The nervous system orchestrates and integrates craniofacial development: a review
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Development of a head is a dazzlingly complex process: a number of distinct cellular sources including cranial ecto- and endoderm, mesoderm and neural crest contribute to facial and other structures. In the head, an extremely fine-tuned developmental coordination of CNS, peripheral neural components, sensory organs and a musculo-skeletal apparatus occurs, which provides protection and functional integration. The face can to a large extent be considered as an assembly of sensory systems encased and functionally fused with appendages represented by jaws. Here we review how the developing brain, neurogenic placodes and peripheral nerves influence the morphogenesis of surrounding tissues as a part of various general integrative processes in the head. The mechanisms of this impact, as we understand it now, span from the targeted release of the morphogens necessary for shaping to providing a niche for cellular sources required in later development. In this review we also discuss the most recent findings and ideas related to how peripheral nerves and nerve-associated cells contribute to craniofacial development, including teeth, during the post- neural crest period and potentially in regeneration.
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The spectrum of functions performed by nervous systems is broader than communication and information exchange between the central nervous system, the rest of the body and the environment.
“However, the spectrum of functions performed by nervous systems is much broader.”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [114]
Non-canonical functions of nervous systems may include roles in regeneration, development of innervated tissues, tissue homeostasis, and bidirectional communication with the commensal microbiota.
“Non-canonical functions may include a role in regeneration, development of innervated tissues, and tissue homeostasis [113,114] as well as bidirectional communication with the commensal microbiota [115–120].”
From Back to the Basics: Cnidarians Start to Fire (2017) · cites this paper as [114]
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- Authors
- Adameyko, I., & Fried, K.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Adameyko, Igor
- Fried, Kaj
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2016-02-19
- Volume
- 7
- Pages
- 49-49
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC4759458
- OpenAlex
- W2274993389
- Cited by
- 69
- References
- 187
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 5 · 2023: 14 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 10 · 2018: 6 · 2017: 3 · 2016: 3
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Swedish Research Council
- Karolinska Institutet
- Bertil Hållstens Forskningsstiftelse
- Åke Wiberg Stiftelse
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Craniofacial Disorders and Treatments
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- craniofacial development, nervous system, peripheral nerves, neural crest, morphogens, head morphogenesis, jaw development, neural crest-derived cells, tissue regeneration
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