut.2009.03.012 · Cited by 315 · see citing works
Nutritional and Metabolic Complications of Bariatric Surgery
Malinowski, S. S. (2006) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200604000-00009 · Cited by 310 · see citing works
Bult, M. J. F., van Dalen, T., & Muller, A. F. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0145 · Cited by 308 · see citing works
Best Practice Updates for Pediatric/Adolescent Weight Loss Surgery
Pratt, J. S. A., Lenders, C. M., Dionne, E. A., Hoppin, A. G., Hsu, G. L. K., Inge, T. H., Lawlor, D. F., Marino, M. F., Meyers, A. F., Rosenblum, J., et al. (2009) · Obesity · doi:10.1038/oby.2008.577 · Cited by 304 · see citing works
Inter-disciplinary European guidelines on surgery of severe obesity
Fried, M., Hainer, V., Basdevant, A., Buchwald, H., Deitel, M., Finer, N., Greve, J.-W. M., Horber, F., Mathus-Vliegen, E. M. H., Scopinaro, N., et al. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803560 · Cited by 301 · see citing works
Simulated increases in body fat and errors in bone mineral density measurements by DXA and QCT
Yu, E. W., Thomas, B. J., Brown, J. K., & Finkelstein, J. S. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.506 · Cited by 300 · see citing works
Preoperative Nutritional Status of Patients Undergoing Roux-en-Y Gastric Bypass for Morbid Obesity
Flancbaum, L., Belsley, S., Drake, V., Colarusso, T., & Tayler, E. B. (2006) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2006.03.004 · Cited by 293 · see citing works
Fleischer, J., Stein, E. M., Bessler, M., Badia, M. D., Restuccia, N., Olivero-Rivera, L., McMahon, D. J., & Silverberg, S. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0481 · Cited by 278 · see citing works
Follow-up of Nutritional and Metabolic Problems After Bariatric Surgery
Fujioka, K. (2005) · Diabetes Care · doi:10.2337/diacare.28.2.481 · Cited by 260 · see citing works
Obesity and Bone: A Complex Relationship
Rinonapoli, G., Pace, V., Ruggiero, C., Ceccarini, P., Bisaccia, M., Meccariello, L., & Caraffa, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413662 · Cited by 271 · see citing works
Bone, Body Weight, and Weight Reduction: What Are the Concerns?
Shapses, S. A., & Riedt, C. S. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.6.1453 · Cited by 247 · see citing works
Nutritional deficiency after gastric bypass: diagnosis, prevention and treatment
Poitou, C., Ciangura, C., Coupaye, M., Czernichow, S., Bouillot, J., & Basdevant, A. (2007) · Diabetes & Metabolism · doi:10.1016/j.diabet.2006.11.004 · Cited by 232 · see citing works
Fracture risk following bariatric surgery: A population-based study
Nakamura, K. M., Haglind, E. G. C., Clowes, J. A., Achenbach, S. J., Atkinson, E. J., Melton, L. J., & Kennel, K. A. (2014) · Osteoporosis International · doi:10.1007/s00198-013-2463-x · Cited by 227 · see citing works
Bone Metabolism After Bariatric Surgery
Yu, E. W.-Y. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2226 · Cited by 212 · see citing works
Change in fracture risk and fracture pattern after bariatric surgery: nested case-control study
Rousseau, C., Jean, S., Gamache, P., Lebel, S., Mac‐Way, F., Biertho, L. D., Michou, L., & Gagnon, C. (2016) · BMJ · doi:10.1136/bmj.i3794 · Cited by 203 · see citing works
Bone loss after bariatric surgery: causes, consequences, and management
Stein, E. M., & Silverberg, S. J. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70183-9 · Cited by 199 · see citing works
Oh, K. W., Lee, W., Rhee, E., Baek, K. H., Yoon, K., Kang, M. I., Yun, E. J., Park, C., Ihm, S. H., Choi, M. G., et al. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02312.x · Cited by 198 · see citing works
Mechanick, J. I., Kushner, R. F., Sugerman, H. J., González-Campoy, J. M., Collazo–Clavell, M. L., Guven, S., Spitz, A. F., Apovian, C. M., Livingston, E. H., Brolin, R. E., et al. (2008) · Endocrine Practice · doi:10.4158/ep.14.s1.1 · Cited by 193 · see citing works
Self-citationCoupaye, M., Puchaux, K., Bogard, C., Msika, S., Jouet, P., Clerici, C., Larger, E., & Ledoux, S. (2009) · Obesity Surgery · doi:10.1007/s11695-008-9571-2 · Cited by 190 · see citing works
Bariatric surgery for pediatric extreme obesity: now or later?
Inge, T. H., Xanthakos, S. A., & Zeller, M. H. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803525 · Cited by 188 · see citing works
Johnson, J. M., Maher, J. W., Samuel, I., Heitshusen, D. S., Doherty, C., & Downs, R. W. (2005) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2005.07.012 · Cited by 179 · see citing works
Bone Health After Bariatric Surgery
Gagnon, C., & Schafer, A. L. (2018) · JBMR Plus · doi:10.1002/jbm4.10048 · Cited by 177 · see citing works
Lalmohamed, A., de Vries, F., Bazelier, M. T., Cooper, A., van Staa, T.-P., Cooper, C., & Harvey, N. C. (2012) · BMJ · doi:10.1136/bmj.e5085 · Cited by 173 · see citing works
Interdisciplinary European Guidelines on Surgery of Severe Obesity
Fried, M., Hainer, V., Basdevant, A., Buchwald, H., Deitel, M., Finer, N., Greve, J. W. M., Horber, F., Mathus-Vliegen, E. M. H., Scopinaro, N., et al. (2008) · Obesity Facts · doi:10.1159/000113937 · Cited by 171 · see citing works
True fractional calcium absorption is decreased after Roux-en-Y gastric bypass surgery
Riedt, C. S., Brolin, R. E., Sherrell, R. M., Field, M. P., & Shapses, S. A. (2006) · Obesity · doi:10.1038/oby.2006.226 · Cited by 166 · see citing works
Interdisciplinary European Guidelines for Surgery for Severe (Morbid) Obesity
Fried, M., Hainer, V., Basdevant, A., Buchwald, H., Deitel, M., Finer, N., Greve, J. W. M., Horber, F., Mathus-Vliegen, E. M. H., Scopinaro, N., et al. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9025-2 · Cited by 166 · see citing works
Mechanism Underlying the Weight Loss and Complications of Roux-en-Y Gastric Bypass. Review
Abdeen, G., & le Roux, C. (2016) · Obesity Surgery · doi:10.1007/s11695-015-1945-7 · Cited by 162 · see citing works
Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery
Carlin, A. M., Rao, D. S., Meslemani, A. M., Genaw, J. A., Parikh, N. J., Levy, S., Bhan, A., & Talpos, G. B. (2006) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2005.12.001 · Cited by 162 · see citing works
Metabolic Bone Disease after Gastric Bypass Surgery for Obesity
Prisco, C. D., & Levine, S. N. (2005) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200502000-00001 · Cited by 161 · see citing works
The Bone-Adipose Axis in Obesity and Weight Loss
Gómez‐Ambrosi, J., Rodrı́guez, A., Catalán, V., & Frühbeck, G. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9548-1 · Cited by 159 · see citing works
Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes
Capozzi, M. E., DiMarchi, R. D., Tschöp, M. H., Finan, B., & Campbell, J. E. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00117 · Cited by 153 · see citing works
Bone Loss After Bariatric Surgery: Discordant Results Between DXA and QCT Bone Density
Yu, E. W.-Y., Bouxsein, M., Roy, A. E., Baldwin, C. M., Cange, A., Neer, R. M., Kaplan, L. M., & Finkelstein, J. S. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2063 · Cited by 153 · see citing works
Nutritional deficiencies after bariatric surgery
Davies, D. J., Baxter, J. M., & BAXTER, J. N. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9208-x · Cited by 152 · see citing works
Fracture Risk After Bariatric Surgery
Lu, C., Chang, Y., Chang, H., Kuo, C.-S., Huang, C.-T., Hsu, C., & Huang, K. (2015) · Medicine · doi:10.1097/md.0000000000002087 · Cited by 153 · see citing works
Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis
Liu, C., Wu, D., Zhang, J., Xu, D., Xu, W., Chen, Y., Liu, B., Li, P., & Li, L. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1724-5 · Cited by 151 · see citing works
Two-Year Changes in Bone Density After Roux-en-Y Gastric Bypass Surgery
Yu, E. W.-Y., Bouxsein, M., Putman, M. S., Monis, E. L., Roy, A. E., Pratt, J. S. A., Butsch, W. S., & Finkelstein, J. S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4341 · Cited by 148 · see citing works
Savvidis, C., Tournis, S., & Dede, A. D. (2018) · HORMONES · doi:10.1007/s42000-018-0018-4 · Cited by 144 · see citing works
Clinical Management After Bariatric Surgery: Value of a Multidisciplinary Approach
McMahon, M. M., Sarr, M. G., Clark, M. M., Gall, M. M., Knoetgen, J., Service, F. J., Laskowski, E. R., & Hurley, D. L. (2006) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)61179-8 · Cited by 144 · see citing works
Bariatric surgery results in cortical bone loss
Stein, E. M., Carrelli, A., Young, P., Bucovsky, M., Zhang, C., Schrope, B., Bessler, M., Zhou, B., Wang, J., Guo, X. E., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2394 · Cited by 139 · see citing works
Calorie Intake and Meal Patterns up to 4 Years after Roux-en-Y Gastric Bypass Surgery
Wardé-Kamar, J., Rogers, M., Flancbaum, L., & Laferrère, B. (2004) · Obesity Surgery · doi:10.1381/0960892041975668 · Cited by 140 · see citing works
Risks and benefits of bariatric surgery: current evidence.
Brethauer, S. A., Chand, B., & Schauer, P. R. (2006) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.73.11.993 · Cited by 139 · see citing works
Self-citationGrethen, E., Hill, K. M., Jones, R., Cacucci, B. M., Gupta, C. E., Acton, A., Considine, R. V., & Peacock, M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2280 · Cited by 136 · see citing works
Vilarrasa, N., San José, P., García, I., Gómez-Vaquero, C., Medina Miras, P., de Gordejuela, A. G. R., Masdevall, C., Pujol, J., Soler, J., & Gómez, J. M. (2011) · Obesity Surgery · doi:10.1007/s11695-010-0338-1 · Cited by 129 · see citing works
Bariatric surgery, bone loss, obesity and possible mechanisms
Brzozowska, M. M., Sainsbury, A., Eisman, J. A., Baldock, P. A., & Center, J. R. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01050.x · Cited by 128 · see citing works
Carlin, A. M., Rao, D. S., Yager, K. M., Parikh, N. J., & Kapke, A. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.08.004 · Cited by 128 · see citing works
Bruno, C., Fulford, A. D., Potts, J. R., McClintock, R., Jones, R., Cacucci, B. M., Gupta, C. E., Peacock, M., & Considine, R. V. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0265 · Cited by 121 · see citing works
Kendler, D. L., Borges, J. L. C., Fielding, R. A., Itabashi, A., Krueger, D., Mulligan, K., Camargos, B. M., Sabowitz, B., Wu, C.-H., Yu, E. W., et al. (2013) · Journal of Clinical Densitometry · doi:10.1016/j.jocd.2013.08.020 · Cited by 121 · see citing works
Comparison of the Absorption of Calcium Carbonate and Calcium Citrate after Roux-en-Y Gastric Bypass
Tondapu, P., Provost, D. A., ADAMS-HUET, B. A., Sims, T. L., Chang, C., & Sakhaee, K. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9850-6 · Cited by 122 · see citing works
Anemia After Bariatric Surgery: More Than Just Iron Deficiency
von Drygalski, A., & Andris, D. A. (2009) · Nutrition in Clinical Practice · doi:10.1177/0884533609332174 · Cited by 121 · see citing works
Evers, S. S., Sandoval, D. A., & Seeley, R. J. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034423 · Cited by 118 · see citing works
Surgical Treatment of Morbid Obesity
Crookes, P. F. (2006) · Annual Review of Medicine · doi:10.1146/annurev.med.56.062904.144928 · Cited by 116 · see citing works
Nobili, V., Vajro, P., Dezsőfi, A., Fischler, B., Hadžić, N., Jahnel, J., Lamireau, T., McKiernan, P. J., McLin, V. A., Socha, P., et al. (2015) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000715 · Cited by 115 · see citing works
Vitamin D and the Bariatric Surgical Patient: A Review
Compher, C. W., Badellino, K. O., & Boullata, J. I. (2008) · Obesity Surgery · doi:10.1007/s11695-007-9289-6 · Cited by 113 · see citing works
Weight, Dietary and Physical Activity Behaviors Two Years after Gastric Bypass
Silver, H. J., Torquati, A., Jensen, G. L., & Richards, W. O. (2006) · Obesity Surgery · doi:10.1381/096089206777822296 · Cited by 112 · see citing works
Wei, J.-H., Lee, W., Chong, K., Lee, Y.-C., Chen, S.-C., Huang, P., & Lin, S. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2932-y · Cited by 112 · see citing works
Ledoux, S., Msika, S., Moussa, F., Larger, É., Boudou, P., Salomon, L., Roy, C., & Clérici, C. (2006) · Obesity Surgery · doi:10.1381/096089206778026415 · Cited by 106 · see citing works
Fernando Carrasco, N., Basfi-fer, K., Rojas, P., Valencia, A., Csendes, A., Codoceo, J., Inostroza, J., & Manuel Ruz, O. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1179-0 · Cited by 104 · see citing works
Lindeman, K. G., Greenblatt, L. B., Rourke, C., Bouxsein, M., Finkelstein, J. S., & Yu, E. W.-Y. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01496 · Cited by 103 · see citing works
Agha‐Mohammadi, S., & Hurwitz, D. J. (2008) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0b013e31817d6023 · Cited by 102 · see citing works
Metabolic Complications of Bariatric Surgery: Diagnosis and Management Issues
Mason, M. E., Jalagani, H., & Vinik, A. I. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2004.12.008 · Cited by 102 · see citing works
Scibora, L. M., Ikramuddin, S., Buchwald, H., & Petit, M. A. (2012) · Obesity Surgery · doi:10.1007/s11695-012-0596-1 · Cited by 100 · see citing works
Schafer, A. L., Kazakia, G. J., Vittinghoff, E., Stewart, L., Rogers, S. J., Kim, T. Y., Carter, J. T., Posselt, A. M., Pasco, C., Shoback, D., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3371 · Cited by 99 · see citing works
Contraceptive use among women with a history of bariatric surgery: a systematic review
Paulen, M. E., Zapata, L. B., Cansino, C. D., Curtis, K. M., & Jamieson, D. J. (2010) · Contraception · doi:10.1016/j.contraception.2010.02.008 · Cited by 99 · see citing works
Nutritional consequences of bariatric surgery
Xanthakos, S. A., & Inge, T. H. (2006) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/01.mco.0000232913.07355.cf · Cited by 99 · see citing works
Vilarrasa, N., Gómez, J. M., Elio, I., Gómez-Vaquero, C., Masdevall, C., Pujol, J., Virgili, N., Burgos, R., Sánchez-Santos, R., de Gordejuela, A. G. R., et al. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9843-5 · Cited by 91 · see citing works
Approach to the patient with secondary osteoporosis
Hofbauer, L. C., Hamann, C., & Ebeling, P. R. (2010) · European Journal of Endocrinology · doi:10.1530/eje-10-0015 · Cited by 93 · see citing works
Osteoporosis in Children and Adolescents
Baroncelli, G. I., Bertelloni, S., Sodini, F., & Saggese, G. (2005) · Pediatric Drugs · doi:10.2165/00148581-200507050-00003 · Cited by 94 · see citing works
Benchmarking Best Practices in Weight Loss Surgery
Lim, L., Blackburn, G., & Jones, D. B. (2010) · Current problems in surgery · doi:10.1067/j.cpsurg.2009.11.003 · Cited by 84 · see citing works
Campanha-Versiani, L., Pereira, D. A. G., Ribeiro-Samora, G. A., Ramos, A. V., Diniz, M. F. H. D. S., Marco, L. A. D., & Soares, M. M. S. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2618-5 · Cited by 93 · see citing works
Shanbhogue, V. V., Støving, R. K., Frederiksen, K. H., Hanson, S., Brixen, K., Gram, J., Jørgensen, N. R., & Hansen, S. G. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0014 · Cited by 93 · see citing works
Impact of bariatric surgery on oral health conditions: 6-months cohort study
de Moura‐Grec, P. G., Yamashita, J. M., Marsicano, J. A., Ceneviva, R., Leite, C. V. D. S., Brito, G. B., Brienze, S. L. A., & Peres, S. H. D. C. S. (2014) · International Dental Journal · doi:10.1111/idj.12090 · Cited by 92 · see citing works
Giusti, V, Gasteyger, C., Suter, M., Heraief, E., Gaillard, R. C., & Burckhardt, P. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803040 · Cited by 91 · see citing works
Bone and mineral metabolism in patients undergoing Roux-en-Y gastric bypass
Hage, M. P., & Fuleihan, G. E. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2480-9 · Cited by 91 · see citing works
Vitamin D in Adipose Tissue and Serum 25‐Hydroxyvitamin D After Roux‐en‐Y Gastric Bypass
Pramyothin, P., Biancuzzo, R. M., Lu, Z., Hess, D. T., Apovian, C. M., & Holick, M. F. (2011) · Obesity · doi:10.1038/oby.2011.170 · Cited by 88 · see citing works
Vilarrasa, N., de Gordejuela, A. G. R., Gómez‐Vaquero, C., Pujol, J., Elío, I., José, P. S., Toro, S., Casajoana, A., & Gómez, J. M. (2013) · Obesity Surgery · doi:10.1007/s11695-013-1016-x · Cited by 88 · see citing works
Valderas, J. P., Velasco, S., Solari, S., Yéssica Liberona, Z., Paola Viviani, G., Alberto Maiz, G., Escalona, A., & González, G., V (2009) · Obesity Surgery · doi:10.1007/s11695-009-9890-y · Cited by 88 · see citing works
Bariatric surgery and bone disease: from clinical perspective to molecular insights
Folli, F. B., Sabowitz, B., Schwesinger, W. H., Fanti, P., Guardado‐Mendoza, R., & Muscogiuri, G. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.115 · Cited by 87 · see citing works
Saltzman, E. J., Anderson, W., Apovian, C. M., Boulton, H. R. W., Chamberlain, A., Cullum‐Dugan, D., Cummings, S., Hatchigian, E., Hodges, B., Keroack, C. R., et al. (2005) · Obesity Research · doi:10.1038/oby.2005.32 · Cited by 87 · see citing works
Nutrition management of the post-bariatric surgery patient.
Handzlik-Orlik, G., Holecki, M., Orlik, B., Wylezol, M., & Duława, J. (2015) · Nutrition in clinical practice · doi:10.1177/0884533614564995 · Cited by 69 · see citing works
Mahdy, T., Attia, S. M., Farid, M., & Adulatif, A. (2008) · Obesity Surgery · doi:10.1007/s11695-008-9653-1 · Cited by 86 · see citing works
Sinha, N., Shieh, A., Stein, E. M., Strain, G. W., Schulman, A., Pomp, A., Gagner, M., Dakin, G. F., Christos, P. J., & Bockman, R. S. (2011) · Obesity · doi:10.1038/oby.2011.133 · Cited by 84 · see citing works
Dixon, J. B., Strauss, B. J., Laurie, C., & O’Brien, P. E. (2007) · Obesity · doi:10.1038/oby.2007.639 · Cited by 83 · see citing works
Murai, I. H., Roschel, H., Dantas, W. S., Gil, S. D. S., Merege-Filho, C. A. A., de Cleva, R., de Sá‐Pinto, A. L., Lima, F., Santo, M. A., Benatti, F. B., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00074 · Cited by 84 · see citing works
Risk of secondary hyperparathyroidism after laparoscopic gastric bypass surgery in obese women
Youssef, Y., Richards, W. O., Sekhar, N., Kaiser, J., Spagnoli, A., Abumrad, N., & Torquati, A. (2007) · Surgical Endoscopy · doi:10.1007/s00464-007-9228-6 · Cited by 82 · see citing works
Vitamin D Insufficiency/Deficiency in Gastrointestinal Disorders
Bikle, D. D. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.07s208 · Cited by 81 · see citing works
Nogués, X., Goday, A., Peña, M. J., Benaiges, D., de Ramón, M., Crous, X., Vial, M., Pera, M., Grande, L., Díez-Pérez, A., et al. (2010) · Cirugía Española · doi:10.1016/j.ciresp.2010.04.008 · Cited by 79 · see citing works
Bone mass loss after sleeve gastrectomy: A prospective comparative study with gastric bypass
Nogués, X., Goday, A., Peña, M. J., Benaiges, D., Ramón, M., Crous, X., Vial, M., Pera, M., Grande, L., Díez‐Pérez, A., et al. (2010) · Cirugía Española (English Edition) · doi:10.1016/s2173-5077(10)70015-6 · Cited by 80 · see citing works
Vitamin D alteration associated with obesity and bariatric surgery
Lespessailles, É., & Toumi, H. (2017) · Experimental Biology and Medicine · doi:10.1177/1535370216688567 · Cited by 77 · see citing works
- Authors
- Coates, P. S., Fernstrom, J. D., Fernstrom, M. H., Schauer, P. R., & Greenspan, S. L.
- Affiliations
- University of Pittsburgh (US)
- ORCID
- Schauer, Philip R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-03-01
- Volume
- 89
- Issue
- 3
- Pages
- 1061-1065
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2116196260
- Cited by
- 423
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 1 · 2022: 10 · 2021: 14 · 2020: 25 · 2019: 9 · 2018: 16 · 2017: 23 · 2016: 21 · 2015: 20 · 2014: 33 · 2013: 23 · 2012: 20
- FWCI
- 29.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (M01RR000056, M01-RR00056-39)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- laparoscopic Roux-en-Y gastric bypass, morbid obesity, bone turnover, bone mineral density, bone mineral content, bone resorption, osteocalcin, N-telopeptide, weight loss, bariatric surgery
- MeSH terms
- Adult, Bone and Bones, Calcium, Dietary, Female, Humans, Longitudinal Studies, Male, Middle Aged, Obesity, Morbid, Prospective Studies, Vitamin D, Gastric Bypass, Weight Loss, Bone Density, Bone Remodeling
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
