Cited by 120Health disparities and outcomesTryptophan and brain disordersStress Responses and Cortisol

The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.

Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States

Open access

Nersesian, Paula V., Han, Hae-Ra, Yenokyan, Gayane, Blumenthal, Roger S., Nolan, Marie T., Hladek, Melissa D., Szanton, Sarah L.·2018·Social Science & Medicine

DOI 10.1016/j.socscimed.2018.04.007PMC PMC6013269

Open this paper in CoChat — free account

Abstract

Objective Middle-aged adults who are lonely have an elevated likelihood of death. Systemic inflammation may contribute to these increased odds. Using population-level data, this study tested if systemic inflammation is associated with loneliness in a broad age range of middle-aged adults in the United States.Methods This study used data from the Midlife in the US (MIDUS) survey Biomarker Project, which collected data on psychological, social, and physiological measures from a sample of middle-aged adults. This sample included the 927 participants who were 35-64 years at Biomarker Project data collection. MIDUS collected baseline data from 1995-1996 and a follow-up survey was conducted from 2004-2006. The baseline Milwaukee sample of African Americans was collected in 2005-2006 and the biomarker database was collected in 2004-2009. Biomarkers were obtained from a fasting blood sample. Self-reported loneliness was categorized as feeling lonely or not feeling lonely. Hierarchical regressions examined the association between biomarkers of systemic inflammation (interleukin-6, fibrinogen, C-reactive protein) and feeling lonely, adjusted for covariates.Results Twenty-nine percent of the sample reported feeling lonely most or some of the time. There was a positive significant relationship between loneliness and the three systemic inflammation biomarkers after controlling for covariates: interleukin-6 (n = 873) (b [se] = 0.07 [0.03], p = .014); fibrinogen (n = 867) (b [se] = 18.24 [7.12], p = .011); and C-reactive protein (n = 867) (b [se] = 0.08 [0.04], p = .035).Conclusions Feeling lonely is associated with systemic inflammation in middle-aged community-dwelling US adults.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.socscimed.2018.04.007

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
A heteroskedasticity-consistent covariance matrix estimator and a direct test for heteroskedasticity
White, H. (1980) · Econometrica · doi:10.2307/1912934 · Cited by 25,861
Happiness is everything, or is it? Explorations on the meaning of psychological well-being.
Ryff, C. D. (1989) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.57.6.1069 · Cited by 14,847
Social Relationships and Mortality Risk: A Meta-analytic Review
Holt-Lunstad, J., Smith, T. B., & Layton, J. B. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000316 · Cited by 7,272 · cited 1×
“The feeling of loneliness is subjective and quite distinct from social isolation, which is an objective measure (Holt-Lunstad et al., 2010).”
Social Relationships and Health
House, J. S., Landis, K. R., & Umberson, D. (1988) · Science · doi:10.1126/science.3399889 · Cited by 7,073
Loneliness and Social Isolation as Risk Factors for Mortality: A Meta-Analytic Review
Holt-Lunstad, J., Smith, T. B., Baker, M., Harris, T., & Stephenson, D. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691614568352 · Cited by 6,043
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595
Untitled work
(1967) · Project Euclid (Cornell University) · Cited by 4,720
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Social Well-Being
Keyes, C. L. M. (1998) · Social Psychology Quarterly · doi:10.2307/2787065 · Cited by 2,924
Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century
Case, A., & Deaton, A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518393112 · Cited by 2,759
A Meta-Analysis of Interventions to Reduce Loneliness
Masi, C. M., Chen, H.-Y., Hawkley, L. C., & Cacioppo, J. T. (2011) · Personality and Social Psychology Review · doi:10.1177/1088868310377394 · Cited by 1,995 · cited 1×
“Tests of loneliness interventions have demonstrated some success (Masi et al., 2011; Theeke et al., 2016b).”
Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies
Valtorta, N. K., Kanaan, M., Gilbody, S., Ronzi, S., & Hanratty, B. (2016) · Heart · doi:10.1136/heartjnl-2015-308790 · Cited by 1,971
Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the chicago health, aging, and social relations study
Cacioppo, J. T., Hawkley, L. C., & Thisted, R. A. (2010) · Psychology and Aging · doi:10.1037/a0017216 · Cited by 1,757
Fibrinogen and risk of cardiovascular disease. The Framingham Study
Kannel, W. B. (1987) · JAMA · doi:10.1001/jama.258.9.1183 · Cited by 1,387
Loneliness, health, and mortality in old age: A national longitudinal study
Luo, Y., Hawkley, L. C., Waite, L. J., & Cacioppo, J. T. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2011.11.028 · Cited by 1,232
Plasma Fibrinogen Level and the Risk of Major Cardiovascular Diseases and Nonvascular Mortality
Danesh, J., Lewington, S., Thompson, S. G., Lowe, G. D. O., Collins, R., Kostis, J. B., Wilson, A. C., Folsom, A. R., Wu, K., Benderly, M., et al. (2005) · JAMA · doi:10.1001/jama.294.14.1799 · Cited by 1,162
Loneliness, social isolation, and behavioral and biological health indicators in older adults.
Shankar, A., McMunn, A., Banks, J., & Steptoe, A. (2011) · Health Psychology · doi:10.1037/a0022826 · Cited by 1,100
Social Isolation and Health, with an Emphasis on Underlying Mechanisms
Cacioppo, J. T., & Hawkley, L. C. (2003) · Perspectives in Biology and Medicine · doi:10.1353/pbm.2003.0049 · Cited by 887
Loneliness and health in older adults: a mini-review and synthesis
Ong, A. D., Uchino, B. N., & Wethington, E. (2016) · Gerontology · doi:10.1159/000441651 · Cited by 868
Loneliness as a Public Health Issue: The Impact of Loneliness on Health Care Utilization Among Older Adults
Gerst-Emerson, K., & Jayawardhana, J. (2015) · American Journal of Public Health · doi:10.2105/ajph.2014.302427 · Cited by 843
Social regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745
Loneliness predicts increased blood pressure: 5-year cross-lagged analyses in middle-aged and older adults.
Hawkley, L. C., Thisted, R. A., Masi, C. M., & Cacioppo, J. T. (2010) · Psychology and Aging · doi:10.1037/a0017805 · Cited by 726
Correlates and predictors of loneliness in older-adults: a review of quantitative results informed by qualitative insights
Cohen-Mansfield, J., Hazan, H., Lerman, Y., & Shalom, V. (2016) · International Psychogeriatrics · doi:10.1017/s1041610215001532 · Cited by 691
From Social Structural Factors to Perceptions of Relationship Quality and Loneliness: The Chicago Health, Aging, and Social Relations Study
Hawkley, L. C., Hughes, M. E., Waite, L. J., Masi, C. M., Thisted, R. A., & Cacioppo, J. T. (2008) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/63.6.s375 · Cited by 666
Predictors and subjective causes of loneliness in an aged population
Savikko, N., Routasalo, P., Tilvis, R. S., Strandberg, T. E., & Pitkälä, K. H. (2005) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2005.03.002 · Cited by 641
Feelings of loneliness, but not social isolation, predict dementia onset: results from the Amsterdam Study of the Elderly (AMSTEL)
Holwerda, T. J., Deeg, D. J. H., Beekman, A. T. F., van Tilburg, T. G., Stek, M. L., Jonker, C., & Schoevers, R. A. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302755 · Cited by 633
Social Isolation and Health, with an Emphasis on Underlying Mechanisms
Cacioppo, J. T., & Hawkley, L. C. (2003) · Perspectives in biology and medicine · doi:10.1353/pbm.2003.0063 · Cited by 624
Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women
Steptoe, A., Owen, N., Kunz-Ebrecht, S. R., & Brydon, L. (2004) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00086-6 · Cited by 620 · cited 3×
“In studies that applied an acute stressor to participants in a laboratory setting, a significant relationship was found between loneliness and elevated fibrinogen and loneliness and IL-6 levels (Hackett et al., 2012; Jaremka et al., 2013; Steptoe et al., 2004).”
Loneliness in everyday life: Cardiovascular activity, psychosocial context, and health behaviors.
Hawkley, L. C., Burleson, M. H., Berntson, G. G., & Cacioppo, J. T. (2003) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.85.1.105 · Cited by 608 · cited 2×
“The health risks of loneliness are comparable to smoking about 15 cigarettes per day (Cacioppo and Hawkley, 2003; Hawkley et al., 2003; House et al., 1988; Shavelle et al., 2008).”
The prevalence of, and risk factors for, loneliness in later life: a survey of older people in Great Britain
VICTOR, C. R., SCAMBLER, S. J., BOWLING, A., & BOND, J. (2005) · Ageing and Society · doi:10.1017/s0144686x04003332 · Cited by 572
Social isolation
Cacioppo, J. T., Hawkley, L. C., Norman, G. J., & Berntson, G. G. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06028.x · Cited by 554
Handbook of Midlife Development
Lachman, M. E. (2001) · Medical Entomology and Zoology · Cited by 531
Loneliness is a unique predictor of age-related differences in systolic blood pressure.
Hawkley, L. C., Masi, C. M., Berry, J. D., & Cacioppo, J. T. (2006) · Psychology and Aging · doi:10.1037/0882-7974.21.1.152 · Cited by 488
Gender Differences in Loneliness
Borys, S., & Perlman, D. (1985) · Personality and Social Psychology Bulletin · doi:10.1177/0146167285111006 · Cited by 476
Perceived social isolation, evolutionary fitness and health outcomes: a lifespan approach
Hawkley, L. C., & Capitanio, J. P. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0114 · Cited by 468
Social Contacts and Their Relationship to Loneliness among Aged People – A Population-Based Study
Routasalo, P. E., Savikko, N., Tilvis, R. S., Strandberg, T. E., & Pitkälä, K. H. (2006) · Gerontology · doi:10.1159/000091828 · Cited by 369
Pain, depression, and fatigue: Loneliness as a longitudinal risk factor.
Jaremka, L. M., Andridge, R. R., Fagundes, C. P., Alfano, C. M., Povoski, S. P., Lipari, A. M., Agnese, D. M., Arnold, M. W., Farrar, W. B., Yee, L. D., et al. (2014) · Health Psychology · doi:10.1037/a0034012 · Cited by 346
Exercise, inflammation and aging.
(2012) · Europe PMC (PubMed Central) · Cited by 345
Bioindicators in the MIDUS National Study: Protocol, Measures, Sample, and Comparative Context
Dienberg Love, G., Seeman, T. E., Weinstein, M., & Ryff, C. D. (2010) · Journal of Aging and Health · doi:10.1177/0898264310374355 · Cited by 333 · cited 1×
“The baseline MIDUS sample enrolled non-institutionalized middle-aged and older adults in the coterminous United States through random digit dialing from 1995 to 1996 (N=7108) (Dienberg Love et al., 2010).”
Psychosocial and Behavioral Predictors of Inflammation in Middle-Aged and Older Adults: The Chicago Health, Aging, and Social Relations Study
McDade, T. W., Hawkley, L. C., & Cacioppo, J. T. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221371.43607.64 · Cited by 326
Women, Loneliness, and Incident Coronary Heart Disease
Thurston, R. C., & Kubzansky, L. D. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181b40efc · Cited by 323
Myeloid differentiation architecture of leukocyte transcriptome dynamics in perceived social isolation
Cole, S. W., Capitanio, J. P., Chun, K., Arevalo, J. M. G., Ma, J., & Cacioppo, J. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514249112 · Cited by 310
Inflamm-aging does not simply reflect increases in pro-inflammatory markers
Morrisette-Thomas, V., Cohen, A. A., Fülöp, T., Riesco, É., Legault, V., Li, Q., Milot, E., Dusseault-Bélanger, F., & Ferrucci, L. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.06.005 · Cited by 283
Loneliness and social isolation as risk factors for CVD: implications for evidence-based patient care and scientific inquiry
Holt‐Lunstad, J., & Smith, T. B. (2016) · Heart · doi:10.1136/heartjnl-2015-309242 · Cited by 282
Loneliness, lack of emotional support, lack of companionship, and the likelihood of having a heart condition in an elderly sample
Sorkin, D., Rook, K. S., & Lu, J. L. (2002) · Annals of Behavioral Medicine · doi:10.1207/s15324796abm2404_05 · Cited by 277
Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults
Varadhan, R., Yao, W., Matteini, A., Beamer, B. A., Xue, Q.-L., Yang, H., Manwani, B., Reiner, A., Jenny, N., Parekh, N., et al. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt023 · Cited by 273
Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women
Hackett, R. A., Hamer, M., Endrighi, R., Brydon, L., & Steptoe, A. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.016 · Cited by 272
National Survey of Midlife Development in the United States (MIDUS II), 2004-2006
Ryff, C. D., Almeida, D. M., Ayanian, J. Z., Carr, D., Cleary, P. D., Coe, C. L., Davidson, R. J., Krueger, R. F., Lachman, M. E., Marks, N. F., et al. (2007) · ICPSR Data Holdings · doi:10.3886/icpsr04652 · Cited by 269
Loneliness Promotes Inflammation During Acute Stress
Jaremka, L. M., Fagundes, C. P., Peng, J., Bennett, J. M., Glaser, R., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013) · Psychological Science · doi:10.1177/0956797612464059 · Cited by 255
Trends in premature mortality in the USA by sex, race, and ethnicity from 1999 to 2014: an analysis of death certificate data
Shiels, M. S., Chernyavskiy, P., Anderson, W. F., Best, A. F., Haozous, E. A., Hartge, P. A., Rosenberg, P. S., Thomas, D. A., Freedman, N. D., & de González, A. B. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30187-3 · Cited by 252
National Survey of Midlife Development in the United States (MIDUS), 1995-1996
Brim, O. G., Baltes, P. B., Bumpass, L. L., Cleary, P. D., Featherman, D. L., Hazzard, W. R., Kessler, R. C., Lachman, M. E., Markus, H. R., Marmot, M. G., et al. (1999) · ICPSR Data Holdings · doi:10.3886/icpsr02760 · Cited by 243
Contribution of Clinical Correlates and 13 C-Reactive Protein Gene Polymorphisms to Interindividual Variability in Serum C-Reactive Protein Level
Kathiresan, S., Larson, M. G., Vasan, R. S., Guo, C., Gona, P. N., Keaney, J. F., Wilson, P. W. F., Newton‐Cheh, C., Musone, S. L., Camargo, A. L., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.591271 · Cited by 229
Loneliness, health and social network among elderly people—a follow-up study
Holmén, K., & Furukawa, H. (2002) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(02)00049-3 · Cited by 214
Use of Direct Versus Indirect Approaches to Measure Loneliness in Later Life
Shiovitz-Ezra, S., & Ayalon, L. (2012) · Research on Aging · doi:10.1177/0164027511423258 · Cited by 201
A systematic review of loneliness and smoking: small effects, big implications
Dyal, S. R., & Valente, T. W. (2015) · Substance Use & Misuse · doi:10.3109/10826084.2015.1027933 · Cited by 187
Loneliness Among Older Adults: A National Survey of Adults 45+
Anderson, G. O. (2010) · doi:10.26419/res.00064.001 · Cited by 187
Sociodemographic and Health-Related Risks for Loneliness and Outcome Differences by Loneliness Status in a Sample of U.S. Older Adults
Theeke, L. A. (2010) · Research in Gerontological Nursing · doi:10.3928/19404921-20091103-99 · Cited by 186
The Role of Social Relationships in Predicting Loneliness: The National Social Life, Health, and Aging Project
Shiovitz‐Ezra, S., & Leitsch, S. A. (2010) · Social Work Research · doi:10.1093/swr/34.3.157 · Cited by 176
The Midlife in the United States (MIDUS) Series: A National Longitudinal Study of Health and Well-being
Radler, B. (2014) · Open Health Data · doi:10.5334/ohd.ai · Cited by 164
What are the keys to a longer, happier life? Answers from five decades of health psychology research
Johnson, B. T., & Acabchuk, R. L. (2017) · Social Science & Medicine · doi:10.1016/j.socscimed.2017.11.001 · Cited by 160
Inflammaging (inflammation + aging): A driving force for human aging based on an evolutionarily antagonistic pleiotropy theory?
Goto, M. (2008) · PubMed · Cited by 154
Loneliness and the metabolic syndrome in a population-based sample of middle-aged and older adults.
Whisman, M. A. (2010) · Health Psychology · doi:10.1037/a0020760 · Cited by 133
Association Between Obesity, High-Sensitivity C-Reactive Protein ≥2 mg/L, and Subclinical Atherosclerosis
Blaha, M. J., Rivera, J. J., Budoff, M. J., Blankstein, R., Agatston, A. A., O’Leary, D. H., Cushman, M., Gilchrist, S. C., Criqui, M. H., Szklo, M., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.223768 · Cited by 98
National Survey of Midlife Development in the United States (MIDUS), 1995-1996
Brim, O. G., Baltes, P. B., Bumpass, L. L., et al. (1999) · ICPSR Data Holdings · doi:10.3886/icpsr02760.v8 · Cited by 89
Population differences in proinflammatory biology: Japanese have healthier profiles than Americans
Coe, C. L., Love, G. D., Karasawa, M., Kawakami, N., Kitayama, S., Markus, H. R., Tracy, R. P., & Ryff, C. D. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.013 · Cited by 83
Smoking habit and mortality: a meta-analysis.
Shavelle, R. M., Paculdo, D. R., Strauss, D., & Kush, S. J. (2008) · PubMed · Cited by 80
Predictors of loneliness in centenarians: A parallel study
Martin, P. G., Hagberg, B., & Poon, L. W. (1997) · Journal of Cross-Cultural Gerontology · doi:10.1023/a:1006587502257 · Cited by 78
Social Relationships and Hypertension in Late Life: Evidence From a Nationally Representative Longitudinal Study of Older Adults
Yang, Y. C., Boen, C., & Mullan Harris, K. (2015) · Journal of Aging and Health · doi:10.1177/0898264314551172 · Cited by 71
Life Events and Personality Predicting Loneliness Among Centenarians: Findings From the Georgia Centenarian Study
Hensley, B., Martin, P., Margrett, J. A., MacDonald, M. M., Siegler, I. C., & Poon, L. W. (2011) · The Journal of Psychology · doi:10.1080/00223980.2011.613874 · Cited by 69
Stress and chronic illness: The inflammatory pathway
Acabchuk, R. L., Kamath, J., Salamone, J. D., & Johnson, B. T. (2017) · Social Science & Medicine · doi:10.1016/j.socscimed.2017.04.039 · Cited by 66
Fibrinogen in Obesity Before and After Weight Reduction
Ditschuneit, H. H. M., Flechtner‐Mors, M., & Adler, G. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00119.x · Cited by 64
Relationship Among Circulating Inflammatory Proteins, Platelet Gene Expression, and Cardiovascular Risk
McManus, D. D., Beaulieu, L. M., Mick, E. O., Tanrıverdi, K., Larson, M. G., Keaney, J. F., Benjamin, E. J., & Freedman, J. E. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.301112 · Cited by 62
Effectiveness of LISTEN on loneliness, neuroimmunological stress response, psychosocial functioning, quality of life, and physical health measures of chronic illness
Theeke, L. A., Mallow, J. A., Moore, J. E., McBurney, A., Rellick, S. L., & VanGilder, R. L. (2016) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2016.08.004 · Cited by 62
National Survey of Midlife Development in the United States (MIDUS II), 2004-2006
Ryff, C. D., Almeida, D. M., Ayanian, J. S., et al. (2007) · ICPSR Data Holdings · doi:10.3886/icpsr04652.v6 · Cited by 51
Loneliness, Depression, and Inflammation: Evidence from the Multi-Ethnic Study of Atherosclerosis
Mezuk, B. R., Choi, M., DeSantis, A. S., Rapp, S. R., Roux, A. V. D., & Seeman, T. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158056 · Cited by 49
Loneliness and vascular biomarkers: the Dublin Healthy Ageing Study
O’Luanaigh, C., O'Connell, H. P., Chin, A., Hamilton, F., Coen, R. F., Walsh, C., Walsh, J. B., Coakley, D., Molloy, A. M., Scott, J. M., et al. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2695 · Cited by 48
National Survey of Midlife Development in the United States (MIDUS II): Biomarker Project, 2004-2009
Ryff, C. D., Seeman, T. E., & Weinstein, M. (2010) · ICPSR Data Holdings · doi:10.3886/icpsr29282 · Cited by 48
An index of the ratio of inflammatory to antiviral cell types mediates the effects of social adversity and age on chronic illness
Simons, R. L., Lei, M.-K., Beach, S. R. H., Barr, A. B., Cutrona, C. E., Gibbons, F. X., & Philibert, R. A. (2017) · Social Science & Medicine · doi:10.1016/j.socscimed.2017.03.005 · Cited by 38
Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: Insights from identical and fraternal twins
Amaral, W. Z., Krueger, R. F., Ryff, C. D., & Coe, C. L. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.05.010 · Cited by 28
National Survey of Midlife Development in the United States (MIDUS II), 2004-2006
Ryff, C. D., Almeida, D. M., Ayanian, J. S., et al. (2007) · ICPSR Data Holdings · doi:10.3886/icpsr04652.v3 · Cited by 19
The Influence Of Neuroticism On Stress Perception And Its Resultant Negative Affect
Abbasi, I. S. (2011) · doi:10.31979/etd.tufh-avq4 · Cited by 10
Using Gene Expression Analysis to Examine Changes in Loneliness, Depression and Systemic Inflammation in Lonely Chronically Ill Older Adults
Theeke, L. A., Mallow, J. A., Moore, J., McBurney, A., VanGilder, R. L., Barr, T. L., Theeke, E., Rellick, S. L., & Petrone, A. B. (2016) · Open Journal of Nursing · doi:10.4236/ojn.2016.68066 · Cited by 9
National Survey of Midlife Development in the United States (MIDUS II): Biomarker Project, 2004-2009
Ryff, C. D., Seeman, T. E., & Weinstein, M. (2010) · ICPSR Data Holdings · doi:10.3886/icpsr29282.v4 · Cited by 9
People Who Are Not in the Labor Force: Why Aren't They Working?
Hipple, S. (2015) · eCommons (Cornell University) · Cited by 6
National Survey of Midlife Development in the United States (MIDUS II): Biomarker Project, 2004-2009
Ryff, C. D., Seeman, T. E., & Weinstein, M. (2010) · ICPSR Data Holdings · doi:10.3886/icpsr29282.v3 · Cited by 5

Research works printed but not linked: 4

Cohen-Mansfield, 2015, Correlates and predictors of loneliness in older-adults: a review of quantitative results informed by qualitative insights, Int. Psychogeriatr., 1
Howden, 2011, vol. 2010
Humes, 2011, vol. 2010
Ilg, 2001, Who was affected as teh economy started to slow?, Issues Labor Stat, 01–05, 16

Sorted by citations

Social Isolation and Loneliness in Older Adults: Review and Commentary of a National Academies Report
Donovan, N. J., & Blazer, D. (2020) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.08.005 · Cited by 739
Does loneliness contribute to mild cognitive impairment and dementia? A systematic review and meta-analysis of longitudinal studies
Lara, E., Martín-María, N., De la Torre-Luque, A., Koyanagi, A., Vancampfort, D., Izquierdo, A., & Miret, M. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.03.002 · Cited by 351
The association between loneliness, social isolation and inflammation: A systematic review and meta-analysis
Smith, K. J., Gavey, S., Riddell, N. E., Kontari, P., & Victor, C. R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.002 · Cited by 364
Social engagement and loneliness are differentially associated with neuro-immune markers in older age: time-varying associations from the English Longitudinal Study of Ageing
Walker, E., Ploubidis, G., & Fancourt, D. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.08.189 · Cited by 104
Social isolation, loneliness, and inflammation: A multi-cohort investigation in early and mid-adulthood
Matthews, T., Rasmussen, L. J. H., Ambler, A. P., Danese, A., Eugen‐Olsen, J., Fancourt, D. E., Fisher, H. L., Iversen, K. K., Schultz, M., Sugden, K., et al. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.11.022 · Cited by 117

See all 120

Authors: Nersesian, P. V., Han, H.-R., Yenokyan, G., Blumenthal, R. S., Nolan, M. T., Hladek, M. D., & Szanton, S. L.
Affiliations: Johns Hopkins University (US)
Corresponding author: Nersesian, Paula V.
ORCID: Nersesian, Paula V.
Han, Hae-Ra
Yenokyan, Gayane
Blumenthal, Roger S.
Nolan, Marie T.
Hladek, Melissa D.
Szanton, Sarah L.
Venue: Social Science & Medicine
Publisher: Elsevier BV
Published: 2018-07
Volume: 209
Pages: 174-181
ISSN: 0277-9536 (ISSN-L)
DOI: 10.1016/j.socscimed.2018.04.007
PMC: PMC6013269
OpenAlex: W2800183257
Cited by: 120
References: 87
Citations by year: 2026: 5 · 2025: 20 · 2024: 14 · 2023: 19 · 2022: 18 · 2021: 17 · 2020: 14 · 2019: 12 · 2018: 1
FWCI: 11.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 347 d)
Locations: Social Science & Medicine (acceptedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: the Pre-doctoral Clinical Research Training Program (TR001078)
Johns Hopkins Institute for Clinical and Translational Research
National Center for Research Resources (1UL1TR001079)
NCATS, NIH (UL1TR000427)
Interdisciplinary Training in Cardiovascular Health Research (5T32NR012704-04, 5T32NR012704-03)
Johns Hopkins University School of Nursing
National Institute of Nursing Research, NIH
the Jonas Nurse Scholars Program
the NEF Liesel M. Hiemenz scholarship
John D. and Catherine T. MacArthur Foundation Research Network on Successful Midlife Development
National Institute on Aging (P01-AG020166)
General Clinical Research Centers Program (M01-RR023942, M01-RR00865)
Topics: Social Sciences › Health › Health disparities and outcomes
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: loneliness, systemic inflammation, middle-aged adults, interleukin-6, fibrinogen, C-reactive protein, biomarkers, MIDUS, African Americans, mortality risk
MeSH terms: Adult, C-Reactive Protein, Female, Fibrinogen, Humans, Inflammation, Loneliness, Male, Middle Aged, United States, Biomarkers, Interleukin-6

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Loneliness in middle age and biomarkers of systemic inflammation: Findings from Midlife in the United States

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks