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A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs
Open accessAbstract
Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, principally pericytes, in multiple human organs including skeletal muscle, pancreas, adipose tissue, and placenta, on CD146, NG2, and PDGF-Rbeta expression and absence of hematopoietic, endothelial, and myogenic cell markers. Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. Irrespective of their tissue origin, long-term cultured perivascular cells retained myogenicity; exhibited at the clonal level osteogenic, chondrogenic, and adipogenic potentials; expressed MSC markers; and migrated in a culture model of chemotaxis. Expression of MSC markers was also detected at the surface of native, noncultured perivascular cells. Thus, blood vessel walls harbor a reserve of progenitor cells that may be integral to the origin of the elusive MSCs and other related adult stem cells.
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“MSCs can function as perivascular-like support cells, physically associating with endothelial networks and promoting their architecture through direct contact mechanisms (Au et al., 2008; Crisan et al., 2008).”
From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Crisan et al., 2008
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Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
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“Another hypothesis is that pericytes and mesenchymal stromal cells (MSCs) with multipotent regeneration capacity arise from the same pool of cells (73).”
BackgroundPericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik, A., Genové, G., & Betsholtz, C. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.07.001 · Cited by 2,653
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BackgroundBone Tissue Engineering: Recent Advances and Challenges
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“Intriguingly, cells carrying the same surface marks can be isolated from various tissues, including pancreas, adipose, and placenta and differentiate into skeletal muscle cells when cultured in vitro, irrespective of their origins (118).”
Background
Metadata
- Authors
- Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., Norotte, C., Teng, P.-N., Traas, J., Schugar, R., Deasy, B. M., Badylak, S., Bűhring, H.-J., Giacobino, J.-P., Lazzari, L., Huard, J., & Péault, B.
- Affiliations
- University of Pittsburgh (US)
- Centre National de la Recherche Scientifique (FR)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- McGowan Institute for Regenerative Medicine (US)
- Children's Hospital of Philadelphia (US)
- Corresponding author
- Péault, Bruno
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2008-09
- Volume
- 3
- Issue
- 3
- Pages
- 301-313
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2076491580
- Cited by
- 3,991
- References
- 47
- Citations by year
- 2026: 77 · 2025: 92 · 2024: 130 · 2023: 175 · 2022: 173 · 2021: 247 · 2020: 240 · 2019: 247 · 2018: 271 · 2017: 259 · 2016: 291 · 2015: 296 · 2014: 281 · 2013: 305 · 2012: 301
- FWCI
- 91.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1816 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Medical Center, University of Pittsburgh
- National Heart, Lung, and Blood Institute (R21HL083057)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR049684, R01 AR49684-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- mesenchymal stem cells, perivascular cells, pericytes, stem cell origin, CD146, NG2, osteogenic differentiation, chondrogenic differentiation, adipogenesis, chemotaxis, skeletal muscle, pancreas, adipose tissue, placenta, adult stem cells, vascular wall
- MeSH terms
- Adolescent, Adult, Aged, Cell Movement, Fetus, Flow Cytometry, Humans, Middle Aged, Pericytes, Muscle Development, Fetal Stem Cells, Adult Stem Cells, Mesenchymal Stem Cells
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