Longitudinal evaluation of efficacy, safety and nutritional status during one-year treatment with the duodenal-jejunal bypass liner
Abstract
Background The endoscopic duodenal-jejunal bypass liner (DJBL) represents a novel temporary endoscopic approach for treatment of obesity-associated type 2 diabetes. Recent results from the German DJBL registry confirmed substantial positive metabolic effects of the DJBL in type 2 diabetes. However, the last Food and Drug Administration trial was stopped due to a high occurrence of hepatic abscesses (3.5%). Objectives Here, we analyzed time courses of development of co-morbidities, nutritive changes, and occurrence of adverse events during the 1-year treatment phase with the DJBL in the German DJBL registry. Methods Sixty-six patients from the registry were analyzed for efficacy, safety, and nutritional status. Patient data sets were analyzed at implantation, 3 and 6 months after implantation, and at explantation visits. Results Weight, body mass index, glycated hemoglobin, and low-density lipoprotein cholesterol primarily declined during the first 3 months after implantation, whereas systolic and diastolic blood pressure were predominantly reduced during the second half of the treatment phase. Severe DJBL-associated side effects were mainly documented at the explantation visit (intestinal obstruction [1.7%], dislocation [1.7%], and liver abscess [1.7%]). Measurements of serum concentrations of ferritin, albumin, vitamin B12, folic acid, 25-hydroxyvitamin D3 (25 OH-Vit-D3), and calcium provided suggestive evidence of a possible decrease of nutritional absorption of vitamins and trace elements by the DJBL. Conclusions The DJBL demonstrates high efficacy with substantial improvement of all parameters of the metabolic syndrome and the potential for reduction of comedications in overweight patients with type 2 diabetes. These registry results are important to optimize recommendations for adaptation of concomitant medication, surveillance of adverse events, nutritional status and supplementation, and adaptation of the implantation period of the DJBL.
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DJBL use is associated with malabsorption-related deficiencies in ferritin, albumin, vitamin B12, and folic acid.
“Notably, DJBL use has been associated with malabsorption-related deficiencies in ferritin, albumin, vitamin B12, and folic acid [104].”
From Impact of Bariatric Surgery and Endoscopic Therapies on Liver Health in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Review (2025) · cites this paper as [104]
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- Authors
- Riedel, N., Laubner, K., Lautenbach, A., Schön, G., Schlensak, M., Stengel, R., Eberl, T., Dederichs, F., Aberle, J., & Seufert, J.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Freiburg (DE)
- Emschergenossenschaft (DE)
- Marienhospital Gelsenkirchen (DE)
- Corresponding author
- Riedel, Nina
- Venue
- Surgery for Obesity and Related Diseases
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 14
- Issue
- 6
- Pages
- 769-779
- ISSN
- 1550-7289 (ISSN-L)
- OpenAlex
- W2790718648
- Cited by
- 15
- References
- 30
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgery for Obesity and Related Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
- Health Sciences › Medicine › Surgery › Minimally Invasive Surgical Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- duodenal-jejunal bypass liner, endoscopic obesity treatment
- MeSH terms
- Blood Pressure, Diabetes Mellitus, Type 2, Duodenum, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Insulin, Jejunum, Cholesterol, LDL, Longitudinal Studies, Male, Middle Aged, Nutritional Status, Obesity, Morbid, Postoperative Complications, Registries, Abdominal Pain, Body Mass Index, Endoscopy, Gastrointestinal, Treatment Outcome, Prostheses and Implants, Bariatric Surgery
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