Implementation of first episode psychosis intervention in India – A case study in a low-and middle-income country
Open accessAbstract
First Episode Psychosis (FEP) is a serious mental illness affecting adolescents and young persons. While many effective interventions are available, there has not been much research to understand the implementation of such interventions in India and other low- and middle-income countries (LMIC). We studied the implementation of an FEP intervention program in a specialist mental health facility in Chennai, India, using a well-established framework for doing so, the Consolidated Framework for Implementation Research (CFIR). We conducted 27 in-depth interviews with the service users (15 persons with FEP and 12 family caregivers of persons with FEP). We also conducted a focus group discussion with 8 service providers and in-depth interviews with 7 other service providers including those in the service management. A thematic analysis approach was used to identify emerging themes. First, we found CFIR effectively accommodated implementation challenges evident in LMICs; that is, it is transferable to LMIC settings. Second, we highlight barriers to implementation that include cost, limited human resources, cultural and professional hierarchy, divergence from evidence-based guidelines, and lack of awareness and stigma in the wider community. Third, we highlight facilitators for implementation such as, leadership engagement, the need for change that was recognized within the service, cosmopolitan perspectives derived from clinicians' local and international collaborative experiences and expertise, compatibility of the intervention with the existing systems within the organization, accommodating the needs of the service users, and rapport developed by the service with the service users. Fourth, we propose a model of service delivery incorporating a task-sharing approach for first episode psychosis in resource restricted settings based on the feedback from the stakeholders.
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A relatively understudied phenomenon in Indian settings is the exploration of initial experiences and understandings of illness and treatment from the perspective of both patients and caregivers.
“A relatively understudied phenomenon in Indian settings is the exploration of initial experiences and understandings of illness and treatment from the perspective of both patients and caregivers, though there are rare exceptions from Central and South India (Dutta et al., 2019, Vaitheswaran et al., 2021).”
From Qualitative study to explore the perspectives and mental health experiences of first episode psychosis patients and their caregivers in North India (2024) · cites this paper as Vaitheswaran et al., 2021
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Using thematic analysis in psychology
Braun, V., & Clarke, V. (2006) · Qualitative Research in Psychology · doi:10.1191/1478088706qp063oa · Cited by 194,414 · see citing works
How Many Interviews Are Enough?: An Experiment with Data Saturation and Variability
Guest, G., Bunce, A., & Johnson, L. (2006) · Field Methods · doi:10.1177/1525822x05279903 · Cited by 20,808 · see citing works
Damschroder, L. J., Aron, D. C., Keith, R. E., Kirsh, S. R., Alexander, J. A., & Lowery, J. C. (2009) · Implementation Science · doi:10.1186/1748-5908-4-50 · Cited by 14,496 · see citing works
Diffusion of Innovations in Service Organizations: Systematic Review and Recommendations
GREENHALGH, T., ROBERT, G., MACFARLANE, F., BATE, P., & KYRIAKIDOU, O. (2004) · The Milbank Quarterly · doi:10.1111/j.0887-378x.2004.00325.x · Cited by 7,448 · see citing works
Making sense of implementation theories, models and frameworks
Nilsen, P. (2015) · Implementation Science · doi:10.1186/s13012-015-0242-0 · Cited by 4,447 · see citing works
Danaei, G., Ding, E. L., Mozaffarian, D., Taylor, B., Rehm, J., Murray, C. J. L., & Ezzati, M. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000058 · Cited by 2,860 · see citing works
Welcome to Implementation Science
Eccles, M. P., & Mittman, B. S. (2006) · Implementation Science · doi:10.1186/1748-5908-1-1 · Cited by 2,254 · see citing works
A systematic review of the use of the Consolidated Framework for Implementation Research
Kirk, M. A., Kelley, C., Yankey, N., Birken, S. A., Abadie, B., & Damschroder, L. (2015) · Implementation Science · doi:10.1186/s13012-016-0437-z · Cited by 1,496 · see citing works
Bridging Research and Practice
Tabak, R. G., Khoong, E. C., Chambers, D. A., & Brownson, R. C. (2012) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2012.05.024 · Cited by 1,386 · see citing works
Engaging patients to improve quality of care: a systematic review
Bombard, Y., Baker, G. R., Orlando, E., Fancott, C. A., Bhatia, P., Casalino, S., Oñate, K., Denis, J., & Pomey, M. (2018) · Implementation Science · doi:10.1186/s13012-018-0784-z · Cited by 1,312 · see citing works
Barriers to improvement of mental health services in low-income and middle-income countries
Saraceno, B., van Ommeren, M., Batniji, R., Cohen, A., Gureje, O., Mahoney, J., Sridhar, D., & Underhill, C. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61263-x · Cited by 1,088 · see citing works
Schizophrenia and suicide: Systematic review of risk factors
Hawton, K. E., Sutton, L., Haw, C., Sinclair, J., & Deeks, J. J. (2005) · The British Journal of Psychiatry · doi:10.1192/bjp.187.1.9 · Cited by 777 · see citing works
Kontos, P. C., & Poland, B. D. (2009) · Implementation Science · doi:10.1186/1748-5908-4-1 · Cited by 760 · see citing works
Penttilä, M., Jääskeläinen, E., Hirvonen, N., Isohanni, M., & Miettunen, J. (2014) · British Journal of Psychiatry · doi:10.1192/bjp.bp.113.127753 · Cited by 716 · see citing works
Treatment engagement of individuals experiencing mental illness: review and update
Dixon, L. B., Holoshitz, Y., & Nossel, I. (2016) · World Psychiatry · doi:10.1002/wps.20306 · Cited by 550 · see citing works
Means, A. R., Kemp, C. G., Gwayi-Chore, M.-C., Gimbel, S., Soi, C., Sherr, K., Wagenaar, B. H., Wasserheit, J. N., & Weiner, B. J. (2020) · Implementation Science · doi:10.1186/s13012-020-0977-0 · Cited by 418 · see citing works
Movsisyan, A., Arnold, L., Evans, R., Hallingberg, B., Moore, G., O’Cathain, A., Pfadenhauer, L. M., Segrott, J., & Rehfuess, E. (2019) · Implementation Science · doi:10.1186/s13012-019-0956-5 · Cited by 331 · see citing works
Eassom, E., Giacco, D., Dirik, A., & Priebe, S. (2014) · BMJ Open · doi:10.1136/bmjopen-2014-006108 · Cited by 288 · see citing works
Padmanathan, P., & De Silva, M. J. (2013) · Social Science & Medicine · doi:10.1016/j.socscimed.2013.08.004 · Cited by 278 · see citing works
Dieleman, M. A., Gerretsen, B., & van der Wilt, G. J. (2009) · Health Research Policy and Systems · doi:10.1186/1478-4505-7-7 · Cited by 247 · see citing works
Patel, V., & Thornicroft, G. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000160 · Cited by 237 · see citing works
Braithwaite, J., Herkes, J., Ludlow, K., Lamprell, G., & Testa, L. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-013758 · Cited by 225 · see citing works
Advancement in the maturing science of cultural adaptations of evidence-based interventions.
Chu, J., & Leino, A. (2017) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000145 · Cited by 225 · see citing works
Austin, S. F., Mors, O. N., Budtz–Jørgensen, E., Secher, R. G., Hjorthøj, C. R., Bertelsen, M., Jeppesen, P., Petersen, L., Thorup, A. A. E., & Nordentoft, M. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.07.021 · Cited by 203 · see citing works
Amminger, G. P., Henry, L. P., Harrigan, S., Harris, M., Álvarez‐Jiménez, M., Herrman, H., Jackson, H. J., & McGorry, P. D. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.009 · Cited by 144 · see citing works
Kirkbride, J. B., Hameed, Y. A., Ankireddypalli, G., Ioannidis, K., Crane, C. M., Nasir, M., Kabacs, N., Metastasio, A., Jenkins, O., Espandian, A., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16010103 · Cited by 144 · see citing works
Braithwaite, J., Clay‐Williams, R., Vecellio, E., Marks, D., Hooper, T. D., Westbrook, M. T., Westbrook, J. I., Blakely, B. D., & Ludlow, K. (2016) · BMJ Open · doi:10.1136/bmjopen-2016-012467 · Cited by 134 · see citing works
Wauben, L. S. G. L., Doorn, C. M. D.-V., van Wijngaarden, J. D. H., Goossens, R., Huijsman, R., Klein, J., & Lange, J. F. (2011) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzq079 · Cited by 124 · see citing works
Teamwork on inpatient medical units: assessing attitudes and barriers
O’Leary, K. J., Ritter, C., Wheeler, H., Szekendi, M. K., Brinton, T. S., & Williams, M. V. (2010) · BMJ Quality & Safety · doi:10.1136/qshc.2008.028795 · Cited by 124 · see citing works
Mindlines: making sense of evidence in practice
Gabbay, J., & le May, A. (2016) · British Journal of General Practice · doi:10.3399/bjgp16x686221 · Cited by 121 · see citing works
Steinkamp, J., Goldblatt, N. P., Borodovsky, J. T., LaVertu, A. E., Kronish, I. M., Marsch, L. A., & Schuman‐Olivier, Z. (2018) · JMIR Mental Health · doi:10.2196/12493 · Cited by 106 · see citing works
Fretheim, A., Munabi-Babigumira, S. K., Oxman, A. D., Lavis, J. N., & Lewin, S. A. (2009) · Health Research Policy and Systems · doi:10.1186/1478-4505-7-s1-s6 · Cited by 101 · see citing works
Alvarez-Jimenez, M., O’Donoghue, B., Thompson, A., Gleeson, J. F., Bendall, S., Gonzalez-Blanch, C., Killackey, E., Wunderink, L., & McGorry, P. D. (2016) · CNS Drugs · doi:10.1007/s40263-016-0331-x · Cited by 80 · see citing works
Neilson, E., Smith, K. C., Steinwachs, D. M., Phelan-Emrick, D. F., Lawrence, R. S., Bowie, J. V., & Cohen, B. J. (2015) · Implementation Science · doi:10.1186/1748-5908-10-s1-a52 · Cited by 69 · see citing works
Factors Contributing to Engagement During the Initial Stages of Treatment for Psychosis
Stewart, K. D. (2012) · Qualitative Health Research · doi:10.1177/1049732312468337 · Cited by 67 · see citing works
Longitudinal assessment of an anti-stigma campaign related to common mental disorders in rural India
Maulik, P. K., Devarapalli, S., Kallakuri, S., Tripathi, A. P., Koschorke, M., & Thornicroft, G. (2019) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.190 · Cited by 67 · see citing works
Mental health policy in South Africa: development process and content
Draper, C. E., Lund, C., Kleintjes, S., Funk, M., Omar, M. A., & Flisher, A. J. (2009) · Health Policy and Planning · doi:10.1093/heapol/czp027 · Cited by 66 · see citing works
Abidi, S., Mian, I. A., Ortega, I., Lecomte, T., Raedler, T. J., Jackson, K., Jackson, K., Pringsheim, T. M., & Addington, D. E. (2017) · The Canadian Journal of Psychiatry · doi:10.1177/0706743717720197 · Cited by 63 · see citing works
Selick, A., Durbin, J., Vu, N., O’Connor, K., Volpe, T., & Lin, E. H. B. (2017) · Early Intervention in Psychiatry · doi:10.1111/eip.12400 · Cited by 60 · see citing works
Iyer, S. N., Mangala, R., THARA, R., & MALLA, A. K. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.05.032 · Cited by 58 · see citing works
Improving Medication Adherence With Telemedicine for Adults With Severe Mental Illness
Schulze, L. N., Stentzel, U., Leipert, J., Schulte, J., Langosch, J. M., Freyberger, H. J., Hoffmann, W. U., Grabe, H. J., & van den Berg, N. (2019) · Psychiatric Services · doi:10.1176/appi.ps.201800286 · Cited by 57 · see citing works
O’Keeffe, D., Hannigan, A., Doyle, R., Kinsella, A., Sheridan, A., Kelly, A., Madigan, K. V., Lawlor, E., & Clarke, M. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867419827648 · Cited by 57 · see citing works
Cultural Specificity of Emotional Overinvolvement: A Systematic Review
Singh, S. P., Harley, K., & Suhail, K. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr170 · Cited by 55 · see citing works
Krzystanek, M., Borkowski, M., Skałacka, K., & Krysta, K. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.08.016 · Cited by 49 · see citing works
MALLA, A. K., Iyer, S. N., THARA, R., Ramachandran, P., Mohan, G., Taksal, A., Margolese, H. C., Schmitz, N., & Joober, R. (2020) · The British Journal of Psychiatry · doi:10.1192/bjp.2020.126 · Cited by 46 · see citing works
Self-citationEarly intervention in psychosis in low‐ and middle‐income countries: a WPA initiative
Singh, S. P., Javed, A., & Psychosis, O. B. O. T. W. E. I. A. P. F. E. I. I. (2020) · World Psychiatry · doi:10.1002/wps.20708 · Cited by 45 · see citing works
Reed, J. E., Green, S. A., & Howe, C. (2018) · International Journal for Quality in Health Care · doi:10.1093/intqhc/mzy158 · Cited by 32 · see citing works
How do health care organizations take on best practices? A scoping literature review
Innis, J., Dryden‐Palmer, K., Perreira, T., & Berta, W. B. (2015) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000049 · Cited by 26 · see citing works
Paddison, C. A. M., Abel, G., Burt, J., Campbell, J. L., Elliott, M. N., Lattimer, V., & Roland, M. O. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-018690 · Cited by 24 · see citing works
Shidhaye, R. R. (2015) · Australasian Psychiatry · doi:10.1177/1039856215609771 · Cited by 22 · see citing works
Early intervention for psychosis in low- and middle-income countries needs a public health approach
Farooq, S. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.113761 · Cited by 21 · see citing works
Singh, G., Manjunatha, N., Rao, S., Shashidhara, H. N., Moirangthem, S., Madegowda, R. K., Bhaskarapillai, B., & Varghese, M. (2017) · Indian Journal of Psychological Medicine · doi:10.4103/0253-7176.207325 · Cited by 21 · see citing works
Family caregivers’ needs of young patients with first episode psychosis: A qualitative study
Kumar, G., Sood, M., Verma, R., Mahapatra, A., & Chadda, R. K. (2019) · International Journal of Social Psychiatry · doi:10.1177/0020764019852650 · Cited by 21 · see citing works
Intervention for first episode psychosis in India – The SCARF experience
THARA, R., Ramamurthy, M., Mohan, G., Joseph, J., & John, S. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.01.011 · Cited by 21 · see citing works
Self-citationWaddington, C. S., McLeod, C., Morris, P. S., Bowen, A. C., Naunton, M., Carapetis, J. R., Grimwood, K., Robins-Browne, R. M., Kirkwood, C. D., Baird, R., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019632 · Cited by 20 · see citing works
Stoner, C. R., Chandra, M., Bertrand, E., Du, B., Durgante, H. B., Klaptocz, J., Krishna, M., Lakshminarayanan, M., Mkenda, S., Mograbi, D. C., et al. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.00342 · Cited by 19 · see citing works
Self-citationChavan, B., Das, S. C., Garg, R., Puri, S., & Banavaram, A. B. A. (2018) · International Journal of Social Psychiatry · doi:10.1177/0020764018792590 · Cited by 14 · see citing works
Medication adherence in first-episode psychosis and its association with psychopathology
Raghavan, V., Mohan, G., Gopal, S., Ramamurthy, M., & THARA, R. (2019) · Indian Journal of Psychiatry · doi:10.4103/psychiatry.indianjpsychiatry_148_17 · Cited by 12 · see citing works
Self-citationEARLY DETECTION AND INTERVENTION FOR PSYCHOSIS: PERSPECTIVES FROM NORTH AMERICA.
Compton, M. T., Goulding, S. M., Ramsay, C. E., Addington, J., Corcoran, C. M., & Walker, E. F. (2008) · PubMed · Cited by 12 · see citing works
Social functioning in individuals with first episode psychosis: One-year follow-up study
Raghavan, V., Ramamurthy, M., & Rangaswamy, T. (2017) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2017.09.004 · Cited by 11 · see citing works
Raghavan, V., Ramachandran, P., Mohan, G., Chandrasekaran, S., Paul, V., Pattabiraman, R., Mohan, M., Iyer, S. N., THARA, R., & Singh, S. P. (2020) · Early Intervention in Psychiatry · doi:10.1111/eip.12979 · Cited by 5 · see citing works
Self-citation
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Kaur, A., Kallakuri, S., Mukherjee, A., Wahid, S. S., Kohrt, B. A., Thornicroft, G., & Maulik, P. K. (2023) · International Journal of Mental Health Systems · doi:10.1186/s13033-023-00577-8 · Cited by 54 · see citing works
Farooq, S., Fonseka, N., Ali, M. W., Milner, A., Hamid, S., Sheikh, S., Khan, M. F., Azeemi, M. M. U. H., Ariyadasa, G., Khan, A. J., et al. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae025 · Cited by 22 · see citing works
Paquin‐Goulet, M., Krishnadas, R., & Beattie, L. (2023) · Early Intervention in Psychiatry · doi:10.1111/eip.13466 · Cited by 8 · see citing works
Sood, M., Chadda, R. K., Chawla, N., Shukla, T., Patil, V., Ratra, D., Rajhans, P., Padmavati, R., Thara, R., Raghavan, V., et al. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104121 · Cited by 5 · see citing works
Self-citationScarabelot, L. F., Araújo, J. M., Leal, L. R., Pessoa, R. M. D. P., Zuelli, F. M. D. G. C., Loureiro, C. M., Corrêa‐Oliveira, G. E., & Del‐Ben, C. M. (2024) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2024.104119 · Cited by 3 · see citing works
THARA, R., Mohan, G., & Rao, S. (2025) · Indian Journal of Psychiatry · doi:10.4103/indianjpsychiatry_657_25 · Cited by 1 · see citing works
Self-citationBurgess, N. J., Currie, G., & Hardy, A. (2023) · Organizational behaviour in health care · doi:10.1007/978-3-031-24212-0_1
Self-citationValle, R., Velez, C., & Iyer, S. N. (2025) · medRxiv · doi:10.1101/2025.11.11.25340030
Laxmi, R., Sahoo, S., Nehra, R., & Grover, S. (2025) · Journal of Psychosocial Rehabilitation and Mental Health · doi:10.1007/s40737-025-00510-x
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Rai, B. (2026) · Future Health · doi:10.25259/fh_91_2025 · Cited by 1 · see citing works
Valle, R., Morrison, N., Raghavan, V., & Iyer, S. N. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2026.103795
Valle, R., Velez, C., & Iyer, S. N. (2026) · PLOS Global Public Health · doi:10.1371/journal.pgph.0005531
Venkatesan, S., Livingston, G., Vaitheswaran, S., Nagarajan, G., Srinivasan, N., Ramanujam, V., Sargunan, S., Fisher, E., Rapaport, P., & Spector, A. E. (2026) · Aging & Mental Health · doi:10.1080/13607863.2026.2631447
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- Authors
- Vaitheswaran, S., Currie, G., Dhandapani, V. R., Mohan, G., Rangaswamy, T., & Preet Singh, S.
- Affiliations
- Schizophrenia Research Foundation (IN)
- University of Warwick (GB)
- Corresponding author
- Vaitheswaran, Sridhar
- Venue
- SSM - Mental Health
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 1
- Pages
- 100018
- ISSN
- 2666-5603 (ISSN-L)
- PMC
- PMC8654684
- OpenAlex
- W3196842701
- Cited by
- 13
- References
- 61
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 3
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- SSM - Mental Health (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute for Health Research
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- first-episode psychosis, implementation research, Consolidated Framework for Implementation Research, task sharing, low- and middle-income countries, mental health service delivery, barriers and facilitators, stigma, family caregivers, service user perspectives, leadership engagement, resource-limited settings
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