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Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States

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Nersesian, Paula V., Han, Hae-Ra, Yenokyan, Gayane, Blumenthal, Roger S., Nolan, Marie T., Hladek, Melissa D., Szanton, Sarah L.·2018·Social Science & Medicine
DOI 10.1016/j.socscimed.2018.04.007PMC PMC6013269
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Abstract

Objective Middle-aged adults who are lonely have an elevated likelihood of death. Systemic inflammation may contribute to these increased odds. Using population-level data, this study tested if systemic inflammation is associated with loneliness in a broad age range of middle-aged adults in the United States.Methods This study used data from the Midlife in the US (MIDUS) survey Biomarker Project, which collected data on psychological, social, and physiological measures from a sample of middle-aged adults. This sample included the 927 participants who were 35-64 years at Biomarker Project data collection. MIDUS collected baseline data from 1995-1996 and a follow-up survey was conducted from 2004-2006. The baseline Milwaukee sample of African Americans was collected in 2005-2006 and the biomarker database was collected in 2004-2009. Biomarkers were obtained from a fasting blood sample. Self-reported loneliness was categorized as feeling lonely or not feeling lonely. Hierarchical regressions examined the association between biomarkers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein) and feeling lonely, adjusted for covariates.Results Twenty-nine percent of the sample reported feeling lonely most or some of the time. There was a positive significant relationship between loneliness and the three systemic inflammation biomarkers after controlling for covariates: interleukin-6 (n = 873) (b [se] = 0.07 [0.03], p = .014); fibrinogen (n = 867) (b [se] = 18.24 [7.12], p = .011); and C-reactive protein (n = 867) (b [se] = 0.08 [0.04], p = .035).Conclusions Feeling lonely is associated with systemic inflammation in middle-aged community-dwelling US adults.

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Research works printed but not linked: 4

  1. Cohen-Mansfield, 2015, Correlates and predictors of loneliness in older-adults: a review of quantitative results informed by qualitative insights, Int. Psychogeriatr., 1
  2. Howden, 2011, vol. 2010
  3. Humes, 2011, vol. 2010
  4. Ilg, 2001, Who was affected as teh economy started to slow?, Issues Labor Stat, 01–05, 16

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Metadata

Authors
Nersesian, P. V., Han, H.-R., Yenokyan, G., Blumenthal, R. S., Nolan, M. T., Hladek, M. D., & Szanton, S. L.
Affiliations
Johns Hopkins University (US)
Corresponding author
Nersesian, Paula V.
ORCID
Venue
Social Science & Medicine
Publisher
Elsevier BV
Published
2018-07
Volume
209
Pages
174-181
ISSN
0277-9536 (ISSN-L)
DOI
10.1016/j.socscimed.2018.04.007
PMC
PMC6013269
OpenAlex
W2800183257
Cited by
120
References
87
Citations by year
2026: 5 · 2025: 20 · 2024: 14 · 2023: 19 · 2022: 18 · 2021: 17 · 2020: 14 · 2019: 12 · 2018: 1
FWCI
11.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Social Science & Medicine (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Funders
  • the Pre-doctoral Clinical Research Training Program (TR001078)
  • Johns Hopkins Institute for Clinical and Translational Research
  • National Center for Research Resources (1UL1TR001079)
  • NCATS, NIH (UL1TR000427)
  • Interdisciplinary Training in Cardiovascular Health Research (5T32NR012704-04, 5T32NR012704-03)
  • Johns Hopkins University School of Nursing
  • National Institute of Nursing Research, NIH
  • the Jonas Nurse Scholars Program
  • the NEF Liesel M. Hiemenz scholarship
  • John D. and Catherine T. MacArthur Foundation Research Network on Successful Midlife Development
  • National Institute on Aging (P01-AG020166)
  • General Clinical Research Centers Program (M01-RR023942, M01-RR00865)
Topics
  • Social Sciences › Health › Health disparities and outcomes
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
loneliness, systemic inflammation, middle-aged adults, interleukin-6, fibrinogen, C-reactive protein, biomarkers, MIDUS, African Americans, mortality risk
MeSH terms
Adult, C-Reactive Protein, Female, Fibrinogen, Humans, Inflammation, Loneliness, Male, Middle Aged, United States, Biomarkers, Interleukin-6

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