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Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice
Open accessAbstract
Summary Some of the most common causes of blindness involve the degeneration of photoreceptors in the neural retina; photoreceptor replacement therapy might restore some vision in these individuals. Embryonic stem (ES) cells could in principle provide a source of photoreceptors to repair the retina. We have previously shown that retinal progenitors can be efficiently derived from human ES cells. We now show that retinal cells derived from human ES cells will migrate into mouse retinas following intra-ocular injection, settle into the appropriate layers and express markers for differentiated cells, including both rod and cone photoreceptor cells. After transplantation of the cells into the subretinal space of adult Crx -/- mice (a model of Leber's Congenital Amaurosis), the hES cell derived retinal cells differentiate into functional photoreceptors and restore light responses to the animals. These results demonstrate that hES cells can, in principle, be used for photoreceptor replacement therapies.
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Cited by
Yamanaka, S. (2009) · Cell · doi:10.1016/j.cell.2009.03.034 · Cited by 659
Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait
Wright, A. F., Chakarova, C. F., Abd El-Aziz, M. M., & Bhattacharya, S. S. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2717 · Cited by 631
Modeling early retinal development with human embryonic and induced pluripotent stem cells
Meyer, J. S., Shearer, R. L., Capowski, E. E., Wright, L. S., Wallace, K. A., McMillan, E. L., Zhang, S.-C., & Gamm, D. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905245106 · Cited by 601
Functional architecture of the retina: Development and disease
Hoon, M., Okawa, H., Della Santina, L., & Wong, R. O. L. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.003 · Cited by 585
Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina
Swaroop, A., Kim, D., & Forrest, D. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2880 · Cited by 560
Metadata
- Authors
- Lamba, D. A., Gust, J., & Reh, T. A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 4
- Issue
- 1
- Pages
- 73-79
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2153411657
- Cited by
- 603
- References
- 0
- FWCI
- 20.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lamba, D. A., Gust, J., & Reh, T. A. (2009). Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice. Cell Stem Cell. https://doi.org/10.1016/j.stem.2008.10.015
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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