Long-term incidence of gallstone disease after bariatric surgery

Abstract

Background Gallstone disease is a known short-term complication of bariatric surgery; little is known of the long-term incidence. Objectives The aim of this study was to investigate the association between bariatric surgery and long-term incidence of gallstone disease. Settings A total of 25 surgery departments and 480 primary healthcare centers in Sweden. Methods The Swedish Obese Subjects study is a prospective, controlled study comparing the effects of bariatric surgery with usual care with a follow-up of 20 years, including 4047 individuals. The current report includes all participants without previous or concomitant cholecystectomy (n = 3597). Operative techniques used in the surgery group (n = 1755) were gastric bypass (n = 236), vertical banded gastroplasty (n = 1202), and gastric banding (n = 317). The control group (n = 1842) received customary treatment for obesity. Gallstone disease was a predefined secondary endpoint in the Swedish Obese Subjects study and the primary endpoint of this report. Data were obtained by cross-checking our study database with the Swedish National Patient Register of diagnosis and procedures. Results In the surgery and control groups, respectively, there were 307 and 252 first-time events of symptomatic gallstone disease and 230 and 170 cholecystectomies (log-rank P Conclusions Bariatric surgery increases the risk for symptomatic gallstone disease and cholecystectomy, especially during the first years following treatment.