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A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs
Open accessAbstract
Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, principally pericytes, in multiple human organs including skeletal muscle, pancreas, adipose tissue, and placenta, on CD146, NG2, and PDGF-Rbeta expression and absence of hematopoietic, endothelial, and myogenic cell markers. Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. Irrespective of their tissue origin, long-term cultured perivascular cells retained myogenicity; exhibited at the clonal level osteogenic, chondrogenic, and adipogenic potentials; expressed MSC markers; and migrated in a culture model of chemotaxis. Expression of MSC markers was also detected at the surface of native, noncultured perivascular cells. Thus, blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
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“MSCs can function as perivascular-like support cells, physically associating with endothelial networks and promoting their architecture through direct contact mechanisms (Au et al., 2008; Crisan et al., 2008).”
From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Crisan et al., 2008
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Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Human Adipose Tissue Is a Source of Multipotent Stem Cells
Zuk, P. A., Zhu, M., Ashjian, P. H., Ugarte, D. A. D., Huang, J. I., Mizuno, H., Alfonso, Z. C., Fraser, J. K., Benhaim, P., & Hedrick, M. H. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0105 · Cited by 6,762
Caplan, A. I. (1991) · Journal of Orthopaedic Research® · doi:10.1002/jor.1100090504 · Cited by 6,559
Sacchetti, B., Funari, A., Michienzi, S., Di Cesare, S., Piersanti, S., Saggio, I., Tagliafico, E., Ferrari, S., Robey, P. G., Riminucci, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.025 · Cited by 2,226
Isolation of multipotent adult stem cells from the dermis of mammalian skin
Toma, J. G., Akhavan, M., Fernandes, K. J. L., Barnabé‐Heider, F., Sadikot, A. F., Kaplan, D. R., & Miller, F. D. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-778 · Cited by 1,593
In Search of the In Vivo Identity of Mesenchymal Stem Cells
da Silva Meirelles, L., Caplan, A. I., & Nardi, N. B. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1122 · Cited by 1,077
Surface protein characterization of human adipose tissue‐derived stromal cells
Gronthos, S., Franklin, D. M., Leddy, H. A., Robey, P. G., Storms, R. W., & Gimble, J. M. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1138 · Cited by 1,049
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells
Dellavalle, A., Sampaolesi, M., Tonlorenzi, R., Tagliafico, E., Sacchetti, B., Perani, L., Innocenzi, A., Gálvez, B. G., Messina, G., Roberta Morosetti, A., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1542 · Cited by 1,021
Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain
Jiang, Y., Vaessen, B., Lenvik, T. R., Blackstad, M., Reyes, M., & Verfaillie, C. M. (2002) · Experimental Hematology · doi:10.1016/s0301-472x(02)00869-x · Cited by 862
Identification of a novel population of muscle stem cells in mice
Qu‐Petersen, Z., Deasy, B. M., Jankowski, R., Ikezawa, M., Cummins, J. H., Pruchnic, R., Mytinger, J. R., Cao, B., Gates, C., Wernig, A., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108150 · Cited by 848
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Correa, D., Somoza, R. A., Lin, P. Y., Schiemann, W. P., & Caplan, A. I. (2015) · International Journal of Cancer · doi:10.1002/ijc.29709 · Cited by 72
Emerging biology of vascular wall progenitor cells in health and disease
Tilki, D., Hohn, H., Ergün, B., Rafii, S., & Ergün, S. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.09.004 · Cited by 72
Human Blood-Vessel-Derived Stem Cells for Tissue Repair and Regeneration
Chen, C.-W., Corselli, M., Péault, B., & Huard, J. (2012) · BioMed Research International · doi:10.1155/2012/597439 · Cited by 72
“The application of pericytes in regenerative medicine was first examined in SCID mouse models of injured and dystrophic skeletal muscle [26].”
BackgroundInfluentialSelf-citationSPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity
Rivera, L. B., & Brekken, R. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201011143 · Cited by 72
“SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-1 activity”
Stem Cell-based Tissue Engineering Approaches for Musculoskeletal Regeneration
Brown, P. T., Handorf, A. M., Jeon, W. B., & Li, W. (2013) · Current Pharmaceutical Design · doi:10.2174/13816128113199990350 · Cited by 75
Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis
Qian, W., Gong, L., Cui, X., Zhang, Z., Bajpai, A., Liu, C., Castillo, A. B., Teo, J. C. M., & Chen, W. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b16314 · Cited by 73
The nervous system orchestrates and integrates craniofacial development: a review
Adameyko, I., & Fried, K. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00049 · Cited by 69
“It has been suggested that pericytes (also called adventitial or Rouget cells) may represent mesenchymal stem or progenitor cells (Crisan et al., 2008), since they can differentiate into a variety of MSC cell types, such as fibroblasts, chondroblasts, osteoblasts, odontoblasts, adipocytes, vascular…”
BackgroundMabuchi, Y., Houlihan, D. D., Akazawa, C., Okano, H., & Matsuzaki, Y. (2013) · Stem Cells International · doi:10.1155/2013/507301 · Cited by 71
“[58] used immunohistochemistry to examine various tissue types (e.”
BackgroundMethodPeriodontal Tissue Regeneration Using Syngeneic Adipose-Derived Stromal Cells in a Mouse Model
Lemaitre, M., Monsarrat, P., Blasco‐Baqué, V., Loubières, P., Burcelin, R., Casteilla, L., Planat‐Benard, V., & Kémoun, P. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2016-0028 · Cited by 71
Self-citationMizuno, M., Katano, H., Mabuchi, Y., Ogata, Y., Ichinose, S., Fujii, S., Otabe, K., Komori, K., Ozeki, N., Koga, H., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0870-9 · Cited by 71
“To better characterize this heterogeneity, surface markers have been investigated for bone marrow MSCs from the osteoblast region [8], endosteum region [9], and perivascular region [10].”
BackgroundOn, S.-W., Cho, S.-W., Byun, S., & Yang, B. (2021) · Antioxidants · doi:10.3390/antiox10050680 · Cited by 71
Distinct skeletal stem cell types orchestrate long bone skeletogenesis
Ambrosi, T. H., Sinha, R., Steininger, H. M., Hoover, M. Y., Murphy, M. P., Koepke, L. S., Wang, Y., Lu, W.-J., Morri, M., Neff, N. F., et al. (2021) · eLife · doi:10.7554/elife.66063 · Cited by 70
Martin, E. C., Qureshi, A. T., Dasa, V., Freitas, M. A., Gimble, J. M., & Davis, T. A. (2015) · Biochimie · doi:10.1016/j.biochi.2015.02.012 · Cited by 71
Regulation of Mesenchymal Stem Cell Activity by Endothelial Cells
Saleh, F., Whyte, M., Ashton, P. D., & Genever, P. G. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0168 · Cited by 71
Human Adipose Tissue as a Source of Cells with Angiogenic Potential
Szöke, K., Beckstrøm, K. J., & Brinchmann, J. E. (2011) · Cell Transplantation · doi:10.3727/096368911x580518 · Cited by 71
Mascarenhas, M. I., Parker, A., Dzierzak, E. A., & Ottersbach, K. (2009) · Blood · doi:10.1182/blood-2009-06-230037 · Cited by 71
Grisendi, G., Annerén, C., Cafarelli, L., Sternieri, R., Veronesi, E., Cervo, G. L., Luminari, S., Maur, M., Frassoldati, A., Palazzi, G., et al. (2010) · Cytotherapy · doi:10.3109/14653241003649510 · Cited by 71
Kimmel, H. M., Rahn, M., & Gilbert, T. W. (2010) · Journal of the American College of Clinical Wound Specialists · doi:10.1016/j.jcws.2010.11.002 · Cited by 71
Avolio, E., Rodríguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002043 · Cited by 71
Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment
Brennen, W. N., Denmeade, S. R., & Isaacs, J. T. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0151 · Cited by 75
“…peripheral tissues, including fat, skin, dental pulp, and pancreas (Zuk et al. 2002, da Silva Meirelles et al. 2006, Zhang et al. 2006, Davani et al. 2007, Crisan et al. 2008, Blasi et al. 2011) and are likely present in all tissues at low levels as part of a homeostatic surveillance mechanism.”
InfluentialSun, Y., Chen, S., Xicheng, Z., & Pei, M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312425 · Cited by 71
“There is another opinion suggesting that ADSC populations may be identical to pericytes.(53,73) Traktuev et al(50) demonstrated that CD34+ ADSCs are indeed resident pericytes that”
ResultKlimczak, A., Kozłowska, U., & Kurpisz, M. K. (2018) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-018-0509-7 · Cited by 72
“Pericytes Muscle resident pericytes are the next muscle progenitors of mesenchymal origin with a cell marker signature identical to MSCs (Birbrair et al. 2014; Caplan and Correa 2011; Crisan et al. 2008; Dellavalle et al. 2011; Traktuev et al. 2008).”
Fathi‐Achachelouei, M., Keskin, D. S., Bat, E., Vrana, N. E., & Tezcaner, A. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34544 · Cited by 71
Ogle, M. E., Doron, G., Levy, M. J., & Temenoff, J. S. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0030 · Cited by 71
“12,13 The in vivo MSC perivascular environment and in vitro tissue culture poly-styrene (TCP) substrates differ fundamentally in elastic modulus.”
Long, J. T., Leinroth, A. P., Liao, Y., Ren, Y., Mirando, A. J., Nguyen, T., Guo, W., Sharma, D., Rouse, D., Wu, C., et al. (2022) · eLife · doi:10.7554/elife.76932 · Cited by 71
Potential of adipose-derived stem cells in muscular regenerative therapies
Forcales, S. V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00123 · Cited by 71
“For instance, many works report that CD146 is not expressed by ASCs, however there is data suggesting that a subset of ASCs express CD146 and localize to areas surrounding blood vessels (Crisan et al., 2008; Zannettino et al., 2008; Cai et al., 2011), arguing in favor that a pericyte multipotent population resides in…”
BackgroundKluth, S. M., Buchheiser, A., Houben, A. P., Geyh, S., Krenz, T., Radke, T. F., Wiek, C., Hanenberg, H., Reinecke, P., Wernet, P., et al. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0070 · Cited by 70
“[ 41 ], MSC derived from pericytes exhibit a very strong adipogenic differentiation even on a clonal level.”
Paul, J., Coulombe, K. L. K., Tóth, P. T., Zhang, Y., Marsboom, G., Bindokas, V. P., Smith, D. W., Murry, C. E., & Rehman, J. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.09.005 · Cited by 74
Brain mesenchymal stem cells: The other stem cells of the brain?
Appaix, F. (2014) · World Journal of Stem Cells · doi:10.4252/wjsc.v6.i2.134 · Cited by 71
Rakian, A., Yang, W.-C., Gluhak‐Heinrich, J., Cui, Y., Harris, M. A., Villarreal, D., Feng, J. Q., MacDougall, M. J., & Harris, S. E. (2013) · International Journal of Oral Science · doi:10.1038/ijos.2013.41 · Cited by 70
Braun, J., Kurtz, A., Barutcu, N., Bodo, J., Thiel, A., & Dong, J. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0263 · Cited by 70
“…from virtually all vascularized human tissues, for example, bone marrow, placenta, and adipose tissue-derived MSC (AT-MSC) [2–4]; (ii) The frequency of MSC progenitors depends on the degree of tissue vascularization [5]; and (iii) MSC progenitors can be enriched by the pericyte marker CD146 [6,7].”
InfluentialAicher, W. K., Bühring, H., Hart, M. L., Rolauffs, B., Badke, A., & Klein, G. (2010) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2010.12.004 · Cited by 70
Self-citationMultidistrict human mesenchymal vascular cells: pluripotency and stemness characteristics
Pasquinelli, G., Pacilli, A., Alviano, F., Foroni, L., Ricci, F., Valente, S., Orrico, C., Lanzoni, G., Buzzi, M., Tazzari, P. L., et al. (2010) · Cytotherapy · doi:10.3109/14653241003596679 · Cited by 70
Adipose derived pericytes rescue fractures from a failure of healing – non-union
Tawonsawatruk, T., West, C., Murray, I. R., Soo, C. B., Péault, B., & Simpson, H. (2016) · Scientific Reports · doi:10.1038/srep22779 · Cited by 70
Self-citationUsing biomaterials to rewire the process of wound repair
Stejskalová, A., & Almquist, B. D. (2017) · Biomaterials Science · doi:10.1039/c7bm00295e · Cited by 71
Su, S., Guntur, A. R., Nguyen, D. C., Fakory, S. S., Doucette, C. C., Leech, C. M., Lotana, H., Kelley, M., Kohli, J. S., Martino, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.037 · Cited by 70
“T2 iPSC-adipogenic precursors also displayed increased surface expression of the mural cell markers CD146 and NG2 and the adipogenic precursor marker MSCA1 (Figure 6B).”
BackgroundMukherjee, S., Darzi, S., Paul, K., Werkmeister, J. A., & Gargett, C. E. (2019) · Interface Focus · doi:10.1098/rsfs.2018.0089 · Cited by 74
Huynh, N. P. T., Zhang, B., & Guilak, F. (2018) · The FASEB Journal · doi:10.1096/fj.201800534r · Cited by 68
“Mesenchymal stem/stromal cells (MSCs) were originally identifiedas amultipotent cell type found in thebone marrow (3), and more recently, similar cells have been identified throughout the body as populationsof pericytes (4, 5).”
BackgroundRagni, E., Orfei, C. P., Luca, P. D., Colombini, A., Viganò, M., & de Girolamo, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051582 · Cited by 70
“MSCs are multipotent cells with a high capacity for self-renewal that, in adult life, are found dormant in vivo as pericytes and, once activated, take part in tissue repair [9].”
BackgroundThe vascularization paradox of non-union formation
Menger, M. M., Laschke, M. W., Nussler, A. K., Menger, M. D., & Histing, T. (2022) · Angiogenesis · doi:10.1007/s10456-022-09832-x · Cited by 69
“Pericytes are vital for the stabilization and maturation of blood microvessels [41].”
BackgroundLin, P. Y., Correa, D., Kean, T. J., Awadallah, A., Dennis, J. E., & Caplan, A. I. (2013) · Molecular Therapy · doi:10.1038/mt.2013.221 · Cited by 69
Zheng, Z. S., Jia, J., Zhang, X., Zara, J. N., Yin, W., Chiang, M., Liu, Y., Wang, J., Pang, S., Ting, K., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.049 · Cited by 68
“Half of the medium was renewed every 4 days [22].”
BackgroundMethodPericyte Regulation of Vascular Remodeling Through the CXC Receptor 3
Bodnar, R. J., Rodgers, M. E., Chen, W. C. W., & Wells, A. H. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302012 · Cited by 69
“with microvascular structures (arterioles, venules, and capillaries), thus are designated as pericytes.(19) These pericytes”
BackgroundMethodHuman endothelial stem/progenitor cells, angiogenic factors and vascular repair
Watt, S. M., Athanassopoulos, A., Harris, A. L., & Tsaknakis, G. (2010) · Journal of The Royal Society Interface · doi:10.1098/rsif.2010.0377.focus · Cited by 69
“…the subendothelial zone of the intima or in the 'vasculogenic zone' in the adventitia close to the medial layer, with both regions also containing MSCs (Zengin et al. 2006; Ergun et al. 2007; Crisan et al. 2008; Passman et al. 2008; Campagnolo et al. 2010; Klein et al. 2010; Watt et al. in press).”
BackgroundDiabetes Irreversibly Depletes Bone Marrow–Derived Mesenchymal Progenitor Cell Subpopulations
Januszyk, M., Sorkin, M., Glotzbach, J. P., Vial, I. N., Maan, Z. N., Rennert, R. C., Duscher, D., Thangarajah, H., Longaker, M. T., Butte, A. J., et al. (2014) · Diabetes · doi:10.2337/db13-1366 · Cited by 72
“In addition, it has been shown that bone marrow-derived MPCs contribute to postnatal vasculogenesis (17; 34-36), and some groups have suggested a supportive role for these cells as vascular pericytes that promote vasculogenesis locally through the release of growth factors (37; 38).”
BackgroundDrouet, M., & Hérodin, F. (2010) · International Journal of Radiation Biology · doi:10.3109/09553001003789604 · Cited by 69
“) may be members of the large pericyte family (Crisan et al. 2009).”
BackgroundKaneko, J., Enya, A., Enomoto, K., Ding, Q., & Hisatsune, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-12785-7 · Cited by 67
Mesenchymal stromal/stem cells as potential therapy in diabetic retinopathy
Fiori, A., Terlizzi, V., Kremer, H., Gebauer, J. E., Hammes, H., Harmsen, M. C., & Bieback, K. (2018) · Immunobiology · doi:10.1016/j.imbio.2018.01.001 · Cited by 69
Castellano, G., Franzin, R., Stasi, A., Divella, C., Sallustio, F., Pontrelli, P., Lucarelli, G. T., Battaglia, M., Staffieri, F., Crovace, A., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01002 · Cited by 71
Ryu, B., Sekine, H., Homma, J., Kobayashi, T., Kobayashi, E., Kawamata, T., & Shimizu, T. (2019) · Journal of neurosurgery · doi:10.3171/2018.11.jns182331 · Cited by 68
Gong, L., Zhang, Y., Zhu, Y., Lee, U., Luo, A. C., Li, X., Wang, X., Chen, D., Pu, W. T., Lin, R., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.05.014 · Cited by 73
Yang, W., Guo, D., Harris, M. A., Cui, Y., Gluhak‐Heinrich, J., Wu, J., Chen, X., Skinner, C., Nyman, J. S., Edwards, J., et al. (2013) · Journal of Cell Science · doi:10.1242/jcs.118596 · Cited by 67
Yoshida, T., Washio, K., Iwata, T., Okano, T., & Ishikawa, I. (2012) · International Journal of Dentistry · doi:10.1155/2012/307024 · Cited by 68
“One group of researchers demonstrated that MSCs are localised in the perivascular compartment [44].”
BackgroundTsang, W. P., Shu, Y., Kwok, P. L., Zhang, F., Lee, K. K., Tang, F. M. K., Li, G., Chan, K. M., Chan, W., & Wan, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076153 · Cited by 68
“HUCPVCs are rich in source, highly clonogenic [14], biologically potent [24], immunosuppressive and non-alloreactive [25].”
BackgroundCharacterization of OP9 as authentic mesenchymal stem cell line
Gao, J., Yan, X., Ren, L., Liu, Y., He, W., Sun, S., Zhang, Y., Liu, B., Xiong, J., & Mao, N. (2010) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(09)60067-9 · Cited by 68
Identity of tendon stem cells – how much do we know?
Lui, P. P. Y. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12007 · Cited by 68
“Some studies further suggested that MSCs were derived from pericytes [19, 25].”
BackgroundOdgren, P. R., Witwicka, H., & Reyes‐Gutierrez, P. (2016) · Connective Tissue Research · doi:10.3109/03008207.2016.1140752 · Cited by 68
“Recent reviews have examined roles for microRNAs in this process (61,97).”
Mesenchymal Stem Cells: Roles and Relationships in Vascularization
Melchiorri, A. J., Nguyen, B. B., & Fisher, J. P. (2014) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2013.0541 · Cited by 72
“MSCs have been found in close association with blood vessels in a wide variety of tissues.(13,14) Even though MSCs are located very closely to vascular structures, they are often still found in a relatively low oxygen environment, which further supports the finding that a hypoxic surrounding may be necessary in order…”
BackgroundSpinal cord injuries: how could cell therapy help?
Badner, A., Siddiqui, A. M., & Fehlings, M. G. (2017) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2017.1308481 · Cited by 67
“Present in adult and fetal tissues, MSCs can be isolated from bone marrow, cartilage, adipose tissue, placenta, umbilical cord, and the perivascular niche of most organs [28].”
BackgroundPericytes as a Source of Osteogenic Cells in Bone Fracture Healing
Supakul, S., Yao, K., Ochi, H., Shimada, T., Hashimoto, K., Sunamura, S., Mabuchi, Y., Tanaka, M., Akazawa, C., Nakamura, T., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051079 · Cited by 68
“Pericytes are defined as the cells that surround the endothelial cells of capillaries and microvessels [9].”
BackgroundNano‐Enabled Approaches for Stem Cell‐Based Cardiac Tissue Engineering
Kharaziha, M., Memić, A., Akbari, M., Brafman, D. A., & Nikkhah, M. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600088 · Cited by 69
Mesenchymal stem cell modification of endothelial matrix regulates their vascular differentiation
Lozito, T. P., Taboas, J. M., Kuo, C. K., & Tuan, R. S. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22166 · Cited by 67
“MSCs have recently been shown to occupy a perivascular niche [Crisan et al., 2008], making studies investigating the interactions between MSCs and EC-matrix particularly poignant.”
BackgroundCipriani, P., Marrelli, A., Benedetto, P. D., Liakouli, V., Carubbi, F., Ruscitti, P., Alvaro, S., Pantano, I., Campese, A. F., Grazioli, P., et al. (2013) · Angiogenesis · doi:10.1007/s10456-013-9338-9 · Cited by 67
“Pericytes help endothelial cells to form networks and lead their maturation through direct contact and interactions [49] by synthesis of growth factors [50] and formation of the mural wall of new blood vessels [19, 51].”
BackgroundLionetti, V., Cantoni, S., Cavallini, C., Bianchi, F., Valente, S., Frascari, I., Olivi, E., Aquaro, G. D., Bonavita, F., Scarlata, I., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.087254 · Cited by 67
Montemurro, T., Andriolo, G., Montelatici, E., Weissmann, G., Crisan, M., Colnaghi, M. R., Rebulla, P., Mosca, F., Péault, B., & Lazzari, L. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01047.x · Cited by 67
“Extending these previous observations, some of us validated the CD146 NG2 PDGF-R ALP CD34 CD45 vWF CD144 phenotype as an indicator of pericyte/perivascular cell identity throughout human foetal and adult organs including muscle, pancreas, bone marrow, adipose tissue and placenta [13].”
InfluentialSelf-citationRecent insights into the identity of mesenchymal stem cells
Murray, I. R., Corselli, M., Petrigliano, F. A., Soo, C. B., & Péault, B. (2014) · The Bone & Joint Journal · doi:10.1302/0301-620x.96b3.32789 · Cited by 67
Self-citationCellular strategies to promote vascularisation in tissue engineering applications
Costa‐Almeida, R., Granja, P. L., Soares, R. A., & Guerreiro, S. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a05 · Cited by 71
The pericyte microenvironment during vascular development
Payne, L. B., Zhao, H., James, C. C., Darden, J. A., McGuire, D. R., Taylor, S., Smyth, J. W., & Chappell, J. C. (2019) · Microcirculation · doi:10.1111/micc.12554 · Cited by 69
Mesenchymal Stem Cells in Cardiology
White, I. A., Sanina, C., Balkan, W., & Hare, J. M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3584-0_4 · Cited by 68
“MSCs being pericytic or adventitial cells require adhesion to a substrate to maintain viability, which in vivo constitutes perivascular adhesion to sinusoids or large vessels, respectively[29, 160].”
Impaired regeneration: A role for the muscle microenvironment in cancer cachexia
Talbert, E. E., & Guttridge, D. C. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.009 · Cited by 71
Effects of Stem Cell Treatment in Human Patients With Peyronie Disease
Levy, J., Marchand, M., Iorio, L., Zribi, G., & Zahalsky, M. (2015) · The Journal of the American Osteopathic Association · doi:10.7556/jaoa.2015.124 · Cited by 61
Hierarchization of Myogenic and Adipogenic Progenitors Within Human Skeletal Muscle
Pisani, D. F., Clément, N., Loubat, A., Plaisant, M., Sacconi, S., Kurzenne, J., Desnuelle, C., Dani, C., & Dechesne, C. A. (2010) · Stem Cells · doi:10.1002/stem.537 · Cited by 71
Todorčević, M., Škugor, S., Krasnov, A., & Ruyter, B. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-39 · Cited by 67
“Isolated pericytes differentiate into mesenchymal stem cells (MSCs), which in turn, give rise to various cell types including osteoblasts, chondrocytes, smooth muscle cells, fibroblasts, macrophages and adipocytes [5-9].”
BackgroundBone marrow Derived Pluripotent Cells are Pericytes which Contribute to Vascularization
Cai, X., Lin, Y., Friedrich, C. C., Neville, C. M., Pomerantseva, I., Sundback, C. A., Sharma, P., Zhang, Z., Vacanti, J. P., Hauschka, P. V., et al. (2009) · Stem Cell Reviews and Reports · doi:10.1007/s12015-009-9097-6 · Cited by 66
“But now we can use FACS to enrich bone marrow stem cells by some typical markers of pericytes, such as Desmin, α-SMA CD146, NG2, and PDGF-Rβ and so on [ 7 ].”
BackgroundMethodResultInfluentialBouacida, A., Rosset, P., Trichet, V., Guilloton, F., Espagnolle, N., Cordonier, T., Heymann, D., Layrolle, P., Sensebé, L., & Deschaseaux, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048648 · Cited by 66
“Hence, whatever their origin, BM or adipose tissue, MSCs were recently classified as pericytic cells, even if all pericytes are not MSCs [11].”
BackgroundBakopoulou, A., Leyhausen, G., Volk, J., Koidis, P. T., & Geurtsen, W. (2013) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2013.06.018 · Cited by 66
“CD146 on the other hand, has been found to be expressed in all types of human endothelial cells,(26) but also in various types of dental MSCs(27) and is considered as a typical marker of the perivascular SC niche.(12) In the present study, CD146 showed medium to high initial expression in different SCAP cultures (47.”
BackgroundCellular Kinetics of Perivascular MSC Precursors
Chen, W. C. W., Park, T. S., Murray, I. R., Zimmerlin, L., Lazzari, L., Huard, J., & Péault, B. (2013) · Stem Cells International · doi:10.1155/2013/983059 · Cited by 68
“These human blood vesselderived precursor cell subsets, including pericytes (PCs) [23], adventitial cells (ACs) [24], and myogenic endothelial cells (MECs) [25], can be isolated via fluorescence-activated cell sorting (FACS) based on their unique expression of cell surface antigens.”
BackgroundMethodInfluentialSelf-citationαSMA-Expressing Perivascular Cells Represent Dental Pulp Progenitors In Vivo
Zdrilić, I. V., Banerjee, A., Fatahi, R., Matthews, B. G., Dyment, N. A., Kalajzić, I., & Mina, M. (2016) · Journal of Dental Research · doi:10.1177/0022034516678208 · Cited by 66
“Many of these studies indicated that MSCs in many organs reside in a perivascular niche and that MSCs originate from pericytes, which are perivascular cells that wrap around endothelial cells in capillaries and microvessels (Crisan et al. 2008; Crisan et al. 2009; Crisan et al. 2011; Gökçinar-Yagci et al. 2015).”
BackgroundInfluentialBack to the future: Moving beyond “mesenchymal stem cells”
Bianco, P. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23103 · Cited by 66
Wu, J., Sun, Y. W., Block, T. J., Marinkovic, M., Zhang, Z.-L., Chen, R., Yin, Y., Song, J., Dean, D. D., Lu, Z., et al. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0437-6 · Cited by 65
“Such a correlation may be explained by the fact that CD146 is a marker for pericytes which have been proposed to give rise to MSCs [37].”
BackgroundLozito, T. P., & Tuan, R. S. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22744 · Cited by 65
“MSCs have been shown to be perivascular (Crisan et al., 2008), and their interaction with microECs and MPs is physiologically relevant.”
BackgroundSchneider, R. K., Anraths, J., Kramann, R., Bornemann, J., Bovi, M., Knüchel, R., & Neuß, S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.07.003 · Cited by 65
“Recent reports proposed that MSC can function as vascular pericytes and identified the vascular tube as their stem cell niche [4].”
BackgroundStem Cell Interactions in a Bone Marrow Niche
Isern, J., & Méndez‐Ferrer, S. (2011) · Current Osteoporosis Reports · doi:10.1007/s11914-011-0075-y · Cited by 69
“MSCs in human bone marrow and elsewhere are subendothelial cells [34] that express the surface markers STRO1 [35] or CD146 [36].”
BackgroundBone regeneration: the stem/progenitor cells point of view
Deschaseaux, F., Pontikoglou, C. G., & Sensebé, L. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00878.x · Cited by 66
“CD31 PECAM-1 (platelet endothelial cell adhesion molecule) [59, 60] [18] [114]”
BackgroundRole of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis
Kawabe, J.-I., & Hasebe, N. (2014) · BioMed Research International · doi:10.1155/2014/701571 · Cited by 65
“Multipotent pericytes can differentiate into mesodermal and ectodermal cell lineage, including smooth muscle cells, osteoblasts, adipocytes, and skeletal muscle cells [12–16].”
BackgroundMesenchymal Stem Cells Maintain Long-Term In Vitro Stemness During Explant Culture
Otte, A., Bucan, V., Reimers, K., & Hass, R. (2013) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2013.0007 · Cited by 66
Vasculogenic Cytokines in Wound Healing
Wong, V., & Crawford, J. D. (2013) · BioMed Research International · doi:10.1155/2013/190486 · Cited by 67
“Another cell population intimately involved in vascular morphogenesis is the pericyte, a supportive stromal-like cell that retains the pluripotency of mesenchymal stem cells (MSCs) [28].”
BackgroundHuman Placental Pericytes Poorly Stimulate and Actively Regulate Allogeneic CD4 T Cell Responses
Maier, C. L., & Pober, J. S. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.217117 · Cited by 65
Human Perivascular Stem Cell-Based Bone Graft Substitute Induces Rat Spinal Fusion
Chung, C. G., James, A. W., Asatrian, G., Chang, L., Nguyen, A. T., Le, K., Bayani, G., Lee, R. E., Stoker, D., Pang, S., et al. (2014) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0027 · Cited by 65
“Consequently, two populations of cells were sorted according to their cell surface markers to constitute hPSC, distinct pericytes (CD34-, CD146+, CD45-), and adventitial cells (CD34+, CD146-, CD45-)[25,28,29].”
BackgroundMethodSelf-citationAdult adipose-derived stem cells and breast cancer: a controversial relationship
Bielli, A., Scioli, M. G., Gentile, P., Agostinelli, S., Tarquini, C., Cervelli, V., & Orlandi, A. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-345 · Cited by 65
“In fact, transmission electron microscopy of human breast adipose tissue showed the presence of cells featuring ASCs arranged around the endothelial cells of small vessels (Figure 1B), strongly supporting their perivascular origin (Traktuev et al. 2008; Crisan et al. 2008).”
BackgroundBlache, U., Metzger, S., Vallmajó-Martín, Q., Martín, I., Djonov, V., & Ehrbar, M. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500795 · Cited by 65
Carstens, M. H., Gómez, A., Cortés, R., Turner, E., Pérez, C., Ocon, M., & Correa, D. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.12.001 · Cited by 65
Takayama, K., Kawakami, Y., Mifune, Y., Matsumoto, T., Tang, Y., Cummins, J. H., Greco, N., Kuroda, R., Kurosaka, M., Wang, B., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.03.036 · Cited by 71
Self-citationLalu, M. M., Montroy, J. R., Dowlatshahi, D. D., Hutton, B., Juneau, P., Wesch, N. L., Zhang, S. Y., McGinn, R. N., Corbett, D., Stewart, D. J., et al. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00736-5 · Cited by 64
Preneoplastic stromal cells promote BRCA1-mediated breast tumorigenesis
Nee, K., Ma, D., Nguyen, Q., Pein, M., Pervolarakis, N., Insua‐Rodríguez, J., Gong, Y., Hernandez, G. A., Alshetaiwi, H. S., Williams, J., et al. (2023) · Nature Genetics · doi:10.1038/s41588-023-01298-x · Cited by 64
Desiderio, V., Francesco, F. D., Schiraldi, C., Rosa, A. D., Gatta, A. L., Paino, F., d’Aquino, R., Ferraro, G. A., Tirino, V., & Papaccio, G. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24336 · Cited by 64
Hutton, D. L., Moore, E., Gimble, J. M., & Grayson, W. L. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0752 · Cited by 67
Body Management: Mesenchymal Stem Cells Control the Internal Regenerator
Caplan, A. I., & HARIRI, R. J. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0291 · Cited by 64
Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells
Mirshekar-Syahkal, B., Haak, E., Kimber, G. M., van Leusden, K., Harvey, K., O'Rourke, J., Laborda, J., Bauer, S. R., Bruijn, M. F. T. R. D., Ferguson‐Smith, A. C., et al. (2012) · Haematologica · doi:10.3324/haematol.2012.070789 · Cited by 64
“Mesenchymal stem/stromal cells have been shown to be crucial components of the HSC niche in adult bone marrow, where they are thought to reside in a perivascular location.(32,33) Cells with mesenchymal stem/stromal cell potential have also been identified in the AGM at the time of HSC emergence.”
BackgroundFroelich, K., Mickler, J., Steußloff, G., Technau, A., Tirado, M. R., Scherzed, A., Hackenberg, S., Radeloff, A., Hagen, R., & Kleinsasser, N. H. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2012.12.009 · Cited by 64
“Because the freshly isolated SVF consists of multiple cell types (20), especially an initially high amount of endothelial and mesenchymal progenitors (48,56,57), the SVF may be sufficient to be used immediately for cellular therapies (39,59).”
Background
Metadata
- Authors
- Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P.-N., Traas, J., Schugar, R., Deasy, B. M., Badylak, S., Bűhring, H.-J., Giacobino, J.-P., Lazzari, L., Huard, J., & Péault, B.
- Affiliations
- University of Pittsburgh (US)
- Centre National de la Recherche Scientifique (FR)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- McGowan Institute for Regenerative Medicine (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Péault, Bruno
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 3
- Pages
- 301-313
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2076491580
- Cited by
- 3,991
- References
- 47
- Citations by year
- 2026: 77 · 2025: 92 · 2024: 130 · 2023: 175 · 2022: 173 · 2021: 247 · 2020: 240 · 2019: 247 · 2018: 271 · 2017: 259 · 2016: 291 · 2015: 296 · 2014: 281 · 2013: 305 · 2012: 301
- FWCI
- 91.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Medical Center, University of Pittsburgh
- National Heart, Lung, and Blood Institute (R21HL083057)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049684, R01 AR49684-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, perivascular cells, pericytes, stem cell origin, CD146, NG2, osteogenic differentiation, chondrogenic differentiation, adipogenesis, chemotaxis, skeletal muscle, pancreas, adipose tissue, placenta, adult stem cells, vascular wall
- MeSH terms
- Adolescent, Adult, Aged, Cell Movement, Fetus, Flow Cytometry, Humans, Middle Aged, Pericytes, Muscle Development, Fetal Stem Cells, Adult Stem Cells, Mesenchymal Stem Cells
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